Clinical trials: Fluorescence Imaging
Prostate Cancer Patients Undergoing Radical Prostatectomy, Prostate CA
Research on PSMA-Targeted Intraoperative Fluorescent Imaging Agents
Phase I: Primary Research Objective: Evaluate the safety, tolerability, and pharmacokinetic characteristics of a single dose of DGPR1008 in healthy subjects.
- Trial name
- DGPR1008 (NCT07101354)
- Testing
- 0.01mg/kg DGPR1008 Injection Dose Group 1 (n=6), 0.02mg/kg DGPR1008 Injection Dose Group 2 (n=6), 0.04mg/kg DGPR1008 Injection Dose Group 3 (n=6)
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Haitao Niu, MD
Coronary Artery Disease, Aortic Valve Disease
Deploying Novel Imaging Modalities Towards a Three-dimensional (3D) CARDIOvascular PATHology
The goal of the 3D-CARDIOPATH study is to investigate the potential added value of emerging 3D imaging modalities by imaging ex vivo cardiac specimens (diseased coronary arteries, calcific aortic valves, and thrombotic materials)…
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Aortic Valve Calcification, STEMI
- Trial name
- 3D-CARDIOPATH (NCT05975567)
- Testing
- Three-dimensional imaging of the collected cardiac specimens
- Volunteers
- 70 people
- Sponsor
- Aristotle University Of Thessaloniki
Endometrial Cancer, Near Infrared Fluorescence Imaging
CYTALUX for Intraoperative Imaging of Patients With Endometrial Cancer
The research study is being done to assess the safety and ability of an investigational drug called CYTALUX (pafolacianine) and a special camera system for the detection of cancer in patients undergoing surgical resection for…
- Conditions
- Endometrial Cancer, Near Infrared Fluorescence Imaging, CYTALUX (Pafolacianine) Injection, Planned Diagnostic Laparoscopies
- Trial name
- CYTALUX ISS (NCT07278986)
- Testing
- CYTALUX™ (pafolacianine), 1788 4K Camera System with Advanced Imaging Modality
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Breast Neoplasm, Lymphedema
Effectiveness of Fluoroscopy-guided MLD for Treatment of BCRL
The main scientific objective of this multicentric double-blinded randomised controlled trial entails examining the effectiveness of fluoroscopy-guided MLD versus traditional MLD versus placebo MLD, applied as part of the…
- Trial name
- EFforT-BCRL (NCT02609724)
- Testing
- Information, Skin care, Compression therapy
- Where
- 3 sites in Belgium
- Volunteers
- 194 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer
VEGF-targeted Fluorescent Tracer Imaging in Breast Cancer
The purpose of this study is to determine the uptake, (semi-)quantification and localization of the VEGF targeting fluorescent tracer bevacizumab-IDRye800CW in breast cancer tissue, surrounding healthy tissue, tumor margins and…
- Trial name
- NCT01508572
- Testing
- bevacizumab-IRDye800CW
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Head and Neck Cancer
NIR Fluorescence Imaging During Neck Dissection in Head and Neck Cancer Patients After iv Injection of ICG
The purpose of this study is to determine if NIR fluorescent imaging is an effective approach to detect the margins of head and neck tumours or lymph nodes draining the tumour
- Trial name
- NCT02027831
- Testing
- Indocyanine Green
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Jules Bordet Institute
Colorectal Cancer
Early Detection of Polyps and Colon Cancer by Fluorescence Imaging - a Dose-finding Study
Patients referred for colon inspection (colonoscopy) due to suspicion of colon polyps/cancer will receive local administration of hexaminolevulinate (HAL) prior to colon inspection.
- Trial name
- NCT00285701
- Testing
- hexaminolevulinate
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Photocure
Lung Cancer, Esophageal Cancer
NIR Fluorescence Imaging Technique in Thoracic Surgery With ICG
This study aims to first apply near-infrared fluorescence imaging technology in thoracic surgery with indocyanine green in China.
- Trial name
- NCT02611245
- Testing
- Indocyanine green
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Chinese Academy of Sciences
Lung Cancer
A Study to Evaluate Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Lung Malignancies
This Phase 2 study is an open-label, single-arm trial where each patient is his/her own "intrapatient" control. All patients will receive a single dose of pegsitacianine prior to standard of care surgery.
- Trial name
- NCT05048082
- Testing
- pegsitacianine, Tumor resection surgery
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- OncoNano Medicine, Inc.
Erythroplakia, Fanconi Anemia
Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for Developing Oral Cancer
This clinical trial studies widefield fluorescence and reflectance imaging, fluorescence spectroscopy, and tissue samples in regularly examining (monitoring) participants at risk for developing oral cancer.
- Conditions
- Erythroplakia, Fanconi Anemia, Lichen Planus, Oral Cavity and Lip Precancerous Condition
- Trial name
- NCT00542373
- Testing
- Cytology Specimen Collection Procedure, Diagnostic Microscopy, Diagnostic Procedure
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- M.D. Anderson Cancer Center
Torsion Testis, Scrotum Disease
Is ICG Imaging Safe and Accurate to Predict Testicular Torsion?
Testicular torsion is a time critical condition for children and young people (CYP). It is difficult to diagnose without an operation. Missing it means the child will lose a testicle.
- Trial name
- NCT07545278
- Testing
- Indocyanine green fluorescence injection and near infra red spectroscopy image capture
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sheffield Children's NHS Foundation Trust
Oesophageal Cancer
Laser Speckle Contrast Imaging, Surgical Eye & ICG Fluorescence Imaging for Perfusion Assessment of the Gastric Conduit
Rationale Globally, esophageal cancer is the seventh most common cancer type, with over half a million cases reported in 2020. The survival of gastroesophageal cancer is poor and the prognosis is primarily determined by the…
- Trial name
- CONDOR-I (NCT05685862)
- Testing
- Laser Speckle Contrast Imaging using the PerfusiX-Imaging device
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Frisius Medisch Centrum
Malignant Brain Tumors, Glioma
Fluorescence-Guided Imaging of Brain Tumors: A Safety Study Using SBK2-ICG
Participants in this research study are people who are likely to have, or have been diagnosed with a brain tumor, for which surgical removal (or "resection") is the standard of care treatment.
- Trial name
- NCT07438860
- Testing
- SBK2-ICG, Craniotomy (Standard of Care)
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Tiffany Hodges
Non Small Cell Lung Cancer (NSCLC)
Efficacy and Safety of a Single Dose of LS301-IT for Fluorescence Intraoperative Molecular Imaging (IMI) for Patients Undergoing Lung Cancer Resection for Non Small Cell Lung Cancer
The aim of this Phase 2 study is to investigate the efficacy and safety of a single dose of LS301-IT, a novel fluorescence imaging agent developed by Integro Theranostics (IT), administered by intravenous (IV) infusion in…
- Trial name
- NCT07276789
- Testing
- LS301-IT 0.1 mg/kg
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Integro Theranostics
Fat Necrosis
Indocyanine Green for Perfusion Assessment of DIEP Flaps
Currently during DIEP flap reconstruction, the perfusion of the flap is assessed by the clinical view of the surgeon. Identification of demarcated ischemic zones of the DIEP flap could be optimized by using fluorescence imaging…
- Trial name
- FAFI (NCT05507710)
- Testing
- Near-infrared fluorescence imaging of perfusion
- Where
- 2 sites in Netherlands
- Volunteers
- 280 people
- Sponsor
- Leiden University Medical Center
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Cellular-Level Fluorescence Imaging for Intraoperative Margin Assessment in Breast Cancer
Accurate intraoperative margin assessment in breast cancer surgery remains challenging. Current reliance on frozen section pathology is limited by prolonged processing time, sampling constraints, and resource intensity…
- Trial name
- FLASH (NCT07311317)
- Where
- 3 sites in China
- Volunteers
- 165 people
- Sponsor
- West China Hospital
Wound
Evaluation of MolecuLight i:X as an Adjunctive Fluorescence Imaging Tool to Clinical Signs and Symptoms for the Identification of Bacteria-containing Wounds
This is a non-randomized evaluation for which 160 adult patients will be imaged at outpatient wound care clinics who present with a wound of unknown infection diagnostic status and are receiving standard treatment.
- Trial name
- NCT03540004
- Testing
- MolecuLight i:X Imaging Device
- Where
- 14 sites in United States
- Volunteers
- 367 people
- Sponsor
- MolecuLight Inc.
Trauma Injury
ICG Fluorescence Imaging in Post-traumatic Infection
The focus of this prospective observational study is to (1) establish the range and variation associated with bone/soft tissue perfusion in fracture patients, using ICG fluorescence imaging; (2) examine the relationship between…
- Trial name
- NCT04403204
- Testing
- Immunofluorescence Imaging, DCE-MRI
- Where
- 4 sites in United States
- Volunteers
- 104 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Head and Neck Neoplasms
Sentinel Lymph Node Mapping of Oral Cancer Using Near-Infrared Fluorescence Imaging
Cervical lymph node involvement, in head and cancer neck patients, is one of the most important prognostic factors. Currently patients undergo neck dissection removing some or all nodes and neck involvement is retrospectively…
- Trial name
- SLN Mapping (NCT02478138)
- Testing
- Sentinel lymph node mapping, Indocyanine Green (ICG), near-infrared fluorescence (NIR) imaging (Pinpoint, Novadaq, Waterloo)
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University Health Network, Toronto
Neck Pain, Back Pain
Near-infrared Fluorescence Lymphatic Imaging Assessment of Lymphatic Response to Pneumatic Back/Neck Lymphatic Drainage Delivered by a Pneumatic Manual Lymphatic Drainage Device
The purpose of this study is to objectively assess lymphatic function before, during, and immediately after Neuroglide treatment in lower trunk and leg lymphatic vessels, torso, axillary regions, inguinal regions, upper…
- Trial name
- NCT05946837
- Testing
- Indocyanine green (ICG) dye, NIRF-LI imaging, Neuroglide pad
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center, Houston