Clinical trials: Foot/Ankle
CMT - Charcot-Marie-Tooth Disease, Peripheral Neuropathy
Effect of Orthoses and Underfoot Vibration on Balance in Neuropathy
A cross-sectional study which will look at the effects of AFO's and vibrating insoles on balance performance in people with CMT disease.
- Conditions
- CMT - Charcot-Marie-Tooth Disease, Peripheral Neuropathy, Hereditary Peripheral Neuropathy, CMT1A
- Trial name
- NCT03278093
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- St George's, University of London
Cerebral Palsy Spastic Diplegia
Ankle Foot Orthosis on Muscle Activity in Cerebral Palsy
To compare the effect of solid ankle foot orthosis and ground reaction foot orthosis on the muscle activity in children with spastic diplegic cerebral palsy (Gross Motor Functional Classification Scale III).
- Trial name
- NCT06291974
- Testing
- electromyography
- Volunteers
- 30 people
- Sponsor
- Delta University for Science and Technology
Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
Platelet Rich Plasma for Musculoskeletal Conditions
The primary purpose of this study is to follow patients with various musculoskeletal (MSK) conditions over a one-year follow-up period after receiving a platelet rich plasma (PRP) injection, assessing changes in their pain…
- Conditions
- Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Shoulder
- Trial name
- PRP for MSK (NCT07231471)
- Testing
- Platelet Rich Plasma Injection, Platelet Rich Plasma Preparation
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Utah
Plantar Fasciitis
Observation on the Efficacy of Improving Ankle Dorsiflexion Limitation in Patients With Plantar Fasciitis
This study aims to design a randomized controlled trial to treat plantar fasciitis by combining conventional rehabilitation with the improvement of ankle dorsiflexion function, and to explore its clinical efficacy by combining…
- Trial name
- NCT06542211
- Testing
- Intervention plan for improving ankle dorsiflexion limitation group (experimental group), Plantar fasciitis routine rehabilitation group
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Elective Foot and Ankle Surgery.
Use of Platelet-Rich Plasma (PRP) and Platelet-Poor Plasma (PPP) to Prevent Infection and Delayed Wound Healing
The purpose of this study is to see if applying PRP and PPP to surgical sites and the closing incision helps prevent infection and slow wound healing.
- Trial name
- PRP (NCT01639144)
- Testing
- PRP and PPP
- Where
- United States
- Volunteers
- 515 people
- Sponsor
- Gary M. Kiebzak, Ph.D.
Arthritis
A Study Evaluating Amplex Compared To Autograft Bone In Foot and Ankle Fusion Surgery
The current research study evaluates an investigational medical device called Amplex B2A(TM) Peptide Enhanced Ceramic Granules ("Amplex") for use in foot and ankle fusion. Amplex is a synthetic bone graft material.
- Trial name
- NCT01224119
- Testing
- Amplex, Autograft bone
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- BioSurface Engineering Technologies, Inc
Diabete Mellitus, Diabete Type 2
A Pilot Study of the Effectiveness of Foot-Ankle and Walking Exercises in Patients With Diabetes Mellitus
This pilot feasibility and exploratory study, conducted to prepare for a definitive Randomized Controlled Trial (RCT), compares a structured foot-ankle exercise program with a walking exercise program in adults with Diabetes…
- Conditions
- Diabete Mellitus, Diabete Type 2, Diabetic Peripheral Neuropathy, Diabetic Foot
- Trial name
- NCT07270328
- Testing
- Foot-ankle exercise group, Walking exercise group, Control group
- Where
- 3 sites in Indonesia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Defect of Articular Cartilage, Degenerative Joint Disease of Ankle and/or Foot
Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in Their Ankle
The objective of this study is to evaluate the efficacy and safety of Chondron (Autologus Chondrocyte) in patients with cartilage defects in their ankle for 18 months
- Conditions
- Defect of Articular Cartilage, Degenerative Joint Disease of Ankle and/or Foot, Ankle (Ligaments); Instability, Familial
- Trial name
- NCT02537067
- Testing
- CHONDRON
- Where
- 2 sites in South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Traumatic Lower Limb Injury
The Effects of Heel Distraction Height on Foot Loading With Carbon Fiber Custom Dynamic Orthoses
Carbon fiber custom dynamic orthoses (CDOs) and unloading ankle foot orthoses (AFOs) have shown varying levels of success in reducing forces acting on different regions of the bottom of the foot during gait.
- Trial name
- CDODistract (NCT06127316)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Iowa
Hemiparesis;Poststroke/CVA, Gait, Hemiplegic
Comparison of Thermo-plastic Versus Carbon Foot Ankle Orthosis to Improve Gait and Reduce Fatigue in Post-stroke Patients: a Biomechanical and Neurophysiological Study
Approximately 20% of stroke survivors have difficulties to dorsiflex the ankle and clear the ground during walking. This impairment, termed as "foot drop", is caused by an association of weak dorsiflexors and increased spasticity…
- Trial name
- MECASPRY (NCT04323943)
- Testing
- Ankle Foot orthosis (AFO)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Thuasne
Instability, Joint
Effect of Core Stability Training With Foot Exercises in Chronic Ankle Instability Patients
This study aims to investigate the effects of various treatments on lumbar and ankle proprioception, balance, and foot function in patients with chronic ankle instability.
- Trial name
- NCT07731035
- Testing
- conventional physical therapy, Core stability training, intrinsic foot muscle exercises
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Diabetes Mellitus, Type 2
The Effect Of Acupressure and Foot Exercise on Ankle Brachial Index in Individuals With Type 2 Diabetes
This study was planned with a randomized controlled experimental design to examine the effects of acupressure and ankle exercises on ankle brachial index in individuals with Type 2 diabetes.
- Trial name
- NCT06271382
- Testing
- Acupressure Group, Foot Ankle Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Fracture of Fifth Metatarsal Bone
Comparison of Conservative and Operative Treatment of Jones Fracture
The study deals with the topic of treatment of Jones fracture, comparing surgical and conservative approach. The fracture occurs especially in highly active individuals.
- Trial name
- NCT04037540
- Testing
- Operational approach, Conservative approach
- Where
- Czechia
- Volunteers
- 27 people
- Sponsor
- University Hospital Ostrava
Foot Deformities, Acquired, Disorder of Joint of Foot
A Clinical Study of Outcomes in Foot and Ankle Bone Grafting Using map3® Cellular Allogeneic Bone Graft
This is a single arm pilot study in patients requiring surgical fusion in the foot or ankle. Patients will receive map3® Cellular Allogeneic Bone Graft containing donor matched stem cells.
- Conditions
- Foot Deformities, Acquired, Disorder of Joint of Foot, Fracture of Foot, Deformity of Bone
- Trial name
- NCT02161016
- Testing
- map3
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- RTI Surgical
Motion Capture, Foot and Ankle Joint
Markerless Motion Capture in Foot and Ankle Surgery
Proof of Concept: ROM measured by the markerless system compared to clinical examination using a goniometer and motion capture analysis.
- Conditions
- Motion Capture, Foot and Ankle Joint, AI
- Trial name
- ROM OpenCap (NCT07848282)
- Testing
- Markerless motion capture in foot and ankle surgery
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Aging Problems
Effects of Feet and Ankle Mobilization on Balance of Older Adults
This study aims to assess whether mobilization of the ankle and foot produces significant improvements in the balance of the elderly.
- Trial name
- FEET_BALANCE (NCT03092869)
- Testing
- Feet and Ankle Mobilization, Proprioceptive Training
- Where
- 2 sites in Spain
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Pain, Postoperative, Pain, Acute Postoperative
Exparel Use in Peripheral Nerve Blocks and Local Infiltration for Foot and Ankle Surgery
Liposomal Bupivacaine (Exparel) has been recently studied as the active agent utilized in various nerve block. Due to its liposomal form allowing for extended delivery, Exparel has been used in various peri-operative nerve blocks…
- Conditions
- Pain, Postoperative, Pain, Acute Postoperative, Ankle Fractures, Ankle Injuries and Disorders
- Trial name
- NCT05494645
- Testing
- Exparel, Peripheral Nerve Block
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- St. Luke's Hospital, Pennsylvania
Foot Surgery, Ankle Surgery
Periarticular Injection Versus Popliteal Block
This study aims to determine the effectiveness and safety of two standard of care perioperative procedures for controlling pain following ankle and hindfoot osteotomy or fusion or ankle fracture repair.
- Trial name
- PvP (NCT04575688)
- Testing
- Exparel, Bupivicaine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Campbell Clinic
Injury; Muscle, Ankle, and Foot, Multiple
Effect of Preoperative Mobility Device Training on Postoperative Fall Incidence
The purpose of this study is to determine whether preoperative mobility device training is beneficial in reducing incidence of postoperative falls in patients undergoing elective foot and ankle surgery requiring a postoperative…
- Trial name
- NCT03857945
- Testing
- Preoperative mobility device(s) training
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Alabama at Birmingham
Knee Arthroplasty
Continuous Monitoring of Physiology and Self-reported Pain Score Amongst Post-surgical Knee Patients
The aim of this observational study is to assess whether patient reported pain levels correlate with a Pain Index derived from deviations in multivariate physiology biomarkers captured in real-world setting.
- Trial name
- ObservePAIN (NCT03789630)
- Testing
- Continuous physiology monitoring in ambulatory setting pre and post surgery
- Where
- Singapore
- Volunteers
- 55 people
- Sponsor
- Biofourmis Singapore Pte Ltd.