Clinical trials: Fontan Circulation
Single-ventricle, Fontan Circulation
Venous Compression in Fontan
The aim of this study is to investigate whether venous compression garments increase exercise stroke volume in patients with Fontan circulation. To address this aim, we will test the following hypotheses: 1.
- Trial name
- NCT07220226
- Testing
- Lower extremity compression garments, Without compression garments
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Fontan Circulation
Fontan Circulation and Reproductive Health in a National Swedish Cohort
In the Swedish registry for congenital heart defects, SWEDCON, over 230 patients with single-ventricle circulation are registered in the adult section.
- Trial name
- NCT06258382
- Testing
- Questionnaires and functional test
- Where
- 15 sites in Sweden
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Caroline Lilliecreutz
Patient Participation, Heart Defects, Congenital
Liver Disease, Myocardial Fibrosis and Collaterals in the Adult Fontan Patient a Metabolomics and Proteomics Approach
Out objective is to identify the mechanisms that promote hepatic and myocardial fibrosis, and collateral vessel formation in patients with complex congenital heart disease and Fontan circulation.
- Conditions
- Patient Participation, Heart Defects, Congenital, Liver Diseases, Collateral Circulation, Any Site
- Trial name
- NCT04764305
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Congenital Heart Disease
Fontan Circulation and Cardiopulmonary Function: Prognostic Factors, Hemodynamics and Long-term Effects
Cross-sectional study of a national cohort of adolescents with univentricular congenital heart defects and Fontan type palliation.
- Trial name
- NCT02378857
- Where
- Norway
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Lymphatic Abnormalities, Lymphatic Edema
Lymphatic Function in Patients With a Fontan-Kreutzer Circulation
The lymphatics regulate the interstitial fluid by removing excessive fluid. It represents an extremely important step in the prevention of edema.
- Conditions
- Lymphatic Abnormalities, Lymphatic Edema, Univentricular Heart
- Trial name
- NCT03379805
- Testing
- Near Infrared Fluorescence Imaging, Non-contrast MRI, Strain Gauge Plethysmography
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Fontan Circulation, Fontan Procedure
Gut, Inflammation and Nutrition in Adult Patients After Fontan Operation
This observational case-control study aims to investigate intestinal barrier dysfunction, systemic inflammation, and nutritional status in adult patients after Fontan operation.
- Trial name
- GIN-Fontan (NCT06731322)
- Where
- Slovenia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Fontan Circulation
The Effects of Sildenafil on Exercise Function and Capacity in Patients With Fontan Circulation
The study will test the hypothesis that a single dose of sildenafil can increase the exercise capacity of pediatric patients with a Fontan Circulation.
- Trial name
- NCT00964782
- Testing
- Sildenafil, Sildenafil 2
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Single-ventricle
Inspiratory Muscle Therapy in Subjects With Fontan Circulations
Individuals who have undergone the Fontan procedure are uniquely dependent upon respiratory mechanics to support pulmonary blood flow (PBF).
- Trial name
- NCT03339466
- Testing
- Inspiratory muscle therapy
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Lymphatic Abnormality, Plastic Bronchitis
Lymphatic Morphology of Fontan Patients
The Fontan procedure has revolutionized the treatment of patients born with a congenital univentricular heart defect. However, over time, it is associated with severe lymphatic complications such as plastic bronchitis…
- Conditions
- Lymphatic Abnormality, Plastic Bronchitis, Protein-Losing Enteropathies, Univentricular Heart
- Trial name
- NCT04163653
- Testing
- Non-contrast MRI, Cardiopulmonary exercise test
- Where
- Denmark
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Fontan Procedure, Altitude
Cardiopulmonary Adaptation of Short Term Exposure to High Altitude in Fontan Patients: Swiss Fontan & ALtitude COllaboratioN (FALCON) Study
Important advances in cardiac surgery, intensive care, and diagnostic modalities over the last decades have led to a steady growth in the number of adults with congenital heart defects.
- Trial name
- FALCON (NCT02237274)
- Testing
- High altitude exposition
- Where
- Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Fontan Circulation
Impact of Therapy Using Colesevelam Treatment Reducing Bile Acids in Patients With Fontan Circulation.
This is the first pilot study proposing a novel therapeutic option treating patients with Fontan circulation (FC), a high-risk condition that has no definite treatment options available, other than heart or heart-liver…
- Trial name
- MYSTIC (NCT06197763)
- Testing
- Colesevelam, Control Arm
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- St. Boniface Hospital
Univentricular Heart, Lymphatic Abnormalities
Lymphatic Function in Patients With a Fontan Circulation From Brazil
It is suggested that the elevated central venous pressure in patients with a Fontan circulation can provoke manifestation of lymphatic dysfunction, met as plastic bronchitis, peripheral oedema and most feared protein-losing…
- Conditions
- Univentricular Heart, Lymphatic Abnormalities, Lymphatic Edema
- Trial name
- NCT04394507
- Testing
- Near-Infrared Fluorescence imaging, Strain Gauge Plethysmography
- Where
- 2 sites in Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Aarhus