Clinical trials: Fluorides, Dental Caries
Dental Caries in Children
Cost-effectiveness of Topical Fluoride in Preventing Deciduous Dental Caries in Preschool Children
Fluoride foam and fluoride varnish are effectiveness in prevention deciduous dental caries. However, the relative clinical efficacy and cost-effectiveness of these two interventions are uncertain.
- Trial name
- NCT05025163
- Testing
- 1.23% fluoride foam application, 2.26% fluoride varnish application
- Volunteers
- 1,083 people
- Sponsor
- National Center for Chronic and Noncommunicable Disease Control and Prevention, China CDC
Dental Caries
Evaluation of Preventive Regimens With Different Toothpastes vs Fluoride Varnish & Toothpaste in High Caries Patients
This study will be conducted in order to determine the prevention effect of caries preventive regimen using herbal toothpaste and regimen using fluoride toothpaste versus fluoride toothpaste and fluoride varnish on the caries…
- Trial name
- NCT04436913
- Testing
- Himalaya complete care toothpaste, Signal toothpaste, Signal toothpaste and fluoride varnish
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Cairo University
Prevention of Dental Caries
Comparative Analysis of Interventions for Prevention of Dental Caries in School Children
A study aims to assess the most effective preventive interventions to address the widespread issue of dental caries, affecting an estimated 2 billion people in permanent teeth and over 500 million children in primary teeth…
- Trial name
- NCT06602765
- Testing
- Tooth brushing, tooth paste containing 1450ppm fluoride
- Where
- Pakistan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bahria University
Early Childhood Caries, Dental Caries in Children
Treatment of Early Childhood Caries Using Silver Diammine Fluoride and Sodium Fluoride Tricalciumphosphate and the Effects on Oral Health Related Quality of Life
There is still a need for the assessment of different minimal intervention strategies and treatments focusing on the prevention and arrest of carious lesions of primary molars The evidence-based clinical practice guideline on…
- Conditions
- Early Childhood Caries, Dental Caries in Children, Dental Caries Extending Into Dentin, Dental Caries
- Trial name
- NCT05772039
- Testing
- Topical application of 38% Silver Diammine Fluoride Solution, Topical application of 5% Sodium Fluoride with functional Tricalcium phosphate Varnish
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Universiti Sains Malaysia
Dental Caries of Root Surface, Root Caries
Root Caries Prevention Using Fluoride Varnish Fortified With SBGC
The goal of this 36-month double-blind randomized controlled trial is to compare the effects of 5% sodium fluoride varnish (22,600 ppm fluoride) with or without Strontium-doped bioactive glass (SBGC) on root caries development in…
- Trial name
- SBGC (NCT06131957)
- Testing
- Fluoride varnish with SBGC, Fluoride varnish
- Where
- Hong Kong
- Volunteers
- 540 people
- Sponsor
- The University of Hong Kong
Dentin Hypersensitivity
Effect of Gluma and Bioactive Glass Desensitizers in Treatment of Dentin Hypersensitivity in Cervical Non-Carious Lesions
Type of study: (A Randomized Controlled Clinical Trial) Aim :The aim of this randomized controlled clinical trial is to evaluate the effect of Gluma, Bioactive Glass and combination of both, compared to Flouride Varnish on the…
- Trial name
- NCT07063433
- Testing
- Gluma Desensitizer, Bioactive glass, Fluoride varnish
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- British University In Egypt
Caries, Dental, Calcium Hypophosphite
Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)
The aim of the study is to compare the caries-preventive effect of the test and control toothpaste in order to proof the non-inferiority of the test toothpaste compared to the control.
- Conditions
- Caries, Dental, Calcium Hypophosphite, Fluoridation
- Trial name
- NCT07068204
- Testing
- 2% Calcium Hypophosphite Toothpaste, Sodium Fluoride Toothpaste (1450 ppm F)
- Where
- 2 sites in Poland
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Dr. Joachim Enax
Dental Caries
Pharmacokinetics of Advantage Arrest in Children
The purpose of this study is to characterize basic PK parameters (Cmax, t1/2, AUC) in healthy children to contribute to evidence for the safety of Advantage Arrest, consistent with Guidance for Industry--Exposure--Response…
- Trial name
- NCT04186663
- Testing
- Silver Diamine Fluoride
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Dental Diseases
Intensive Preventative Dental Program Pilot Study
Radiation therapy to treat cancer may cause a dry mouth from damage to salivary glands which may increase the risk of cavities on the teeth.
- Trial name
- IPDP (NCT07218068)
- Testing
- Fluoride varnish, Regular Care, Medical Oncology Care Team
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Wake Forest University Health Sciences
Dental Caries
To Determine the Ability of a New Product Formulation to Remineralize an Early Caries Lesion by an In-situ Study
This is a double blind, cross-over, controlled clinical trial utilizing thirty (30) adults to evaluate remineralization of early caries lesions.
- Trial name
- NCT02388178
- Testing
- Control toothpaste containing no anti-cavity ingredients, Experimental toothpaste containing fluoride and amino acid (arginine), Fluoride toothpaste containing fluoride as the anti-cavity ingredient
- Volunteers
- healthy volunteers welcome
- Sponsor
- Colgate Palmolive
MIH, Molar-Incisor Hypomineralization
Effects of Silver Diamine Fluoride and Intraoral Cryotherapy on Local Anesthesia in MIH-Affected Molars
Molar-incisor hypomineralization (MIH) is a developmental enamel defect of unclear etiology that affects permanent first molars and often permanent incisors, leading to increased porosity, hypersensitivity, and poor prognosis.
- Conditions
- MIH, Molar-Incisor Hypomineralization, Caries Assessment
- Trial name
- NCT07326241
- Testing
- Standard Local Anesthesia, Intraoral Cryotherapy, Silver Diamine Fluoride (SDF)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Dental Caries
Effective Fluoride Concentration In Toothpaste For Dental Caries Prevention
to identify the Effective Fluoride Concentration In Toothpaste For Dental Caries Prevention after 18 months of randomized controlled trial.
- Trial name
- DMFT (NCT02016001)
- Testing
- toothpaste 1 with maximum fluoride concentration, toothpaste 2 with 1000 ppm of fluoride
- Where
- Pakistan
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Tooth Loss, Periodontal Disease
"Clinical Trials to Enhance Elders' Oral Health" ("TEETH")
The purpose of this study is to determine if regular rinsing with chlorhexidine is effective as a long-term preventive method for reducing the incidence of tooth loss in low income older adults.
- Conditions
- Tooth Loss, Periodontal Disease, Tooth Decay
- Trial name
- NCT00004640
- Testing
- Chlorhexidine rinse
- Where
- 2 sites in United States, Canada
- Volunteers
- 1,101 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dental Caries in Children
Cost Effectiveness of Sodium Fluoride Varnish in Prevention of Dental Caries in School Children
Fluoride varnish application is universally accepted as a dental caries prevention method. This study was aimed in assessment of clinical outcome and cost effectiveness in using that method in Sri Lankan school children
- Trial name
- NCT03571815
- Testing
- 5% sodium fluoride varnish, WATER ON TEETH
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- University of Peradeniya
Root Caries
Prevention and Arrest of Root Caries Lesions with High Fluoride Concentration Mouthwash Versus Normal Fluoride Concentration Mouthwash in Elderly Patients
The study evaluats the effectiveness of regular fluoride 220 ppm F with erythritol and high fluoride 500 ppm F with erythritol mouthwashes against a placebo (regular fluoride 220 ppm F mouthwash) in the prevention of new root…
- Trial name
- NCT06723054
- Testing
- regular fluoride 220 ppm F mouthwash without erythritol, regular fluoride 220 ppm F mouthwash with erythritol, high fluoride 500 ppm F mouthwash with erythritol
- Where
- Switzerland
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Murali Srinivasan, Dr. med. dent., BDS, MDS, MBA, MAS
Dental Caries
Optimised Fluoride Prevention by Double Rinse With Fluoride and Calcium
Aim: to determine the optimal Ca2+ concentration with 905 ppm F as NaF. Study design: Experimental study in 10 volunteers. Single blind mouth rinse with calcium lactate solution (150; 75; 0 mM Ca-lactate) is immediately followed…
- Trial name
- Fluor-Ca (NCT01473537)
- Testing
- calcium lactate solution
- Where
- Sweden
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Dental Caries
Fluoride Varnish in the Prevention of Dental Caries in Aboriginal and Non-aboriginal Children
The purpose of this study is to determine whether semi-annual fluoride varnish applications combined with caregiver counseling are effective in preventing and reducing a severe form of dental decay, known as early childhood…
- Trial name
- NCT00435500
- Testing
- Fluoride varnish
- Where
- Canada
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Dental Caries
Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults
This study is a randomized clinical trial lasting for 30 months. A total of 300 subjects will be recruited from social centres for elders located in different districts in Hong Kong.
- Trial name
- NCT02360124
- Testing
- silver diammine fluoride, saturated potassium iodide solution
- Where
- China
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Caries Roots, Flouride Varnish
Effectiveness Silver Diamine Fluoride Versus Sodium Fluoride in Arresting Caries Around Crown Margins in Older Adults
Dental caries is a multifactorial, progressive disease which is the major causes of dental pain, infection and tooth loss. Dental caries can substantially compromise the quality of life in older adults 1 2.
- Conditions
- Caries Roots, Flouride Varnish, Caries; Dentin, Caries Arrested
- Trial name
- NCT04255251
- Testing
- Silver Diammine Fluoride, Fluoride Varnishes
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of New England
Dental Caries
Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas
This study was a randomized clinical trial lasting for 24 months in two study sites, Hong Kong (water fluoridated) and Guangzhou (non-fluoridated area).
- Trial name
- NCT02742142
- Testing
- silver diammine fluoride
- Where
- 2 sites in China
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong