Clinical trials: Fluorescence Imaging
Pancreatic Neoplasms, Pancreatic Cancer
Indocyanine Green-Guided Versus Standard Laparoscopic Distal Pancreatectomy for Pancreatic Body and Tail Lesions
Postoperative pancreatic fistula is the most important complication after laparoscopic distal pancreatectomy for tumors of the body and tail of the pancreas. It can cause infection, bleeding, longer hospital stay, and even death.
- Trial name
- ICG-LDP (NCT07656571)
- Testing
- ICG Fluorescence-Guided Laparoscopic Distal Pancreatectomy, Standard Laparoscopic Distal Pancreatectomy
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Alexandria University
Pediatric Central Nervous System Tumor
Study of Tozuleristide and the Canvas Imaging System in Pediatric Subjects With CNS Tumors Undergoing Surgery
Many types of cancer are primarily treated with surgery and patient survival is directly related to the extent to which the tumor is able to be removed.
- Trial name
- NCT03579602
- Testing
- tozuleristide, Canvas System
- Where
- 9 sites in United States
- Volunteers
- 118 people
- Sponsor
- Blaze Bioscience Inc.
Glioma
Enhanced Detection in Glioma Excision
The purpose of this study is to determine whether use of an ultra-high sensitivity camera with enhanced imaging technology can be used during surgery to detect areas of brain tissue affected by diffuse glioma, a type of brain…
- Trial name
- EDGE (NCT04556929)
- Testing
- Intra-operative imaging of 5-ALA fluorescence using ultra-high sensitivity camera, Intra-operative imaging of 5-ALA fluorescence using in-built operative microscope camera, Biopsies
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- University of Oxford
Prostate Cancer Patients Undergoing Radical Prostatectomy
PSMA-Targeted Intraoperative Fluorescent Imaging Agents (DGPR1008): Validation Across Different Time Windows
a Phase II, single-arm, open-label, multi-center study to evaluate safety, tolerability, pharmacokinetics, and the effectiveness of near-infrared fluorescence imaging during surgery.
- Trial name
- DGPR1008-04 (NCT07387510)
- Testing
- 12 h before RP, 24 h before RP, 36 h before RP
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Haitao Niu, MD
Pancreas Adenocarcinoma, Cholangiocarcinoma
FLUOPANC-trial - Fluorescence-guided Surgery of Pancreatic and Bileduct Tumors Using cRGD-ZW800-1
Pancreas as well as Cholangiocarcinoma have a dismal prognosis at time of diagnosis, due to late onset of clinical symptoms, patients present with advance disease.
- Trial name
- FLUOPANC (NCT05518071)
- Testing
- CRGD-ZW800-1, Intraoperative near-infrared fluorescence imaging
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Leiden University Medical Center
Prostate Cancer
ICG-based Fluorescence Imaging in Localization of Prostate Cancer and Metastatic Lymph Nodes
This study aims to evaluate the feasibility of indocyanine green (ICG)-based fluorescence imaging in the detection of prostate tumors and metastatic lymph nodes.
- Trial name
- NCT02840617
- Testing
- Indocyanine Green (ICG)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Skin Lesion
Non-invasive Melanoma Assessment Using a Topical Fluorescence Reagent and Optical Imaging
The use of MDS to access the presence of melanoma in the skin.
- Trial name
- NCT02193581
- Testing
- MDS
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Orlucent, Inc
NMIBC
Trop2-Targeted Near-Infrared Fluorescence Imaging-Guided Precise Resection of Non-Muscle Invasive Bladder Cancer
Research Objective Taking Trop2, a specific target of bladder urothelial carcinoma, as the research basis, this study adopts a Trop2-targeted near-infrared (NIR) fluorescent probe combined with an intravesical rapid incubation…
- Trial name
- NCT07800507
- Testing
- TTP-ICG NIR fluorescent diagnostic agent
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yunnan Cancer Hospital
Head and Neck Squamous Cell Carcinoma
Indocyanine Green With Near Infrared Imaging for Intraoperative Visualization of Head and Neck Squamous Cell Carcinoma
This observational study will examine how closely first-window indocyanine green (ICG) fluorescence corresponds to the extent of head and neck squamous cell carcinoma identified by tissue biopsy.
- Trial name
- NCT07825597
- Testing
- Indocyanine green, Near-infrared fluorescence imaging
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Uterine Cervical Neoplasms, Uterine Neoplasms
Early Feasibility Study of the "Easy Light" Fluorecence Imaging System
This is an early feasibility study to evaluate the device functionality of an open-field handheld wireless fluorecence imaging system for detection of sentinel lymph nodes in women with cervical and uterine cancers who underwent…
- Trial name
- NCT05004623
- Testing
- Sentinel Lymph Node Biopsy
- Where
- Brazil
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Hepatobiliary Surgery
Fluorescence Imaging in Hepatobiliary Surgery
A current gap in the use indocyanine green fluorescence to isolate the biliary system is the dosing amount necessary to fluoresce the biliary system without "over" fluorescing the liver and gallbladder.
- Trial name
- NCT03946761
- Testing
- Cancer goggle system
- Sponsor
- Washington University School of Medicine
Prostate Cancer (Diagnosis), ACP3
68Ga-XMFH01 PET/Fluorescence Imaging in Prostate Cancer
This study aims to evaluate the feasibility, safety, and diagnostic performance of 68Ga-XMFH01, a novel ACP3-targeted dual-modality PET and fluorescence imaging probe, for preoperative PET/CT imaging and intraoperative…
- Conditions
- Prostate Cancer (Diagnosis), ACP3, PET / CT
- Trial name
- NCT07885423
- Testing
- 68Ga-XMFH01 PET/CT
- Where
- China
- Volunteers
- 25 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Fat Necrosis
Indocyanine Green for Perfusion Assessment of DIEP Flaps
Currently during DIEP flap reconstruction, the perfusion of the flap is assessed by the clinical view of the surgeon. Identification of demarcated ischemic zones of the DIEP flap could be optimized by using fluorescence imaging…
- Trial name
- FAFI (NCT05507710)
- Testing
- Near-infrared fluorescence imaging of perfusion
- Where
- 2 sites in Netherlands
- Volunteers
- 280 people
- Sponsor
- Leiden University Medical Center
Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma
Two-photon Fluorescence Microscopy of Dermatologic Biopsies
The goal of this study is to investigate the ability of two-photon fluorescence microscopy to evaluate dermatologic biopsies. The main questions it aims to answer are: How well do two-photon fluorescence images of biopsies taken…
- Conditions
- Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma, Melanocytic Lesion, Adult
- Trial name
- NCT07773688
- Testing
- Two photon microscopy imaging
- Where
- United States
- Volunteers
- 644 people
- Sponsor
- University of Rochester
Cholecystitis
SPY Fluorescence Imaging Systems and Indocyanine Green to Determine the Percentage of Successful Critical Anatomy Recognition in Laparoscopic Cholecystectomy Surgeries.
This is a prospective single arm, single center study estimating percentage of successful critical anatomy recognition in laparoscopic cholecystectomy surgeries using SPY fluorescence imaging and ICG, with each surgery also…
- Trial name
- NCT05006950
- Testing
- Stryker1688 Fluorescence imaging system
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stryker Endoscopy
Acute Cholecystitis, Biliary Complications
Acute Cholecystitis Biliary Complications - ICG
Acute cholecystitis is a common indication for emergency laparoscopic cholecystectomy. Inflammatory changes and distorted anatomy may increase the risk of biliary complications, including bile duct injury and bile leak, which are…
- Trial name
- ICG-ACBC (NCT07481760)
- Testing
- ICG
- Where
- Spain
- Volunteers
- 296 people
- Sponsor
- Hospital del Mar
Gastric Cancer
Identification of Complete Lymph Node Removal by Application of Near Infrared Fluorescence Imaging in Laparoscopic and Robotic Gastrectomy
Lymph node dissection in gastric cancer surgery is a very important factor not only for exact acquisition of stage but also proper treatment.
- Trial name
- NCT01926743
- Testing
- Near infrared fluorescence imaging during laparoscopic or robotic gastrectomy
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Endometrial Cancer, Sentinel Lymph Node Detection
Indocyanine Green and Near-infrared Fluorescence Imaging to Detect Sentinel Lymph Nodes in Patients With Endometrial Cancer
Patients with endometrial cancer who have planned robotic laparoscopic hysterectomy and full bilateral pelvic and para-aortic lymphadenectomy will receive injections of a fluorescent dye, Indocyanine green (ICG).
- Trial name
- NCT02131558
- Testing
- ICG Dye
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Lahey Clinic
Non-Small Cell Lung Cancer, PET/CT
FAP-targeted PET/NIR in Lung Malignant Tumors
Single center, prospective, diagnostic study. Patients with stage II-IIIB resectable NSCLC diagnosed by pathology were included.
- Conditions
- Non-Small Cell Lung Cancer, PET/CT, Neoadjuvant Therapy
- Trial name
- NCT07498933
- Testing
- PET/CT scans
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
To Investigate the Effect of 100% Oxygen Breathing on Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) in Healthy Subjects
The Effect of Hyperoxia and Hypoxia on Fluorescence Lifetime Imaging Ophthalmoscopy in Healthy Subjects- a Randomized, Double Blind, Crossover Study
The present study aims to investigate whether FLIO can also detect shorttime changes in retinal metabolism induced by hyperoxia and hypoxia.
- Trial name
- NCT04094285
- Testing
- SAUERSTOFF, STICKSTOFF
- Where
- Austria
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna