Clinical trials: Folate
Perinatal DHA and Folate Status, Neurological Development
Fish Oil and Folate Supplementation During Pregnancy
Pregnant women are randomised to supplementation with fish oil, methyl tetrahydro folic acid, both or a placebo during the second half of pregnancy.
- Trial name
- NUHEAL (NCT01180933)
- Testing
- fish oil, folate, fish oil + folate
- Where
- 3 sites in Germany, Hungary and 1 more
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Pregnancy, Maternal Nutrition
Effects of Maternal Folate and Folic Acid Supplementation on DNA Methylation in the Newborn Infant
An overwhelming body of evidence of the protective effect of folic acid supplementation on neural tube defect affected pregnancies led to mandatory folic acid fortification in Canada in 1998.
- Conditions
- Pregnancy, Maternal Nutrition, Fetal Health, Epigenetics
- Trial name
- NCT02244684
- Where
- Canada
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Healthy
Increasing Folate Status of a General Population(FOLSUPP STUDY)
The aim of this study is to determine the best source of folate to raise the folate status of a general population over a 16 week intervention period.
- Trial name
- NCT00372645
- Testing
- Folic acid (supplement), Metafolin (supplement), Folate rich foods
- Where
- 2 sites in United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Infertility
Comparison of Acetyl- L- Carnitine& Folic Acid Versus Coenzyme Q10& Folic Acid on Semen& Hormonal Parameters& Semen Oxidative Status in Patients of Primary Infertility. A Double Blind Randomized Clinical Trial
The investigators aim is to conduct a double blind randomized clinical trial, to study the effects of Acetyl-L-Carnitine and folic acid versus Coenzyme Q10 and folic acid on Semen and hormonal parameters and semen oxidative…
- Trial name
- NCT05616000
- Testing
- Acetyl-l-carnitine, folic acid
- Where
- Pakistan
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Maternal Dietary Diversity, Iron-Folic Acid Supplementation
A Feasibility Study of Integrating Maternal Nutrition Interventions Into Antenatal Care Services in Ethiopia
Alive \& Thrive (A\&T) is an initiative that supports the scaling up of nutrition interventions to save lives, prevent illnesses, and contribute to healthy growth and development through improved maternal nutrition, breastfeeding…
- Conditions
- Maternal Dietary Diversity, Iron-Folic Acid Supplementation, Early Initiation of Breastfeeding
- Trial name
- NCT04125368
- Testing
- Health Facility Interventions, Community Interventions, Health System Interventions
- Where
- United States
- Volunteers
- 4,256 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Dietary Zinc Absorption
Effects of Dietary Folate and Phytate Zinc Absorption: Zinc Amino Acid Complexes vs. Zinc-chloride
The purpose of this study is to determine the effects of consuming a small breakfast of juice and toast with added phytate or with taking a folic acid supplement on the absorption of a small amount of zinc that is either bound to…
- Trial name
- NCT05273710
- Testing
- Regular toast and juice, High phytate toast and juice, Regular toast and juice, with folic acid
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Anemia
School-Based Assessment of Micronutrient Interventions in Adolescents in Burkina Faso
This purpose of this study is to assess effects of iron and folic acid supplementation and multiple micronutrient supplementation on anemia status, school performance/attendance and development outcomes among adolescents in…
- Trial name
- SAMIA (NCT04657640)
- Testing
- Iron and folic acid (IFA), Multiple Micronutrient Supplements (MMS) and loading dose of Iron and Folic Acid (IFA)
- Where
- Burkina Faso
- Volunteers
- 3,123 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Folate
Assessing Colonic Folate Absorption & Metabolism
Folate, a B-vitamin, is necessary in metabolic processes such as amino acid and nucleotide synthesis. Since folate cannot be synthesized by mammals, it must be consumed as foods and dietary supplements or generated by bacteria…
- Trial name
- NCT03421483
- Testing
- Folic Acid supplementation, Adult Multivitamin
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
ASC-US, Human Papilloma Virus
Can B12 and Folate Levels Predict HPV Penetration in Patients With ASCUS?
Non-classified atypical squamous cells (ASCUS) is the most common abnormal cervical cytology (%39). The risk of cervical intraepithelial neoplasia 2-3 is 5% and the risk of carcinoma is around 0.1% after diagnosis.
- Trial name
- NCT03903952
- Testing
- Vitamin B12 and folate
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Early Memory Loss, Mild Cognitive Impairment
NAC-003 P.L.U.S. Program (Progress Through Learning Understanding & Support)
This study will be an observational study in which patients who have been prescribed CerefolinNAC® are invited to participate in surveys regarding their experiences with CerefolinNAC®.
- Conditions
- Early Memory Loss, Mild Cognitive Impairment, Alzheimer's Disease, Vascular Dementia
- Trial name
- NCT01370954
- Testing
- CerefolinNAC®
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Pamlab, Inc.
Mild Hyperhomocysteinemia
Does B Vitamin Supplementation Decrease Homocysteine Concentrations in Newborns
The purpose of this study is to determine whether supplementation with folinic acid, a B vitamin, lowers the concentrations of total homocysteine in newborns.
- Trial name
- NCT00877227
- Testing
- 5-formyltetrahydrofolate (10 mg/ml) (Pharmachemie bv)
- Where
- Netherlands
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Weight Gain, Anemia, Iron Deficiency
Egg Intervention During Pregnancy in Indonesia
The study consists of two arms: 1) intervention group using eggs as supplementary food given from 2nd trimester of pregnancy to birth, and 2) observational group of pregnant mothers.
- Conditions
- Weight Gain, Anemia, Iron Deficiency, Birth Weight, Birth Length
- Trial name
- PRECODE (NCT04694235)
- Testing
- Egg intervention
- Where
- Indonesia
- Volunteers
- 702 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Drug Abuse, Genotoxicity
Effect of Folic Acid on the Presentation of Nuclear Abnormalities in People With a History Drug Abuse
Background: Multiple studies have pointed to the harmful potential of licit and illicit drugs. as agents associated with neoplastic processes and other non-communicable diseases, for which reason It has become a problem of global…
- Trial name
- NCT05712044
- Testing
- Folic Acid 5 MG
- Where
- Mexico
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centro Universitario de Tonalá
Major Depressive Disorder
Deplin® P.L.U.S. Program (Progress Through Learning Understanding & Support)
This study will be an observational study in which patients who have been prescribed Deplin® are invited to participate in surveys regarding their experiences with Deplin®.
- Trial name
- NCT01369030
- Testing
- Deplin®
- Where
- 2 sites in United States
- Volunteers
- 554 people, healthy volunteers welcome
- Sponsor
- Pamlab, Inc.
Healthy, Cardiovascular Diseases
Effect of Betaine and Folic Acid on Vascular Function in Healthy Humans
The purpose of this study is to determine whether lowering of fasting homocysteine concentrations improves vascular function in healthy volunteers, irrespective of the homocysteine-lowering agent.
- Trial name
- NCT00102843
- Testing
- supplementation with folic acid and betaine
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wageningen Centre for Food Sciences
Thrombosis
Plasma Vitamin and Homocysteine Levels and Thrombosis in Patients With Ph-negative MPNs
Hyperhomocysteinemia is a risk for thrombosis. Thrombosis is more frequent in myeloproliferative neoplasms (MPNs) than the normal population.
- Trial name
- NCT01878916
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Istanbul University
Neural Tube Defects
Efficacy of Weekly Versus Daily Folic Acid Supplementation
Investigate the efficacy of weekly versus daily of folic acid supplementation on improving folate, vitamin B12,
- Trial name
- NCT00394862
- Testing
- multivitamin
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Emory University
Red Blood Cell Folate
Bioavailability of Folic Acid Fortified Bread
Folic acid is the synthetic form of vitamin folate. Because of its high stability and bioavailability, it is the form of folate added to bread in Canada to reduce birth defects.
- Trial name
- NCT01570088
- Testing
- Folic acid, L-5-MTHF
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Unipolar Depression
Natural Supplements for Unipolar Depression
This study is being conducted to determine the clinical response rate for the regimen of L-methionine, betaine and folate for unipolar depression.
- Trial name
- NCT00226356
- Testing
- Supplements of L-methionine, betaine and folate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Colorectal Neoplasms
Study of Folic Acid, Calcium and Vitamin D in Preventing Colorectal Polyps and Colorectal Cancer
Folic acid (FA) and its derivatives (folate) which play a role in nucleotide synthesis and methylation reactions as well as calcium and vitamin D are assumed to be effective in the prevention of colorectal polyps and Colorectal…
- Trial name
- NCT02066688
- Testing
- folic acid, folic acid calcium vitamin D3, calcium
- Where
- China
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine