Clinical trials: For Oncologic Patients
Gastro-intestinal Cancer, Lung Cancer
The Impact of a Patient Education Intervention for Ambulatory Oncology Patients
This study will test the impact of newly created and available symptom management patient education brochures on symptom burden [measured via the Edmonton Symptom Assessment System (ESAS)], health-related quality of life…
- Conditions
- Gastro-intestinal Cancer, Lung Cancer, Head and Neck Cancer, Breast Cancer
- Trial name
- NCT02038114
- Testing
- Instructed to read patient education pamphlets
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- Sunnybrook Health Sciences Centre
Oncology, Cancer Pain
Pain ASsessment in CAncer Patients by Machine LEarning (PASCALE)
In cancer patients, the integration between anticancer therapies and palliative care is of fundamental importance. In this context, telemedicine can improve the quality of life (QoL) of chronic patients through self-management…
- Conditions
- Oncology, Cancer Pain, Quality of Life
- Trial name
- PASCALE (NCT04726228)
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute, Naples
Breast Neoplasms, Colorectal Neoplasms
Nurse-led Care Program for Cancer Patients in Chemotherapy Day Center
A nurse-led care program for cancer patients receiving chemotherapy in an outpatient setting was formulated. The aim of the study was to assess the effect of this nurse-led care program on cancer patients who received…
- Trial name
- NCT02228200
- Testing
- Nurse-led care, Routine care
- Where
- China
- Volunteers
- 150 people
- Sponsor
- The Hong Kong Polytechnic University
Cardiotoxicity
Exercise for Ameliorating Chemotherapy Cardiotoxicity
Chemotherapy is a common treatment for breast cancer but can damage the heart and blood vessels. Exercise, such as cycling, may stop chemotherapy from damaging the heart and blood vessels.
- Trial name
- NCT06595316
- Testing
- Exercise intervention group
- Volunteers
- 30 people
- Sponsor
- University of Hull
Neoplasms
Salivary Cytokines as Biomarker for Oral Health
Oral complications during and after cancer treatment are common. A key role in maintaining oral health plays saliva. In the last decade numerous studies have investigated immunological biomarkers such as cytokines in saliva…
- Trial name
- Cytosal (NCT02807519)
- Testing
- collection of salivary cytokines
- Where
- 3 sites in Switzerland
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Mastectomy, Rhomboid Intercostal Block
Effects of Rhomboid Intercostal Block on Postoperative Pain Management and Chronic Pain Incidence in Mastectomies
The goal of this clinical trial is to evaluate the effects of the Rhomboid Intercostal Block (RIB) on postoperative chronic pain prevalence at 3 months (primary outcome) and on acute pain control, total opioid consumption, and…
- Conditions
- Mastectomy, Rhomboid Intercostal Block, Chronic Pain Following Surgical Procedure for Cancer
- Trial name
- NCT06756048
- Testing
- Rhomboid Intercostal Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Koç University
Small Cell Lung Cancer, Large Cell Neuroendocrine (NE) Tumors
Genomic and Methylation Markers in SCLC and LCNEC for Chemo-Immunotherapy Resistance Prediction (STRATUS)
The goal of this observational study is to understand how genomic and epigenetic factors contribute to resistance against chemo-immunotherapy in adults diagnosed with extensive-stage small cell lung cancer (ES-SCLC) or metastatic…
- Conditions
- Small Cell Lung Cancer, Large Cell Neuroendocrine (NE) Tumors, Treatment Failure, Biomarkers / Blood
- Trial name
- STRATUS (NCT06717243)
- Testing
- Carboplatin/Cisplatin -Etoposide - Atezolizumab
- Where
- 2 sites in United States, Greece
- Volunteers
- 111 people
- Sponsor
- Oncology Center of Biochemical Education And Research
Solid Tumor, Hematological Malignancies
Nurse-initiated Conversations for Early Integration of Palliative Care in Pediatric Oncology
This study aims to develop and implement a pediatric palliative care (PPC) program. It is an open-label, randomized trial (2:1 randomization) in pediatric oncology department of Children's Hospital of Fudan University.
- Trial name
- NiCE (NCT05306509)
- Testing
- NiCE, Routine PPC
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Children's Hospital of Fudan University
Relapsed Adult AML, Primary Refractory Acute Myeloid Leukemia
Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia
This research study is evaluating whether primary palliative care is an alternative strategy to specialty palliative care for improving quality of life, symptoms, mood, coping, and end of life outcomes in patients with acute…
- Conditions
- Relapsed Adult AML, Primary Refractory Acute Myeloid Leukemia, High Risk Acute Myeloid Leukemia
- Trial name
- SCOPE-L (NCT05237258)
- Testing
- Specialty Palliative Care, Primary Palliative Care
- Where
- 20 sites in United States
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Solid Tumor
A Study to Evaluate the Efficacy and Safety of TL118 in Solid Tumors Patients
The main objective of the study will be to evaluate the efficacy of TL118 in participants with solid tumors harboring NTRK gene fusions
- Trial name
- NCT06010342
- Testing
- TL118 Capsule
- Where
- 20 sites in United States, China
- Volunteers
- 60 people
- Sponsor
- Teligene US
Heart Failure, Coronary Artery Disease
PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study
This is a single-center, double-arm, open-label, randomized feasibility study that will determine whether a novel clinical decision aid accessed via the electronic health record will be acceptable to both cancer survivors and…
- Conditions
- Heart Failure, Coronary Artery Disease, Peripheral Artery Disease, Ischemia
- Trial name
- NCT05377320
- Testing
- Clinical Decision Aid, Standard Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical College of Wisconsin
Pancreas Cancer
Supportive Oncology Care at Home for Patients With Pancreatic Cancer Receiving Preoperative FOLFIRINOX
The goal of this research is to study an intervention, which the investigators call "Supportive Oncology Care at Home," that entails both remote patient monitoring (e.g.
- Trial name
- NCT03798769
- Testing
- Supportive Oncology Care at Home
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Cardiac Inflammation
Heart Analysis in GATED-PET in Patients Having a Gallium-68-DOTATOC PET/CT Exam for Oncology Indication
Gallium-68-DOTATOC binds primarily with high affinity to somatostatin subtype 2 (SSTR2) receptors and these somatostatin receptors are also overexpressed on inflammation cells when activated.
- Trial name
- GATEDOTA (NCT06467968)
- Testing
- Cardiac ECG-gated PET imaging will added
- Where
- France
- Volunteers
- 99 people
- Sponsor
- Central Hospital, Nancy, France
Cancer
Effectiveness of an Individual Mindfulness-based Intervention for Cancer Patients in a Advanced Stage of the Disease and Their Relatives
The importance of emotional regulation interventions in cancer patients and primary caregivers is clearly established, since it helps them manage their emotions.
- Trial name
- NCT03492073
- Testing
- Emotional Supportive Mindfulness-based Program, Emotional Supportive Program
- Volunteers
- 30 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Pediatric Cancer, Febrile Neutropenia
Feasibility of Monitoring Health Data in Pediatric Patients Undergoing Chemotherapy
In this pilot study the feasibility of continous monitoring of health data with a small, on-skin wearable device (the Everion®, by Biovotion, Zurich) in pediatric patients under chemotherapy for cancer, is studied.
- Conditions
- Pediatric Cancer, Febrile Neutropenia, Chemotherapy-induced Neutropenia, Oncology
- Trial name
- NCT04134429
- Testing
- Everion
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Autologous Stem Cell Transplantation
Stem Cell Harvesting Using GCSF Plus Plerxiafor, in First -Line, for Heavily Pre- Treated Pediatric Oncology Patients.
Plerixafor has been intensively used in recent years for harvesting autologous stem cells from lymphoma and myeloma adult patients. Its use is indicated after failure to harvest with GCSF alone.
- Trial name
- GCSF (NCT02006225)
- Testing
- Plerixafor
- Volunteers
- 30 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Gynecologic Cancer
Olanzapine for the Prevention of Chemotherapy Induced Nausea and Vomiting in Gynecologic Oncology Patients
The objective of this study is to investigate the efficacy of olanzapine as compared to neurokinin-1 receptor antagonists (NK1-RAs) in the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients with gynecologic…
- Trial name
- NCT04503668
- Testing
- Ondansetron, Dexamethasone, Neurokinin-1 Receptor Antagonist (NK1-RA)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Michigan Rogel Cancer Center
Infections, Covid19
Rosmalip® for Cancer Infections Prevention
This study is designed to assess the safety and efficacy of Rosmalip® nutritional supplement compared to placebo in subjects with solid cancer for the prevention of infections including COVID-19.
- Conditions
- Infections, Covid19, Cancer
- Trial name
- OnCOVInf (NCT05080920)
- Testing
- Rosmalip®
- Where
- Spain
- Volunteers
- 109 people
- Sponsor
- Fundación Investigación E Innovación Biomédica Hospital Universitario Infanta Sofia-Henares
Participants Undergoing Anthracycline Chemotherapy
Remote Ischemic Conditioning in Oncology
This is a feasibility study at a single site, Cincinnati Children's Hospital Medical Center. Patients undergoing anthracycline chemotherapy for Hodgkin disease and soft-tissue and bone sarcoma who meet eligibility requirements…
- Trial name
- RICO (NCT04805346)
- Testing
- autoRIC®
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Colorectal Cancer
Robotic vs Laparoscopic D3-D4 Lymphadenectomy for Colorectal Cancer
Approximately one third of patients with colorectal cancer are diagnosed as locally advanced stage with metastasis to N3 - N4 lymph nodes requiring a D3 - D4 lymphadenectomy.
- Trial name
- NCT05961423
- Testing
- Robotic surgery
- Where
- Taiwan
- Volunteers
- 286 people
- Sponsor
- National Taiwan University Hospital