Clinical trials: Former Smokers
Nicotine Addiction, E-Cig Use
Quit Smoking Study for People Who Use E-Cigarettes
The overarching aim of this proposed randomized controlled trial (RCT) is to test nicotine replacement therapy (NRT) with text message support for two smoking cessation approaches among young adult dual users of combustible…
- Conditions
- Nicotine Addiction, E-Cig Use, Quitting Smoking
- Trial name
- NCT04946825
- Testing
- Nicotine replacement therapy patch, Nicotine replacement therapy lozenge, Quit electronic cigarettes
- Where
- United States
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- University of Vermont
COPD, Asthma
Biomarker Assay Validation in Healthy Smokers and COPD Smokers and Ex-smokers
This study will collect sputum samples from healthy smokers, COPD smokers and COPD ex-smokers to analyse biomarkers of inflammation
- Trial name
- NCT02490358
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Respivert Ltd
Chronic Obstructive Pulmonary Disease (COPD)
Cross-Sectional Study of COPD Prevalence Among Smokers, Ex-smokers and Never-Smokers in Almaty, Kazakhstan
The purpose of this study is to assess the prevalence of COPD among individuals aged 35 - 59 years based results of spirometry before and after bronchodilator, presence of structural changes in lungs (emphysema, inflammatory…
- Trial name
- NCT02926534
- Where
- Kazakhstan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Kazakhstan Academy of Preventive Medicine
Substance Use Disorder (SUD)
Mobile Phone-based Smoking Cessation Program
In this online, randomized controlled trial (RCT), the participants will be randomized and allocated in 1:1 ratio to mobile phone-based intervention group or to the wait-list control group.
- Trial name
- NCT06747182
- Testing
- mobile phone-based intervention
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Smoking in IBD Patients
Influence of Smoking Cessation or Switching to THS on Disease Activity in IBD Patients.
The main goal of this study is to evaluate the effects of smoking cessation or switching from cigarette smoking to THS (tobacco heat system) on the clinical course of UC (ulcerative colitis) and CD (Crohn´s disease) in adult…
- Trial name
- NCT05196282
- Testing
- Smoking cessation
- Volunteers
- 100 people
- Sponsor
- HaFCED e.K.
Alcoholism, Smoking
Smoking Cessation in Alcoholism Treatment
This study is designed to increase understanding of the processes that affect the treatment outcome of individuals with both alcohol and nicotine dependence.
- Trial name
- NCT00000454
- Testing
- nicotine replacement patch
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Yale University
Non-small Cell Lung Cancer, Squamous Lung Dysplasia
Inositol in Preventing Lung Cancer in Current or Former Smokers With Bronchial Dysplasia
This randomized phase II trial is studying inositol to see how well it works compared with a placebo in preventing lung cancer in current or former smokers with bronchial dysplasia.
- Trial name
- NCT00783705
- Testing
- inositol
- Where
- 4 sites in United States, Canada
- Volunteers
- 85 people
- Sponsor
- National Cancer Institute (NCI)
Current Smoker, Former Smoker
Acetylsalicylic Acid Compared to Placebo in Treating High-Risk Patients With Subsolid Lung Nodules
This randomized phase II trial studies acetylsalicylic acid compared to placebo in treating high-risk patients with subsolid lung nodules. A nodule is a growth or lump that may be malignant (cancer) or benign (not cancer).
- Conditions
- Current Smoker, Former Smoker, Multiple Pulmonary Nodules, Tobacco Use Disorder
- Trial name
- NCT02169271
- Testing
- Aspirin, Laboratory Biomarker Analysis
- Where
- 2 sites in United States, Italy
- Volunteers
- 109 people
- Sponsor
- National Cancer Institute (NCI)
Smoking Cessation Counseling Ability, Smoking Cessation Counseling Practice
Instant Messaging Reinforcement for Smoking Cessation Counseling Training
This research aims to assess the impact of instant messaging reinforcement on the learning outcomes of smoking cessation counseling (SCC) training among master of nursing (MN) students at the University of Hong Kong.
- Trial name
- NCT06374082
- Testing
- WhatsApp message
- Where
- Hong Kong
- Volunteers
- 42 people
- Sponsor
- The University of Hong Kong
Non-squamous Non-small Cell Lung Cancer
Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Investigator's Choice of Standard Chemotherapy in Adults Receiving First Cytotoxic Chemotherapy for Metastatic or Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC) and Who Are Current or Former Smokers
The purpose of this study is to evaluate the safety and efficacy of veliparib plus carboplatin and paclitaxel versus the Investigator's choice of standard chemotherapy in adults with metastatic or advanced non-squamous non-small…
- Trial name
- NCT02264990
- Testing
- Paclitaxel, Carboplatin, Cisplatin
- Where
- 140 sites in United States, Argentina and 18 more
- Volunteers
- 595 people
- Sponsor
- AbbVie
Lung Cancer, Precancerous Condition
Green Tea Extract in Treating Current or Former Smokers With Bronchial Dysplasia
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of Polyphenon E, a substance found in green tea, may keep cancer from forming in current or former smokers with bronchial dysplasia.
- Conditions
- Lung Cancer, Precancerous Condition, Tobacco Use Disorder
- Trial name
- NCT00611650
- Testing
- defined green tea catechin extract
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- British Columbia Cancer Agency
Smoking Cessation, Nicotine Dependence
Neuropsychological Prognosis Factors of Smoking Cessation
The low overall effectiveness of available smoking cessation treatment so far, indicate the need for new and more efficacious ways to help smokers maintain abstinence. Smokers are a highly heterogeneous population.
- Trial name
- NCT01554436
- Testing
- neuropsychological assessment
- Where
- France
- Volunteers
- 135 people
- Sponsor
- University Hospital, Montpellier
Smoking Cessation
Study on the Model of Smoking Cessation Intervention and Service Ability Improvement
This is a observation non-randomized control trial, and a follow-up study on the smoking cessation.
- Trial name
- NCT01935505
- Testing
- Consulting, Nicotine patch, Telephone intervention
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Smoking Cessation
A Multi-National Study To Assess How Effective And Safe The Smoking Cessation Medicine Varenicline Is In Smokers Who Have Already Tried Varenicline In The Past As A Prescription Medicine From Their Usual Healthcare Provider
The main purpose of this study is to compare the effectiveness and safety of the re-treatment of smokers with varenicline with placebo for smoking cessation during the last 4 weeks of a 12 week course of treatment.
- Trial name
- NCT01244061
- Testing
- Varenicline
- Where
- 37 sites in United States, Australia and 6 more
- Volunteers
- 498 people
- Sponsor
- Pfizer
Respiratory Disorders
A Study to Test if a Third Dose of the Vaccine is Safe in Current and Former Smokers Aged 40 to 80 Years Old and to Gather Information on the Immune Response Following the Third Dose of the Vaccine
The purpose of this study is to test two different vaccine schedules to be used for administering the investigational NTHi Mcat vaccine that will be targeting patients with chronic obstructive pulmonary disease (COPD) to prevent…
- Trial name
- NCT03443427
- Testing
- NTHi Mcat investigational vaccine (GSK3277511A)
- Where
- 8 sites in Canada, Germany and 1 more
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Male Infertility
Tobacco and Sperm Genome: Effects of Smoking Cessation
Tobacco is a male infertility risk factor. Many studies comparing smokers to non-smokers have shown effects on spermatogenesis and the quality of the male gamete.
- Trial name
- TABAGERM (NCT03552081)
- Testing
- Fragmented DNA evaluation in blood and semen samples
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Use and Dissemination of Smoking Cessation Intervention, Cessation of Smoking
Study of the Diffusion of a Smoking Cessation Application Through an Online Network
Effective evidence-based interventions exist for smoking cessation delivered over the Internet, but consumer acceptance and adherence remains low.
- Trial name
- NCT01746472
- Testing
- Facebook app - condition t, Facebook app - condition z, Facebook app - condition B-active
- Where
- United States
- Volunteers
- 11,413 people, healthy volunteers welcome
- Sponsor
- Truth Initiative
Non-Squamous Non-Small Cell Lung Cancer
A Study of Erlotinib [Tarceva] as Monotherapy or Intermittent Dosing With Docetaxel in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer. (TALISMAN)
This randomized parallel group study will assess the efficacy and safety of erlotinib [Tarceva], as monotherapy or intermittent dosing with docetaxel, in second-line setting in former-smoker male patients with advanced or…
- Trial name
- NCT01204697
- Testing
- docetaxel, erlotinib [Tarceva]
- Where
- 20 sites in Italy
- Volunteers
- 74 people
- Sponsor
- Hoffmann-La Roche
Cigarette Smoking-Related Carcinoma, Lung Carcinoma
Evaluation of Canakinumab in High-Risk Former-Smokers
This phase II trial tests the impact of canakinumab on biologic samples (buccal, nasal, and blood) from former smokers with increased risk of cancer.
- Trial name
- NCT06038526
- Testing
- Biospecimen Collection, Bronchoscopy, Canakinumab
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Peter Shields
Non-small Cell Lung Cancer
Pemetrexed (ALIMTA) and Gefitinib (IRESSA®) in Never-Smoker and Adenocarcinoma Patients With Non-Small Cell Lung Cancer Previously Treated With Platinum-Based Chemotherapy
Pemetrexed was known to be effective to pulmonary adenocarcinoma and gefitinib was known to be more effective to non-small cell lung cancer (NSCLC) patients with clinical characteristics such as adenocarcinoma, never smoker and…
- Trial name
- NCT01066195
- Testing
- iressa, alimta
- Where
- South Korea
- Volunteers
- 129 people
- Sponsor
- Samsung Medical Center