Clinical trials: Foot & Ankle
Spasticity of the Plantar Flexors
Impact of a Sequential Isokinetic Fatigue Protocol Followed by Ankle Strengthening After Botulinum Toxin Injection Into Spastic Plantar Flexors on Foot Lift Strength and Walking
Spastic foot drop (speed- and force-dependent hypertonia) is one of the most common neuro-orthopaedic disorders following brain injury.
- Trial name
- ISOTOX (NCT07260565)
- Testing
- Isokinetic rehabilitation protocol., standard rehabilitation programme
- Volunteers
- 30 people
- Sponsor
- Clinique Victor Pauchet
Ankle Osteoarthritis
Ankle Osteoarthritis
Ankle osteoarthritis is a progressive degenerative joint disease that is characterized by severe pain, loss of autonomy, diminished health-related quality of life, functional disability and diminished physical ability to fulfill…
- Trial name
- AO-IFAB (NCT03157141)
- Testing
- Ankle arthrodesis, Total ankle replacement
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Foot Fusion
Augment® Bone Graft (Formerly GEM OS™1 Bone Graft) Compared to Autologous Bone Graft in Foot and Ankle Fusions
STUDY OBJECTIVES: Demonstrate equivalent clinical and radiologic outcomes to the "gold standard" (ABG) in a representative clinical model (hindfoot and ankle fusions) STUDY HYPOTHESIS: Augment® Bone Graft is an equivalent bone…
- Trial name
- NCT00583375
- Testing
- Augment® Bone Graft, Standard of Care
- Where
- 37 sites in United States, Canada
- Volunteers
- 414 people
- Sponsor
- BioMimetic Therapeutics
Ankle Inversion Sprain, Chronic Instability of Joint
Effectiveness of Balance Training and Dynamic Neuromuscular Stabilization Training in Amateur Athletes with Chronic Ankle Instability
The goal of this clinical trial is to determine and compare the effects of balance and dynamic neuromuscular stabilization training on ankle function ability, functional instability severity, physical activity level, muscle…
- Conditions
- Ankle Inversion Sprain, Chronic Instability of Joint, Chronic Pain, Athlete Foot
- Trial name
- NCT06296537
- Testing
- Dynamic Neuromuscular Stabilization Training (DNS), Balance Training, Conventional Training
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Medipol University
Hyperpronated Foot, Reconstruction Surgeries of the Foot
Evaluate the Continued Safety and Performance of the Foot and Ankle Products
The objective of the registry is to evaluate the continued safety and performance of Arthrex foot and ankle products, including the ProStop® implant for hyperpronated foot; Bio-Compression Screw for reconstruction surgeries of…
- Conditions
- Hyperpronated Foot, Reconstruction Surgeries of the Foot, Fixation of Fractures and Fusion (Bunionectomy Osteotomies) of the Foot/Ankle, Fixation of Small Bone Fragments of the Foot/Ankle
- Trial name
- NCT04715139
- Testing
- Products listed in Group/Cohort Description
- Where
- 7 sites in United States, Germany and 1 more
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Arthrex, Inc.
Stroke, Hemiplegia
Rehabilitation of Early Stroke Patients Using an AFO: an RCT
Stroke is a major cause of disabilities worldwide. Stroke survivors commonly exhibit walking defects which lead to an altered, slow speed and asymmetric gait pattern.
- Trial name
- NCT01006772
- Testing
- Solid Ankle Foot Orthosis
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Strathclyde
Foot Injuries and Disorders, Ankle Injuries and Disorders
Dexamethasone vs. Dexmedetomidine for Popliteal Nerve Block in Pain Management After Pediatric Ankle and Foot Surgery
Effect of perineurial dexamethasone and dexmedetomidine on popliteal nerve block duration for pediatric, ankle or foot surgery
- Trial name
- NCT06233565
- Testing
- 0.9%sodium chloride, Dexamethasone, Dexmedetomidine
- Where
- 2 sites in Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Ankle Arthropathy, Anesthesia; Functional
The Impact of a Preoperative Nerve Block in Foot and Ankle Surgery on the Consumption of Sevoflurane
Reconstructive foot and ankle surgery is performed under general anesthesia. Included in this spectrum of surgery are ankle arthroplasties, various fusions, corrective arthrodesis, and more.
- Conditions
- Ankle Arthropathy, Anesthesia; Functional, Ankle Arthritis
- Trial name
- NCT04022057
- Testing
- Ropivacaine injection, Dextrose 5
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Injury
Stories to Educate Patients With Ankle, Foot, and Knee Injuries
Study will test the use of narratives on patient satisfaction and translation of an evidence-based approach to the use of X-rays for leg injuries in the Emergency Department (ED).
- Trial name
- NCT01810523
- Testing
- Narrative, Control
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Spinal Cord Injury
C-Brace II Spinal Cord Injury
A randomized, repeated measures comparative design study to compare use of a micro-processor controlled knee-ankle-foot orthosis vs.
- Trial name
- NCT03930056
- Testing
- C-Brace II, Traditional Care KAFO intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Shirley Ryan AbilityLab
Joint Instability
Gait Adaptations to Passive Dynamic Ankle-Foot Orthosis Use
This study will collect information on the different ways that people walk, that is, their gait, when they use ankle braces. Patients will visit NIH on at least three and as many as nine separate occasions.
- Trial name
- NCT00115401
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Sensorimotor Gait Disorder, Neurologic Ambulation Disorder
Clinical Study of the L300 Versus Ankle-foot Orthosis (AFO) on Post-Stroke Subjects With Foot Drop
The objective of this study is to determine the effectiveness of the NESS L300 (L300) in improving gait parameters, function, and quality of life among stroke subjects (greater than or equal to 3 months post stroke)with drop foot.
- Conditions
- Sensorimotor Gait Disorder, Neurologic Ambulation Disorder, Gait, Drop Foot, Poststroke Hemiparesis
- Trial name
- L300 (NCT01138995)
- Testing
- Ness L300, Ankle-foot orthosis
- Where
- 11 sites in United States
- Volunteers
- 197 people
- Sponsor
- Bioness Inc
Femur Fracture, Tibia Fracture
Outpatient Floor Pedal Bike Utilization
The goals of this clinical trial are: to test the feasibility of identifying patients and getting patients the floor pedal bikes, to test how well floor pedal bikes help patients with lower body injuries heal, and to test methods…
- Conditions
- Femur Fracture, Tibia Fracture, Ankle Injuries
- Trial name
- NCT06586190
- Testing
- Floor Pedal Bike with Guided Instructions for Home
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Total Knee Artroplasty
Influence of Weight-bearing Mechanical Axis on Foot and Ankle in Patients Following Total Knee Arthroplasty
This comprehensive scientific research will investigate the influence of the weight-bearing mechanical axis on foot and ankle following total knee arthroplasty.
- Trial name
- NCT05751954
- Testing
- Postero-anterior weight-bearing full-leg radiograph, Pedobarographic analysis
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- Clinic for Orthopedics Lovran
Rheumatoid Arthritis
Anti-TNFα Use During Elective Foot and Ankle Surgery in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a frequent inflammatory arthritis that can lead to severe joint deformity and often requires orthopaedic surgical interventions.
- Trial name
- NCT02242474
- Testing
- Anti-TNF suspended perioperatively, Anti-TNFα continued perioperatively
- Where
- Canada
- Volunteers
- 660 people
- Sponsor
- CHU de Quebec-Universite Laval
Medial Malleolus Fracture, Lisfranc Injury
Performance and Safety Evaluation of Inion CompressOn Screw in Foot and Ankle Surgeries. PMCF Investigation
The study in question is a post market clinical follow up (PMCF) study to evaluate the safety and performance of bioabsorbable headless compression screw Inion CompressOn in selected fracture, osteotomy and arthrodeses operations…
- Conditions
- Medial Malleolus Fracture, Lisfranc Injury, Lisfranc Fracture, Talus Fracture
- Trial name
- NCT05555459
- Testing
- Operation
- Where
- Finland
- Volunteers
- 125 people
- Sponsor
- Inion Oy
Being Between 40-80 Years Old, Being Diagnosed With Haemiplegia
The Relationship Between Lower Limb Functionality, Foot Joint Position Sensation and Balance in Haemiplegic Patients
Stroke is defined as a neurological disorder resulting from acute focal damage to the central nervous system caused by vascular factors, which may include cerebral infarction, intracerebral haemorrhage and subarachnoid…
- Conditions
- Being Between 40-80 Years Old, Being Diagnosed With Haemiplegia, Getting 20 Points or More in the Mini Mental Test, Volunteering to Participate in the Study
- Trial name
- NCT06043960
- Testing
- Humac Norm İsokinetic Machine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Medial or Lateral Instability Repairs/Reconstructions, Hallux Valgus Repairs
Safety and Performance of PEEK Anchors in Extremities
Safety and performance of the study devices in extremities up to 12 months post-surgery
- Conditions
- Medial or Lateral Instability Repairs/Reconstructions, Hallux Valgus Repairs, Achilles Tendon Repairs/Reconstructions, Midfoot Reconstructions
- Trial name
- NCT03782298
- Testing
- Spyromite, Dynomite, Raptomite, Footprint Ultra PK SL
- Where
- 4 sites in United States, Canada
- Volunteers
- 140 people
- Sponsor
- Smith & Nephew, Inc.
Hallux Valgus (Bunions)
Liposome Bupivacaine for ANKLE Blocks
Postoperative analgesia for hallux valgus surgery (bunionectomy) is inconsistent and may even result in rebound pain when the (ankle) blocks wear off.
- Trial name
- NCT03106545
- Testing
- Liposome bupivacaine
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Catherine Vandepitte, M.D.
Foot and Ankle Surgery
Immediate Weight-bearing Verses Non-Weight-bearing After Foot & Ankle Surgery
The primary objective of this study is to determine whether immediate weight-bearing following foot and ankle surgery provides similar or superior results to the traditional non-weight-bearing post-operative course, while…
- Trial name
- NCT03996707
- Testing
- Weight Bearing, Strict non-weight bearing
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)