Clinical trials: Fluid and Electrolyte Imbalance
Hydration, Fluid Retention
Hydration Dynamics and Influence of Beverage Composition
The study examines interactions between fluid availability in the gut and fluid retention in the body. The relative rate of fluid uptake, the expansion of the plasma volume, and percent of fluid retained by the body will be…
- Conditions
- Hydration, Fluid Retention, Dehydration
- Trial name
- NCT05111392
- Testing
- Oral Rehydration Solution 1, Oral Rehydration Solution 2
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
SIAD - Syndrome of Inappropriate Antidiuresis
Urea for Treatment of Hyponatremia in Patients With SIAD Unresponsive to Fluid Restriction
Hyponatremia due to SIAD is frequently insufficiently corrected by fluid restriction alone, which remains the first-line therapy but is often poorly tolerated. Urea supplementation is recommended as second-line therapy.
- Trial name
- UREA-BIVA (NCT07528365)
- Testing
- urea
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Turin, Italy
Hyponatremia, Hyponatremia With Extracellular Fluid Depletion
Hypotonic Hyponatremia: Criteria for the Correct Classification of Its Etiology and of Patient Volume Status
Hyponatremia is the most frequent electrolyte disorder encountered in clinical practice. The patient approach, however, is still problematic, above all because hyponatremia is a manifestation correlated to various pathological…
- Conditions
- Hyponatremia, Hyponatremia With Extracellular Fluid Depletion, Hyponatremia With Normal Extracellular Fluid Volume, Hyponatremia With Excess Extracellular Fluid Volume
- Trial name
- NCT04402190
- Where
- Italy
- Volunteers
- 123 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Hyponatremia With Normal Extracellular Fluid Volume
Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Oral Lixivaptan Capsules in Subject With Euvolemic Hyponatremia
The present study is designed to confirm and extend the observation from previous studies that lixivaptan therapy corrects hyponatremia, in euvolemic subject, including subjects with SIADH.
- Trial name
- NCT00660959
- Testing
- lixivaptan
- Where
- 71 sites in United States, Belgium and 4 more
- Volunteers
- 106 people
- Sponsor
- CardioKine Inc.
Hypotension, Anomaly; Venous Return
Perioperative Fluid Management in Morbidly Obese Patients
In bariatric surgery functional and feasible non- or mini-invasive modalities for monitoring, and ideal/lean body weight estimates are addressed to meet up individual variability in hydration needs, and to avoid hyperhydration.
- Conditions
- Hypotension, Anomaly; Venous Return, Dehydration
- Trial name
- NCT01873183
- Testing
- Goal directed fluid therapy
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Umeå University
Dehydration, Rehydration
Clinical Trial to Evaluate the Effects of Two Novel Hydration Beverage Formulas on Rehydration in Healthy Adults
Dehydration lowers both physical and mental performance if it is severe enough. Performance declines are more pronounced in hot conditions or after prolonged strenuous activity such as exercise.
- Conditions
- Dehydration, Rehydration, Exercise Performance, Exercise Recovery
- Trial name
- NCT05428761
- Testing
- TP1, TP2
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Liquid I.V.
Obstructive Sleep Apnea, Overhydration
Effect of Renal Transplantation on Obstructive Sleep Apnea in End Stage Renal Disease Patients (SASinTx)
The purpose of this study is to investigate the effect of renal transplantation on fluid overload and its consequence on the severity of obstructive sleep apnea, in patients with end stage chronic kidney disease.
- Conditions
- Obstructive Sleep Apnea, Overhydration, End Stage Renal Disease, Renal Transplantation
- Trial name
- SASinTx (NCT02020642)
- Testing
- Renal transplantation
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Hyponatremia, Hypernatremia
Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial
Children who are undergoing surgery need intravenous fluids to prevent dehydration and maintain their electrolyte balance. The current standard of care in these children is to use a fluid which is low in sodium (hypotonic fluid).
- Trial name
- NCT00734214
- Testing
- 0.9% NaCl, 0.45%NaCl
- Where
- Canada
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Diabetes Type 2, Weight Gain
Effects of Insulin Detemir and NPH Insulin on Renal Handling of Sodium, Fluid Retention, and Weight in Type 2 Diabetic Patients
Hypothesis: Changing type 2 patients treatment from Insulin Insulatard to Insulin Detemir will increase their excretion of sodium in the urine and thereby decrease their extracellular volume and body weight.
- Trial name
- Le-Na (NCT00742976)
- Testing
- Insulin Detemir; Insulin Insulatard, Insulin Detemir, Insulin Insulatard
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Gastroenteritis, Dehydration
Study Investigating the Use of Intravenous Fluids With Dextrose for Dehydrated Children
Infants and young children often become infected with gastroenteritis leading to vomiting and diarrhea. This can lead to dehydration, one of the most common complaints in the Pediatric Emergency Department.
- Trial name
- NCT01343758
- Testing
- 5% dextrose in normal saline
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Hyponatremia
Maintenance Intravenous Fluids in Children
Hyponatraemia arises in between 20% and 45% of sick hospitalized children. An important reason for this high incidence could be use of hypotonic fluids in sick children for maintenance fluid therapy.
- Trial name
- NCT00621348
- Testing
- Isotonic fluid, Hypotonic fluid
- Where
- India
- Volunteers
- 167 people
- Sponsor
- All India Institute of Medical Sciences
Hyponatremia
Tolvaptan to Reduce Length of Stay in Hospitalized Patients With Cirrhosis and Hyponatremia
Hyponatremia is a condition in which there is a low sodium level in the blood. Individuals with cirrhosis may develop low blood sodium as a complication of their liver disease.
- Trial name
- NCT01890694
- Testing
- Tolvaptan, Hepatic Encephalopathy Assessment, Quality of Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- NYU Langone Health
Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion
Tolvaptan Versus Fluid Restriction in SIADH
Context. The relevance of hyponatremia has been acknowledged by guidelines from the United States of America (2013) and Europe (2014). However, treatment recommendations differ due to limited evidence. Objective.
- Conditions
- Hyponatremia, Syndrome of Inappropriate ADH (SIADH) Secretion, Pituitary
- Trial name
- NCT04119206
- Volunteers
- 334 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Dehydration, Electrolyte Imbalance
Buoy Electrolyte Study on Hydration Status of Active Men and Women
Buoy is an all-natural, organic, FDA compliant dietary electrolyte supplement that can be dissolved in 8-12oz water (or other liquid) and provide electrolytes in servings of 1/3 teaspoon.
- Conditions
- Dehydration, Electrolyte Imbalance, Electrolyte Depletion, Fluid and Electrolyte Imbalance
- Trial name
- NCT05768789
- Testing
- Buoy Electrolyte, Water only, Nuun Electrolyte
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Hyponatremia
0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Hospitalized Children
The primary objective of this study is to compare the mean serum sodium at 48 hours following the initiation of therapy with either 0.45% NaCl/dextrose 5% or 0.9% NaCl/dextrose 5%, in children requiring maintenance IV fluid…
- Trial name
- NCT00632775
- Testing
- Hypotonic (0.45% NaCl/5% dextrose) IV maintenance fluids, Isotonic (0.9% NaCl/5% dextrose) IV maintenance fluids
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- The Hospital for Sick Children
Anesthesia, Thirst; Due to Deprivation of Water
Benefits of Drinking Clear Fluids Until Called to the Operating Room in Adult Surgical Patients
The purpose of this study is to show if - compared to standard practice - allowing adults undergoing surgical procedures under anaesthesia care to drink clear fluids up to a volume of 200 ml between 2 h prior to the operation and…
- Conditions
- Anesthesia, Thirst; Due to Deprivation of Water, Aspiration
- Trial name
- HYDRATE (NCT06253052)
- Testing
- Additional pre-OP-visit, Liberal fasting regime
- Where
- Germany
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Stroke, Dehydration
BUN/Cr-based Hydration Therapy to Improve Outcomes for Dehydrated Patients With Acute Ischemic Stroke.
The investigators' preliminary findings suggest that providing patients with acute ischemic stroke hydration therapy on the basis of their presenting BUN/Cr ratio may help reduce the occurrence of stroke-in-evolution(SIE) and…
- Trial name
- HYDO (NCT02099383)
- Testing
- normal saline
- Where
- Taiwan
- Volunteers
- 244 people
- Sponsor
- Chang Gung Memorial Hospital
Hyperkalaemia Requiring Postoperative Dialysis, Metabolic Acidosis
Perioperative Fluid Management in Patients Receiving Cadaveric Renal Transplants
In this study we want to show that the choice of a balanced type fluid solution for the perioperative fluid management of patients receiving cadaveric renal transplantation results in less occurrence of intra- and postoperative…
- Trial name
- NCT01075750
- Where
- Austria
- Volunteers
- 150 people
- Sponsor
- Medical University of Vienna
Hyponatremia
THE BALANCE Study: Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation
The purpose of this study is to determine the safety and efficacy of lixivaptan in the treatment of hyponatremia in patients with congestive heart failure.
- Trial name
- NCT00578695
- Testing
- lixivaptan
- Where
- 287 sites in United States, Argentina and 13 more
- Volunteers
- 652 people
- Sponsor
- CardioKine Inc.
Fluid Retention, Sodium Retention
The Effect of AMP Human Sodium Bicarbonate Lotion on Dehydrated Heat Stress
The primary purpose of the proposed study is to evaluate the effects of a topical sodium bicarbonate lotion (PR Lotion, AMP Human, Park City, UT) on measures of hydration status and fluid balance in humans when exposed to the…
- Conditions
- Fluid Retention, Sodium Retention, Heat Stress, Dehydration (Physiology)
- Trial name
- AMP2 (NCT05092854)
- Testing
- PR Lotion - AMP Human Performance, AminoVital - Rapid Recovery
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Connecticut