Clinical trials: Fluoride
Dentin Sensitivity
A Clinical Study to Evaluate the Anti-Sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers
The aim of this study is to confirm the clinical Dentin Hypersensitivity (DH) efficacy of a 0.454 percent (%) Stannous Fluoride (SnF2) toothpaste.
- Trial name
- NCT06354270
- Testing
- Stannous fluoride toothpaste, Regular fluoride toothpaste (Crest Cavity Protection)
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- HALEON
Gingival Diseases
A Study to Measure the Effect of Two Fluoride Toothpastes on Gingival Health Over a Six Month Period
This study is a double-blind, randomised, parallel group efficacy study. A minimum of 240 healthy female and male participants aged over 18 years will participate. The participants will be randomised into two groups.
- Trial name
- NCT03027908
- Testing
- Fluoride Toothpaste 1, Fluoride Toothpaste 2
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Dentin Sensitivity
A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching
The aim of this study is to investigate the efficacy of a marketed dentifrice containing 5 percent (%) NovaMin (Calcium Sodium Phosphosilicate) to reduce tooth sensitivity during and post tooth bleaching compared to a marketed…
- Trial name
- NCT06608368
- Testing
- Test Dentifrice (Sensodyne Repair and Protect Original Mint), Positive Control Dentifrice (Sensodyne Fresh Mint), Reference Dentifrice (Crest Cavity Protection Regular)
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- HALEON
Partial Caries Removal
Clinical and Radiographic Evaluation of Deep Occlusal Carious Molars Treated With Partial Caries Removal With and Without Using Silver Diamine Fluoride (SDF) Prior to Resin Composite Restoration.
The aim of the study is to evaluate the effect of SDF in maintaining pulp health after partial caries removal in permanent teeth with deep occlusal carious lesion clinically and radiographically
- Trial name
- NCT04561934
- Testing
- Silver diamine fluoride, resin modified glassionomer cement
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesion, Orthodontic Treatment
Comparison of Three Toothpastes for the Prevention and Reduction of White Spot Lesions
The purpose of the study is to determine if Clinpro™ 5000, Clinpro™ Tooth Crème, or MI-Paste Plus has an effect on the formation and resolution of white spot lesions for patients undergoing orthodontic treatment.
- Conditions
- White Spot Lesion, Orthodontic Treatment, Decalcification; Teeth
- Trial name
- NCT03440996
- Testing
- Clinpro™ 5000, Clinpro™ Tooth Crème, MI-Paste Plus
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Molar Incisor Hypomineralization
Silver Diamine Fluoride Modified Restoration In Treating Hypomineralized First Permanent Molar.
A randomized clinical trial to compare silver modified glass ionomer restorations to non silver glass ionomer restorations in hypo-mineralized first permanent molars in children and to measure the amount of wear of restoration in…
- Trial name
- NCT05931822
- Testing
- Silver Diamine Fluoride 38%, fluoride varnish
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Caries
Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas
This study was a randomized clinical trial lasting for 24 months in two study sites, Hong Kong (water fluoridated) and Guangzhou (non-fluoridated area).
- Trial name
- NCT02742142
- Testing
- silver diammine fluoride
- Where
- 2 sites in China
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dental Caries
Enamel Caries in Orthodontic Patients
This randomized double-blind two arm controlled clinical trials evaluates the hypothesis that the regular use of a tooth paste containing microcrystalline hydroxylapatite provides a caries preventive effect in caries-susceptible…
- Trial name
- ECOP (NCT02705456)
- Testing
- Tooth Brushing HA, Tooth Brushing FL
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Carious Lesion
Clinical Evaluation of SDF Combined With KI Versus SDF in Management of Class I Carious Lesions
To evaluate the clinical performance of High-Viscosity Glass Ionomer (EQUIA) versus Silver Diamine Fluoride combined with Potassium Iodide (Riva Star) and Sliver Diamine Fluoride (SDF) under High-Viscosity Glass Ionomer (EQUIA)…
- Trial name
- NCT05485272
- Testing
- Silver Diamine Fluoride combined with Potassium Iodide., Silver Diamine Fluoride., High-Viscosity Glass Ionomer.
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Effectiveness of Fluoride Varnish in Prevention of Dental Caries in School Children
Despite the availability of free health dental service in Sri Lanka, the prevalence and severity of dental caries among 6year old school children stand at a very high level according to the results of national oral health survey…
- Trial name
- NCT02877888
- Testing
- fluoride varnish 22600ppm
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Peradeniya
Prevention of Dental Caries
Comparative Analysis of Interventions for Prevention of Dental Caries in School Children
A study aims to assess the most effective preventive interventions to address the widespread issue of dental caries, affecting an estimated 2 billion people in permanent teeth and over 500 million children in primary teeth…
- Trial name
- NCT06602765
- Testing
- Tooth brushing, tooth paste containing 1450ppm fluoride
- Where
- Pakistan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bahria University
Dental Caries
Clinical Efficacy of Fluoride Toothpastes Using an In Situ Caries Model
The purpose of this study is to evaluate the effect of the test toothpaste containing 1150 parts per million (ppm) of fluoride (F) on the mineral content of demineralized enamel specimens, in an in situ caries model system, by…
- Trial name
- NCT02436473
- Testing
- Toothpaste containing 1150ppm F, Toothpaste containing 0ppm F, Toothpaste containing 250ppm F
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Hypersensitivity
Silver and Fluoride Salivary Levels After the Application of Silver Fluoride
The aim of the study is to measure salivary fluoride and silver levels up to 7 days post-treatment. The participants will be 6 healthy adults.
- Trial name
- NCT01860391
- Testing
- Diammine Silver Fluoride
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Universidad Peruana Cayetano Heredia
Dental Caries on Smooth Surface Limited to Enamel, Tooth Demineralization
Resin Infiltration and Fluoride Varnish Lesion Arresting Efficacy on Non-cavitated Proximal Lesion
Protection of dental hard tissues is one of the most important points of cariology. For this purpose, oral hygiene training (effective brushing and motivation), non-invasive approaches such as flouride varnish applications and…
- Conditions
- Dental Caries on Smooth Surface Limited to Enamel, Tooth Demineralization, Dental Caries, Dentistry, Operative
- Trial name
- NCT05202665
- Testing
- ICON DMG Resin Infiltration (micro-invasive approach), ClinproTM White Varnish, 3M ESPE Fluoride Varnish (non-invasive approach)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ege University
Dental Caries in Children
Effectiveness of Silver Diamine Fluoride in Arresting Dental Caries
The present study aims to evaluate, through a controlled clinical randomized study,the effectiveness of silver diamine fluoride in arresting dentin caries lesions in primary molars when compared to atraumatic restorative…
- Trial name
- NCT03063307
- Testing
- Atraumatic Restorative Treatment, Silver Diamine Fluoride
- Where
- Brazil
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Dental Caries
Preventive Regimens With Herbal and Fluoride Toothpaste on Remineralization in High Caries Patients With Initial Lesions
This study will be conducted to assess the effect of different preventive regimens using herbal toothpaste versus fluoride toothpaste on the management of remineralization and caries risk in high caries risk patients.
- Trial name
- NCT04446390
- Testing
- Himalaya complete care toothpaste, colgate cavity protection
- Where
- 2 sites in Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries Arrested
Clinical and Laboratory Assessments of Effectiveness of Silver Diamine Fluoride (SDF) in Arresting Caries Among Children and Parental Satisfaction
Globally, it is estimated that 2.4 billion people suffer from caries of permanent teeth and 486 million children suffer from caries of primary teeth .
- Trial name
- NCT04642846
- Testing
- Silver Diamine Fluoride (SDF)
- Where
- Saudi Arabia
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Khalood Saeed Bahammam
White Spot Lesion of Tooth
Effect of Different Remineralizing Agents on White Spot Lesions Treatment in Children
One hundred children with white spot lesions on their teeth were divivided into 5 groups of different remineralizing agents to assess their effect on color change and remineralization
- Trial name
- RCT (NCT06821724)
- Testing
- Casein phosphopeptide-amorphous calcium phosphate, Casein phosphopeptide-amorphous calcium phosphate + fluoride, Nano hydroxyapatite paste
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Periodontitis
Effectiveness of a Triclosan Containing Toothpaste in Maintaining Periodontal Health in a Type 2 Diabetic Population
Clinical research study to determine the effectiveness of a triclosan/copolymer/fluoride toothpaste in maintaining periodontal health and therefore glycaemic control in a type 2 diabetic population.
- Trial name
- NCT00762762
- Testing
- Triclosan/copolymer/fluoride, Fluoride
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Caries, Dental Fluorosis
Anticaries Potential and Fluorosis Risk From Different Fluoride Toothpastes
Fluoride toothpaste has been associated not only with declining dental caries prevalence but also with an increase in dental fluorosis.
- Trial name
- NCT01589991
- Testing
- Toothpaste
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil