Clinical trials: Foot Injuries
Diabetic Foot Ulcer
Diabetes Related Foot Ulcers With Negative Pressure Wound Therapy
The goal of this study is to learn if the clinical effects of Negative Pressure Wound Therapy (NPWT) is better, worse or the same as standard wound care for patients with diabetic foot ulcers (DFUs).
- Trial name
- DIANE (NCT06721754)
- Testing
- Negative Pressure Wound Treatment
- Where
- 2 sites in Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital, Akershus
Anterior Cruciate Ligament Rupture
The Effect of Subtalar Joint Antipronation Taping on the Dynamic Knee Valgus in Female Volleyball Players with Low Medial Arch
This study aims to investigate the biomechanical mechanisms of dynamic knee valgus and the impact of subtalar pronation, particularly due to decreased medial longitudinal arch, on knee injury risk, highlighting the importance of…
- Trial name
- NCT06752109
- Testing
- Antipronation Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Ankara Yildirim Beyazıt University
Diabetic Foot, Wound Heal
The Effect of Combined 650 nm and Infrared Laser on Chronic Diabetic Foot Ulcer Surface Area:
Objective: investigate the effect of combined 650 nm and infrared laser on chronic diabetic foot ulcer surface area. Participants: The forty five patients will assigned randomly into three equal groups, each group consist of 15…
- Trial name
- wounds (NCT05517863)
- Testing
- laser therapy
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Heidy F. Ahmed
Severe Distal Tibia Injury, Severe Ankle Injury
Outcomes Following Severe Distal Tibia, Ankle and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation Protocol
The primary aim this prospective longitudinal observational outcomes study is to compare 18 month functional outcomes and health related quality of life (HRQoL) of patients undergoing salvage versus amputation following severe…
- Conditions
- Severe Distal Tibia Injury, Severe Ankle Injury, Severe Foot Injury, Major Soft Tissue Loss
- Trial name
- OUTLET (NCT01606501)
- Where
- 33 sites in United States
- Volunteers
- 664 people
- Sponsor
- Major Extremity Trauma Research Consortium
Abscess, Wound Infection
Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection
Patients, who are considered suitable by their physicians to take part in this research, will have a physical examination (including an Electrocardiogram (ECG)), blood and urine samples taken, as well as a sample of the…
- Conditions
- Abscess, Wound Infection, Diabetic Foot, Ulcer
- Trial name
- NCT00402727
- Testing
- Moxifloxacin (Avelox, BAY12-8039), Piperacillin/Tazobactam & Amoxicillin/Clavulanic acid
- Where
- 123 sites in Austria, Belgium and 18 more
- Volunteers
- 813 people
- Sponsor
- Bayer
Diabetic Foot Ulcer
Prospective, Multicenter, RCT of the Tenex Ultrasound System
The goal of this multicenter randomized controlled trial is compare standard of care (SOC) to Tenex MicroTip ultrasound therapy plus SOC in patients with Wagner 1-2 diabetic foot ulcers.
- Trial name
- NCT06137222
- Testing
- Tenex TXB MicroTip Ultrasound system plus SOC, Standard of Care for diabetic foot ulcer
- Where
- 2 sites in United States
- Volunteers
- 148 people
- Sponsor
- Tenex Health Inc.
Pain, Ankle Injuries
Erector Spinae Plane Block and Ankle and Foot Surgery
Regional anesthesia is commonly used in orthopedic and surgical procedures in ankle and foot surgery to manage pain. The ultrasound-guided nerve block is a safe and effective regional anesthesia technique that provides effective…
- Trial name
- NCT05708742
- Testing
- Ultrasound, Bupivacaine Hydrochloride, saline solution
- Where
- Egypt
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Wound Heal
Impact of Cilostazol Versus Cilostazol and Selenium Combination on the Healing of Diabetic Foot Ulcer Patients
The growing incidence of DM can lead to the increased prevalence of diabetic foot complications, which have become a serious medical, social, and economic concern of global importance.
- Trial name
- NCT06117436
- Testing
- Cilostazol, Selenium
- Where
- Egypt
- Volunteers
- 206 people
- Sponsor
- Ain Shams University
Wound Infection Bacterial, Ulcer Foot
Wound Infection Detection Evaluation, WIDE
Chronic wounds, such as diabetic foot ulcers, place a huge burden on healthcare systems and can lead to complications with high morbidity, particularly if the wound if infected.
- Conditions
- Wound Infection Bacterial, Ulcer Foot, Diabetic Foot, Diagnostic Self Evaluation
- Trial name
- WIDE (NCT03883230)
- Testing
- GLYWD
- Where
- United Kingdom
- Volunteers
- 256 people
- Sponsor
- Cumbria Partnership NHS Foundation Trust
Lower Limb Injury, Ankle Foot Orthosis (AFO)
IM ABLE 2: Injuries Managed With Advanced Bracing for Lower Extremities
The purpose of the study is to test different categories of ankle foot orthoses (AFOs) with patients who have had lower limb salvage, reconstruction or other problems impacting limb function.
- Conditions
- Lower Limb Injury, Ankle Foot Orthosis (AFO), Lower Limb Trauma
- Trial name
- IM ABLE 2 (NCT07721792)
- Testing
- Advanced Ankle Foot Orthosis (AFO), Conventional Ankle Foot Orthosis (AFO)
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of South Florida
Neonatal Resuscitation
Back Rubs or Foot Flicks for Neonatal Stimulation at Birth in a Low-resource Setting
Physical stimulation is the most common intervention during neonatal stabilization/resuscitation at birth and is recommended by neonatal resuscitation guidelines in high as well low-income settings.
- Trial name
- NCT04056091
- Testing
- Back rub stimulation, Foot flicks stimulation
- Where
- Uganda
- Volunteers
- 186 people
- Sponsor
- University Hospital Padova
Diabetic Foot Ulcer, Pressure Ulcer
A Prospective, Open Label, Multicenter Trial for Evaluating the Efficacy of Treating and Managing Wounds in Elderly Population in Specialized Nursing Facilities Using RD1
The study is a prospective, single arm, multicenter efficacy study, consisting of 60 subjects who will complete the study (note: if any patients are lost to follow-up or withdrawn, enrollment will increase to compensate for loss…
- Conditions
- Diabetic Foot Ulcer, Pressure Ulcer, Venous Leg Ulcer, Trauma Injury
- Trial name
- NCT04577183
- Testing
- RD1 System
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- RedDress Ltd.
Diabetic Foot Ulcer
Comparing Synthetic Hybrid-Scale Fiber Matrix With Standard of Care in Treating Diabetic Foot Ulcers
The purpose of the following prospective, randomized, controlled clinical trial is to compare synthetic hybrid-scale fiber matrix (Restrata®, Acera Surgical, Inc.) with standard of care in treating diabetic foot ulcers in human…
- Trial name
- NCT04918784
- Testing
- Restrata®, Wound Dressing
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Acera Surgical, Inc.
Chronic Wound, Burn Wound
Wound Healing Endpoint and Recurrence
This study is a continuation of a previously approved protocol conducted at Ohio State University and Indiana University. The first two aims of the original protocol have been completed, and this protocol will finish enrollment…
- Conditions
- Chronic Wound, Burn Wound, Diabetic Foot Ulcers, Pressure Ulcers
- Trial name
- NCT02577120
- Testing
- Epiceram Skin Barrier Function, Vaseline Petroleum Jelly
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Sashwati Roy
Diabetic Foot Ulcer
Adjunct Collection of Additional Biorepository Data From Patients Enrolled in Diabetic Foot Consortium (DFC) Trials
The Biorepository will guide the Diabetic Foot Consortium (DFC) activities for collection and storing biosamples and data from participants enrolled in other current and future DFC research studies.
- Trial name
- NCT05092620
- Where
- 5 sites in United States
- Volunteers
- 142 people
- Sponsor
- University of Michigan
Foot Injury, Ankle Injury
Ideal Anatomic Location for Saphenous Nerve Blocks: A Prospective Clinical Evaluation
This research is being done to compare two different saphenous nerve block locations and will help to determine which site best maintains knee strength and pain control.
- Trial name
- NCT02645097
- Testing
- Saphenous Nerve Block
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Paul J. Juliano, M.D.
Diabetic Foot Ulcer, Diabetes Mellitus (DM)
Evaluating the Efficacy of Pulsating Electromagnetic Field Therapy by CRAD ULCER X-01 for Diabetic Foot Ulcers
Background: Diabetic foot ulcer (DFU) is a frequent complication of chronic, uncontrolled diabetes mellitus (DM). Treatment with antibiotics, daily dressing, wound debridement, and wound off-loading is often prescribed.
- Trial name
- NCT07465640
- Testing
- Pulsating electromagnetic field
- Where
- Malaysia
- Volunteers
- 32 people
- Sponsor
- National Defence University of Malaysia
Diabetic Foot
Cold Plasma Therapy for Acceleration of Wound Healing in Diabetic Foot
Diabetic foot is a common complication of diabetes mellitus and requires specialized treatment. Wounds are characterized by persistent infection and chronic inflammatory processes, impeding well directed matrix remodelling and…
- Trial name
- NCT04205942
- Testing
- Argon Plasma Jet
- Volunteers
- 65 people
- Sponsor
- Ruhr University of Bochum
Muscle Injury, Nerve Injury
Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer
Foot drop deformity is a life limiting condition characterized by loss of ankle dorsiflexion and eversion. Main condition leading to drop foot condition include irrecoverable muscle and nerve injuries, poliomyelitis, drug…
- Conditions
- Muscle Injury, Nerve Injury, Poliomyelitis, Leprosy
- Trial name
- NCT01751503
- Testing
- Interosseous route of TPTT, Extra membranous route of TPTT
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Iva Hauptmannova
Wounds
Positive Predictive Value of the MolecuLight i:X Imaging Device to Predict the Presence of Bacteria in Chronic Wounds
This is a non-randomized evaluation for which 50 patients will be imaged at the Southwest Regional Wound Care Center, Lubbock, Texas, who present with a chronic wound and are receiving standard treatment.
- Trial name
- NCT02682069
- Testing
- MolecuLight i:X Imaging Device
- Volunteers
- 30 people
- Sponsor
- MolecuLight Inc.