Clinical trials: Fluid-therapy
Lung Cancer
Cerebrospinal Fluid Levels of Erlotinib in Patients Receiving Erlotinib For Stage III Non-Small Cell Lung Cancer
RATIONALE: Determining whether erlotinib passes into the cerebrospinal fluid may help in planning treatment for some types of cancer.
- Trial name
- NCT00305617
- Testing
- antitumor drug screening assay
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Cleveland Clinic
Fluid Overload, Congestion
Determinants of Portal Vein Pulsatility Index
The pulsatile pattern of the portal vein is considered a marker of right ventricular dysfunction, but volemia may also contribute to this phenomenon.
- Trial name
- NCT06582368
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Surgery, Hypovolemic Shock
Kinetics of the Sublingual Microcirculation During Fluid Bolus
Fluid therapy is one of the cornerstones of the treatment of organ failure. The investigators assume that fluid bolus will increase the delivery of oxygen to the cells and resolve the shock.
- Trial name
- NCT02675725
- Testing
- Measurement of sublingual microcirculation with Cytocam-IDF camera
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Frisius Medisch Centrum
Cardiac Surgical Procedures, Retained Blood Syndrome
CPPF After General Cardiac Surgery
In two randomized clinical trials the investigators have demonstrated that continuous postoperative pericardial flushing (CPPF) therapy can reduce postoperative blood loss and bleeding-related complications after cardiac surgery…
- Conditions
- Cardiac Surgical Procedures, Retained Blood Syndrome, Cardiac Tamponade, Postoperative Hemorrhage
- Trial name
- FLUID (NCT05308589)
- Testing
- CPPF
- Where
- 4 sites in Netherlands
- Volunteers
- 164 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Liver Tumor
Evaluation of the Safety and Effectiveness of Pringle Method Combined With IVC Flow Limiting and Blocking Method in Laparoscopic Hepatectomy Based on Non-restrictive Fluid Therapy Strategy
The relevant data of 220 patients undergoing laparoscopic hepatectomy in our hospital were collected. Based on randomization, blindness and inclusion and exclusion criteria, the patients were divided into group A (which included…
- Trial name
- NCT06594289
- Testing
- In laparoscopic hepatectomy, the subhepatic inferior vena cava was restricted and the patient was given non-restricted intraoperative fluid intake
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Wounds and Injuries
Processed Amniotic Fluid (pAF) for the Treatment of Chronic Wounds
A prospective randomized controlled study to determine the safety and feasibility of using processed amniotic fluid (pAF) to expedite healing in chronic wounds.
- Trial name
- NCT04438174
- Testing
- Processed Amniotic Fluid, Standard of Care Wound Treatment Regimen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Utah
Gastric Cancer
Liquid Biopsy in Monitoring the Therapeutic Efficacy of Targeted Therapy in Advanced/Metastatic Gastric Cancer
To evaluate the clinical significance of cell free DNA (cfDNA) and circulating tumor cells (CTCs) in real-time monitoring the therapeutic response during HER2-targeted therapy in histologically confirmed HER2 positive…
- Trial name
- NCT02610218
- Testing
- CTC and cfDNA analysis
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Peking University
Hypotension Drug-Induced
Comparison of Different Protocols of Fluid Therapy in Severe Preeclamptic Patients Under Spinal Anesthesia
To compare the effect of two different protocol of fluid therapy in sever preeclamptic patients under spinal anesthesia : Hemodynamic and kidney function .
- Trial name
- NCT03478618
- Testing
- Lactated Ringer
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pulpitis, Healthy
Measurement of Pro-resolving Inflammation Biomarkers in Saliva, Gingival Fluid, and Dental Pulp in Patients With Symptomatic Pulpitis and Healthy Controls
This observational study aims to better understand inflammation inside the dental pulp (the inner tissue of the tooth) in patients with symptomatic pulpitis compared with healthy individuals.
- Trial name
- SMART-PULP (NCT07450235)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Université de Nantes
Heart Failure, Congestive Heart Failure
PROSPECT: Predictors of Response to Cardiac Re-Synchronization Therapy
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes.
- Conditions
- Heart Failure, Congestive Heart Failure, Cardiomyopathy
- Trial name
- NCT00253357
- Where
- 28 sites in United States, Austria and 11 more
- Volunteers
- 450 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Septic Shock
Fluid Resuscitation for Suspected Sepsis in Paediatric Emergency Departments
With 25.2 million children affected and 3.4 million deaths in 2017, paediatric sepsis is the leading cause of under-five mortality worldwide and has recently been described as "significant global health threat" by the World…
- Trial name
- FRESSPED (NCT05066464)
- Testing
- Fluid Resuscitation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aggressive Periodontitis
Non Surgical Periodontal Treatment Effect on Il-17 and Il-18 in Aggressive Periodontitis
clinical parameters and IL-17 and Il-18 GCF levels were measured in 25 aggressive periodontitis patients compared to 25 periodontally healthy individuals.
- Trial name
- NCT05297084
- Testing
- non surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Colon Cancer, Parenteral Nutrition
Peripheral Parenteral Nutrition vs Conventional Fluid in Colorectal Resection in ERAS
Assess if administration of early nutrition support with Perioperative Peripheral Nutrition (PeriOliclimonel) N4-E) in patients undergoing colon cancer resection in an Enhanced Recovery After Surgery (ERAS) Protocol improve the…
- Conditions
- Colon Cancer, Parenteral Nutrition, Fast-track
- Trial name
- NCT03606863
- Testing
- Perioperative peripheral parenteral nutrition
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Antonio Arroyo Sebastian
Intracranial Hypertension
CSF Biomarkers in Idiopathic Intracranial Hypertension
Aim of the study is to high lighten the rule of CSF biomarkers in early diagnosis of IIH and in follow up to reach to a definite clinically based decision if this patient will improved on medical treatment or that patient is in…
- Trial name
- NCT05647837
- Testing
- lumper puncture
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Advanced Colorectal Cancer
FOLICOLOR TRIAL: Following Therapy Response Through Liquid Biopsy in Metatstatic Colorectal Cancer Patients
The FOLICOLOR trial aims to evaluate whether a liquid biopsy-guided follow-up strategy can improve outcomes in patients with unresectable, metastatic colorectal cancer (mCRC) receiving first-line systemic treatment.
- Trial name
- FOLICOLOR (NCT07558083)
- Testing
- Evaluation therapy through Liquid Biopsy
- Where
- 9 sites in Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Antwerp
Malaria, Sepsis
Optimal Fluid Management in Adult Severe Malaria
Optimal fluid therapy in severe falciparum malaria has not been well defined, especially in resource poor settings where access to mechanical ventilation is limited.
- Trial name
- DRIPICCO (NCT01936766)
- Where
- Bangladesh
- Volunteers
- 156 people
- Sponsor
- University of Oxford
Hydrocephalus
A Study Comparing Two Treatments for Infants With Hydrocephalus
The purpose of this study is to study whether infants with triventricular hydrocephalus (TVH) have a better long-term outcome at 5 years when they are treated with a new procedure, endoscopic third ventriculostomy (ETV), than…
- Trial name
- NCT00652470
- Testing
- Endoscopic Third Ventriculostomy, CSF Shunt Insertion
- Where
- 22 sites in United States, Argentina and 14 more
- Volunteers
- 182 people
- Sponsor
- The Hospital for Sick Children
Stroke, Dehydration
BUN/Cr-based Hydration Therapy to Improve Outcomes for Dehydrated Patients With Acute Ischemic Stroke.
The investigators' preliminary findings suggest that providing patients with acute ischemic stroke hydration therapy on the basis of their presenting BUN/Cr ratio may help reduce the occurrence of stroke-in-evolution(SIE) and…
- Trial name
- HYDO (NCT02099383)
- Testing
- normal saline
- Where
- Taiwan
- Volunteers
- 244 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Dehydration
The Fluid Therapy Strategy of the Non-dehydrated Patients With Acute Ischemic Stroke.
The investigators previously found that a blood urea nitrogen/creatinine (BUN/Cr) ratio >15 is an independent predictor of early deterioration after acute ischemic stroke.
- Trial name
- NCT02668848
- Testing
- water
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Kidney Injury, Kidney Replacement
Proactive Prescription-based Fluid Management vs Usual Care in Critically Ill Patients on Kidney Replacement Therapy
A pilot randomized clinical trial comparing a protocol-based fluid management strategy to usual care in critically ill patients receiving kidney replacement therapy.
- Conditions
- Acute Kidney Injury, Kidney Replacement, Critical Illness
- Trial name
- Probe-Fluid (NCT05473143)
- Testing
- Protocol-based fluid management, Usual care
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)