Clinical trials: Fluorescence
Surgery, Fluorescence
ICG Indocyanine Green in Reconstructive Surgery
The success or failure of a reconstruction is largely related to the vascularization of the operated area. Near infrared fluorescence (also near infrared fluorescence angiography, NIR FA) with ICG administration is an innovative…
- Trial name
- ICG-R (NCT06129669)
- Testing
- Indocyanine green
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Chylothorax, Esophageal Cancer
FLOTOR Pilot Study
This is a non-randomised study assessing the technique of using indocyanine green as a fluorescent dye to highlight the thoracic duct during oesophectomy.
- Conditions
- Chylothorax, Esophageal Cancer, Thoracic Duct Intra-Operative Injury
- Trial name
- FLOTOR (NCT03292757)
- Testing
- Indocyanine Green
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Hepatic Failure, Liver Failure
Cardiox Liver Function Test Pivotal Trial
Performance evaluation of LFT Dye Monitor System using ICG - plasma disappearance rate value (PDR) to assess liver function in normal patients as well as in patients with mild to severe hepatic impairment compared to manual Serum…
- Trial name
- LFT-0002 (NCT02552901)
- Testing
- 0.1 mg/kg ICG Dose, 0.5 mg/kg ICG dose
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cardiox Corporation
To Investigate the Effect of 100% Oxygen Breathing on Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) in Healthy Subjects
The Effect of Hyperoxia and Hypoxia on Fluorescence Lifetime Imaging Ophthalmoscopy in Healthy Subjects- a Randomized, Double Blind, Crossover Study
The present study aims to investigate whether FLIO can also detect shorttime changes in retinal metabolism induced by hyperoxia and hypoxia.
- Trial name
- NCT04094285
- Testing
- SAUERSTOFF, STICKSTOFF
- Where
- Austria
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Univentricular Heart, Lymphatic Abnormalities
Lymphatic Function in Patients With a Fontan Circulation From Brazil
It is suggested that the elevated central venous pressure in patients with a Fontan circulation can provoke manifestation of lymphatic dysfunction, met as plastic bronchitis, peripheral oedema and most feared protein-losing…
- Conditions
- Univentricular Heart, Lymphatic Abnormalities, Lymphatic Edema
- Trial name
- NCT04394507
- Testing
- Near-Infrared Fluorescence imaging, Strain Gauge Plethysmography
- Where
- 2 sites in Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Dental Caries, Occlusal Caries
Polishing vs Hydrogen Peroxide: Effect on DIAGNOdent Readings in Stained Fissures
This study compared two methods of cleaning stained pits and grooves (fissures) on the chewing surfaces of back teeth before measuring them with a laser fluorescence device (DIAGNOdent), which is used to help detect early tooth…
- Trial name
- NCT07763470
- Testing
- Mechanical Polishing with Fluoride-Free Prophylaxis Paste, 35% Hydrogen Peroxide Application
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Özlem Erçin Sultanzade
Caries, Diagnoses Disease
Evaluation of Caries Detection Methods
The investigators aim will be to compare the diagnostic performance of clinical visual examination (ICDAS II), intraoral/bite wing radiography (BW), near infrared light transillumination (NIR-LT), and laser fluorescence (LF), in…
- Trial name
- NCT05064566
- Testing
- caries assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Nazan Kocak Topbas
Reconstructive Surgical Procedures
DIEP Flap Perfusion Evaluated by DIRT and ICG-FA.
Patients selected for DIEP breast reconstruction were examined with preoperative CTA, Doppler Ultrasound, dynamic infrared thermography (DIRT) and Indocyanin green fluorescent angiography (ICG-FA) for perforator mapping.
- Trial name
- NCT04115995
- Testing
- Dynamic infrared thermography (DIRT) and indocyanine green fluorescence angiography (ICG-FA)
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Dental Caries, Tooth Wear
DIMOH: New Digital Methods for Monitoring Oral Health. An in Vivo Assessment
The objectives of this study are i) to monitor the oral health of young people over a period of one year and ii) to assess the ability of a new intraoral scanner combining fluorescence with 3D imaging to detect and monitor…
- Trial name
- NCT04050306
- Where
- 2 sites in Denmark, Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Complication of Personal Oral Hygiene
The Use of Quantitative Light Induced Fluorescence Digital as an Oral Hygiene Evaluation Tool in Orthodontics
During orthodontic treatment bacterial plaque readily accumulates on the teeth. This is because food easily accumulates around the braces and it is more difficult to clean when the braces are in place.
- Trial name
- NCT02545660
- Testing
- QLF Image, White Light Image
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
White Spot Lesion
The Effect of Fluoride Varnish on White Spot Lesion in Clear Aligner Orthodontic Patients
Fluoride varnish is being applied on the teeth surfaces of patients undergoing orthodontic treatment just before receiving their clear aligners.
- Trial name
- NCT06403371
- Testing
- Fluoride varnsh, Normal saline
- Where
- Jordan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
White Spot Lesion
Clinical Evaluation of White Spot Lesions Treated by S-PRG and ICON
Randomized with (1:1) prospective, double-blind, controlled trial. Subjects will be randomized to receive S-PRG and the control group receives ICON.
- Trial name
- NCT05550116
- Testing
- Giomer, Two composite resin sealants
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Respiratory Tract Diseases
Safety and Accuracy of Alveoscopy in Interstitial Lung Diseases
Fibered confocal fluorescence microscopy (FCFM), also referred to as Cell-Vizio® (MaunaKea Technologies, France) is a new technique that produces microscopic imaging in a living tissue, through a 1 mm fiberoptic miniprobe that…
- Trial name
- ALVEOLE (NCT00377338)
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Mild Cognitive Impairment, Alzheimer's Disease
Aftobetin-HCl and Fluorescence Detection Measured by Sapphire II to Determine the Number and Timing of Administrations
This is an open-label study to evaluate Aftobetin-HCl and florescence detection as measured by the Sapphire II device. Performance of Part I of the study has been completed (15 subjects received a single administration of…
- Trial name
- NCT02928211
- Testing
- Sapphire II, Aftobetin-HCl, Positron Emission Tomography
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Cognoptix, Inc.
Autofluorescence Imaging, Neuroimaging
Measurement of Retinal Auto Fluorescence With a Fluorescence Lifetime Imaging Ophthalmoscope
Fluorescent lifetime microscopy has emerged as a useful tool to study fluorescent lifetimes in vitro. Fluorescence lifetime represents the average amount of time a fluorophore remains in the excited state following excitation and…
- Trial name
- FLIO-Group (NCT01981148)
- Testing
- Fluorescence lifetime ophthalmoscope
- Where
- Switzerland
- Volunteers
- 892 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Tongue Coating, Oral Biofilm
Comparison of Three Tongue Cleaners for Removing Tongue Coating
This randomised three-period crossover study compared the effectiveness of three tongue-cleaning devices - a bristled tongue brush, a plastic tongue scraper and a metal tongue scraper - in removing tongue biofilm.
- Conditions
- Tongue Coating, Oral Biofilm, Oral Hygiene, Dental Plaque
- Trial name
- NCT07767721
- Testing
- Bristled tongue brush, Plastic tongue scraper, Metal tongue scraper
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Kent University
Breast Neoplasms, Breast Cancer
Surgical Outcome of BCS Using ICG-F in Breast Cancer Patients After Preoperative Chemotherapy
Neoadjuvant chemotherapy for advanced breast cancer has led to an increased rate of breast-conserving surgery (BCS) in these patients.
- Trial name
- NCT06780735
- Testing
- The margin-positive rate using the localization technique
- Where
- South Korea
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Dental Caries (Diagnosis), Dental Plaque
Clinical Assessment of Caries and Dental Plaque Based on Auto-fluorescence Imaging System
The purpose of this study was to evaluate the applicability of auto-fluorescence imaging system to detect and quantify caries and dental plaque.
- Conditions
- Dental Caries (Diagnosis), Dental Plaque, Optical Imaging
- Trial name
- NCT03038412
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hui Chen
White Spot Lesion of Tooth
Effect of Bioactive Resin Material Containing S-PRG Filler on White Spot Lesions
the effect of bioactive resin composite containing S-PRG filler will be tested as the material of choice for attachments bonded on teeth prior to the use of orthodontic clear aligners compared to the conventionally used flowable…
- Trial name
- NCT07715942
- Testing
- Bioactive resin composite containing S-PRG filler, Conventional flowable composite is used for the attachments for the clear orthodontic aligners
- Where
- Jordan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Fissure Sealant
Clinical Efficacy of Different Fissure Sealant Materials in the Newly Erupted Non-Carious First Permanent Molars
The aim of this study is to compare the clinical retention rates, marginal adaptation, marginal discoloration and secondary caries formation of two different types of resin-modified glass ionomers (Fuji® II LC; Clinpro™ XT…
- Trial name
- NCT04854720
- Testing
- Fuji® II LC CAPSULE, Clinpro™ XT Varnish, Beautifil Flow
- Where
- Turkey (Türkiye)
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University