Clinical trials: Foot Pathology
Critical Limb Ischemia, Diabetic Foot
Autologous Peripheral Blood Mononuclear Cells in Diabetic Foot Patients With No-option Critical Limb Ischemia
The objective of this trial is to determine whether PBMNCs in diabetic patients with critical, non revascularizable limb ischemia can prevent major amputation and affect mortality and healing.
- Trial name
- NCT04255004
- Testing
- Pall Celeris System, point of care device for human cell therapy
- Volunteers
- 76 people
- Sponsor
- Ospedale San Donato
Hallux Valgus
Efficacy and Safety of Intranasal Morphine for Pain After Bunion Surgery
Study designed to evaluate the efficacy and safety of Intranasal (IN) Morphine Nasal Spray (MNS075) 3.75 mg, 7.5 mg, 15 mg, and 30 mg, intravenous (IV) morphine 7.5 mg, or IN placebo in patients with moderate to severe…
- Trial name
- NCT00388011
- Testing
- Intranasal Morphine (MNS075) 3.75 mg, Intravenous Morphine 7.5 mg, Intranasal morphine (MNS075) 7.5 mg
- Volunteers
- 187 people
- Sponsor
- Javelin Pharmaceuticals
Diabetic Foot, Arterial Occlusive Disease
Urokinase Therapy in Patients With Diabetic Foot Syndrome
The purpose of this study is to determine whether the additional therapy with low dose urokinase is more effective than only a conventional standard therapy concerning ulcer-healing, rate of major amputation and survival.
- Conditions
- Diabetic Foot, Arterial Occlusive Disease, Ischemia
- Trial name
- NCT00823225
- Testing
- standard therapy, Urokinase
- Where
- 6 sites in Germany
- Volunteers
- 5 people
- Sponsor
- medac GmbH
Chronic Plantar Fasciitis, Control Group
Frequency of Neuropathic Pain in Patients With Plantar Fasciitis
Study Design This prospective cross-sectional study was undertaken between November 2023 and March 2024. Written and verbal informed consent was obtained from all patients.
- Trial name
- NCT06348017
- Where
- Turkey (Türkiye)
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Yozgat City Hospital
Arthralgia, Bunion
A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain From Bunionectomy.
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of the administration of 2 different dose levels of tapentadol (CG5503) compared with oxycodone and with placebo in subjects who have…
- Conditions
- Arthralgia, Bunion, Hallux Valgus, Pain
- Trial name
- NCT00613938
- Testing
- Tapentadol (CG5503), oxycodone
- Where
- 7 sites in United States
- Volunteers
- 901 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Low Back Pain
Foot Reflexology Therapy and Non-specific Low Back Pain
The aim of this study was to investigate whether the eight therapy session with foot reflexology can reduce pain intensity when applied as an addition to the standards care of low back pain according to the Malaysian low back…
- Trial name
- NCT02887430
- Testing
- foot reflexology therapy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universiti Sultan Zainal Abidin
Dermatophytosis, Tinea Corporis
In Vitro Susceptibility of Dermatophytes to Terbinafine and Itraconazole: MIC Distributions and Elevated-MIC Isolates in Faisalabad, Pakistan
Dermatophyte infections of the skin, hair and nails are common in Pakistan, and treatment failure with standard antifungal drugs is increasingly reported.
- Conditions
- Dermatophytosis, Tinea Corporis, Tinea Cruris, Tinea Pedis
- Trial name
- NCT07898475
- Testing
- In vitro antifungal susceptibility testing
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Dr. Amara Safdar
Diabetic Foot Ulcer, Venous Leg Ulcer
Real World Evidence with the Debritom+ TM Novel Micro Water Jet Technology At a Single Wound Center
Prospective, single-blinded, single-center, parallel group, randomized controlled trial (RCT) to assess rate and frequency of wound healing and associated financial savings, when using Medaxis debritom+ versus standard of care as…
- Conditions
- Diabetic Foot Ulcer, Venous Leg Ulcer, Surgical Wound Dehiscence, Traumatic Wounds
- Trial name
- EVIDENT (NCT04920253)
- Testing
- Study Device Debridement, SOC Debridement
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Medaxis, LLC
Healthy Participants
Investigation of the Effect of Foot Muscle Fatigue on the Foot Sole and Tendon Structural Properties
In healthy individuals, fatigue in the foot muscles increases the load and stress on the feet. The extrinsic muscles of the foot, which investigators aimed to create fatigue in this study, are closely related anatomically and…
- Trial name
- NCT06025266
- Testing
- Evaluation of Viscoelastic and mechanical properties with MyotonPRO
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Simge Dönmez
Hemiplegia, Gait, Hemiplegic
The Effects of Proximal And Distal Tibiofibular Joint Manipulations on Foot Posture, Ankle Range of Motion, and Balance
Limited ankle dorsiflexion adversely affects the weight bearing capacity, increases the knee extensor moment and causes insufficient maneuvers to change the center of gravity of the body in patients with hemiplegia.
- Conditions
- Hemiplegia, Gait, Hemiplegic, Mobility Limitation
- Trial name
- NCT04178369
- Testing
- Proximal And Distal Tibiofibular Joint Manipulations, Bobath Treatment
- Volunteers
- 28 people
- Sponsor
- Hacettepe University
Diabetic Foot Ulcer, Infection
Topical PluroGel PN for the Treatment of Mildly Infected Diabetic Foot Ulcers
This is an open label study of subjects who have failed Protocol PGN-1300. Adult subjects (greater than 18 years old) who present with a mildly infected diabetic foot ulcer (IDSA criteria) having full thickness (i.e., through the…
- Trial name
- NCT02119754
- Testing
- Plurogel PN
- Where
- 15 sites in United States
- Volunteers
- 15 people
- Sponsor
- PluroGen Therapeutics, Inc
Diabetic Foot, DFU
Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers
The purpose of this study is to evaluate the efficacy of human placental membrane products and standard of care versus standard of care alone in the management of nonhealing diabetic foot ulcers and venous leg ulcers.
- Conditions
- Diabetic Foot, DFU, Diabetic Foot Ulcer, Foot Ulcer, Diabetic
- Trial name
- BIOCAMP (NCT07089602)
- Testing
- Standard of Care DFU, Tri-Membrane Wrap™ DFU, Membrane Wrap™ DFU
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- BioLab Holdings
Patellofemoral Pain Syndrome
Effects of Agility Training With and Without Foot Mobilization In Patellofemoral Pain Syndrome.
Patellofemoral pain syndrome (PFPS) is referred to as peripatellar or retro-patellar pain, which is characterized by alterations in the physical and biomechanical features of the patellofemoral joint.
- Trial name
- NCT06674707
- Testing
- Agility Training with Foot mobilization., Agility Training without Foot mobilization
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Tinea Pedis
Cumulative Irritation Test
The purpose of this study is to determine the cumulative irritation potential of the products listed by the Sponsor.
- Trial name
- NCT00781664
- Testing
- AN2718, Sodium Lauryl Sulfate
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pfizer
Peripheral Artery Disease, Quality of Life
VADOplex Critical Limb Ischemia Study
In patients with critical limb ischemia (CLI) and foot ulcers wound healing is an important goal which can normally only be achieved after sufficient treatment of the underlying ischemia (revascularization either by an operation…
- Conditions
- Peripheral Artery Disease, Quality of Life, Wound Healing
- Trial name
- NCT02034539
- Testing
- VADOplex system
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH
Pain, Postoperative, Bunion
Safety and Efficacy of COV795 in Moderate to Severe Post-Operative Bunionectomy Pain With an Open-label Extension
The primary objective of this study is to show the effectiveness of repeated doses of COV795 versus placebo, using the summed pain intensity difference over the first 48 hours in subjects with acute moderate to severe pain…
- Trial name
- NCT01484652
- Testing
- COV795
- Where
- 5 sites in United States
- Volunteers
- 329 people
- Sponsor
- Mallinckrodt
Hemiparesis;Poststroke/CVA, Gait, Hemiplegic
Comparison of Thermo-plastic Versus Carbon Foot Ankle Orthosis to Improve Gait and Reduce Fatigue in Post-stroke Patients: a Biomechanical and Neurophysiological Study
Approximately 20% of stroke survivors have difficulties to dorsiflex the ankle and clear the ground during walking. This impairment, termed as "foot drop", is caused by an association of weak dorsiflexors and increased spasticity…
- Trial name
- MECASPRY (NCT04323943)
- Testing
- Ankle Foot orthosis (AFO)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Thuasne
Diabetic Peripheral Vascular Disease
Measurement of Endothelial Function With Peripheral Arterial Tonometry in Patients Undergoing Hyperbaric Oxygen Therapy
The purpose of this clinical study is to test whether or not patients treated with HBOT for diabetic foot ulcers will demonstrate measurable changes of the blood vessel function during the course of HBOT treatments. , i.e.
- Trial name
- NCT02221466
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Ole Hyldegaard
Diabetic Foot, Ulcer Foot
Dehydrated Human Amnion Membrane and Standard of Care Versus Standard of Care Alone in Nonhealing Diabetic Foot Ulcers
The purpose of this study is to evaluate the efficacy of dehydrated human amnion membrane (dhAM) and standard of care (SOC) versus SOC alone in the closure of nonhealing diabetic foot ulcers (DFUs).
- Conditions
- Diabetic Foot, Ulcer Foot, Foot Ulcer, Diabetic Foot Ulcer
- Trial name
- NCT06550596
- Testing
- Standard of Care, Axolotl DualGraft + SOC
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Axolotl Biologix
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg
A Comparison of Two Injection Locations in Obese Patients Having Lower Leg/Foot Surgery
One technique for the nerve block involves injecting the numbing medicine where the nerve is together (higher up in the back of the thigh).
- Conditions
- Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/ or Foot
- Trial name
- NCT01550094
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jose Soberon, MD