Clinical trials: Fluoride
Caries
Evaluation of Dentifrice Formulations to Remineralize Enamel and Dentine Subsurface Lesions in a Double-Blind In-Situ Clinical Trial
To compare the remineralization and demineralization inhibition potential of early subsurface carious lesions in enamel in situ after rinsing with five different aqueous slurries of toothpaste formulations.
- Trial name
- NCT06140745
- Testing
- 0 ppm Fluoride Dentifrice 1, 1100 ppm NaF Fluoride Dentifrice, 1500 ppm NaMFP Fluoride Dentifrice
- Where
- Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dental Caries
In Situ Remineralisation Response of Different Artificial Caries-like Enamel Lesions to Home-care and Professional Fluoride Treatments
This study mainly compared the response of the artificial carious enamel lesions to remineralisation in situ. The tested in vitro demineralising protocols were: MC gel, PA gel, MHDP and Buffer solutions.
- Trial name
- NCT02637830
- Testing
- Application of fluoride varnish (22600 ppm F, Duraphat) at the begining of the study, Application of fluoride toothpaste (1500 ppm F, Crest) twice a day for 3 days of the study
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dental Caries
Fluoride Varnish Randomized Clinical Trial
The purpose of this study is to compare the efficacy of fluoride varnish (FV) applied once or twice a year with counseling to counseling alone in preventing early childhood caries (ECC) (tooth decay in children under the age of…
- Trial name
- NCT00066963
- Testing
- Fluoride Varnish
- Where
- United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
White Spot Lesion
Effectiveness of Different Remineralizing Strategies on the Management of Early Carious Lesions in Primary Teeth
the primary aim of the study is remineralization of early carious lesions in primary teeth using different remineralizing agents of different remineralizing strategies when applied in an intensive mode.
- Trial name
- NCT06566833
- Testing
- self assmbling peptide p11-4 combined with 0.05% fluoride, Casein phosphopeptide amorphous calcium phosphate, 5% sodium fluoride varnish
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Dental Caries, Cervical Caries
Clinical Performance of High Viscous Glass Ionomer Cervical Restorations With Silver-Modified Atraumatic Restorative Technique (SMART) Versus Conventional Treatment in Elderly Cancer Patients. (A 12-month Randomized Clinical Trial)
This study will evaluate the clinical performance of glass ionomer cervical restorations placed using the Silver-Modified Atraumatic Restorative Technique (SMART) compared with conventional restorative treatment in elderly cancer…
- Trial name
- NCT07803757
- Testing
- Silver Diamine Fluoride (SDF, 38%), Conventional Tooth Preparation, High-Viscosity Glass Ionomer Cement
- Volunteers
- 30 people
- Sponsor
- Cairo University
ATTR-CM
Quantitative-imaging in Cardiac Transthyretin Amyloidosis
Transthyretin amyloid cardiomyopathy (ATTR-CM), is a heart muscle disease that's stops the heart muscle working properly. With an ageing population, it is increasingly common but untreated, it has a poor prognosis.
- Trial name
- I-CARE (NCT05776212)
- Testing
- 18F-fluoride PET
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- University of Edinburgh
Dental Caries
SDF With or Without Fluoride Varnish for Caries Arrest in Primary Teeth of Young Children
Tooth decay (dental caries) occurs when acids dissolve tooth structure. If not treated, cavities in primary teeth can progress quickly, leading to caries, infection and early tooth loss.
- Trial name
- SDF-FV (NCT07153328)
- Testing
- Silver Diamine Fluoride (SDF, 38%) and Sodium Fluoride Varnish (NaF, 5%), Silver Diamine Fluoride (SDF, 38%)
- Where
- 2 sites in Albania
- Volunteers
- 104 people
- Sponsor
- Beaty Dent
Caries
Evaluation of the Fluoride Dose Response Using In Situ Caries Model
The purpose of this study is to evaluate the fluoride dose response of different dentifrice fluoride concentrations - 0, 250, 1100 and 2800 ppm fluoride as sodium monofluorophosphate (MFP) and a fifth leg of 1100 ppm Stannous…
- Trial name
- NCT04763044
- Testing
- 0 ppm F, 250 ppm F as MFP, 1100 ppm as MFP
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Early Childhood Caries
Clinical Efficiency and Treatment Failure of Hall Versus SDF Techniques in the Management of Carious Primary Molar.
This study will compare two non- invasive treatment options: Hall technique and 38% Silver diamine fluoride. Both are methods used to create a more favorable environment without removal of caries leading to the arrest of the…
- Trial name
- NCT04765904
- Testing
- SDF, Hall technique
- Volunteers
- 120 people
- Sponsor
- Cairo University
White Spot Lesion of Tooth
White Spot Lesions Prevention During Orthodontic Fixed Appliance Treatment: a Randomized Clinical Trial
The aim of this study is to evaluate the effectiveness of calcium fluoride nanoparticles containing orthodontic primer in preventing or decreasing the incidence WSLs over a period of 6 months in patients with fixed orthodontic…
- Trial name
- NCT04994314
- Testing
- nCaF2 primer, Control primer
- Where
- Iraq
- Volunteers
- 31 people
- Sponsor
- University of Baghdad
Dental Devices, Home Care
Comparative Efficacy of Dental Flossing Before or After Tooth Brushing on Interproximal Plaque Reduction and Fluoride Retention in That Area
This randomized controlled crossover trial conducted on 25 dental students. in the preliminary session each volunteer was given a toothbrush(Trisa, soft, Switzerland) and toothpaste(Pooneh, Iran) and Dental Floss( Mina, Iran)to…
- Trial name
- NCT02971514
- Testing
- Flossing before Brushing, Brushing before Flossing
- Where
- Iran
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Gingivitis
A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate and Sodium Hyaluronate on Gingivitis
The aim of this study is to develop a daily use toothpaste containing sodium bicarbonate, sodium hyaluronate and sodium fluoride with the intention of providing improved/ fast gum healing.
- Trial name
- NCT04737538
- Testing
- Experimental Dentrifrice, Positive control dentifrice, Negative control dentifrice
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cancer, Bone Metastases
F-18 PET Bone Scans Versus Tc-99m Bone Scans for the Diagnosis of Bone Metastases
The purpose of this study is to compare 18F-Fluoride PET bone scans to traditional 99mTc-MDP bone scan to determine if one is better for diagnosing bone metastases.
- Trial name
- NCT01254929
- Testing
- F-18 PET bone scan, Tc-99m bone scan
- Where
- United States
- Volunteers
- 299 people
- Sponsor
- Seattle Nuclear Medicine
Extrinsic Dental Stain, Oral Hygiene
Study to Investigate the Stain Control of Two Stannous Fluoride Dentifrices
The purpose of this study is to evaluate and compare the stain build up of two stannous fluoride (SnF2) / sodium tripolyphosphate (STP) dentifrices of differing abrasivity levels, with a marketed standard fluoride dentifrice and…
- Trial name
- NCT03160703
- Testing
- Stannous fluoride (SnF2, 0.454%), Sodium tripolyphosphate (STP, 5%), 2.0% abrasive silica, Stannous fluoride (SnF2, 0.454%), Sodium tripolyphosphate (STP, 5%), abrasive silica (3.5%), Sodium Monofluorophosphate (1000 ppm fluoride ), RDA~80
- Where
- Canada
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Caries
In Situ Caries Model of Fluoride Toothpastes
This study is to evaluate the effect of fluoride dentrifrices on enamel with artificial caries lesions in an in situ model
- Trial name
- NCT01005966
- Testing
- Sodium Fluoride Toothpaste, Amine Fluoride Toothpaste, Sodium monofluorophosphate/Sodium Fluoride Toothpaste
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cardiovascular Diseases, Atherosclerosis
Rosuvastatin Effect on Atherosclerotic Plaque Metabolism
Atherosclerotic plaque uptake of 18F-sodium fluoride (NaF) in positron emission tomography with computed tomography (PET-CT) was recently shown to correlate with clinical instability in patients with CV disease.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Molecular Imaging
- Trial name
- ROPPET-NAF (NCT03233243)
- Testing
- Rosuvastatin Oral Tablet
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- University of Coimbra
Chronic Low Back Pain
F-18 Sodium Fluoride PET/CT Guided Versus Ultrasound- Guided Intra-articular Injections in Chronic Low Backache
The goal of this open-label randomized controlled trial explored the efficacy of ultrasound guided versus F-18 Sodium Fluoride PET/CT guided local anesthetic and steroid injections in managing chronic low back pain caused by…
- Trial name
- PET-FACET (NCT07632508)
- Testing
- intra-articular injection
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Caries
Total Salivary Fluoride Concentration of Healthy Adult Subjects Following Toothbrushing With Different Formulations of Fluoridated Toothpastes With and Without Post-brushing Water Rinsing.
Caries prevalence has declined significantly since the introduction of fluoridated toothpastes. Since then, different toothpaste formulations and concentrations have been introduced to the market with varying levels of efficacy.
- Trial name
- NCT02740803
- Testing
- Sodium fluoride toothpaste 1,450 ppmF, sodium monofluorophosphate toothpaste 1,450 ppmF, stannous fluoride combined with sodium fluoride toothpaste 1,450 ppmF
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Dental Plaque, Dental Caries
Family-based Counseling Models for Young Children
The purpose of this study is to compare the effects of two new family-based oral health promotion programs with the routine program in use earlier in Vantaa public dental service.
- Conditions
- Dental Plaque, Dental Caries, Behaviorial Habits
- Trial name
- NCT01854502
- Testing
- Oral hygiene and fluoride use, Diet and use of xylitol
- Where
- Finland
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- University of Turku
Dental Caries in Children, Dental Caries Class II
Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective…
- Conditions
- Dental Caries in Children, Dental Caries Class II, Dental Caries
- Trial name
- NCT03770286
- Testing
- 5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles