Clinical trials: Flushing
Flushing
MK0524A Phase IIb Study (0524A-011)(COMPLETED)
Part A: This study will determine that MK0524 is well tolerated and does not effect lipids and blood glucose when given alone. Part B: Determine dose ranges for MK0524 and MK0524 plus Niaspan(R) on the effects of lipids and blood…
- Trial name
- NCT00536237
- Testing
- Comparator: niacin / Duration of Treatment: 17 Weeks, MK0524A, niacin (+) laropiprant / Duration of Treatment: 17 Weeks
- Volunteers
- 154 people
- Sponsor
- Merck Sharp & Dohme LLC
Flushing
Advancing Niacin by Inhibiting Flushing (ANTI-FLUSH)
Niacin, or vitamin B3, is known to improve cholesterol disorders and is the most effective drug to raise HDL, or the "good cholesterol".
- Trial name
- ANTI-FLUSH (NCT00913081)
- Testing
- Quercetin
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Neuroendocrine Carcinoma
P:II Above-Label Octreotide-LAR With Insufficiently Controlled Carcinoid Syndrome
The primary purpose of the study is to investigate the effects of high-dose octreotide on flushing, diarrhea, and quality of life in patients whose disease-related symptoms are inadequately controlled by the maximum approved dose…
- Trial name
- NCT01886287
- Testing
- Octreotide LAR
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Hypercholesterolemia, Flushing
Alternative Options to Minimize Niacin-Induced Flushing
Niacin (Vitamin B3) is known to effectively and safely treat hypercholesterolemia. However, use of niacin is limited due to incidents of flushing which limits its acceptability.
- Trial name
- NCT00895193
- Testing
- Apple pectin, Aspirin 325 mg
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Patrick Moriarty, MD, FACP, FACC
Acne Rosacea
Effects of PRK 124 Lotion in Acne Rosacea
The purpose of this open-label study is to determine the tolerance and efficacy of twice-daily application of PRK 124 (Pyratine-6)(0.125%) moisturizing lotion for improving the signs and symptoms of mild to moderate facial…
- Trial name
- NCT00580723
- Testing
- PRK 124
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Irvine
Healthy Subjects, Dyslipidaemias
A Study To See If GSK256073A Can Block Niacin-Induced Flushing In Healthy Volunteers
To test the ability of GSK256073 to block niacin-induced flushing when GSK256073 and niacin are co-administered as single doses to HVTs.
- Trial name
- NCT00608699
- Testing
- GSK256073A tablets + IR niacin tablets
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Flushing
Role of Prostaglandins on Niacin-Induced Flushing
This study will focus on investigating the nicotinic acid stimulated release of prostaglandin D2 in normal controls. In subsequent studies, the investigators would like to further explore this pathway in people with type 2…
- Trial name
- NCT00930839
- Testing
- Niacin and aspirin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Mastocytosis, Anaphylaxis
Blood Factors in Mastocytosis and Unexplained Anaphylaxis and Flushing
This study will 1) identify characteristics of bone marrow mast cells in patients with unexplained anaphylaxis and flushing or with mastocytosis and 2) determine whether mastocytosis might be the underlying cause of unexplained…
- Trial name
- NCT00047918
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)