Clinical trials: Fracture, Ankle
Trauma
Unimalleolar Versus Bimalleolar Fixation in Bi- or Trimalleolar Ankle Fracture
A one third of all ankle fractures are bi- or trimalleolar. Traditionally these fractures are treated by both medial and lateral osteosynthesis, sometimes accompanied by osteosynthesis of the posterior malleolus.
- Trial name
- NCT01757951
- Testing
- Unimalleolar fixation, Bimalleolar fixation
- Where
- Finland
- Volunteers
- 126 people
- Sponsor
- University of Oulu
Ankle Fractures
Intramedullary Nailing Versus Plate Fixation of Ankle Fractures. A Prospective, Randomized Controlled Trial.
The purpose of this study is to make a survey of functional outcome, radiological outcome and complication rate after intramedullary nailing (IMN) and plate fixation of Weber B ankle fractures in elderly patients, and contribute…
- Trial name
- NCT03377205
- Testing
- Compression screws and neutralization plate, Acumed Fibular Rod System
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Ankle Fractures
Combined Randomised and Observational Study of Type B Ankle Fracture Treatment
This study will determine whether operative management confers improved short and long-term outcomes for patients with isolated AO type 44-B1 distal fibula fractures when compared with non-operative management.
- Trial name
- CROSSBAT (NCT01134094)
- Testing
- Open reduction internal fixation of the ankle, Non Operative
- Where
- 21 sites in Australia
- Volunteers
- 160 people
- Sponsor
- The University of New South Wales
Syndesmotic Injuries
Syndesmotic Screw in Neutral Position Versus Maximum Ankle Dorsiflexion in Ankle Fractures; Comparative Study.
Ankle fracture is one of the most common orthopedic injuries. Approximately, 20% of surgically treated ankle fractures are associated with syndesmotic instability.According to the mechanism of the injury the syndesmotic…
- Trial name
- NCT06313177
- Testing
- syndesmosis fixation with screws
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sohag University
Post-traumatic; Arthrosis, Tibial Fractures
Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures?
High-energy tibial pilon fractures have historically been associated with poor outcomes largely due to the elevated risk of severe post-traumatic arthritis.
- Conditions
- Post-traumatic; Arthrosis, Tibial Fractures, Post-Traumatic Osteoarthritis of Ankle
- Trial name
- NCT05652881
- Testing
- Joint Lavage
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Pain, Postoperative, Ankle Fractures
Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures
The purpose of this study is to determine the efficacy and safety of a peri-articular multimodal injection for post-operative pain control following operative management of closed, rotational ankle fractures.
- Trial name
- NCT02967172
- Testing
- Ropivacaine, Epinephrine, Morphine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Iowa
Ankle Fractures, Unstabel Ankle Fractures
Immediate Protected Weight Bearing Versus Conventional Non-Weight Bearing After Surgical Fixation of Unstable Ankle Fractures
This prospective randomized controlled trial evaluates the safety and effectiveness of immediate protected weight bearing following surgical fixation of unstable ankle fractures.
- Trial name
- NCT07814638
- Testing
- Immediate protected weight bearing, Rehabilitation
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Consorci Sanitari Integral
Ankle Fractures
Cryotherapy Reduces Time to Surgery and Local Complication in Patients With Ankle Fractures
Ankle fractures are common injuries and cryotherapy is routinely used to reduce pain, swelling and local skin complications, both before and after surgery. However, the results on ankle surgery are contradictory.
- Trial name
- Cryotherapy (NCT06396364)
- Testing
- Cryotherapy
- Where
- 2 sites in Italy
- Volunteers
- 169 people
- Sponsor
- Azienda Ospedaliera San Camillo Forlanini
Fracture Fixation, Internal
A Clinical Study to Evaluate the Safety and Efficacy of Biologic Hollow Bone Screws
Traditional fracture fixation devices can cause corrosion, allergies, and stress shielding effects. They often require removal after healing, risking secondary damage.
- Trial name
- NCT06942247
- Testing
- Active Comparator: Fracture Fixation (Inion Freedom Screws), Experimental: Fracture Fixation (Biological Hollow Bone Screws)
- Where
- China
- Volunteers
- 160 people
- Sponsor
- FengYafei
Ankle Fractures, Anesthesia, Local
High Ankle Block in Ankle Fractures
The aim of the herein presented double-blinded is to compare the effectiveness of the high foot block against placebo infiltration in simple, uni- and bimalleolar ankle fractures.
- Trial name
- NCT04292691
- Testing
- 40ml of Ropivacaine 0.5% Injectable Solution, 40ml of Ringer's Lactate
- Volunteers
- 60 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Deep Vein Thrombosis, Pulmonary Embolism
The D-KAF (Dalteparin in Knee-to-Ankle Fracture) Trial
It is known that patients who fracture their legs sometimes develop blood clots (known as deep vein thrombosis) in their legs. These clots may cause pain and swelling in the leg or they may detach and travel to the lungs…
- Trial name
- NCT00187408
- Testing
- Low Molecular Weight Heparin (dalteparin)
- Where
- 13 sites in Canada
- Volunteers
- 700 people
- Sponsor
- Sunnybrook Health Sciences Centre
Trimalleolar Fracture, Posterior Malleolus
Fixation of the Posterior Malleolus in Medium-sized Trimalleolar AO Weber-B Fractures.
The optimal treatment of ankle fractures with involvement of the posterior malleolus remains a subject of debate. Despite a large amount of literature on the role of the posterior malleolus in a so-called trimalleolar fracture…
- Conditions
- Trimalleolar Fracture, Posterior Malleolus, Open Reduction and Internal Fixation
- Trial name
- POSTFIX (NCT02596529)
- Testing
- Fixation, NO Fixation
- Where
- 3 sites in Netherlands
- Volunteers
- 84 people
- Sponsor
- Medical Center Haaglanden
Fracture, Ankle, Fracture Leg
Impact of Regional Anesthesia on Blood Pressure in Lower Limb Traumatism
This study aims to compare the hemodynamic impact of two anaesthetic strategies 'Regional anesthesia' versus 'General anesthesia' in leg and ankle fractures surgery.
- Trial name
- IRB (NCT04844372)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Montpellier
Ankle Fractures, Post-traumatic Osteoarthritis
Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle joint. Research suggests that ankle arthritis develops after ankle fracture, in part, due to elevated forces on the cartilage.
- Conditions
- Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
- Trial name
- PRMRP-FPA2 (NCT04562896)
- Testing
- Custom Carbon Fiber Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Post Operative Treatment After Unstable Malleolar Fractures
Early Protected Full Weight-bearing vs. Partial Weight-bearing After Surgical Fixation of Unstable Ankle Fractures, Monitored With Bio-feedback Insoles.
The purpose of this study is to compare the postoperative results after ORIF (Open Reduction Inner Fixation) with a partial weight-bearing protocol versus an early full weight-bearing protocol.
- Trial name
- NCT06023979
- Testing
- Full weight bearing, Partial weight bearing
- Where
- Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Deep Venous Thrombosis
Low-Molecular-Weight Heparin (LMWH) for Deep Venous Thrombosis (DVT) Prophylaxis
1. The use of LMWH following open reduction and internal fixation of ankle fractures will reduce the number of thrombi formed. 2. The rates of clinically significant DVT will be equivalent between two groups.
- Trial name
- NCT01029821
- Testing
- Low-Molecular-Weight Heparin
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Ankle Fracture, Bimalleolar, Ankle Fracture, Trimalleolar
Use of Weightbearing Radiographs to Determine Treatment of bi- and Trimalleolar Ankle Fractures
The aim of this study is to evaluate the outcomes after non-operative treatment of weightbearing stable bi-and trimalleolar ankle fractures.
- Trial name
- NCT05765929
- Testing
- Non-operative treatment
- Where
- Norway
- Volunteers
- 29 people
- Sponsor
- Ostfold Hospital Trust
Fractures Bone
ANKLE TRAUMA Diagnostic Value of Ultrasound Compared to Standard Radiography in the Detection of Fractures
To investigate the diagnostic value of ultrasound performed by a lay experimenter compared to standard radiographic imaging (or standard x-ray) in the detection of fractures in patients with closed acute ankle trauma and positive…
- Trial name
- NCT05528432
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Posterior Malleolus Fractures, Ankle Fractures
Weber B Ankle Fractures With Associated Posterior Malleolus Fracture
Ankle fractures constitute 9% of all fractures and have an incidence of approximately 187 per 100,000 persons per year in Norway.
- Conditions
- Posterior Malleolus Fractures, Ankle Fractures, Syndesmotic Injuries, Patient Reported Outcome Measure
- Trial name
- PMFIX (NCT05413707)
- Testing
- Fixation of the posterior malleolus fractures, Fixation of lateral and/or medial malleolus fractures, Syndesmotic fixation
- Where
- Norway
- Volunteers
- 198 people
- Sponsor
- Haukeland University Hospital
Hyperpronated Foot, Reconstruction Surgeries of the Foot
Evaluate the Continued Safety and Performance of the Foot and Ankle Products
The objective of the registry is to evaluate the continued safety and performance of Arthrex foot and ankle products, including the ProStop® implant for hyperpronated foot; Bio-Compression Screw for reconstruction surgeries of…
- Conditions
- Hyperpronated Foot, Reconstruction Surgeries of the Foot, Fixation of Fractures and Fusion (Bunionectomy Osteotomies) of the Foot/Ankle, Fixation of Small Bone Fragments of the Foot/Ankle
- Trial name
- NCT04715139
- Testing
- Products listed in Group/Cohort Description
- Where
- 7 sites in United States, Germany and 1 more
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Arthrex, Inc.