Clinical trials: For Oncologic Patients
Immunodepressed Patients (Hemato-oncology)
Metagenomic Sequencing for the Identification of Pathogens in Febrile Neutropenic Patients
The development of targeted therapies and intensive protocols in oncohaematology has improved the survival of patients with haematological malignancies.
- Trial name
- ADNEMIA (NCT06075888)
- Testing
- Metagenomic diagnosis (mNGS, DISQVER)
- Where
- 5 sites in France
- Volunteers
- 184 people
- Sponsor
- Poitiers University Hospital
Breast Cancer, Drug-Related Side Effects and Adverse Reactions
Telenursing for the Early Detection and Management of Side Effects Associated With Cyclin-Dependent Kinase Inhibitors in Breast Cancer Patients
This study is a multicenter randomized controlled trial designed to evaluate the effectiveness of a structured telenursing intervention in patients with breast cancer receiving cyclin-dependent kinase (CDK) inhibitor therapy.
- Conditions
- Breast Cancer, Drug-Related Side Effects and Adverse Reactions, Chemotherapy Toxicity, Treatment Adherence
- Trial name
- NCT07524829
- Testing
- Structured Telenursing Follow-up, Standard Nursing Care
- Where
- Italy
- Volunteers
- 124 people
- Sponsor
- Azienda Sanitaria Locale di Asti
Advanced Cancer, Rare Diseases
Umbrella Study for Single Patient Treatments in Oncology
The purpose of this study is to collect data for assessing the improvement of the overall response rate for the overall cohorts and the proportion of patients accessing precision targeted therapy.
- Trial name
- UNIQUE (NCT06285500)
- Testing
- Patient-specific treatments
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- University Health Network, Toronto
Long-term Oncologic Outcome of MILS in Patients With CRLM and Prognostic Indicators
Minimally Invasive Liver Surgery for Metastases From Colorectal Cancer: Oncologic Outcome and Prognostic Factors
Only few reports exist on long-term survival after minimally invasive liver surgery (MILS for colorectal liver metastases. No data are available assessing prognostic factors in the era of current modern treatment strategies.
- Trial name
- NCT01356706
- Where
- Belgium
- Volunteers
- 274 people
- Sponsor
- University Hospital, Gasthuisberg
Palliative Care, Cost and Cost Analysis
Palliative Care Costs for Outpatient Setting Management in Catalunya
Cost-of-illness studies in palliative care (PC) are a growing area of interest in health economics activity. They are, in part, stakeholders' basis for deciding the allocation of the scarce public and private economic resources.
- Conditions
- Palliative Care, Cost and Cost Analysis, Outpatient
- Trial name
- CoCPAC (NCT05412784)
- Volunteers
- 100 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Familial Melanoma, Fear of Cancer Recurrence
EMDR for Fear of Cancer Recurrence in Patients with Familial Melanoma: a Waiting List Control Trial
High fear of cancer recurrence (FCR) impacts patient's quality of life (QoL) and is prevalent among patients with familial melanoma.
- Conditions
- Familial Melanoma, Fear of Cancer Recurrence, Eye Movement Desensitization and Reprocessing, Psychological Intervention
- Trial name
- FAME (NCT06767332)
- Testing
- eye movement desensitization and reprocessing (EMDR)
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Rectal Cancer
Capecitabine, Irinotecan Hydrochloride, Cetuximab, and Radiation Therapy in Treating Patients Undergoing Surgery for Locally Advanced Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- EXCITE (NCT00972881)
- Testing
- cetuximab, capecitabine, irinotecan hydrochloride
- Where
- 5 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- University College, London
Endometrial Hyperplasia
Comparison of Dilatation & Curettage and Endometrial Aspiration Biopsy Accuracy in Patients Treated With Progestin for Endometrial Hyperplasia: A Korean Gynecologic Oncology Group Study
A prospective multicenter trial has been started in Korea to evaluate the diagnostic accuracy of endometrial aspiration biopsy compared with D\&C in patients treated with progestin for endometrial hyperplasia (EH).
- Trial name
- NCT02412072
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Korean Gynecologic Oncology Group
Metastatic Non-Small Cell Lung Cancer (NSCLC)
A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLC
This study is designed to determine the efficacy and safety of durvalumab and/or novel oncology therapies, with or without chemotherapy, for first-line Stage IV Non-Small Cell Lung Cancer (NSCLC)
- Trial name
- MAGELLAN (NCT03819465)
- Testing
- Durvalumab, Danvatirsen, Oleclumab
- Where
- 41 sites in United States, Austria and 7 more
- Volunteers
- 175 people
- Sponsor
- AstraZeneca
Pancreatic Ductal Adenocarcinoma
NGS and TME for Evidence-based Treatment of Pancreatic Cancer
The tumor tissue of patients with pancreatic cancer will be submitted to next-generation sequencing (NGS) and these data will be evaluated with an oncology treatment decision support (TDS) software tool that is a medicinal…
- Trial name
- PePaCaKa-01 (NCT02767700)
- Testing
- NGS
- Volunteers
- 39 people
- Sponsor
- Karolinska University Hospital
Unspecified Adult Solid Tumor, Protocol Specific
Copenhagen Prospective Personalized Oncology (CoPPO)
Patients with advanced solid tumors referred to the Phase 1 Unit are offered mapping of GA for identification of pts who could benefit from a personalized treatment.
- Trial name
- CoPPO (NCT02290522)
- Testing
- Tumor biopsy
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Ulrik Lassen
Liver Cancer, Liver Metastases
DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
The DRAGON registry aims to collect data on combined portal and hepatic vein embolization (PVE/HVE) for liver tumors, a technique expected to enhance liver regeneration compared to standard PVE.
- Trial name
- NCT07717437
- Where
- 31 sites in United States, Australia and 11 more
- Volunteers
- 350 people
- Sponsor
- Maastricht University Medical Center
Rare CNS Tumor, FOXR2-activated
Ultra-Rapid Profiling and Drug Screening for Treatment Selection in Patients With Relapsed or Recurrent Rare Brain Tumors
The current study will use a new treatment approach based on the molecular characteristics of each participant's tumor. The study will test the feasibility in of performing real-time drug screening on tissue taken during surgery…
- Conditions
- Rare CNS Tumor, FOXR2-activated, BCOR ITD Sarcoma, CNS Sarcoma
- Trial name
- SUPERNOVA-RBT (NCT07851636)
- Testing
- Personalized Treatment Recommendation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Adriana Fonseca
Breast Cancer
Improving Surgical/Medical Oncology Collaboration for Breast Cancer Treatment Planning: Pilot Testing the Impact of Continuing Education and Patient Care Planning
This study will explore provider's screening and management practices for eligibility for neoadjuvant therapy from baseline to following the project intervention (use of a novel existing technology, the Carevive Care Planning…
- Trial name
- NCT03161600
- Testing
- Carevive CPS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Carevive Systems, Inc.
Health-Related Quality-of-Life, Cancer
Improving Sexual and Reproductive Health Communication for Adolescent and Young Adult Oncology Patients
The goal of this clinical trial is to learn if ReSPECT, which includes a pre-visit checklist for patients to complete and an informational website, can work well in practice to help adolescent and young adult oncology patients…
- Conditions
- Health-Related Quality-of-Life, Cancer, Health Communication
- Trial name
- ReSPECT (NCT07658937)
- Testing
- ReSPECT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Connecticut Children's Medical Center
Cognitive Decline
CURATE.AI COR-Tx Trial for Post Brain Radiotherapy Patients
Cognitive deficit is common in patients who have undergone whole brain or partial brain radiotherapy. To counteract intellectual deterioration, the conventional strategies includes drug- based treatments such as donezepil and…
- Trial name
- NCT04848935
- Testing
- CURATE.AI
- Where
- 2 sites in Singapore
- Volunteers
- 15 people
- Sponsor
- National University Hospital, Singapore
Malignant Solid Neoplasm
Development of a Digital Tool, MyInspiration, for the Improvement of Spiritual Well-Being in Patients with Cancer
The purpose of this study is to pilot a beta version of a digital resource that supports the religious and spiritual beliefs of cancer patients, "MyInspiration".After receiving a cancer diagnosis, survivors are encouraged to make…
- Trial name
- NCT05198089
- Testing
- Internet-Based Intervention
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Psychosocial Effects of Cancer and Its Treatment, Unspecified Adult Solid Tumor, Protocol Specific
Radiation Therapy Outreach Program for Minority or Low-Income Patients With Newly Diagnosed Cancer
RATIONALE: An outreach program may help minority or low-income cancer patients overcome problems that keep them from receiving quality care.
- Trial name
- NCT00400699
- Testing
- counseling intervention, study of socioeconomic and demographic variables, psychosocial assessment and care
- Where
- 4 sites in United States
- Volunteers
- 3,150 people
- Sponsor
- University of Pittsburgh
Advanced Pancreatic Cancer
Supportive Care Intervention-Pancreas
This is a pilot, randomized controlled trial of an embedded collaborative model of supportive care designed to improve quality of life and decrease use of unwanted healthcare services at the end of life for patients with advanced…
- Trial name
- SCI-P (NCT01885884)
- Testing
- Embedded Supportive Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Cancer
Supportive Oncology Care at Home Post-Discharge
This study is evaluating if a program that involves remote monitoring and home-based care may improve the post-discharge care of recently hospitalized patients with advanced cancer.
- Trial name
- NCT04637035
- Testing
- Supportive Oncology Care at Home
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Massachusetts General Hospital