Clinical trials: Focus of Study
Focus of Study of Healthy Adults
Oral Nitrite and Nitrate in Healthy Normal Volunteer Adults
This proposal hypothesizes that oral supplementation with sodium nitrite or nitrate will result in in vivo conversion of nitrate to nitrite and nitrite to nitric oxide with limited toxicity in the doses proposed in healthy adult…
- Trial name
- NCT01681836
- Testing
- 15Nitrogen(15N)-labeled sodium nitrite, 15Nitrogen(15N)-labeled sodium nitrate
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD
Squamous Cell Carcinoma of the Anal Canal
Tiraglolumab Atezolizumab and Chemoradiotherapy in Localized Anal Carcinoma (TIRANUS)
The peculiarity of anal cancers, with well-established radical chemoradiotherapy that allows tumor-neoantigen formation with platinum-based chemotherapy and radiotherapy with radio-sensitizing chemotherapy could create the…
- Trial name
- TIRANUS (NCT05661188)
- Testing
- Atezolizumab plus Tiraglolumab
- Where
- 13 sites in Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Grupo Espanol Multidisciplinario del Cancer Digestivo
Cardiovascular Disease
Impact of Vaccenic Acid Consumption on the Metabolism of Saturated Fatty Acids: Relationship With Cardiovascular Risk Factors
The investigators' project has for principal objective to evaluate the impact of three specific ruminant milk fats with a Trans Fatty Acid content ranging from 2.9% to 12.2% obtained by modification of the cow's diet on…
- Trial name
- TRANSQUAL WPC (NCT00685581)
- Testing
- Ruminant trans fatty acid enriched diet - lowest ratio, Ruminant trans fatty acid enriched diet - medium ratio, Ruminant trans fatty acid enriched diet - highest ratio
- Where
- France
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Stenosis, Fusion of Spine (Disease)
Anterior Bridging Cage With Bone Substitute Versus Localized Autobone in Transforaminal Lumbar Interbody Arthrodesis
The purpose of this study is to evaluation for the pattern of bone bridging of patients who undergo transforaminal lumbar interbody arthrodesis, the investigators hypothesize that auto local bone mixed with β-calcium phosphate +…
- Trial name
- NCT02485574
- Testing
- transforaminal lumbar interbody arthrodesis
- Where
- South Korea
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Zenoss Co, Ltd
Gingival Recession, Localized
Effect of Vestibular Depth on Predictability of Miller Class III/ RT2 Gingival Recession Coverage
Aim of this study is to assess the influence of vestibular depth on root coverage in Miller class III/ Cairo RT2 gingival recession when treated with minimally invasive technique using connective tissue graft.
- Trial name
- NCT06000228
- Testing
- Recession coverage with CTG using minimally invasive access technique in shallow vestibule, Recession coverage with CTG using minimally invasive access technique in deep vestibule
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Foreskin HIV Susceptibility
Effect of Antibiotics on Penile Microbiome and HIV Susceptibility Study in Ugandan Men
This pilot study will assess the impact of four antimicrobial products (3 topical, one systemic) on the foreskin microbiome and HIV susceptibility of foreskin-derived CD4+ T cells.
- Trial name
- NCT03412071
- Testing
- Oral Tinidazole, Topical metronidazole, Topical Clindamycin
- Where
- Uganda
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Toronto
The Focus of the Study is Healthy Volunteers
Appetite Regulation by a Breakfast Soft Bread
The aim of this study is to evaluate the appetite rating of a soft bread with a high content of fibre and protein (Puravita Breakfast®) as well as its capacity to modulate postprandial levels of glucose, insulin and…
- Trial name
- NCT02090049
- Testing
- Puravita Breakfast, Control
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Puratos
Vaccine Refusal, Compliance, Patient
Vaccinations and People With Disabilities
The goal of this observational study is to learn about vaccinations hesitancy, delay or avoidance in children with chronic diseases, congenital anomalies or disabilities.
- Conditions
- Vaccine Refusal, Compliance, Patient, Disability, Intellectual, Congenital Disorders
- Trial name
- NCT05749419
- Where
- Israel
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Focus of the Study is Insulin Sensitivity
Effects of Dietary Fiber on Insulin Sensitivity
This study will examine the effects of a dietary fiber on insulin sensitivity in overweight and obese women. The fiber will be added to snack foods and women will consume the foods for four weeks.
- Trial name
- NCT01521806
- Testing
- Dietary Fiber
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ingredion Incorporated
Provoked Vestibulodynia
Somatocognitive Therapy in Treatment of Provoked Vestibulodynia - a Feasibility Study
This study examines feasibility of R\&D activities in the planned randomized controlled trial where effectiveness of somatocognitive therapy intervention will be compared to treatment as usual in provoked vestibulodynia.
- Trial name
- ProLoVe (NCT04208204)
- Testing
- somatocognitive physiotherapy
- Where
- Norway
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Focus of the Study is Smoking Cessation and Prevention, Smoking Prevention
Effectiveness Of Project EX: A Classroom-Based Smoking Prevention And Cessation Intervention Program
The goal of this intervention is to learn if Project EX helps in prevention and cessation of smoking in adolescents. The main question it aims to answer is: 1.
- Trial name
- NCT07895784
- Testing
- Project EX
- Where
- Pakistan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Karachi
The Study Focus on no Specific Condition
Interpretation of Health News Items Reporting Results of Phase I/II (Non-randomized) Trials With or Without Spin by English-speaking Population*
The main objective of this study is to compare the interpretation of health news items reporting results of phase I/II (non-randomized) trials with or without spin (i.e., distortion of research results).
- Trial name
- NCT03094091
- Testing
- News items with spin, News items without spin
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Facial Skin Laxity, Skin Aging
Focused Ultrasound Treatment for Facial Skin Laxity
The goal of this clinical trial is to learn if focused ultrasound can improve facial skin laxity in adults. The main questions this study aims to answer are: 1.
- Trial name
- NCT07381218
- Testing
- Focused UltrasoundDot Hand-piece (FUS-D), Focused Ultrasound Micro-focused Hand-piece (FUS-M)
- Where
- China
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Injuries
Incidence of Acute Injuries in Boxing
A prospective cohort study with 9 months follow up was carried out in 2017-2018. Boxers of both sexes 18 years and older from all 7 boxing clubs in Iceland were invited to participate in the study.
- Trial name
- NCT06264323
- Where
- Iceland
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Iceland
Obesity and Cardiovascular Risk
Lifestyle Program Focused on Nourishment, Well-Being, and Health Behaviors in Women With Obesity
Women, Weight and Well-Being is a 12-month research study looking at how a supportive lifestyle program may help women whose weight increases their risk for heart disease.
- Trial name
- NCT07404150
- Testing
- lifestyle change program
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Heather Conradson
Epilepsy, Focal Cortical Dysplasia
First-in-human Experience Using Novel Ultraflexible Low-impedance Electrode Arrays: an IDEAL Stage 1 Study
The goal of this first-in-human study is to evaluate a novel ultraflexible microelectrode in children undergoing neurosurgery to remove tissue that causes epilepsy (seizures) in focal cortical dysplasia (FCD) or long-term…
- Trial name
- NCT06116279
- Testing
- Insertion of electrode during planned neurosurgery for epilepsy
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Hypertension, Brain Tumor
A Pilot Study to Evaluate Efficacy and Safety of Clevidipine in Neurosurgical Patients
This protocol describes a study to gain experience in the use of Clevidipine for perioperative blood pressure control in patients undergoing craniotomy for brain tumor or epilepsy focus resection.
- Conditions
- Hypertension, Brain Tumor, Epilepsy
- Trial name
- NCT00952081
- Testing
- Clevidipine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Moderate or Severe Submental Fullness
Open-Label Study of Deoxycholic Acid for the Reduction of Localized Subcutaneous Fat in the Submental Area
To evaluate the safety of deoxycholic acid subcutaneous injections in the submental area (below the chin).
- Trial name
- NCT01426373
- Testing
- Deoxycholic acid injection
- Where
- 18 sites in United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Kythera Biopharmaceuticals
Adult Cancer Survivors, Adult Cancer Patients
Holistic Evaluation of Approaches to Long-term Health & Survivorship
This study aims at investigating behaviors of cancer patient regarding complementary and alternative medicine (CAM) with mixed methodology.
- Trial name
- HEALTHS (NCT07745205)
- Testing
- Interventional mixed-methods evaluation of cancer patient's behaviour regarding CAMs (focus groups), Quantitative evaluation of cancer patient's use of CAM's
- Where
- Belgium
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jules Bordet Institute
Study Focus is to Define the Usual Gut Microbiota Following Prebiotic Feeding
Effects of Fructan Prebiotics on the Intestinal Microbiota
Prebiotics are carbohydrate polymers believed to improve health by stimulating beneficial gastrointestinal microbial populations.
- Trial name
- NCT01277445
- Testing
- Prebiotic
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Dan Ramdath