Clinical trials: Fluorescence
Glioma
IRDye800CW-BBN PET-NIRF Imaging Guiding Surgery in Patients With Lower Grade Glioma
This is an open-label positron emission tomography/near infrared (PET/NIRF) study to investigate the imaging navigation performance and evaluation efficacy of dual modality imaging probe 68Ga-BBN-IRDye800CW in patients with lower…
- Trial name
- NCT03407781
- Testing
- 68Ga-BBN-IRDye800CW
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Deling Li
Other Lesions of Oral Mucosa
The Investigation of a Fluorescence/Elastic Scattering Spectroscopy (F-ESS) Device for Oral Tissue Characterization
The overall objective of this work is to identify changes in the optical properties of oral tissues to develop a non-invasive tool for the detection, diagnosis and screening of oral pathology so that treatment can be provided at…
- Trial name
- NCT00764569
- Testing
- Fluorescence/Elastic Scattering Spectroscopy
- Where
- 2 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Rheumatoid Arthritis
NIR Fluorescence Imaging of Lymphatic Transport Using ICG
In this phase 1 study, the lymphatic transport will be examined using Near InfraRed Indocyanine Green fluorescence imaging (NIR-ICG) of the upper extremities in healthy individuals using a MultiSpectral Imaging System (MSImager).
- Trial name
- NIR-ICG (NCT02680067)
- Testing
- Indocyanine Green, MultiSpectral Imaging System
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Pregnancy
Prenatal Testing: Amniocentesis Versus Transabdominal Chorionic Villus Sampling (TA CVS)
Prenatal diagnosis can provide information to parents about specific fetal disorders. However, invasive prenatal diagnostic procedures are associated with risks to the fetus.
- Trial name
- NCT00065897
- Testing
- Amniocentesis, Transabdominal chorionic villus sampling (TA CVS)
- Volunteers
- 6,400 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
UTUC, UC (Urothelial Cancer)
Screening for Urological Malignancies Using a Urine Exfoliated Cell Fluorescence Assay in a Hematuria Population
This is a prospective, single-center diagnostic clinical study designed to evaluate the performance of a urine-based immunofluorescence cytology test for the detection of urological malignancies in patients presenting with…
- Trial name
- NCT07813260
- Where
- China
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Rectal Cancer, Sigmoid Cancer
A Study of Perfusion of Colorectal Anastomosis Using FLuorescence AnGiography (FLAG-trial)
This is a randomized, controlled, parallel study to determine the difference in post-operative anastomotic leak rate of colorectal anastomosis where colon and rectal tissue perfusion is evaluated using fluorescence angiography…
- Trial name
- FLAG (NCT03390517)
- Testing
- Fluorescence angiography with indocianyne green
- Where
- Russia
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Urethra Injury, Rectal Cancer
Validation of ICG to Identify the Urethra During Rectal Surgery
This is an open-label feasibility study utilising direct instillation of ICG into the urethra during surgery for low rectal cancers. The trial involves a single intervention taking place during the patient's operation.
- Conditions
- Urethra Injury, Rectal Cancer, Surgery
- Trial name
- NCT03204201
- Testing
- Indocyanine Green Solution
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Small Bowel Obstruction
REsectability Small Bowel Obstruction LAParoscopic (RESBOLAP) Score. Multicentric Data Registry
AIM OF THE STUDY The aim of the study is to develop a Resectability Laparoscopic Score as a helpful instrument during intraoperative decision-making in the setting of emergency laparoscopic surgery for small bowel obstruction…
- Trial name
- RESBOLAP (NCT05842135)
- Testing
- Laparoscopic approach to small bowel obstrcuction
- Where
- Italy
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- San Salvatore Hospital, AST Pesaro-Urbino
Surgical Procedure, Unspecified
Safety and Feasibility of ActivSight(tm) in the Identification of The Ureter Via Riboflavin Fluorescence
The main Objective of this study is to determine the safety and feasibility of a prototype ActivSightTM in identifying the ureter in real-time during elective laparoscopic abdominopelvic surgery after pre-surgical administration…
- Trial name
- NCT06535555
- Testing
- Investigational Safety and Feasibility
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Activ Surgical
Normal Skin
TMFI Enhances Skin Surface and Epidermal PpIX Fluorescence
This study investigates a relatively new device TMFI and incubation of ALA in a cream-vehicle and a gel-vehicle.
- Trial name
- NCT04221126
- Testing
- TMFI, ALA cream, ALA gel
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Merete Haedersdal
Non-Melanoma Skin Cancer (NMSC), Benign Skin Growth
Assessment of Skin Lesions Using a Tissue Oxygen Imager Based on Protoporphyrin IX (PPIX) Fluorescence. This is an Open-label, Non-randomized, Feasibility Study That Includes a One-time Application of an FDA Approved Medication Followed by Local Imaging for Benign Skin Growth and Lesions Clinically
The primary objective of this study is the evaluation of the efficacy of the tissue oxygen imager based on PpIX DF in differentiating benign skin growth from non-melanoma skin cancer (NMSC).
- Trial name
- PPIX (NCT07201376)
- Testing
- Ameluz 10% Topical Gel, Protoporphyrin IX
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Rheumatoid Arthritis
Near InfraRed Fluorescence Using Indocyanine Green and Magnetic Resonance Lymphography of Lymphatic Transport
Lymphatic transport will be examined using Near InfraRed Indocyanine Green fluorescence imaging (NIR-ICG) and magnetic resonance lymphography (MRL) of the upper extremities.
- Trial name
- NIR-ICG MRL (NCT04046146)
- Testing
- Indocyanine Green, MultiSpectral Imaging System
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Plaque, Dental
Clinical Evaluation of an Electric and a Manual Toothbrush in Removal of Dental Plaque
The study aimed to evaluate the efficacy of manual and electric toothbrush on dental plaque removal by using various intraoral imaging systems.
- Trial name
- NCT05372848
- Testing
- Manual toothbrush, Electric toothbrush
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marmara University
Technical Capabilities of the Device
Retinal Metabolic Imaging in a Diverse Population
This research project aims to evaluate use in a clinical context of a novel imaging instrument, the Metabolic Hyperspectral retina Camera (MHRC) from Optina Diagnostics.
- Trial name
- NCT03442816
- Testing
- MHRC Camera
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Optina Diagnostics Inc.
Uterine Cervical Neoplasms, Uterine Neoplasms
Early Feasibility Study of the "Easy Light" Fluorecence Imaging System
This is an early feasibility study to evaluate the device functionality of an open-field handheld wireless fluorecence imaging system for detection of sentinel lymph nodes in women with cervical and uterine cancers who underwent…
- Trial name
- NCT05004623
- Testing
- Sentinel Lymph Node Biopsy
- Where
- Brazil
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Abdominal Skin Redundancy
Laser Fluorescent Imaging of Abdominal Skin During Abdominoplasty
Abdominoplasty is a common cosmetic operation. Some investigators believe that the risk of complications is reduced by limiting the operative dissection. However, this can compromise the quality of the result.
- Trial name
- NCT02196779
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Swanson Center
Hepatocellular Carcinoma
GPC3 Targeted Fluorescence Image Guided Surgery of Hepatocellular Carcinoma
This study is to evaluate whether intraoperative fluorescence imaging targeting GPC3 can aid improve the surgical accuracy of hepatocellular carcinoma.
- Trial name
- NCT05047510
- Testing
- Anti-GPC3-IRDye800CW
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Lung Cancer
Sputum Labeling Utilizing Synthetic Meso Tetra (4-Carboxyphenyl) Porphine (TCPP) for Detection of Lung Cancer
Primary Objective: To determine the clinical sensitivity and specificity of the Biomoda CyPath™ Early Lung Cancer Detection Assay using sputum specimens from two cohorts of participants and estimate the required sample size to…
- Trial name
- NCT00894127
- Testing
- CyPath
- Where
- 3 sites in United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Biomoda Inc.
Biliary Anatomy
A Pilot Dosing and Timing Study to Optimize Imaging When Utilizing Endoscopic Fluorescence Imaging System During Laparoscopic Biliary and Hepatic Operations
Operations on the liver, bile ducts, and gallbladders are some of the most commonly performed abdominal operations in the United States.
- Trial name
- NCT02070068
- Testing
- PINPOINT System
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cervical Cancer
Significance of Fluorescence Colposcopy With Autofluorescence Imaging for Cervical Cancer
Clinical Trial to access Significance of fluorescence colposcopy with autofluorescence imaging for the screening of cervical cancer
- Trial name
- NCT01854983
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center