Clinical trials: For Oncologic Patients
Glioma of Brain, Craniopharyngioma
Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors
Children with brain tumors who have had radiation therapy are at risk for problems with attention, memory, and problem solving. Such problems may cause difficulty in school and daily life.
- Conditions
- Glioma of Brain, Craniopharyngioma, Ependymoma, Germ Cell Tumor
- Trial name
- NCT03194906
- Testing
- Memantine, Cognitive Assessment
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- St. Jude Children's Research Hospital
Cancer
Umbrella Study for Analysis of Data Related to Patients With Cancer
This study is a multisite, minimal risk, non-interventional study using patient electronic health record data collected as part of standard of care to answer cohort-based research questions and create robust real-world data sets.
- Trial name
- Polaris (NCT06018753)
- Where
- 10 sites in United States
- Volunteers
- 77 people
- Sponsor
- Tempus AI
High-Risk Neuroblastoma
Patients Between the Ages of 12 Months to 21 Years With Newly-Diagnosed High-Risk Neuroblastoma Will Receive Children's Oncology Group (COG) Type Recommended Therapy With the Addition of Naxitamab and Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) to Induction Cycles 1-5
This clinical trial will evaluate the safety of chemoimmunotherapy with Naxitamab and COG-type induction chemotherapy in newly-diagnosed patients with high-risk neuroblastoma. We aim to recruit 10 patients over the next 2 years.
- Trial name
- NCT07537400
- Testing
- Naxitamab
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Shaare Zedek Medical Center
Colonic Cancer
Colectomy for Cancer in the Elderly by Laparoscopy or Laparotomy
The purpose of this study is to compare the postoperative global morbidity between patients who have been operated on for a colon cancer by laparotomy and those operated on by laparoscopy
- Trial name
- CELL (NCT03033719)
- Testing
- Laparotomy, Laparoscopy
- Where
- France
- Volunteers
- 276 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma
IFx-Hu2.0 for the Treatment of Patients With Skin Cancer
One hundred patients will receive IFx-Hu2.0 on an outpatient basis at a single time point in a single lesion. These patients will be assessed for any immediate adverse reactions and at Week 4 (Day 28+/-5 days) for any delayed…
- Trial name
- NCT04925713
- Testing
- IFx-Hu2.0
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- TuHURA Biosciences, Inc.
Prostate Cancer
Effects of an Interactive ICT-Platform for Assessment and Management of Symptoms in Patients Treated for Prostate Cancer
The purpose of this study is to evaluate the effects of an interactive ICT-platform for use in a smartphone or tablet in patients treated with radiotherapy for prostate cancer.
- Trial name
- PhONEME (NCT02477137)
- Testing
- smartphone or tablet
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Karolinska Institutet
Triple Negative Breast Neoplasms
A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer
This study is designed to determine the efficacy and safety of durvalumab in combination with novel oncology therapies with or without paclitaxel and durvalumab + paclitaxel for first-line metastatic triple negative breast cancer
- Trial name
- BEGONIA (NCT03742102)
- Testing
- Durvalumab, Capivasertib, Oleclumab
- Where
- 32 sites in United States, Canada and 4 more
- Volunteers
- 243 people
- Sponsor
- AstraZeneca
Survivorship
LiveWell: An Adapted Dialectical Behavioral Therapy Skills Training Protocol for Patients Living With Metastatic Lung Cancer
In this pilot randomized controlled trial, patients with metastatic non-small cell lung cancer and at least mild distress (N=80) will be randomized to receive LiveWell, an adapted Dialectical Behavioral Therapy (DBT) Skills…
- Trial name
- NCT07177846
- Testing
- LiveWell: An Adapted Dialectical Behavioral Therapy Skills Training Program
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medical University of South Carolina
Palliative Care, Advanced Cancer
Coaching in Palliative Surgical Oncology
This study aims to evaluate the effectiveness of a serious illness coaching intervention (CONCORD) in improving quality of serious illness conversation (SIC), treatment decision-making, goal-concordant care delivery and quality…
- Trial name
- NCT07789093
- Testing
- CONCORD coaching intervention
- Where
- Singapore
- Volunteers
- 220 people
- Sponsor
- Singapore General Hospital
Oncology, Periodontitis
PROSpECT-PRIOR-2-CHEMO: PRIOR Dental Intervention Before Chemo to Reduce Chemotherapy Complications
The aim of this feasibility trial is to determine if it is safe and feasible to treat oral health diseases in people with haematological cancers before they start their chemotherapy to reduce complications and disruption to…
- Conditions
- Oncology, Periodontitis, Myeloma, Oral Mucositis
- Trial name
- NCT06450821
- Testing
- PRIOR [Proactive Intensive Oral Review & Treatment]
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Leeds
Oncology, Elderly Patients
Efficacy of Adapted Physical Activity on a Walking Platform in Elderly Patients HOspitalized for Cancer Surgery
The aim of this study was to evaluate the efficacy of daily use of a walking platform to improve recovery of preoperative walking speed at hospital discharge following oncological surgery in patients aged 65 or older.
- Conditions
- Oncology, Elderly Patients, Surgery
- Trial name
- APPAHOCA-2 (NCT06201884)
- Testing
- Early rehabilitation through Adapted Physical Activity
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Francois Baclesse
Febrile Neutropenia (FN), Pediatric Cancer
Early Discontinuation of Antibiotics in Paediatric High-risk Febrile Neutropenia
The goal of this clinical trial is to evaluate whether stopping antibiotic treatment early is safe in paediatric patients with cancer who develop high-risk febrile neutropenia but show good clinical evolution and low biomarker…
- Conditions
- Febrile Neutropenia (FN), Pediatric Cancer, Hematologic Malignancies, Solid Tumors
- Trial name
- E-STOP2 (NCT07590648)
- Testing
- Early Discontinuation of Antibiotics, Standard Antibiotic Continuation Strategy
- Where
- 4 sites in Spain
- Volunteers
- 136 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cancer, Smoking
Smoking Cessation Smartphone App for Cancer Patients (Quit2Heal Study)
The goal of this study is to determine whether the novel smartphone application designed specifically for cancer patients to quit smoking (Quit2Heal) provides higher quit rates than the current standard smoking cessation app.
- Trial name
- Quit2Heal (NCT03600038)
- Testing
- Experimental smoking cessation smartphone app, Standard of care smoking cessation smartphone app
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Fred Hutchinson Cancer Center
Oncology Patients With Gastroparesis
Domperidone Expanded Access Program for Oncology Patients With Gastroparesis Who Have Failed Standard Therapy
Gastroparesis is a digestive disorder in which motility of the stomach is either slowed or absent. The gastroparesis prevents normal digestion from occurring.
- Trial name
- NCT02494687
- Testing
- Oral Domperidone
- Where
- United States
- Sponsor
- Eastern Regional Medical Center
Pain, Cancer
Improvement of Self Management for Oncologic Patients With Pain
This study will test the SCION (Self care improvement through oncology nursing)-PAIN program, a multi-modular structured intervention to improve self management in oncologic patients with pain compared to care as usual (standard…
- Trial name
- NCT00779597
- Testing
- SCION (Self care improvement through oncology nursing)-PAIN program
- Where
- 3 sites in Germany
- Volunteers
- 208 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Head and Neck Cancer, Colon Cancer
A Dose Finding Study of Eribulin Mesylate and Cetuximab For Patients With Advanced Head and Neck and Colon Cancer
The purpose of this study is to determine if the full dose of eribulin mesylate can be safely given with the full dose of cetuximab.
- Trial name
- NCT01744340
- Testing
- Head and neck, Colon- Closed as of May 2014
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- howard safran
Breast Carcinoma, Colorectal Carcinoma
HOPE-Genomics Intervention for the Improvement of Cancer Patient Knowledge of Genomics
This clinical trial studies the effectiveness of a web-based cancer education tool called Helping Oncology Patients Explore Genomics (HOPE-Genomics) in improving patient knowledge of personal genomic testing results and cancer…
- Conditions
- Breast Carcinoma, Colorectal Carcinoma, Lung Carcinoma, Malignant Solid Neoplasm
- Trial name
- NCT04905082
- Testing
- Best Practice, Educational Intervention, Genomic Profile
- Where
- United States
- Volunteers
- 465 people
- Sponsor
- City of Hope Medical Center
Cancer Patients
NEMO - an App for Side Effect Management in Oncology
This study investigates the use of digital and standardized documentation by patients of frequently occurring adverse events in oncological therapies.
- Trial name
- NEMO (NCT04493450)
- Testing
- Documentation of cancer treatment side effects
- Where
- Germany
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Thomas Seufferlein
Cancer, Social Support (Formal and Informal)
Social Needs App for Oncology Patients Phase II
SNAP ON II is a two-arm, parallel-group, multi-center, randomized trial for patients diagnosed with cancer who are planning to undergo expected uncomplicated surgical intervention for their cancer.
- Conditions
- Cancer, Social Support (Formal and Informal), Mobile Application
- Trial name
- SNAP-On II (NCT06688513)
- Testing
- Carealth Phone App, Let's Talk: Sharing information about Family Cancer Risk
- Where
- 3 sites in United States
- Volunteers
- 722 people
- Sponsor
- JHSPH Center for Clinical Trials
Chemotherapy
Educational Program's Impact on Nurses' Skills in Port-A-Catheter Care for Chemotherapy Patients
The goal of this experimental study is to evaluate if an educational intervention can improve nurses' knowledge and practice in caring for patients with implanted Port-A-Catheters among oncology nurses directly involved in…
- Trial name
- NCT06664476
- Testing
- PortCare Professional Training Program
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University