Clinical trials: Folate Bioavailability
Healthy, Pharmacokinetics
Bioavailability Study of Folic Acid in Healthy Women
The purpose of the study is to determine the bioavailability of orally administered folic acid compared with the i.v. administered folic acid, and to use the samples collected to validate the analytical methods for estimation of…
- Trial name
- NCT00709267
- Testing
- Folic acid
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Healthy
Folate Absorption Across the Large Intestine
The objective of this study is to determine whether the intact human colon with an unaltered microflora distribution absorbs folate and to what extent it is absorbed into the systemic circulation using a dual/oral intravenous…
- Trial name
- NCT00941174
- Testing
- 13C5-Calcium-L-Leucovorin
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Iron Deficiency, Folic Acid Deficiency
Relative Bioavailability of Iron and Folic Acid in New Test Supplement
Deficiencies of iron and folic acid during pregnancy can lead to adverse outcomes for the fetus, thus supplements are recommended. Adherence to current tablet-based supplements is documented to be poor.
- Trial name
- NCT00789490
- Testing
- Daminaide 995 - SuppleFem Sprinkles, Materna
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy
Bioavailability Study of Folate in Healthy Subjects
The aim of this prospective interventional study is to compare the bioavailability of the 6S-5-methyltetrahydrofolate (5-MTHF) glucosamine salt versus two other forms of 5- MTHF calcium salts by measuring serum 5-MTHF responses…
- Trial name
- NCT05699473
- Testing
- 5-MTHF glucosamine salt, 5-MTHF calcium salt 1, 5-MTHF calcium salt 2
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lesaffre International
Vitamin B12 Deficiency
Relative Bioavailability of Folic Acid and L-5-Methlytetrahydrofolate
Folic acid, a form of the vitamin folate, is added to grain products in Canada to help reduce birth defects. Folic acid is the synthetic form of folate and is very stable (doesn't break down) when added to foods.
- Trial name
- NCT01584050
- Testing
- L-5-methyltetrahydrofolate (Metafolin ®), folic acid
- Where
- 2 sites in Canada, Malaysia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy
Estimation of Plasma Folate Apparent Volume of Distribution in Adults
The aim of this study is to calculate the plasma apparent volume of distribution of natural folate to give a more accurate value for use in a mathematical model of apparent folate absorption.
- Trial name
- FOLCAN (NCT00975351)
- Testing
- 13C5-labelled 5-methyltetrahydrofolic acid
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Folate Bioavailability, Healthy
Bioavailability of Folate From a Mixed Diet Using a Stable Isotope Method
The main objectives of this project are: 1. to determine the relative bioavailability of dietary folate from a total diet, compared with synthetic folic acid and 2.
- Trial name
- NCT00130585
- Testing
- Controlled diet, folic acid supplement, 13C11-labelled folic acid supplement
- Where
- Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Wageningen Centre for Food Sciences
Red Blood Cell Folate
Bioavailability of Folic Acid Fortified Bread
Folic acid is the synthetic form of vitamin folate. Because of its high stability and bioavailability, it is the form of folate added to bread in Canada to reduce birth defects.
- Trial name
- NCT01570088
- Testing
- Folic acid, L-5-MTHF
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Nutrition Disorders
Influence of Iron and Foliate Transporters on Bioavailability of These Micronutrients in the Organism
The aim of the study is to determine the factors affecting the bioavailability of iron and folic acid during the simultaneous use of iron supplements and folic acid supplements in non-pregnant women of childbearing age.
- Trial name
- WiMKo (NCT03438942)
- Testing
- Folic acid and iron supplementation, Control group
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences
Single Nucleotide Polymorphism
Folate Gene Polymorphisms and Cellular Folate Speciation Pilot Study
This pilot study is designed to investigate differences in folate-related genes (single nucleotide polymorphisms) and their relationship to the species of folate present on red blood cells.
- Trial name
- FolGene (NCT00975364)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience