Clinical trials: Fluorescence Imaging
IVF/ICSI, Frozen Embryo Transfer
Cumulus Cell Mitochondrial Activity as a Non-invasive Marker of Embryo Quality (FLIM)
This study aims to test the extent of association of FLIM parameters of cumulus cells with clinical outcomes (clinical pregnancy, ongoing pregnancy at 12 weeks, and live birth) of the embryos that result from the enclosed oocytes.
- Conditions
- IVF/ICSI, Frozen Embryo Transfer, Cumulus Cell, Fluorescence Lifetime Imaging Microscopy
- Trial name
- NCT05332769
- Testing
- FLIM parameters
- Where
- Vietnam
- Volunteers
- 200 people
- Sponsor
- Mỹ Đức Hospital
Cervical Cancer
Cervical Cancer Screening Study in Brazil
Objectives: Primary Objective: To perform a pilot clinical study to test multi-modal optical imaging for detection of cervical neoplasia in Brazil.
- Trial name
- NCT02335372
- Testing
- Wide-Field White Light Imaging, Acetic Acid, Proflavine Solution
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Adenomatous Polyposis Coli
Molecular Fluorescence Endoscopy in Patients With Familial Adenomatous Polyposis, Using Bevacizumab-IRDye800CW
There is a need for better visualization of polyps during surveillance endoscopy in patients with hereditary colon cancer syndromes like Familial Adenomatous Polyposis (FAP) and Lynch Syndrome (LS), to improve the adenoma…
- Trial name
- FLUOFAP (NCT02113202)
- Testing
- Bevacizumab-IRDye800CW, Near infrared fluorescence endoscopy platform
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- University Medical Center Groningen
Trauma Injury
ICG Fluorescence Imaging in Post-traumatic Infection
The focus of this prospective observational study is to (1) establish the range and variation associated with bone/soft tissue perfusion in fracture patients, using ICG fluorescence imaging; (2) examine the relationship between…
- Trial name
- NCT04403204
- Testing
- Immunofluorescence Imaging, DCE-MRI
- Where
- 4 sites in United States
- Volunteers
- 104 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Respiratory Tract Diseases
Safety and Accuracy of Alveoscopy in Interstitial Lung Diseases
Fibered confocal fluorescence microscopy (FCFM), also referred to as Cell-Vizio® (MaunaKea Technologies, France) is a new technique that produces microscopic imaging in a living tissue, through a 1 mm fiberoptic miniprobe that…
- Trial name
- ALVEOLE (NCT00377338)
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Neurosurgery, Neuro-Oncology
Intraoperative Hyperspectral Imaging for Fluorescence Guided Surgery in Low Grade Gliomas
The purpose of this study is to obtain images of brain tumours during surgery using a new type of surgical camera. The study will assess how the information obtained from the images during surgery matches the removed tissue.
- Conditions
- Neurosurgery, Neuro-Oncology, Brain Tumor
- Trial name
- Neuro-qFHSI (NCT05397574)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College London
Gynecologic Cancers, Ovarian Cancer
Near-Infrared Fluorescence Imaging With Indocyanine Green to Evaluate Bowel Anastomoses in Gynecologic Oncology Surgery
The goal of this study is to evaluate if indocyanine green (ICG) fluorescence imaging helps reduce complications in bowel surgery performed during gynecologic cancer operations.
- Conditions
- Gynecologic Cancers, Ovarian Cancer, Endometrial Cancers, Cervical Cancers
- Trial name
- INOCA (NCT06871787)
- Testing
- Indocyanine Green, Near-Infrared Fluorescence Imaging System
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Dental Caries, Tooth Wear
DIMOH: New Digital Methods for Monitoring Oral Health. An in Vivo Assessment
The objectives of this study are i) to monitor the oral health of young people over a period of one year and ii) to assess the ability of a new intraoral scanner combining fluorescence with 3D imaging to detect and monitor…
- Trial name
- NCT04050306
- Where
- 2 sites in Denmark, Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Wound
Evaluation of MolecuLight i:X as an Adjunctive Fluorescence Imaging Tool to Clinical Signs and Symptoms for the Identification of Bacteria-containing Wounds
This is a non-randomized evaluation for which 160 adult patients will be imaged at outpatient wound care clinics who present with a wound of unknown infection diagnostic status and are receiving standard treatment.
- Trial name
- NCT03540004
- Testing
- MolecuLight i:X Imaging Device
- Where
- 14 sites in United States
- Volunteers
- 367 people
- Sponsor
- MolecuLight Inc.
Breast Neoplasm, Lymphedema
Effectiveness of Fluoroscopy-guided MLD for Treatment of BCRL
The main scientific objective of this multicentric double-blinded randomised controlled trial entails examining the effectiveness of fluoroscopy-guided MLD versus traditional MLD versus placebo MLD, applied as part of the…
- Trial name
- EFforT-BCRL (NCT02609724)
- Testing
- Information, Skin care, Compression therapy
- Where
- 3 sites in Belgium
- Volunteers
- 194 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bone Neoplasms, Soft Tissue Neoplasms
Investigation Into the Safety and Efficacy of ICG-Labeled Fluorescence Imaging Technology in Guiding the Resection of Bone and Soft Tissue Tumors
Investigate the application protocol, feasibility, and efficacy of indocyanine green (ICG)-assisted near-infrared (NIR) fluorescence-guided resection in bone and soft tissue tumors.
- Trial name
- ICG-BST (NCT06979115)
- Testing
- Indocyanine green (ICG)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Guangdong Provincial People's Hospital
Breast Cancer
Fluorescence Guided Surgery in Breast Cancer
A need for further investigation for fluorescence image-guided surgery in breast conserving surgery (BCS) has arisen following the results obtained from a phase I feasibility breast cancer trial (BIRDYE study: ABR NL…
- Trial name
- MARGIN (NCT02583568)
- Testing
- Bevacizumab-800CW
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- University Medical Center Groningen
Atherosclerosis, Atherosclerotic Plaque
Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque
This will be a pilot study of 9 patients undergoing standard-of-care clinically indicated carotid endarterectomy. The nine patients will receive an injection of Indocyanine green (ICG) at a dose of 0.25 mg/kg (maximum 25 mg) as…
- Conditions
- Atherosclerosis, Atherosclerotic Plaque, Carotid Stenosis
- Trial name
- BRIGHT-CEA (NCT01873716)
- Testing
- Indocyanine green
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Trauma Injury
ICG Fluorescence Imaging in Open Fracture Trauma Patients
This is a prospective observational study that will evaluate the association between bone and tissue perfusion, as measured by indocyanine green (ICG) fluorescence imaging, and complications, in an effort to develop ICG…
- Trial name
- NCT04416412
- Testing
- Immunofluorescence Imaging
- Where
- 4 sites in United States
- Volunteers
- 124 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Neoplasm Female, Breast Cancer
Fluorescence Imaging of Carcinoma During Breast Conserving Surgery
Breast conserving surgery (BCS) is performed on patients with breast cancer to resect and completely remove the cancer while conserving as much of the surrounding healthy tissue as possible.
- Trial name
- NCT04815083
- Testing
- Aminolevulinic Acid Hydrochloride, Eagle V1.2 Imaging System
- Where
- 7 sites in United States
- Volunteers
- 57 people
- Sponsor
- SBI ALApharma Canada, Inc.
Head and Neck Cancer
A Microdose Evaluation Study of ABY-029 in Head and Neck Oncology Surgery
The primary study objective is to determine if microdoses of ABY-029 (up to 6X) lead to detectable signals (defined as signal-to-noise ratio, SNR ≥10, with wide-field iFI) in sampled tissues with an EGFR (epidermal growth factor…
- Trial name
- NCT03282461
- Testing
- ABY-029
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Neuroblastoma
An Imaging Study of Anti-GD2-800CW in Patients With Neuroblastoma
This is a non-randomized, open label phase Ib/II dose-escalation and expansion study designed to define the recommended dose of anti-GD2-800CW in pediatric neuroblastoma patients.
- Trial name
- GLOW-FISH (NCT07399821)
- Testing
- anti-GD2-800CW
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Dermatofibrosarcoma Protuberans (DFSP), Skin Squamous Cell Carcinoma
NIFR Image-guided Surgery for Malignant Soft Tissue Tumor With Low-dose SWIG Technique
This research study will evaluate how near-infrared fluorescence (NIRF) imaging with low-dose second window indocyanine green (ICG) can assist in the radical resection and pathologic diagnosis of malignant soft tissue sarcoma…
- Trial name
- NIFR;SWIG (NCT06610071)
- Testing
- ICG administration
- Volunteers
- 592 people
- Sponsor
- The Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Indocyanine Green (ICG), Robotic Surgical Procedure
Assessing the Efficacy of Indocyanine Green for Ureter Identification During Robot-Assisted Surgery in Advanced-Stage Endometriosis
The goal of this side-randomized, self-controlled trial, 1-site study is to explore the efficacy of Indocyanine Green Fluorescence (ICG) for Intraoperative Ureter Identification During Robot-Assisted Single-Site Surgery in…
- Conditions
- Indocyanine Green (ICG), Robotic Surgical Procedure, Deep Infiltrating Endometriosis (DIE), Endometriosis Pelvic
- Trial name
- NCT07144904
- Testing
- Indocyanine Green (ICG)-Assisted Ureteral Identification, Standard Ureteral Identification without ICG
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor College of Medicine
Colon Cancer
Sentinel Lymph Node Mapping and Analysis in Colon Cancer Using Indocyanine Green Dye
Approximately 20-30 % of colon cancer patients who have no metastasis in lymph nodes after definitive colectomy have recurrence with distant metastasis.
- Trial name
- NCT04351009
- Testing
- sentinel lymph node mapping
- Where
- India
- Volunteers
- 48 people
- Sponsor
- Asian Institute of Gastroenterology, India