Clinical trials: Folate
Folate, CML
FLOR3 Gene Polymorphism in Predicting Outcomes of Tyrosine Kinase Inhibitor（TKI）Stopping in Chronic Myeloid Leukemia
For patients with chronic myeloid leukemia in chronic phase (CML-CP) who have achieved a stable deep molecular response (DMR) using BCR-ABL1 tyrosine kinase inhibitors (TKIs), treatment-free remission (TFR) following TKI…
- Conditions
- Folate, CML, Treatment-free Remission
- Trial name
- NTU-CML-001 (NCT05152537)
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Affiliated Hospital of Nantong University
Anemia, Folate Deficiency
Periconceptional Surveillance in India
Women of reproductive age are a high-risk population for anaemia and micronutrient deficiencies. Evidence supports the role of periconceptional nutrition in the development of adverse pregnancy complications.
- Conditions
- Anemia, Folate Deficiency, Vitamin B12 Deficiency
- Trial name
- NCT04048330
- Where
- India
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Cornell University
Folic Acid Deficiency
In Utero Capacity Formation and Socio-economic Outcomes
Because of the high returns of schooling in developing countries, policymakers pay a lot of attention to increasing school access.
- Trial name
- CDS (NCT01412580)
- Testing
- observational follow-up
- Where
- Tanzania
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Harvard University
First Episode Psychosis
Efficacy of Treating First Episode Psychosis With Folic Acid,B12 and B6 in Addition to Antipsychotic Medication
The purpose of this study is to determine whether Vitamin B12,B6 and Folic Acid are effective with antipsychotic medication in the treatment of First Episode Psychosis.The B-complex Vitamins' homocysteine lowering properties may…
- Trial name
- NCT00202280
- Testing
- Folic Acid 5mg, Vitamin B12 0.4mg and B6 50mg
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- Melbourne Health
Thalassemia, Folic Acid Deficiency Anemia
Effect of Folic Acid Supplementation in Pregnant Women Having Thalassaemia Trait
Folic acid supplementation has been recommended for prevention of neural tube defects in pregnancy when taken periconceptionally up to 12 weeks of gestation.
- Trial name
- NCT04310059
- Testing
- Folic acid, Materna
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
5q Minus Syndrome, Myelodysplastic Syndrome
Leucovorin for the Treatment of 5 q Minus Syndrome
The 5 q minus syndrome is a condition that occurs due to a missing segment of chromosome 5 in the normal genetic make-up of the cells responsible for forming blood cells.
- Trial name
- NCT00004997
- Testing
- Leucovorin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
IVF, Body Weight
Nutritional Status of Women Undergoing in Vitro Fertilization
Infertility affects around 15 % of couples in their reproductive years. Even though the use of assisted reproductive technologies (ART) in aforementioned couples is increasing, their success rate is still relatively low.
- Conditions
- IVF, Body Weight, Nutrient Deficiency, Dietary Vitamin B12 Deficiency Anemia
- Trial name
- NCT05865015
- Where
- 2 sites in Slovenia
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Infertility, Female
The Potential Effects of Inofolic Plus on Abnormal Ovarian Reserve Parameters in Subfertile Women
Dr. Roseff and his colleagues are conducting a study to evaluate the effectiveness of a novel substance (Inofolic Plus®) in improving oocyte (egg) parameters in subfertile female patients, as measured through Anti-Mullerian…
- Trial name
- NCT01290432
- Testing
- Inofolic Plus
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Palm Beach Center for Reproductive Medicine
Platinum-resistant Ovarian Cancer
An Extension Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer in China
The purpose of this Chinese extension study is to compare how well Rina-S works against platinum-resistant ovarian cancer compared to chemotherapy drugs that are already approved and used for platinum-resistant ovarian cancer.
- Trial name
- RAINFOL-02 (NCT07604766)
- Testing
- Rina-S, Paclitaxel, Topotecan
- Where
- 17 sites in China
- Volunteers
- 82 people
- Sponsor
- Genmab
Bilateral Breast Carcinoma, Breast Inflammatory Carcinoma
Multi-epitope Folate Receptor Alpha Peptide Vaccine, GM-CSF, and Cyclophosphamide in Treating Patients With Triple Negative Breast Cancer
This randomized phase II trial studies how well multi-epitope folate receptor alpha peptide vaccine, sargramostim (GM-CSF), and cyclophosphamide work to prevent the recurrence of stage 1-3 triple negative breast cancer.
- Conditions
- Bilateral Breast Carcinoma, Breast Inflammatory Carcinoma, Stage IB Breast Cancer AJCC v7, Stage II Breast Cancer AJCC v6 and v7
- Trial name
- NCT03012100
- Testing
- Cyclophosphamide, Laboratory Biomarker Analysis, Multi-epitope Folate Receptor Alpha Peptide Vaccine
- Where
- 12 sites in United States
- Volunteers
- 280 people
- Sponsor
- Academic and Community Cancer Research United
Mild Hyperhomocysteinemia
Does B Vitamin Supplementation Decrease Homocysteine Concentrations in Newborns
The purpose of this study is to determine whether supplementation with folinic acid, a B vitamin, lowers the concentrations of total homocysteine in newborns.
- Trial name
- NCT00877227
- Testing
- 5-formyltetrahydrofolate (10 mg/ml) (Pharmachemie bv)
- Where
- Netherlands
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pancreatic Cancer
Italian Multicenter Study Comparing FOLFOXIRI Versus Gemcitabine as Adjuvant Treatment for Resected Pancreatic Cancer
Patients with resected pancreatic cancer who fulfill the selection criteria will be randomized to receive one of the two treatment arms for a period of 6 months: Gemcitabine, the standard arm, or FOLFOXIRI (the combination of…
- Trial name
- GIP-2 (NCT02355119)
- Testing
- FOLFOXIRI, Gemcitabine
- Where
- Italy
- Volunteers
- 310 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Acute Kidney Injury
Intravenous Administration of Vitamin B Complex Improves Renal Recovery in Patients With AKI
Animal and human studies have shown that the administration of vitamin B3 (niacin) improves renal ischemia; helping to recover from acute kidney injury (AKI) more effectively; Therefore, its use in patients with AKI could improve…
- Trial name
- VIBAKI (NCT04893733)
- Testing
- Vitamin B Complex, STOP AKI protocol
- Where
- Bolivia
- Volunteers
- 260 people
- Sponsor
- Caja Nacional de Salud
Metastatic Colorectal Cancer, Liver Metastases
FOLFIRI and Sunitinib in Metastatic Colorectal Cancer
This is an open label single arm prospective multicenter Phase II study in around 20 patients. The primary objective of this study is to evaluate whether the addition of sunitinib to FOLFIRI results in a significant reduction of…
- Trial name
- NCT00806663
- Testing
- sunitinib added to FOLFIRI
- Where
- 4 sites in Germany
- Volunteers
- 22 people
- Sponsor
- Central European Society for Anticancer Drug Research
Ovarian Cancer, Fallopian Tube
Study of Carboplatin and Mirvetuximab Soravtansine in First-Line Treatment of Patients Receiving Neoadjuvant Chemotherapy With Advanced-Stage Ovarian, Fallopian Tube or Primary Peritoneal Cancer
The proposed study design is a single arm Phase II trial to document the feasibility of carboplatin-mirvetuximab - in patients with advanced-stage EOC.
- Conditions
- Ovarian Cancer, Fallopian Tube, Primary Peritoneal Cancer
- Trial name
- NCT04606914
- Testing
- mirvetuximab soravtansine (MIRV; IMGN853)
- Where
- 9 sites in United States
- Volunteers
- 70 people
- Sponsor
- University of Alabama at Birmingham
Melatonin, Diabetic Nephropathy
Efficacy of Melatonin in the Treatment of Diabetic Nephropathy Compared With Folic Acid
The current study aims to investigate and compare the anti-inflammatory effects of melatonin versus folic acid in patients with diabetic nephropathy.
- Conditions
- Melatonin, Diabetic Nephropathy, Folic Acid
- Trial name
- NCT07825961
- Testing
- Conventional diabetic treatment, Folic acid, Melatonin
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Metastatic Colorectal Cancer
Hepatic Arterial Infusion With FOLFOX Alone or in Combination With IV Chemotherapy in Colon Cancer With Liver Metastasis
In this study, Hepatic Arterial Infusion will be combined with systemic therapy for patients with liver-only or liver-predominant metastases who have failed at least one line of systemic chemotherapy.
- Trial name
- NCT02345746
- Testing
- Oxaliplatin, Folinic Acid, 5-Fluorouracil
- Sponsor
- Western Regional Medical Center
Anemia, Iron-deficiency
Preoperative Anaemia prevaLence In surgiCal patiEnts
Preoperative anaemia is common in surgery, with a prevalence between 10 and 50 %, and is an independent risk factor for morbidity and mortality.
- Conditions
- Anemia, Iron-deficiency, Folic Acid Deficiency, Vitamin B 12 Deficiency
- Trial name
- ALICE (NCT03978260)
- Where
- Germany
- Volunteers
- 2,500 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Prostate Cancer
CYTALUX™for the Intraoperative Imaging of Prostate Cancer
This study is being done to compare how much using Cytalux™ (pafolacianine) with NIR (Near InfraRed) fluorescent imaging improves the detection of malignant (growing in an uncontrolled way) tissue in adult subjects undergoing…
- Trial name
- NCT06434909
- Testing
- Cytalux™ (pafolacianine) for fluorescent imaging, Image Guided Surgery
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Indiana University