Clinical trials: Fracture
Osteoporosis, Postmenopausal, Back Pain
Effect of Teriparatide Compared to Risedronate on Back Pain in Women With a Spine Fracture Caused by Osteoporosis
The purpose of the study is to determine if daily teriparatide reduces back pain more effectively than weekly risedronate in women with osteoporosis who have chronic back pain due to a spinal bone fracture.
- Conditions
- Osteoporosis, Postmenopausal, Back Pain, Spinal Fracture
- Trial name
- NCT00343252
- Testing
- teriparatide, risedronate
- Where
- 72 sites in United States, Argentina and 11 more
- Volunteers
- 712 people
- Sponsor
- Eli Lilly and Company
Foot Deformities, Acquired, Disorder of Joint of Foot
A Clinical Study of Outcomes in Foot and Ankle Bone Grafting Using map3® Cellular Allogeneic Bone Graft
This is a single arm pilot study in patients requiring surgical fusion in the foot or ankle. Patients will receive map3® Cellular Allogeneic Bone Graft containing donor matched stem cells.
- Conditions
- Foot Deformities, Acquired, Disorder of Joint of Foot, Fracture of Foot, Deformity of Bone
- Trial name
- NCT02161016
- Testing
- map3
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- RTI Surgical
Tibial Fractures
A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Proximal Tibial Fractures
This study looks at two types of surgical treatments and hopes to answer the question: which is the best way to surgically treat a proximal tibia fracture? Both procedures being studied are standard of care (used routinely) and…
- Trial name
- NCT00429585
- Testing
- reamed, interlocking intramedullary nail, locking periarticular plate
- Where
- 29 sites in United States, Canada
- Volunteers
- 108 people
- Sponsor
- Boston Medical Center
Orthopedic Surgery of Lower Extremity
Evaluation of Continuous Saphenous Nerve Block to Supplement a Continuous Sciatic Nerve Block After Ankle Surgery
A nerve block catheter is a small tube placed next to a nerve through a needle, and the needle is then removed. Numbing medicine is dripped through the tube to reduce pain sensation from the nerve.
- Trial name
- NCT01167907
- Testing
- 0.2% ropivacaine, saline
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Wake Forest University Health Sciences
Muscle Loss, Fractures
Musculoskeletal Effects of Bicarbonate
With aging, men and women develop a mild and progressive metabolic acidosis. This occurs as a result of declining renal function and ingestion of acid-producing diets.
- Conditions
- Muscle Loss, Fractures, Osteoporosis, Age Related, Fall Injury
- Trial name
- NCT01475214
- Testing
- potassium bicarbonate
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Tufts University
Post Operative Surgical Site Infection
Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA
The overall objective is to compare the effect of Vancomycin and Tobramycin powder combined (treatment) to Vancomycin powder (control) in the reduction of post-fixation infections of tibial plateau and tibial pilon fractures at…
- Trial name
- TOBRA (NCT04597008)
- Testing
- Treatment group, Control group
- Where
- 41 sites in United States
- Volunteers
- 1,660 people
- Sponsor
- Major Extremity Trauma Research Consortium
Rib Fracture, Flail Chest
Clinical Study of the U-Plate Fracture Repair System to Treat Rib Fractures
The purpose of this study is to gather information about a device used to help fix broken ribs. Hypothesis: Rib fracture repair with the U-plate system is clinically durable and safe for the indications of flail chest repair…
- Trial name
- NCT00556543
- Testing
- U-plate fracture repair system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Blunt Injury of Thorax, Multiple Rib Fractures, Involving Three Ribs
Low Dose Ketamine for Blunt Thoracic Trauma
The goal of this Randomized controlled double-blinded trial is to compare the addition of a ketamine infusion to placebo, when added to standard care in adult blunt trauma patients with multiple rib fractures.
- Trial name
- NCT06236113
- Testing
- Ketamine 1 Mg/mL-NaCl 0.9% Intravenous Solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- North Memorial Health Care
Proximal Humeral Fracture, Proximal Tibia Fractures
PMCF Study on the Safety, Performance and Clinical Benefits Data of the Zimmer® Plates and Screws System
The study is a monocentric, retro- and prospective, non-randomized, non-controlled and consecutive series post-market study. The purpose of this study is to confirm safety, performance and clinical benefits of the Zimmer® Plates…
- Conditions
- Proximal Humeral Fracture, Proximal Tibia Fractures, Diaphyseal Fracture
- Trial name
- NCT05215613
- Where
- Italy
- Volunteers
- 57 people
- Sponsor
- Zimmer Biomet
Femoral Shaft Fracture
TRIGEN SURESHOT™ Distal Targeting System Study
The objective of this study is to quantitate the amount of radiation both subjects and surgeons are exposed to during intramedullary nailing of the femur using the TRIGEN SURESHOT Distal Targeting System versus Standard nailing…
- Trial name
- Sureshot (NCT01327508)
- Testing
- TRIGEN SURESHOT Distal Targeting Instrumentation., Free-hand technique
- Where
- 7 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Smith & Nephew, Inc.
Postmenopausal Osteoporosis
A Study of Romosozumab (EVENITY®) in Postmenopausal Women in India With Osteoporosis at a High Risk of Fracture.
The primary objective of this study is to characterize safety and tolerability of romosozumab in postmenopausal women with osteoporosis and a high risk of fracture in India.
- Trial name
- NCT06079476
- Testing
- Romosozumab
- Where
- 10 sites in India
- Volunteers
- 100 people
- Sponsor
- Amgen
Pseudoarthrosis
Humeral Shaft Pseudoarthrosis Treated With Bone Autograft Versus Platelet Rich Plasma
Patients with humeral shaft pseudoarthrosis is going to be treated with a standard protocol with a locking compression plate and bone autograft, and other group of patients treated with platelet rich plasma.
- Trial name
- NCT02520089
- Testing
- bone autograft of iliac crest, Platelet Rich Plasma plus bone autograft
- Where
- Mexico
- Volunteers
- 23 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Rib Fractures
Continuous Intercostal Nerve Blockade for Traumatic Rib Fractures
Rib fractures are common injuries in accident patients and can be associated with significant pain during recovery. If poorly controlled, pain from splinting due to rib fractures can result in difficulty in breathing leading to…
- Trial name
- NCT02604589
- Testing
- hydromorphone hydrochloride, Infusion catheter placement, bupivicaine 0.25%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Anthony Iacco
Hip Fractures, Hip Arthropathy
Optimizing Cerebral Autoregulation During Surgery
The purpose of this study is to conduct a pilot trial to determine the feasibility, safety, and potential efficacy of targeting mean arterial blood pressure (MAP) within the limits of cerebral autoregulation during surgery…
- Conditions
- Hip Fractures, Hip Arthropathy, Surgery, Delirium
- Trial name
- NCT05308290
- Testing
- Blood pressure management according to cerebral autoregulation, Blood pressure management according to usual care
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Supracondylar Fractures
A Comparison of UGSB and GA to IV Narcotics and GA for Post-Op Pain in Children With Supracondylar Fractures.
This study compares nerve blocks to IV pain medicines in children with broken arms. We are trying to see if blocking the nerves in the broken arm results in better pain control and less side effects than injections of morphine…
- Trial name
- NCT02056288
- Testing
- Fentanyl, Ropivacaine
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Distal Radius Fracture
Motor Imagery in Rehabilitation After a Distal Radius Fracture
The aim of this study is to determine whether motor imagery training during the immobilisation period in patients with a distal radius fracture, results in an improved functional outcome compared to patients who do not perform…
- Trial name
- MIDRF (NCT01921062)
- Testing
- Motor imagery
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- University Medical Center Groningen
Displaced Forearm Fractures
Randomized Trial of Casting Techniques for Displaced Forearm Fractures
It is recognized that fractures of the distal radius and forearm occur in approximately one in 100 children and adolescents every year.
- Trial name
- NCT00823823
- Testing
- Bivalved cast, Circumferential cast
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Boston Children's Hospital
Hip Fracture
Body Weight Supported Treadmill Training Following Hip Fracture
Achieving independent ambulation is an important goal of hip fracture rehabilitation, as it is predictive of returning to the community and of future health problems.
- Trial name
- NCT00197496
- Testing
- Body weight supported treadmill training
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McMaster University
Fracture
Anatomical Shoulder™ Fracture PMCF Study
The purpose of this study is to obtain outcomes data on the Anatomical Shoulder Fracture System by analysis of standard scoring systems and radiographs.
- Trial name
- NCT02465398
- Testing
- Fracture Shoulder Arthroplasty
- Where
- 3 sites in Germany, Switzerland and 1 more
- Volunteers
- 52 people
- Sponsor
- Zimmer Biomet
Pain, Fracture
Single Shot Versus OnQ Pump in Extremity Fractures
Peripheral nerve blocks have been well studied in the literature with generally good results for controlling post operative pain following orthopaedic surgery. Regional anesthesia has many benefits.
- Trial name
- NCT02280291
- Testing
- Ankle SSB, Ankle OnQ, DR SSB
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health