Clinical trials: Fluorescence Imaging
Head and Neck Cancer
NIR Fluorescence Imaging During Neck Dissection in Head and Neck Cancer Patients After iv Injection of ICG
The purpose of this study is to determine if NIR fluorescent imaging is an effective approach to detect the margins of head and neck tumours or lymph nodes draining the tumour
- Trial name
- NCT02027831
- Testing
- Indocyanine Green
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Jules Bordet Institute
Adults, Open-field Surgery
Study of LGW16-03 To Identify Nerves
The primary goal of this study is to determine the safety and tolerability of LGW16-03, a novel nerve-labeling fluorophore, in participants undergoing open-field orthopaedic surgery.
- Conditions
- Adults, Open-field Surgery, Major Nerve
- Trial name
- NCT07385430
- Testing
- LGW16-03
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Eric R. Henderson
Leakage, Anastomotic, Colon Cancer
COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green
COLOFLOW is a prospective observational study investigating whether Laser Speckle Contrast Imaging (LSCI), a dye-free and objective perfusion imaging technique, corresponds with the currently used subjective assessment of…
- Conditions
- Leakage, Anastomotic, Colon Cancer, Colon Anastomosis, Colon and Rectal Cancer
- Trial name
- COLOFLOW (NCT07720505)
- Testing
- Laser Speckle Contrast Imaging
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Lung Cancer, Esophageal Cancer
NIR Fluorescence Imaging Technique in Thoracic Surgery With ICG
This study aims to first apply near-infrared fluorescence imaging technology in thoracic surgery with indocyanine green in China.
- Trial name
- NCT02611245
- Testing
- Indocyanine green
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Chinese Academy of Sciences
Breast Cancer, Sentinel Lymph Node Biopsy (SLNB)
Implementation of Indocyanine Green to Identify Sentinel Lymph Nodes During Surgery for Breast Cancer
The goal of this clinical trial is to learn how to successfully introduce a new method for finding the sentinel lymph node during breast cancer surgery into routine hospital care.
- Conditions
- Breast Cancer, Sentinel Lymph Node Biopsy (SLNB), Sentinel Lymph Node Detection, Sentinel Lymph Node
- Trial name
- INFINITE (NCT07146295)
- Testing
- Technetium (99mTc), Indocyanine Green, Sentinel lymph node biopsy
- Where
- 7 sites in Netherlands
- Volunteers
- 1,760 people
- Sponsor
- Isabelle Henskens
Breast Cancer, Sentinel Lymph Node Biopsy (SLNB)
Finding Sentinel Lymph Nodes During Mastectomy Using Indocyanine Green (INIGMA Study)
This pilot study evaluates the diagnostic value of indocyanine green (ICG) fluorescence for sentinel lymph node biopsy (SLNB) performed through the mastectomy incision in breast cancer patients.
- Conditions
- Breast Cancer, Sentinel Lymph Node Biopsy (SLNB), Sentinel Lymph Node Detection, Sentinel Lymph Node
- Trial name
- INIGMA (NCT07362485)
- Testing
- Indocyanine green (ICG)-fluorescence guided sentinel lymph node biopsy
- Where
- 2 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Isabelle Henskens
Anastomotic Leak
The Impact of Indocyanine Green-enhanced Fluorescence Imaging on Bowel Transection in Left-sided Colorectal Resection
The aim of this study was to evaluate the impact of fluorescence imaging on the location of colorectal transection lines based on evaluation of perfusion with indocyanine green, how it's going to affect surgical planning and its…
- Trial name
- NCT02669485
- Testing
- indocyanine green, Fluorescence imaging
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The University of Hong Kong
Lung Cancer
A Study to Evaluate Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Lung Malignancies
This Phase 2 study is an open-label, single-arm trial where each patient is his/her own "intrapatient" control. All patients will receive a single dose of pegsitacianine prior to standard of care surgery.
- Trial name
- NCT05048082
- Testing
- pegsitacianine, Tumor resection surgery
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- OncoNano Medicine, Inc.
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Cellular-Level Fluorescence Imaging for Intraoperative Margin Assessment in Breast Cancer
Accurate intraoperative margin assessment in breast cancer surgery remains challenging. Current reliance on frozen section pathology is limited by prolonged processing time, sampling constraints, and resource intensity…
- Trial name
- FLASH (NCT07311317)
- Where
- 3 sites in China
- Volunteers
- 165 people
- Sponsor
- West China Hospital
Stage III Non-small Cell Lung Cancer, Unresectable Stage III NSCLC
In Vivo Fluorescence Molecular Bronchoscopy of Durvalumab-680LT in Patients With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) After Chemoradiotherapy
PulmoPrint is a clinical study at the University Medical Center Groningen (UMCG) that investigates why some patients with unresectable stage III lung cancer don't respond to immunotherapy after chemoradiotherapy.
- Trial name
- PulmoPrint (NCT07653438)
- Testing
- Fluorescence molecular imaging during bronchoscopy with durvalumab-680LT
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Head and Neck Cancer, Lung Cancer
Fluorescent Light Bronchoscopy Plus White Light Bronchoscopy for Early Detection of Lung Cancer
RATIONALE: Fluorescent bronchoscopy, when used in combination with conventional white light bronchoscopy, may improve the ability to detect early lung cancer.
- Trial name
- NCT00019201
- Testing
- cytology specimen collection procedure, immunohistochemistry staining method, sputum cytology
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Lymphedema of Face, Head and Neck Cancer
Assessing Impact of Early Physiotherapy on Lymphatic Dysfunction in Head and Neck Cancer Survivorship
The goal of this clinical trial is to learn if treating the lymphatics in head and neck cancer survivors before clinical diagnosis of lymphedema will prevent its development or progression.
- Trial name
- NCT05937269
- Testing
- Near-infrared fluorescence lymphatic imaging, advanced pneumatic compression therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The University of Texas Health Science Center, Houston
Wounds
Positive Predictive Value of the MolecuLight i:X Imaging Device to Predict the Presence of Bacteria in Chronic Wounds
This is a non-randomized evaluation for which 50 patients will be imaged at the Southwest Regional Wound Care Center, Lubbock, Texas, who present with a chronic wound and are receiving standard treatment.
- Trial name
- NCT02682069
- Testing
- MolecuLight i:X Imaging Device
- Volunteers
- 30 people
- Sponsor
- MolecuLight Inc.
Neck Pain, Back Pain
Near-infrared Fluorescence Lymphatic Imaging Assessment of Lymphatic Response to Pneumatic Back/Neck Lymphatic Drainage Delivered by a Pneumatic Manual Lymphatic Drainage Device
The purpose of this study is to objectively assess lymphatic function before, during, and immediately after Neuroglide treatment in lower trunk and leg lymphatic vessels, torso, axillary regions, inguinal regions, upper…
- Trial name
- NCT05946837
- Testing
- Indocyanine green (ICG) dye, NIRF-LI imaging, Neuroglide pad
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center, Houston
Breast Cancer
Intraoperative Imaging of Lymph Nodes
One-third of the global population battles cancer, with surgery being the primary treatment for localized forms. Successful treatment often hinges on the thorough removal of primary tumors and pinpointing cancerous sentinel lymph…
- Trial name
- NCT06276439
- Testing
- Surgical removal of breast cancer and lymph nodes
- Where
- North Macedonia
- Volunteers
- 48 people
- Sponsor
- University of Illinois at Urbana-Champaign
Squamous Cell Carcinoma, Pharyngocutaneous Fistula
Use of SPY Imaging System to Minimize Fistulas After Hypopharyngeal Reconstruction
Investigators performing this research want to look at the use of a special imaging process during a specific throat surgery. Using this imaging may help to lower a common complication that called a pharyngocutaneous fistula…
- Trial name
- NCT06831149
- Testing
- Removal of pharyngeal mucosa with decreased perfusion will be performed, SPY-PHI, ICG (Indocyanine Green)
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Matthew Spector
Perfusion, Traumatic Injury
Near-Infrared Imaging for Perfusion Assessment of Traumatic Soft Tissue and Skeletal Injuries
To date, intraoperative assessment of tissue and bone viability is predominantly subjective, depending on the clinical view of the surgeon, resulting in a variation in the thoroughness of debridement.
- Conditions
- Perfusion, Traumatic Injury, Fluorescence Imaging
- Trial name
- IMPACT (NCT06034834)
- Testing
- Near-infrared fluorescence imaging of perfusion
- Where
- 2 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Leiden University Medical Center
Squamous Cell Carcinoma of the Oral Cavity, Oropharynx
Ex Vivo Multimodal Imaging of Upper Aerodigestive Epithelium
The purpose of this research study is to collect information on whether images made using investigational microscopes can improve researchers' ability to evaluate and distinguish between normal and abnormal areas in tissue…
- Conditions
- Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, Larynx, Hypopharynx
- Trial name
- NCT01321892
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Autofluorescence Imaging, Neuroimaging
Measurement of Retinal Auto Fluorescence With a Fluorescence Lifetime Imaging Ophthalmoscope
Fluorescent lifetime microscopy has emerged as a useful tool to study fluorescent lifetimes in vitro. Fluorescence lifetime represents the average amount of time a fluorophore remains in the excited state following excitation and…
- Trial name
- FLIO-Group (NCT01981148)
- Testing
- Fluorescence lifetime ophthalmoscope
- Where
- Switzerland
- Volunteers
- 892 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Non-Melanoma Skin Cancer (NMSC), Benign Skin Growth
Assessment of Skin Lesions Using a Tissue Oxygen Imager Based on Protoporphyrin IX (PPIX) Fluorescence. This is an Open-label, Non-randomized, Feasibility Study That Includes a One-time Application of an FDA Approved Medication Followed by Local Imaging for Benign Skin Growth and Lesions Clinically
The primary objective of this study is the evaluation of the efficacy of the tissue oxygen imager based on PpIX DF in differentiating benign skin growth from non-melanoma skin cancer (NMSC).
- Trial name
- PPIX (NCT07201376)
- Testing
- Ameluz 10% Topical Gel, Protoporphyrin IX
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center