Clinical trials: For Intervention
Pain, Osteoarthritis, Knee
Audio-Recorded vs. Nurse-Led Brief Mindfulness-Based Intervention
This is a single-site, three-arm, parallel-group randomized clinical trial (RCT). The clinical effects of a nurse-led, very brief, preoperative mindfulness-based intervention for hip and knee replacement patients will be…
- Conditions
- Pain, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- NCT05054595
- Testing
- Standard Pain Management, Audio-Recorded Mindfulness-Based Intervention, Nurse-Led Mindfulness-Based Intervention
- Sponsor
- University of Utah
Pericardial Effusion
Drainage or Pericardiocentesis (DROP) Alone for Recurrent Non-malignant Pericardial Effusions Requiring Intervention
The DROP study is a prospective, multi center, randomized, open-label trial to test the efficacy and safety of extended catheter pericardial drainage in patients with non-malignant pericardial effusions.
- Trial name
- DROP (NCT01665495)
- Testing
- Extended pericardial drainage by catheter
- Where
- 7 sites in Italy
- Volunteers
- 122 people
- Sponsor
- Maria Vittoria Hospital
Overweight, Obesity
PACIFIC: Providing Adults Collaborative Interventions For Ideal Changes
The objective of this proposed study is to collect initial efficacy data on ROC and ROC + BWL compared to an active comparator (AC) and to BWL.
- Trial name
- ROC (NCT02516839)
- Testing
- Regulation of Cues (ROC), Behavioral Weight Loss (BWL), BWL + ROC
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- University of California, San Diego
Traumatic Brain Injury (TBI), Post Traumatic Stress Disorder (PTSD)
Occupational Therapy Driving Intervention for Returning Combat Veterans.
Driving is a portal into general life functioning, and impaired driving skill can pose a serious threat to the combat veterans (CV), passengers and others; and involves increased risk of subsequent injuries, medical expenses and…
- Trial name
- NCT02764983
- Testing
- Driving Behavior Interview, Fitness-to-Drive Screening Measure, Clinical Driving Assessment
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Florida
Binge Eating Disorder
Evaluation of a Web-Based Intervention for Binge Eating Disorder
This study evaluates the effectiveness of a web-based intervention specifically designed for patients with Binge Eating Disorder (BED) in a blinded randomized controlled trial.
- Trial name
- NCT04876183
- Testing
- Selfapy for Binge Eating Disorder
- Where
- Germany
- Volunteers
- 154 people
- Sponsor
- Heidelberg University
Coronary Artery Disease, Vascular Access Complication
Anatomical sNuffbox for Coronary anGiography and IntervEntions
This randomized, single-center, prospective study seeks to compare the conventional radial approach with the recently described distal radial approach (anatomical snuffbox) concerning the patency of the radial artery in patients…
- Trial name
- ANGIE (NCT03986151)
- Testing
- Coronary angiography +/- percutaneous coronary intervention
- Where
- Greece
- Volunteers
- 1,042 people
- Sponsor
- University Hospital of Patras
Metastatic Breast Cancer
Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer
Many people living with metastatic breast cancer face challenging symptoms and frequent medical visits. At the same time, conversations about personal goals, values, and preferences for care may not always happen as early or as…
- Trial name
- TARGET-PC (NCT06795529)
- Testing
- Palliative Care Intervention, "TARGET-PC", Enhanced Usual Care
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Massachusetts General Hospital
Prostate Cancer, Cardiovascular Disease
A Study for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients
RADICAL PC1 is a prospective cohort study of men with a new diagnosis of prostate cancer. RADICAL PC2 is a randomized, controlled trial of a systematic approach to modifying cardiovascular and lifestyle risk factors in men with a…
- Trial name
- RADICALPC (NCT03127631)
- Testing
- Nutrition, Exercise, Smoking cessation
- Where
- 61 sites in United States, Australia and 7 more
- Volunteers
- 5,000 people
- Sponsor
- McMaster University
Facial Palsy
Self-guided Psychosocial Intervention for Facial Palsy
Facial palsy affects between 23 to 35 people per 100,000. As well as affecting an individual's appearance, it also can lead to difficulties with: eating, drinking, speaking, eyelid closure, pain and taste.
- Trial name
- NCT03943953
- Testing
- Information and Therapy Guides
- Where
- United Kingdom
- Volunteers
- 97 people
- Sponsor
- Oxford University Hospitals NHS Trust
Tuberculosis, Meningeal, Linezolid
Pharmacokinetic Study of Linezolid for TB Meningitis
Tuberculosis meningitis (TBM) is the most severe manifestation of TB, resulting in death or neurological disability in up to 50% of affected patients, despite antibacterial treatment.
- Trial name
- SIMPLE (NCT03537495)
- Testing
- Linezolid
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Universitas Padjadjaran
Diabetes Mellitus, Type 1
A Research Study Looking at How the Use of NovoPen® 6 for Treatment With Tresiba® & Fiasp® Affects the Blood Sugar Level in Patients With Type 1 Diabetes as Part of Local Clinical Practice
The purpose of this study is to collect information on how NovoPen® 6 works with Tresiba® \& Fiasp® for treatment of people with type 1 diabetes and see if the use of NovoPen® 6 can help participants achieve better blood sugar…
- Trial name
- CONNECT 1 (NCT05069545)
- Testing
- Insulin degludec, Fast-acting insulin aspart
- Where
- 26 sites in Belgium, Denmark and 2 more
- Volunteers
- 411 people
- Sponsor
- Novo Nordisk A/S
Smoking Cessation
Mindfulness Training for Smoking Cessation in Women in Workplaces
This study has the following objectives: 1. To raise the awareness of female smokers about the harmfulness of tobacco towards their life issues 2. To encourage female smokers to stop using tobacco 3.
- Trial name
- NCT02497339
- Testing
- Mindfulness training
- Where
- China
- Volunteers
- 215 people
- Sponsor
- The University of Hong Kong
Restenosis, Coronary, Left Main Coronary Artery Disease
PCI vs. CABG in UPLM-ISR
Left main (LM) coronary artery disease is associated with high morbidity and mortality owing to the large myocardial territory at risk for ischemia.
- Conditions
- Restenosis, Coronary, Left Main Coronary Artery Disease, PTCA Left Main Artery Complications
- Trial name
- LM-DRAGON (NCT04968977)
- Testing
- PCI vs. CABG
- Where
- 11 sites in Italy, Poland
- Volunteers
- 305 people
- Sponsor
- Medical University of Silesia
Substance Use Disorders, Youth Protection Services
Adapting Personality-Targeted Interventions for Reducing Substance Misuse and Related Outcomes in Youth in Youth Protection Services
Substance use problems are major concern in adolescents involved in Youth Protection Services. However, there is an enormous gap between the needs and availability of interventions for youth with substance use problems in the…
- Conditions
- Substance Use Disorders, Youth Protection Services, Early Intervention, Prevention
- Trial name
- NCT04162977
- Testing
- Personality-targeted Interventions
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- St. Justine's Hospital
Health Services, Geriatric
Self Care for Older Persons in Singapore: An Intervention Study
The main aim of the project is to evaluate a self-care intervention program aimed at enhancing the ability of mildly disabled and healthy older persons in Singapore to manage their health.
- Trial name
- SCOPE (NCT01672177)
- Testing
- Chronic disease self-management training
- Where
- 12 sites in Singapore
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Heart Failure, Mental Health
Improving Care and Mental Well-Being for Adults With Heart Failure
Heart failure is a high-risk, chronic condition that impacts patients' mental health. Approximately 50% of heart failure patients experience comorbid mental health conditions, such as stress, depression and anxiety, which affect…
- Conditions
- Heart Failure, Mental Health, Stress, Anxiety
- Trial name
- NCT07313657
- Testing
- Heart Failure and Mental Health Intervention (FRAME)
- Where
- 9 sites in Canada
- Volunteers
- 7,300 people
- Sponsor
- Bruyère Health Research Institute.
Diabetes
Leveraging Interventions for Needs and Knowledge in Diabetes
Unmet social needs and economic burden persist as key reasons why one-third of people with diabetes have poor disease control. The purpose of this study is to learn whether different tools and types of support may help people…
- Trial name
- LINKD (NCT07676188)
- Testing
- FindHelp, Peer Support, Social Work
- Where
- United States
- Volunteers
- 694 people
- Sponsor
- University of Michigan
Multivessel Coronary Artery Disease
Efficacy and Safety of One-Stage Hybrid Coronary Revascularization
Coronary revascularization could be accomplished either by percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG).
- Trial name
- HCR-EAST (NCT04811586)
- Testing
- coronary revascularization
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai East Hospital
Alcohol Use Disorder, Hazardous Alcohol Use
LDART for Alcohol Use Disorder
This study is a pilot randomized controlled trial to evaluate feasibility, acceptability, and preliminary efficacy of a digital intervention called Let's Do Addiction Recovery Together! (LDART) in adults with alcohol use…
- Trial name
- LDART (NCT07221383)
- Testing
- LDART, Psychoeducational control
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Yale University
Diabetes Mellitus, Type 1, Metabolic Disorder
A Telematic Program for Optimization of Metabolic Control in Diabetes Mellitus Type 1 (DM1) Patients
A greater visit frequency between the diabetes mellitus 1 (DM1) patient and the medical team increases the possibilities to improve metabolic control. The support of telematic visits can support the patient and the health system.
- Trial name
- NCT01337141
- Testing
- Control, Telecare system
- Where
- 5 sites in Spain
- Volunteers
- 154 people
- Sponsor
- Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders
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