Clinical trials: For Oncologic Patients
Solid Tumor, Lymphoma
TTX-030 Single Agent and in Combination With Immunotherapy or Chemotherapy for Patients With Advanced Cancers
This is a phase 1/1b study of TTX-030, an antibody that inhibits CD39 enzymatic activity, leading to accumulation of pro-inflammatory adenosine triphosphate (ATP) and reduction of immunosuppressive adenosine, which may change the…
- Trial name
- NCT03884556
- Testing
- TTX-030, Pembrolizumab, Gemcitabine
- Where
- 16 sites in United States
- Volunteers
- 56 people
- Sponsor
- Trishula Therapeutics, Inc.
Bladder Cancer
Early Intervention for Impairments Identified During Comprehensive Geriatric Assessment in Patients With Bladder Cancer
A Comprehensive Geriatric Assessment (CGA) is a set of tests used to evaluate a patient's medical, social, and functional status, and can identify impairments in these domains that may not be noticed otherwise.
- Trial name
- NCT04273724
- Testing
- Targeted Interventions for Impairments Identified During Geriatric Assessment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Bladder Cancer, Breast Cancer
Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer
RATIONALE: Physician-initiated smoking cessation strategies may be effective in getting early-stage cancer patients to quit smoking.
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Head and Neck Cancer
- Trial name
- NCT00002520
- Testing
- nicotine, Usual Care
- Where
- United States
- Volunteers
- 434 people
- Sponsor
- Eastern Cooperative Oncology Group
Advanced or Metastatic Solid Tumor, Relapsed Hematologic Malignancy
Impact of the Coordinated Intervention of the Healthcare Facilities Pharmacist and the Dispensary Pharmacist on the Care Pathway for Cancer Patients Treated With Oral Therapy
The rise of oral therapies in the management of cancers has considerably changed the patient care path. If the oral route is preferred by patients because it offers a better quality of life, it is not without impact for patients…
- Trial name
- IPPACTTO (NCT04327583)
- Testing
- IPPACTTO
- Where
- 7 sites in France
- Volunteers
- 396 people
- Sponsor
- Institut Cancerologie de l'Ouest
Carcinoma, Non-Small-Cell Lung, Lung Neoplasms
Small/Middle Tier Cities and County Lung Cancer Quality Improvement Project (QIP) Study
To evaluate the molecular testing pattern in metastatic NSCLC patients after QIP; To evaluate the treatment pattern in metastatic NSCLC patients after QIP.
- Conditions
- Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Respiratory Tract Neoplasms, Thoracic Neoplasms
- Trial name
- NCT06494241
- Where
- 46 sites in China
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
Breast Cancer
Adjuvant Systemic Treatment for (ER)-Positive HER2-negative Breast Carcinoma in Women Over 70 According to Genomic Grade (GG): Chemotherapy + Endocrine Treatment Versus Endocrine Treatment
The purpose of the study is to evaluate the benefit of adjuvant chemotherapy on overall survival for elderly patients with breast cancer, in a sub group with a high risk of relapse according to Genomic Grade test.
- Trial name
- ASTER 70s (NCT01564056)
- Testing
- HORMONOTHERAPY, CHEMOTHERAPY then HORMONOTHERAPY
- Where
- 84 sites in Belgium, France
- Volunteers
- 1,989 people
- Sponsor
- UNICANCER
Brain Metastases, Lung Tumors
Lapatinib and WBRT for Patients With Brain Metastases From Lung or Breast Tumors
This phase II open-label study will be performed to evaluate the response rate of brain metastases from lung and breast tumors under treatment with WBRT and lapatinib.
- Conditions
- Brain Metastases, Lung Tumors, Breast Tumors
- Trial name
- NCT01218529
- Testing
- Lapatinib
- Where
- 13 sites in Greece
- Volunteers
- 82 people
- Sponsor
- Hellenic Cooperative Oncology Group
Pediatric Cancer, Quality of Life
Parent/Child Dyad Approach to Symptom Screening for Children With Cancer
Symptoms are common and often severely bothersome in pediatric patients receiving cancer treatments. In order to measure the extent of bothersome symptoms, the Symptom Screening in Pediatrics Tool (SSPedi) was developed.
- Conditions
- Pediatric Cancer, Quality of Life, Symptom Screening
- Trial name
- NCT05012917
- Testing
- Patient/Proxy-SSPedi, Co-SSPedi
- Where
- Canada
- Volunteers
- 420 people
- Sponsor
- The Hospital for Sick Children
Symptoms and Signs, Artificial Intelligence
BaiXiaoAi AI Companion for Cancer Patient Follow-up
This is a prospective, single-center, exploratory study designed to evaluate the accuracy, user engagement, and user experience of the BaiXiaoAi Companion AI.
- Conditions
- Symptoms and Signs, Artificial Intelligence, Artificial Intelligence Mobile Application, Needs Assessment
- Trial name
- NCT07396142
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 300 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Prehabilitation, Major Abdominal Surgeries
PROPOSAL FOR A PREOPERATIVE FUNCTIONAL OPTIMIZATION PATHWAY FOR PATIENTS CANDIDATE FOR MAJOR SURGERY (CARDIAC AND ABDOMINAL ONCOLOGY)
The study aims to evaluate a prehabilitation protocol for patients undergoing cardiac and abdominal surgery. The project for a preparation program for cardiac surgery was developed within the framework of ERAS (Enhanced Recovery…
- Conditions
- Prehabilitation, Major Abdominal Surgeries, Cardiac Surgery, Multimodal and Integrated Program
- Trial name
- PRIME CARE (NCT07851350)
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- ASST Sette Laghi
Hematologic Neoplasms, Neoplasms
Animal-Assisted Intervention for Children With Cancer and Their Siblings
This study examined an animal-assisted program for children with hematologic or oncologic disease and their siblings. The program included ten weekly sessions involving dogs and donkeys.
- Trial name
- Ti Sento (NCT07861620)
- Testing
- Dog- and Donkey-Assisted Intervention
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Azienda Ulss 2 Marca Trevigiana
Oncology
Comparative Effectiveness of AKYNZEO® and Standard of Care (Including EMEND®) for the Prevention of Nausea and Vomiting (CINV) in Cancer Patients
This pragmatic trial addresses the clinical gap through the generation of evidence on the comparative effectiveness between AKYNZEO® and Standard of Care (SoC, including EMEND®) in the real-life setting
- Trial name
- NCT03831633
- Testing
- Akynzeo, Standard of Care
- Where
- France
- Volunteers
- 426 people
- Sponsor
- VIFORFRANCE
Laparoscopic Surgery, Gynecologic Oncology Patient
The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology
Laparoscopic surgery, characterized by minimal invasiveness, rapid recovery, and shorter hospital stays, has been widely adopted in Gynecologic Oncology.
- Conditions
- Laparoscopic Surgery, Gynecologic Oncology Patient, Liposomal Bupivacaine, Transversus Abdominis Plane Block
- Trial name
- NCT07458295
- Testing
- Bupivacaine hydrochloride, Liposomal bupivacaine plus bupivacaine
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Beijing Tiantan Hospital
Cancer Support, Oncology Patients
FOCUS ON US: Adapting the FOCUS Program for Sexual and Gender Minority (SGM) Cancer Patients and Caregivers
Our aim for this study is to assess the feasibility and acceptability and explore potential outcomes of the adapted FOCUS On Us intervention in a two-arm pilot trial.
- Conditions
- Cancer Support, Oncology Patients, Caregivers
- Trial name
- NCT06800053
- Testing
- FOCUS ON US
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Charles Kamen
Cancer
Implementation of Shared Decision-Making in Cancer Care
This study aims to evaluate a theoretically and empirically grounded implementation program designed to foster shared decision-making in routine cancer care. The intervention program consists of several components (e.g.
- Trial name
- PREPARED (NCT03393351)
- Testing
- Shared decision-making program, Usual Care
- Where
- 3 sites in Germany
- Volunteers
- 2,131 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Anxiety, Stress
A New Mindfulness Intervention Called Mindfulness Based Swinging Technique (MBST) for Women With Breast Cancer
It is hypothesised to find that the new mindfulness intervention of Mindfulness Based Swinging Technique (MBST) for Women With Breast Cancer is an effective therapeutic intervention to be applied in breast cancer population.
- Conditions
- Anxiety, Stress, Self Efficacy, Depression
- Trial name
- NCT03985267
- Testing
- Mindfulness based Swinging Effect Intervention
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- University of Barcelona
Basal Cell Carcinoma
Quality of Life in Patients With Difficult-to-Treat Basal Cell Carcinoma: An Evaluation of Impact and Surgical Outcomes.
FACE-QoL is an observational, prospective, multicenter study aimed at evaluating the impact of surgical treatment on quality of life in patients with stage IIA and IIIB difficult-to-treat basal cell carcinoma of the face…
- Trial name
- FACE-QOL (NCT06448936)
- Testing
- Patient-reported outcome measures (PROMs)
- Where
- Italy
- Volunteers
- 750 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hematopoietic/Lymphoid Cancer
Stress Management Intervention for Caregivers of Patients Undergoing Bone Marrow Transplant (BMT)
RATIONALE: A stress management intervention may be more effective than usual care in improving quality of life in caregivers of patients undergoing bone marrow transplant.
- Trial name
- NCT00833898
- Testing
- Paced respiration as part of PEPRR, PEPRR
- Where
- 2 sites in United States
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Multiple Myeloma
Study of Bortezomib and Dexamethasone With or Without Cyclophosphamide in Patients With Relapsed or Not Controllable Multiple Myeloma
The purpose of this study is to compare bortezomib, dexamethasone and cyclophosphamide to bortezomib and dexamethasone alone for primary refractory or relapsed multiple myeloma.
- Trial name
- NCT00813150
- Testing
- Dexamethasone, Bortezomib, Cyclophosphamide
- Where
- 40 sites in Germany
- Volunteers
- 96 people
- Sponsor
- Janssen-Cilag G.m.b.H
Radiodermatitis; Acute, Radiation Dermatitis
Novel Skin Care Product for the Management of Acute Radiodermatitis
Notwithstanding the continuous progress in cancer treatment, patients with cancer still have to cope with quality of life (QoL) - impairing complications.
- Trial name
- RTSkin (NCT04929808)
- Testing
- Hydrating emollient for acute radiodermatitis, Standard institutional skin care
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Jessa Hospital