Clinical trials: Folate
Cardiovascular Diseases
Anticoagulation, Vitamins, and Endothelial Function
Determine whether low or high dose B vitamin therapy will lower homocysteine and thrombomodulin in patients anticoagulated with warfarin.
- Trial name
- NCT00018460
- Testing
- Vitamin B
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Depression, Depressive Disorder
Beyond Ageing Project: A Study for the Prevention of Depression
The purpose of this study is to determine whether folate and vitamin B12, physical activity and mental health literacy can prevent depression, and folate and vitamin B12 and physical activity can prevent cognitive impairment in…
- Trial name
- NCT00214682
- Testing
- Folate (400mcg) and Vitamin B12 (100 mcg), mediated physical activity promotion, Mental health literacy
- Where
- Australia
- Volunteers
- 909 people
- Sponsor
- Australian National University
Nutrition Disorders
Influence of Iron and Foliate Transporters on Bioavailability of These Micronutrients in the Organism
The aim of the study is to determine the factors affecting the bioavailability of iron and folic acid during the simultaneous use of iron supplements and folic acid supplements in non-pregnant women of childbearing age.
- Trial name
- WiMKo (NCT03438942)
- Testing
- Folic acid and iron supplementation, Control group
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Spina Bifida or Spinal Dysraphism
Vitamin B9 Supplementation Recommendations in Rennes CHU
The study objective is to assess the knowledge and the follow-up of vitamin B9 supplementation recommendations for women in the periconceptional period to prevent neural tube closure defects.
- Trial name
- QUALI B9 (NCT04195542)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 1,284 people
- Sponsor
- Rennes University Hospital
Subfertility
Mild Versus Conventional Ovarian Stimulation Treatment for In Vitro Fertilization
In vitro fertilization (IVF) is an assisted reproductive technique to achieve pregnancy in subfertile couples of which the average success rate is only 25%.
- Trial name
- FOLFO (NCT00985062)
- Testing
- Mild Ovarian Stimulation Treatment, Conventional Ovarian Stimulation Treatment
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- Erasmus Medical Center
Metastatic Renal Cell Carcinoma
Study Using FolateScan to Identify Subjects With Folate Receptor-Positive Metastatic Renal Cell Carcinoma
Phase 2, multi-center, open-label, single-treatment group, baseline-controlled study to identify subjects with Folate Receptor-Positive Metastatic Renal Cell Carcinoma
- Trial name
- NCT01689766
- Testing
- Technetium Tc 99m EC20
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Endocyte
Renal Cell Carcinoma
A Phase II Study of EC17 (Folate-hapten Conjugate) in Patients With Progressive Metastatic Renal Cell Carcinoma
This is a Phase 2 clinical trial to collect data on tumor responses produced by folate-hapten conjugate therapy (vaccination with EC90 [KLH-FITC] and GPI-0100 adjuvant followed by treatment with EC17 (folate-FITC) in combination…
- Trial name
- NCT00485563
- Testing
- EC90 (KLH-FITC), GPI-0100, EC17 (Folate-FITC)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Endocyte
Colorectal Cancer
Fluorouracil, Leucovorin, and Irinotecan in Treating Patients With Recurrent or Refractory Metastatic Unresectable Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, leucovorin, and irinotecan, use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00075595
- Testing
- FOLFIRI regimen, fluorouracil, irinotecan hydrochloride
- Where
- 15 sites in France
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Contraception
Study of Treatment With the Combination of Drospirenone Plus Ethinyl Estradiol Plus Levomefolate Calcium in Mexican Women Seeking Contraception
The objective of this study is to compare the red blood cell (RBC) and plasma concentrations of folate in subjects treated with drospirenone (DRSP)/ethinyl estradiol (EE) plus levomefolate calcium (L-5-MTHF) at 24 weeks with…
- Trial name
- NCT01902264
- Testing
- EE20/DRSP/L-5-MTHF (Beyaz, BAY98-7071)
- Where
- Mexico
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Bayer
Frailty
Relationship Between Albumin/Creatine Ratio, B12, Folate, and Frailty Index
In the literature, the relationship between frailty and various blood tests such as beta-2 microglobulin, CRP, procalcitonin, vitamin D, IL-1, and IL-6 has been investigated (2).
- Trial name
- NCT06393647
- Testing
- Frailty scale forms (Frailty Scale Version 9)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Etlik City Hospital
Diabetic Foot Ulcer (DFU), Diabetic Symmetrical Polyneuropathy
Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healing
Diabetic symmetrical polyneuropathy (DSPN) is a common complication of diabetes that affects the nerves, especially in the legs and feet. It can cause pain, numbness, tingling, weakness, and loss of sensation.
- Trial name
- NCT07877948
- Testing
- Alpha-Lipoic Acid, Vitamin B1, Vitamin B6, Vitamin B12, Vitamin E, Vitamin B1, Vitamin B6, Vitamin B12
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- BREGO Life Sciences
Overweight and Obesity
Profile Of Methylation and Gene Expression Of Gene ADRB3 And Effects Of Folate Intake
ABSTRACT Epigenetic mechanisms may be involved in the regulation of lipid metabolism and inflammatory markers may therefore contribute to the cardiovascular risk profile, as well as environmental factors have a significant impact…
- Trial name
- NCT02846025
- Testing
- Folate and capsule of oil hazel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Advanced Colorectal Cancer, Adenocarcinoma of the Colon
Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancer
To determine the effect of ABT-869 plus mFOLFOX6 compared to bevacizumab plus mFOLFOX6 on disease progression in advanced colorectal cancer.
- Conditions
- Advanced Colorectal Cancer, Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
- Trial name
- NCT00707889
- Testing
- ABT-869, bevacizumab, oxaliplatin
- Where
- 46 sites in United States, Australia and 12 more
- Volunteers
- 159 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Cancer - Ovarian
A Study to Evaluate Folate Receptor Alpha (FRα) Expression in Adult Participants With Ovarian, Fallopian Tube, and Primary Peritoneal Cancer in Italy
The purpose of this study is to evaluate the prevalence of folate receptor alpha (FRα)-positive status (≥75% viable tumor cells with moderate (2+) and/or strong (3+) membrane staining) in participants with high-grade serous…
- Trial name
- FORCE (NCT07407062)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- AbbVie
Overweight and Obesity
Polymorphism C677T MTHFR and Effects of Folate Intake
The C677T polymorphism in the MTHFR gene is related to several significant biochemical changes, as dyslipidemia, changes in serum levels of homocysteine, folic acid, vitamin B12 and some oxidative stress markers such as the CAT…
- Trial name
- NCT02953522
- Testing
- 191 mcg/day of Folate, 90 mcg / day of Folate
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
the Effect of MTHFR C677T on Folate Metabolism
Effect of Folic Acid on Primary Folate Forms in Relation to MTHFR
The common polymorphism in MTHFR gene (C677T) has a significant effect on (6S)-5-CH3-H4folate after folic acid supplementation. For example, post supplementation differences in (6S)-5-CH3-H4folate between CC and TT are above 30%.
- Trial name
- NCT01105351
- Testing
- folic acid plus B6 and B12, folic acid
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universität des Saarlandes
Parkinson's Disease
An Exploratory, Randomized, Blinded, Placebo-Controlled Trial of Folic Acid and L-methylfolate in Parkinson's Disease
This study is being conducted to assess the impact of folate and L-methylfolate on the progression of Parkinson's. The investigators are specifically looking for the effect of these nutritional supplements in Parkinson's patients…
- Trial name
- NCT00853879
- Testing
- Folic Acid, Vitamin B6, Vitamin B12, B6, B12, L-methylfolate
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Unipolar Depression
Natural Supplements for Unipolar Depression
This study is being conducted to determine the clinical response rate for the regimen of L-methionine, betaine and folate for unipolar depression.
- Trial name
- NCT00226356
- Testing
- Supplements of L-methionine, betaine and folate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Advanced Solid Tumors
A Study of ZW191 in Participants With Solid Tumors
The purpose of this study is to find out if ZW191 is safe and can treat participants with advanced cancers, including ovarian, endometrial, and non-small cell lung cancers.
- Trial name
- NCT06555744
- Testing
- ZW191
- Where
- 27 sites in United States, Australia and 4 more
- Volunteers
- 145 people
- Sponsor
- Zymeworks BC Inc.
Cystic Fibrosis
Effects of 5-Methyltetrahydrofolate and Vitamin B12 Supplemetation on Red Cell Membrane in Children With Cystic Fibrosis
The purpose of this study is to determine whether 5 - methyltetrahydrofolate and vitamin B12 supplementation can ameliorate cell plasma membrane features in pediatric patients with cystic fibrosis
- Trial name
- NCT00730509
- Testing
- 5-methyltetrahydrofolate and vitamin B12
- Where
- Italy
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Universita di Verona