Clinical trials: Focal Dystonia
Essential Tremor, Cervical Dystonia
Neurophysiologic Study of Patient With Essential Tremor and Dystonic Tremor
Background: Essential tremor is when a person has tremor, but no other neurological symptoms. Dystonic tremor is when a person also has dystonia. Dystonia is a condition in which muscle contraction causes changes in posture.
- Conditions
- Essential Tremor, Cervical Dystonia, Focal Dystonia
- Trial name
- NCT03041714
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia
Transcranial Magnetic Stimulation for Focal Hand Dystonia
Background: The brain has natural electrical rhythms of brain activities. These rhythms may be different in people with movement disorders, such as dystonia (involuntary muscle movement, cramps, or tremors).
- Trial name
- NCT01792336
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Essential Tremor, Dystonia
Magnetic Resonance (MR) Guided Functional Ultrasound-Neurosurgery for Movement Disorders
The aim of this study is to asses the efficacy and the clinical safety of the transcranial magnetic resonance guided high intensity focused ultrasound system ExAblate 4000, InSightec Ltd.
- Conditions
- Essential Tremor, Dystonia, Parkinson's Disease
- Trial name
- NCT01698450
- Testing
- Non-invasive intervention with focused ultrasound (ExAblate 4000)
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University Children's Hospital, Zurich
Cerebral Palsy, Dyskinetic, Secondary Dystonia
Focused Ultrasound Pallidotomy for Dyskinetic Cerebral Palsy in Pediatric and Young Adult Subjects
The primary objective of the proposed study is to evaluate the safety of ExAblate Transcranial MRgFUS as a tool for creating bilateral or unilateral lesions in the globus pallidus (GPi) in patients with treatment-refractory…
- Trial name
- NCT06036199
- Testing
- Focused Ultrasound Pallidotomy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's National Research Institute
Blepharospasm, Focal Dystonia
Brain Stimulation to Treat Blepharospasm or Meige Syndrome
This research study will examine whether magnetic or electrical stimulation of the brain can improve the involuntary closure of the eyelids in patients with blepharospasm or Meige syndrome; conditions that belong to a group of…
- Trial name
- NCT00411255
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Movement Disorders, Essential Tremor
ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders
The proposed study is to evaluate the effectiveness of ExAblate Transcranial MRgFUS as a tool for creating a unilateral lesion in the Vim thalamus or the globus pallidus (GPi) in patients with treatment-refractory symptoms of…
- Conditions
- Movement Disorders, Essential Tremor, Holmes Tremor, Parkinson's Disease
- Trial name
- NCT02252380
- Testing
- Transcranial ExAblate System
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- InSightec
Dystonia, Focal Hand Dystonia
Transcranial Electrical Polarization to Treat Focal Hand Dystonia
This study will evaluate the effect of transcranial electrical polarization (TEP), also called direct current (DC) stimulation, on focal hand dystonia in people with writer's cramp.
- Conditions
- Dystonia, Focal Hand Dystonia, FHD
- Trial name
- NCT00106782
- Testing
- Transcranial Electrical Polarization (TEP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Task-Specific Focal Dystonia
MRgFUS Pallidotomy for the Treatment of Task Specific Focal Hand Dystonia (TSFD)
The purpose of this study is to assess the safety and effectiveness of MRI-guided focused ultrasound (MRgFUS) for treating task specific focal hand dystonias (TSFD).
- Trial name
- FUS Dystonia (NCT06367608)
- Testing
- ExAblate Transcranial treatment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Dystonic Disorder, Healthy
Transcranial Magnetic Stimulation (TMS) Studies of Dystonia
This study will use transcranial magnetic stimulation to examine how the brain controls muscle movement in focal and generalized types of dystonia.
- Trial name
- NCT00017875
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Focal Dystonia
EEG and EMG Studies of Hand Dystonia
This study will examine how the brain operates during execution and control of voluntary movement and what goes wrong with these processes in disease.
- Trial name
- NCT00025701
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
X-Linked Dystonia Parkinsonism
High Intensity Focused Ultrasound for X-linked Dystonia-parkinsonism
X-linked dystonia-parkinsonism (XDP) is a rare, X-linked, adult-onset, and progressive movement disorder seen almost exclusively in men from Panay Island in the Philippines.
- Trial name
- NCT05592028
- Testing
- transcranial magnetic resonance-guided focused ultrasound pallidothalamic tractotomy
- Where
- Philippines
- Sponsor
- University of the Philippines Manila - Philippine General Hospital
Dystonia, Focal, Task-specific
Repetitive Transcranial Magnetic Stimulation for the Treatment of Focal Hand Dystonia
This study investigated the short term effects of repeated administrations of repetitive-transcranial magnetic stimulation (rTMS) on clinical changes and investigate neurophysiologic responses to rTMS of the activated motor…
- Trial name
- NCT01884064
- Testing
- rTMS
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Minnesota
Spasmodic Dysphonia, Focal Dystonia
Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia
This study will examine how the brain controls speech in patients with spasmodic dysphonia, a voice disorder that involves involuntary spasms of muscles in the larynx (voice box), causing breaks in speech.
- Trial name
- NCT00713414
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Focal Dystonia
Amlodipine Plus Botulinum Toxin for Focal Dystonia
Objective: To determine if the calcium channel blockers, amlodipine can augment the effect of botulinum toxin injections in the treatment of focal dystonia.
- Trial name
- NCT00015457
- Testing
- Amlodipine plus Botulinum toxin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonic Disorders, Healthy
Surround Inhibition in Patients With Dystonia
This study will use transcranial magnetic stimulation (TMS) to examine how the brain controls muscle movement in dystonia. Dystonia is a movement disorder in which involuntary muscle contractions cause uncontrolled twisting and…
- Trial name
- NCT00029601
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia, Dystonia, Focal
Local Field Potentials in Dystonia
The goal of this clinical trial is to learn whether local field potential (LFP) signals recorded from the globus pallidus interna (GPi) using the Medtronic Percept™ deep brain stimulation (DBS) device can help optimize DBS…
- Conditions
- Dystonia, Dystonia, Focal, Dystonia, Primary
- Trial name
- LFP-DYT (NCT07309133)
- Testing
- Deep Brain Stimulation System
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Dystonia
A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia
Stride Dystonia is a randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of VIM0423 in individuals with isolated dystonia.
- Trial name
- NCT07304089
- Testing
- VIM0423
- Where
- 45 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Vima Therapeutics
Dystonic Disorders
Transcranial Magnetic Stimulation and Electrical Stimulation of Nerves to Study Focal Dystonia
This study will use transcranial magnetic stimulation (TMS) and electrical stimulation of nerves to examine how the brain controls muscle movement in focal hand dystonia (writer's cramp).
- Trial name
- NCT00050024
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Focal Hand Dystonia
Long-Term Motor Learning in Focal Hand Dystonia
This study will examine the effects of long-term practice of repeated finger movements in people with focal hand dystonia, as compared with healthy volunteers.
- Trial name
- NCT00325091
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Focal Dystonia
Survey of Sensory and Motor Tricks in Focal Dystonia
This study will collect information on (tricks) patients with focal dystonia use to relieve their symptoms. Dystonia is a movement disorder caused by sustained muscle contractions often causing twisting and abnormal posturing.
- Trial name
- NCT00054652
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)