Clinical trials: Focal Lesions
Multimoda Lultasound, Thyroid Cancer
Multimodality US Based on Angio Planewave Ultrasensitive Imaging and Shear Wave Elastography to Evaluate the Malignancy Risk Value of Thyroid Nodules
The goal of this clinical trial is to explore the value of a multimodal ultrasound model based on Angio Planewave Ultrasensitive Imaging, Shear Wave Elastography and grayscale ultrasound in the differential diagnosis of benign…
- Conditions
- Multimoda Lultasound, Thyroid Cancer, Microvascular Classification
- Trial name
- NCT06530771
- Testing
- ultrasound
- Where
- China
- Volunteers
- 720 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Low or Intermediate Risk Prostate Cancer
Phase I Study MR-guided SBRT to PCa
1) investigate the feasibility, tolerance, and safety of dose escalation via MR-guided stereotactic body radiation therapy and simultaneous integrated boost to the dominant intraprostatic lesions (DILs), 2) to assess the…
- Trial name
- MRgRTPCa (NCT03935308)
- Testing
- MR guided Linear Accelerator
- Where
- United States
- Sponsor
- Henry Ford Health System
Knee Injury
Evaluation of the CR Plug (Allograft) for the Treatment of a Cartilage Injury in the Knee.
Determine the ability of the allograft plug for the treatment of a cartilage injury in the knee
- Trial name
- NCT00793104
- Testing
- Placement of allograft CR Plug in primary injury site
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- RTI Surgical
Motor Skill Acquisition in Healthy Older Adults
Training in Combination With Non-invasive Brain Stimulation
The goal of this study is to investigate the impact of non-invasive brain stimulation on motor skill acquisition in healthy individuals.
- Trial name
- TrainStim (NCT07059533)
- Testing
- Verum
- Where
- Switzerland
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Friedhelm Hummel
Carcinoma Prostate
Combined LDR Boost and HDR Whole Gland
This is a dose finding Phase I/II study of combined focused LDR brachytherapy boost with whole gland single fraction HDR for men with low and intermediate risk prostate cancer and Dominant Intraprostatic Lesion (DIL) visible on…
- Trial name
- Delight (NCT03323879)
- Testing
- LDR/HDR
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Sunnybrook Health Sciences Centre
Focal Liver Lesions
Auxiliary Diagnosis of Liver Nodules Using cfDNA Whole-genome Signatures
As a prospective, multi-center study, GUIDER will recruit 400 liver nodules participants from different provinces and regions across China.
- Trial name
- GUIDER (NCT05393102)
- Testing
- No interventions
- Where
- 3 sites in China
- Volunteers
- 400 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Adult Primary Liver Cancer, Kidney Tumor
Ultrasound Elastography in Diagnosing Patients With Kidney or Liver Solid Focal Lesions
This clinical trial studies ultrasound elastography in diagnosing patients with kidney or liver solid focal lesions. New diagnostic procedures, such as ultrasound elastography, may be a less invasive way to check for kidney or…
- Trial name
- NCT01908166
- Testing
- ultrasound elasticity imaging
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Stanford University
Focal Liver Lesions, Ultrasonics
Utility of Ultrasound Imaging for Diagnosis of Focal Liver Lesions: A Radiomics Analysis
Ultrasound (US) as first-line imaging technology in detecting focal liver lesions,also plays a crucial role in evaluating image and guiding ablation which is the main treatment for liver lesions.
- Conditions
- Focal Liver Lesions, Ultrasonics, Intelligent Diagnosis, Ablation
- Trial name
- NCT03871140
- Testing
- diagnosis
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Non Small Cell Lung Cancer, Metastatic Lung Cancer
Vapor Ablation for Localized Cancer Lesions of the Lung (VAPORIZE)
This study is a prospective, single-arm, multi-center, pilot trial of Bronchoscopic Thermal Vapor Ablation for Lung Cancer (BTVA-C) in patients with primary lung cancer or metastatic cancer in the lung.
- Conditions
- Non Small Cell Lung Cancer, Metastatic Lung Cancer, Lung Cancer
- Trial name
- VAPORIZE (NCT03198468)
- Testing
- Bronchoscopic Thermal Vapor Ablation
- Where
- Australia
- Volunteers
- 8 people
- Sponsor
- Uptake Medical Technology, Inc.
Hepatic Lesions
Comparative Diagnostic Yield of Contrast-Enhanced Versus Conventional Ultrasound Guidance for Coaxial Biopsy of Hepatic Lesions
This study compared two methods used to guide needle biopsies of suspicious lumps (lesions) in the liver. A biopsy is a procedure where a small sample of tissue is taken to make a diagnosis.
- Trial name
- NCT07249268
- Testing
- CEUS or Contrast enhanced Ultrasound, US
- Where
- China
- Volunteers
- 330 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
High-risk Lung Nodules
Immunoprevention for High-risk Lung Lesions
The main purpose of this study is to assess nadunolimab as an immunoprevention strategy for high-risk lung nodules in participants who are current or former tobacco smokers. The study may last up to 5 years for each participant.
- Trial name
- NCT07284485
- Testing
- Nadunolimab
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Robert Samstein
Liver Lesions
An Efficacy and Safety Study of Sonazoid™ and SonoVue® in Participants With Focal Liver Lesions, Undergoing Pre- and Post-Contrast Ultrasound Imaging
The purpose of this study is to compare the efficacy of Sonazoid™ and SonoVue® in participants with focal liver lesions (FLLs), by comparing pre-and post-contrast ultrasound examination findings with regard to various aspects of…
- Trial name
- NCT03335566
- Testing
- Sonazoid™, SonoVue®
- Where
- 18 sites in China, South Korea and 1 more
- Volunteers
- 424 people
- Sponsor
- GE Healthcare
Focal Cartilage Lesions
Prospective Interventional Clinical Trial of an MRI Based Patient Specific Focal Knee Resurfacing Implant
Lesions in the cartilage are common disorders. Arthroscopy lavage and debridement micro fracturing, mosaic plasticity as well as osteochondral autograft transplantation (OATS) are methods used for treatment of the lesions.
- Trial name
- Episealer (NCT04808700)
- Testing
- Follow-up of Episealer implant
- Where
- Belgium
- Volunteers
- 8 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cartilage Injury, Defect of Articular Cartilage
BioPoly RS Knee Registry Study for Cartilage Defect Replacement
Information will be collected on the pre-op and post-op clinical status of patients with focal cartilage defects of the femoral condyles treated with the BioPoly RS Partial Resurfacing Knee Implant, a permanent orthopaedic…
- Conditions
- Cartilage Injury, Defect of Articular Cartilage, Cartilage Damage
- Trial name
- NCT01473199
- Testing
- BioPoly RS Partial Resurfacing Knee Implant
- Where
- 5 sites in United Kingdom
- Volunteers
- 38 people
- Sponsor
- BioPoly LLC
Gingival Recession, Localized, Tooth Abrasion
Use of a Novel Volume-stable Collagen Matrix (VCMX) in the Treatment of Single Gingival Recession Associated With Non-carious Cervical Lesion Partially Restored
Gingival recessions (GR) are often associated with non-carious cervical lesions (NCCL), resulting, thus, in a combined defect. This mucogingival condition has a different treatment prognosis when compared with a GR without…
- Trial name
- NCT05916716
- Testing
- Restorative procedure, Coronally Advanced Flap (CAF)., Volume-stable collagen matrix (VCMX)
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Liver Neoplasms
Multimodal Ultrasound and Focal Liver Lesions (FLLs)
Background and aim: FLLs are common findings in abdominal ultrasound and differential diagnosis between benign and malignant lesions is often challenging, especially in patients with chronic liver diseases.
- Trial name
- NCT05977764
- Testing
- Ultrasound
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc)
Pragmatic RCT of AI-Assisted Reading for Malignant Hepatic Lesions on CE-CT
The purpose of this multicenter pragmatic randomized controlled trial is to determine whether AI-assisted interpretation of multiphasic liver contrast-enhanced computed tomography (CE-CT) is non-inferior to standard radiology…
- Conditions
- Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (Icc), Hepatic Metastasis, Hepatic Hemangioma
- Trial name
- NCT07768085
- Testing
- AI-assisted abdominal CE-CT reporting, Standard abdominal CE-CT reporting without AI assistance
- Where
- China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Focal Lesions, Focal Brain Lesion
Attention and Visual Perception
The NIMH is conducting studies aimed at gaining a better understanding of the areas of the brain that are involved in different types of mental processes.
- Trial name
- NCT00111293
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Epidermolysis Bullosa Simplex
Injections of Botulinic Toxin in Plantar Lesions of Localized Epidermolysis Bullosa Simplex
The investigators hypothesize that palmar injections of botulinic toxin, via an inhibition of the sudation, would limit the occurrence of blisters in localized epidermolysis bullosa simplex (LEBS).
- Trial name
- EBTox (NCT03453632)
- Testing
- Botulinic toxin
- Where
- 4 sites in France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Stroke Syndrome, Stroke Hemorrhagic
Assessing Accuracy of Clinical Diagnosis and Lesion Location in Acute Neurological Deficits - How Good Are Neurologists?
The emergency setting for acute neurological conditions, such as stroke, is peculiar due to time pressure and limited resources for further diagnostics.
- Conditions
- Stroke Syndrome, Stroke Hemorrhagic, Stroke, Acute, Strokes Thrombotic
- Trial name
- HOGAN (NCT03009656)
- Testing
- No study specific interventions
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern