Clinical trials: For Intervention, open to volunteers
Mild Cognitive Impairment, Mild Cognitive Impairment (MCI)
Community-based Multi-domain Intervention to Detect and Delay Cognitive Decline in Community-dwelling Older Adults: A Pilot Study
The incidence of cognitive impairment and its burden are increasing with a rapidly ageing population. In Singapore, the prevalence of dementia among older adults aged 60 and above is approximately 10%, which will translate to…
- Trial name
- NCT07099040
- Testing
- Social support, Health coaching, Physical Activity
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Percutaneous Coronary Intervention, Peripheral Endovascular Intervention
Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention
V-INTERVENTION will evaluate the effectiveness of inclisiran in preventing major cardiovascular and limb events in patients receiving percutaneous coronary or peripheral arterial revascularization.
- Trial name
- V-INTERVENTION (NCT06909565)
- Testing
- Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL
- Where
- 149 sites in United States
- Volunteers
- 6,000 people
- Sponsor
- Duke University
Cannabis Abuse, Cannabis Dependence
Exercise Intervention as Treatment for People Using Cannabis (ExIT-C)
In Hong Kong, although the total number of drug abusers is trending down in recent years, the number of cannabis users continues to surge.
- Conditions
- Cannabis Abuse, Cannabis Dependence, Cannabis Use Disorder
- Trial name
- ExIT-C (NCT07091292)
- Testing
- Indoor Cycling
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Major Depressive Disorder
Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study
This randomized 2x2 factorial intervention trial administers 8 weekly cognitive behavioral therapy (CBT) sessions (yes/no) and 4 bi-weekly active whole-body hyperthermia (WBH) sessions (yes/no) to adults aged 18 years or older…
- Trial name
- NCT07596914
- Testing
- Cognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Smoking Cessation, Pregnancy
Preliminary Effectiveness of Enhanced Text Message + Incentives
This study is a preliminary evaluation of a smoking cessation intervention designed for pregnant women that combines text message support and financial incentives.
- Trial name
- NCT07420621
- Testing
- Text Messages, Incentives
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Kansas Medical Center
Type 2 Diabetes Mellitus (T2DM)
Endoscopic Band Ligation for Type 2 Diabetes Mellitus (ENDOBAND-DM)
This is a pilot clinical study evaluating the safety and feasibility of Endoscopic Band Ligation (ENDOBAND-DM) applied to the second through fourth parts of the duodenum - from just distal to the ampulla of Vater to the ligament…
- Trial name
- ENDOBAND-DM (NCT07117721)
- Testing
- Endoscopic Band Ligation (ENDOBAND-DM)
- Volunteers
- 10 people
- Sponsor
- El Katib Hospital
Type 2 Diabetes
Virtual Diabetes Care for Adults With Type 2 Diabetes on Medicaid and Insulin Therapy
This 12-month pilot tests a nurse-led, app-based intervention to improve diabetes self-management for Medicaid patients. It includes MyChart messaging to give education, phone help on problem-solving with clinicians, and using a…
- Trial name
- virtual care (NCT06814184)
- Testing
- app-based nurse-led virtual diabetes care
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Rutgers, The State University of New Jersey
Familial Melanoma, Fear of Cancer Recurrence
EMDR for Fear of Cancer Recurrence in Patients with Familial Melanoma: a Waiting List Control Trial
High fear of cancer recurrence (FCR) impacts patient's quality of life (QoL) and is prevalent among patients with familial melanoma.
- Conditions
- Familial Melanoma, Fear of Cancer Recurrence, Eye Movement Desensitization and Reprocessing, Psychological Intervention
- Trial name
- FAME (NCT06767332)
- Testing
- eye movement desensitization and reprocessing (EMDR)
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Emotional Distress, Depression, Anxiety
Temporal Dynamics of Mindfulness Intervention for Emotional Distress: Daily Interventions and Assessments
This research aims to adopt a complex systems perspective to thoroughly examine the impact of online mindfulness interventions on changes in emotional distress, with a particular focus on the mechanisms of action.
- Trial name
- NCT06919406
- Testing
- Mindfulness Intervention for emotional distress(MIED）
- Volunteers
- 100 people
- Sponsor
- Peking University
Primary Dysmenorrhea (PD)
Graded Motor Imagery for Primary Dysmenorrhea
The goal of this clinical trial is to learn if graded motor imagery can reduce pain sensitivity and period pain in women with primary dysmenorrhea (painful periods with no medical cause).
- Trial name
- NCT07618832
- Testing
- Graded Motor Imagery (GMI)
- Where
- Pakistan
- Volunteers
- 81 people
- Sponsor
- Dr. Mehak Naeem
Hematologic Cancer, Leukaemia
Digitalized Exercise Fit Tool Intervention for Adolescents With Blood Cancer
The goal of this clinical trial is to learn if a digitalised Exercise Fit Tool (EFT) mobile application can promote physical activity in adolescents aged 12-18 years who have completed treatment for hematologic cancer (e.g.…
- Conditions
- Hematologic Cancer, Leukaemia, Lymphoma, Physical Activity
- Trial name
- NCT07621887
- Testing
- Digitalized Exercise Fit Tool Intervention, Usual Care
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Insomnia Chronic
Sleep Learning Education and Empowerment for Older Korean Immigrants
Poor sleep is common among Asian Americans. Untreated sleep problems increase the risk of chronic diseases, cognitive decline, and mortality.
- Trial name
- SLEEP-OK (NCT07387406)
- Testing
- CBT-I based sleep intervention, Sleep Education
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, Los Angeles
Cardiovascular Diseases (CVD)
Effectiveness of the "Aktivplan" Digital Intervention for Supporting Regular Heart-Healthy Physical Activity Following Phase II Cardiac Rehabilitation
After a cardiac event like a heart attack or heart surgery, regular heart-healthy exercise is important to reduce the risk of further cardiac events and improve quality of life.
- Trial name
- ACTIVE-CaRe (NCT07878520)
- Testing
- aktivplan
- Where
- Austria
- Volunteers
- 68 people
- Sponsor
- Salzburg Research Forschungsgesellschaft mbH
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Mental Illness Persistent
"CoMBI-SMI Multicenter Study: A Person-Centered Cognitive-Behavioral Intervention for Severe Mental Illness"
This observational multicenter study aims to evaluate whether the Cognitive Model for Behavioral Interventions - Severe Mental Illness (CoMBI-SMI) can reduce challenging behaviors and psychological symptoms in adults (aged 18 and…
- Trial name
- CoMBI-SMI (NCT07006623)
- Testing
- CoMBI-SMI
- Where
- Netherlands
- Volunteers
- 99 people
- Sponsor
- Vrije Universiteit Brussel
Fibromyalgia
Qigong Intervention for Fibromyalgia
This randomized controlled pilot study investigates the comparative efficacy of mobility-intensive Qigong exercises versus static posture-based Qigong exercises in patients diagnosed with fibromyalgia.
- Trial name
- NCT07830186
- Testing
- Mobility-Intensive Qigong Exercise, Static Posture-Based Qigong Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Saglik Bilimleri Universitesi
Musculoskeletal Pain, Chronic Pain
The PROACTIVE Study for Black Elders
Chronic musculoskeletal pain (CMP), while a leading cause of physical disablement, is a neglected national health disparity issue in Black communities.
- Conditions
- Musculoskeletal Pain, Chronic Pain, Osteoarthritis, Pain, Chronic
- Trial name
- PROACTIVE (NCT06512727)
- Testing
- PROACTIVE Intervention
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Posttraumatic Stress Disorder, Depression
Self-Help Cognitive Processing Therapy (CPT)/Women Veterans Network (WoVeN) Study
Posttraumatic stress disorder (PTSD) can have significant impairment on aspects of mental well-being (MWB) including functioning, loneliness, physical health, and quality of life.
- Trial name
- NCT07250061
- Testing
- Self-Help Cognitive Processing Therapy, Women Veterans Network (WoVeN), Treatment as Usual
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston University
Cigarette Smoking
Remote Interventions for Menthol Cigarette Use
The purpose of this study is to evaluate whether a digital, incentive-based program, used in conjunction with traditional quitline (QL) services, can be beneficial to quitline callers who smoke menthol cigarettes.
- Trial name
- NCT07356297
- Testing
- Quitline (QL), Mobile incentive-based intervention
- Volunteers
- 1,200 people
- Sponsor
- University of Michigan
Acute Kidney Injury
Serum Cystatin C for Early Detection of Acute Kidney Injury After Primary Percutaneous Coronary Intervention
This study aims to evaluate whether the serum levels of Cystatin C (CysC) can be used as early biomarkers for the identification of patients who are prone to AKI after cardiac interventional surgeries as primary percutaneous…
- Trial name
- NCT06459362
- Testing
- Serum cystatin C
- Volunteers
- 45 people
- Sponsor
- Assiut University
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