Clinical trials: Fluoride
Atherosclerosis, Complications of Diabetes Mellitus
18F-Sodium Fluoride (18F-NaF) PET-CT Imaging to Identify Vulnerable Plaques in Patients With Diabetes
Coronary artery calcification is a sign of heart disease. A nuclear medicine PET-CT test using sodium fluoride (18F-NaF) radioisotope has been shown to help identify growing calcification plaques early on in the disease process.
- Trial name
- D-NaF (NCT03530176)
- Testing
- 18Fluoride-Sodium Fluoride radio-isotope
- Where
- Canada
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Myocardial Fibrosis
Study of Novel PET Tracer Gallium [68Ga]/ Fluorine [18F] -FAPI-04 in the Diagnosis of Cardiovascular Diseases
The purpose of this study is to evaluate the safety of fibroblast activating protein receptor imaging agent [68Ga]/ Fluorine [18F] -fibroblast activating protein inhibitor (68Ga/18F-FAPI-04) in clinical application and to verify…
- Trial name
- NCT05867589
- Testing
- 68Ga/18F-FAPI-04
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Plaque, Dental Plaque
Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems
Qualified subjects will be enrolled and randomized to either one of the three study groups described above based on their initial modified gingivitis and plaque scores.
- Conditions
- Plaque, Dental Plaque, Gingivitis
- Trial name
- NCT07842991
- Testing
- 0.45% SnF HW with NaF (1450 F), 67% Bicarbonate with NaF (1400 F), Colgate Cavity Protection Toothpaste
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Solid Tumor, Adult
Fluoride-labeled Boronophenylalanine PET Imaging in Patients With Solid Tumors
Recently, new high-dose radiation therapy [e.g., boron neutron capture therapy (BNCT)] absorbed into the tumor tissue has been applied to treat patients with solid tumors.
- Trial name
- NCT05538676
- Testing
- BPA-PET imaging
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xiaohua Zhu
Aortic Stenosis
18-F Sodium Fluoride (18F-NaF) PET for the Assessment of Bioprosthetic Aortic Valve Durability and Outcomes
This is a pilot study in which we will aim to demonstrate successful execution of the imaging protocol and to make observations regarding the calcification activity as measured by 18F-NaF PET/CT and any correlation to 1) valve…
- Trial name
- NCT03095313
- Testing
- 18F-NaF
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Urinary Stress Incontinence
Comparative Study of PDVF and Polypropylene Transobturator Suburethral Tapes
This study evaluates the effectiveness and complications of polyvinylidene fluoride (PVDF) and polypropylene (PP) transobturator suburethral tapes (TOTs) in the treatment of female stress urinary incontinence.
- Trial name
- NCT02886520
- Testing
- PVDF transobturator tape, Polypropylene transobturator tape
- Where
- 9 sites in Spain
- Volunteers
- 286 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Dental Caries
Effectiveness of Fissure Sealant and Topical Fluoride Application in Preventing Dental Caries
Nearly half of the 12-year-old children in China have dental caries (tooth decay) and most of the lesions are in the fissures of the first permanent molars.
- Trial name
- NCT01446107
- Testing
- placement of fissure sealant, fluoride varnish, silver fluoride
- Where
- China
- Volunteers
- 502 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Whitening
Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Peroxide in the Immediate Removal of Tooth Stains After a Single Brushing.
The aim of this study is to evaluate and compare the immediate efficacy of a hydrogen peroxide-containing toothpaste versus a regular fluoride toothpaste without hydrogen peroxide in removing extrinsic tooth stains following a…
- Trial name
- NCT07276672
- Testing
- Optic White Adv Sparkling White (2%HP) Toothpaste, Colgate Great Regular Flavor Toothpaste
- Where
- Dominican Republic
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis
Stannous Fluoride and Gingivitis
8-week study using stannous fluoride toothpaste on subjects with gingivitis ("unhealthy") and without gingivitis ("healthy"). Gingivitis index will be performed at BL, Week 4 and Week 8.
- Trial name
- NCT05326373
- Testing
- Stannous fluoride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Dental Caries in Children
Comparing the Effectiveness of Papain Based Chemico-mechanical Caries Removal Gel and 38% Silver Diamine Fluoride for Treating Active Caries Lesion of Primary Molars
This study aims to investigate the efficacy of silver diamine fluoride (SDF) and Papain-based chemico-mechanical caries removal gel and using ceramic bur as a control in treating dentine caries in primary molars aged 7-8 years…
- Trial name
- NCT06412731
- Testing
- Cera-bur, Brix3000, E-SDF
- Where
- Iraq
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Decay, Dental
General Dentists' Knowledge, Attitudes and Clinical Usage of SDF
This study will look at how dentists in the UK are using Silver Diamine Fluoride (SDF) in their everyday practice. SDF is a liquid treatment that helps stop tooth decay.
- Trial name
- GDPKAUSDF (NCT07405437)
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Caries,Dental, Pain
Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical Trial
Dental caries, particularly in primary molars, significantly affects children's oral health and overall well-being. Traditional management with stainless steel crowns (SSCs) involves significant tooth reduction and advanced…
- Conditions
- Caries,Dental, Pain, Plaque, Dental, Gingival Bleeding
- Trial name
- RCT (NCT06453005)
- Testing
- SMART Hall Technique or procedure
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- C K S Teja Institute Of Dental Sciences & Research
Caries Infiltration, Fluorosis
Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains
Dental fluorosis is a clinical manifestation of chronic exposure to high intakes of fluoride during the tooth development. The present study is planned to evaluate the efficacy of Resin Infiltration technique in improving the…
- Conditions
- Caries Infiltration, Fluorosis, Dental Care
- Trial name
- NCT01733888
- Testing
- Office Bleaching, Resin Infiltration, Resin Infiltration twice
- Where
- 2 sites in India
- Volunteers
- 80 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Dental Caries in Children
SDF for the Management of Dental Caries in Children in Primary Dental Care: Protocol for a Feasibility Study
Dental caries remains a significant health problem in England, effecting 11% of 3-year-olds and 23% of 5-year- olds. Children with dental caries suffer pain, infection and poor oral health-related quality of life.
- Trial name
- NCT06092151
- Testing
- Silver diamine fluoride, Usual dental care
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
White Spot Lesion
Home Remineralization of White Spot Lesions With Two Different Toothpastes.
The aim of the study is to compare white spot lesions before, during and after treatment with New Biorepair Advanced Sensitive toothpaste containing micro crystals of hydroxyapatite and Colgate toothpaste with 1450 ppm of…
- Trial name
- NCT04908293
- Testing
- Biorepair toothpaste, Colgate toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
ATTR-CM
Quantitative-imaging in Cardiac Transthyretin Amyloidosis
Transthyretin amyloid cardiomyopathy (ATTR-CM), is a heart muscle disease that's stops the heart muscle working properly. With an ageing population, it is increasingly common but untreated, it has a poor prognosis.
- Trial name
- I-CARE (NCT05776212)
- Testing
- 18F-fluoride PET
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- University of Edinburgh
Dental Caries
The Use of Antimicrobial Agents in the Inhibition of Mutans Streptococci in Children With Dental Caries
The aim of the present study was to compare salivary MS levels in four different groups of children with caries, that have been submitted to intraoral topical treatment with either 1,23% sodium fluoride, 1% chlorhexidine, 3% or…
- Trial name
- NCT00612469
- Testing
- Sodium Fluoride, vancomycin hydrochloride, chlorhexidine digluconate
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Ceara
To Decrease Dentin Hypersensitivity
Effectiveness of a Bonding and a Fluoride Varnish for Long-term Dentin Hypersensitivity Treatment.
Objectives: The aim of this in vivo randomized clinical trial with split-mouth design was to evaluate the clinical efficacy of one in-office application of a fluoride containing varnish and in office application of a bonding…
- Trial name
- NCT04813848
- Testing
- Application of varnish fluoride desensitizing agent on buccal surfaces of exposed dentin, Application of bonding agent desensitizing agent on buccal surfaces of exposed dentin
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Roma La Sapienza
Early Childhood Caries
Arresting Early Childhood Caries With a Silver Diamine Fluoride Gel
The objective is to determine whether the efficacy of a 38% silver diamine fluoride (SDF) gel is non-inferior to a 38% SDF solution for arresting carious lesions in preschool children when applied at half-yearly intervals over a…
- Trial name
- NCT06241261
- Testing
- Silver diamine fluoride gel, Silver diamine fluoride solution
- Where
- China
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dentin Hypersensitivity
Desensitizing Efficacy of Polymeric Nano Calcium Fluoride Containing Varnish
The aim of this study is to evaluate the Desensitizing efficacy of polymeric nano calcium fluoride containing varnish and its implementation into clinical practice.
- Trial name
- NCT04614727
- Testing
- polymeric nano calcium fluoride containing varnish NANO SEAL
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Samar Saad