Clinical trials: Fracture Bone
Male Osteoporosis
Efficacy in Reducing Fractures and Safety of Zoledronic Acid in Men With Osteoporosis
This study will investigate if the drug zoledronic acid given once yearly is safe and has beneficial effects in treating osteoporosis by reducing bone loss and fractures in men with osteoporosis.
- Trial name
- NCT00439647
- Testing
- Zoledronic acid 5 mg iv
- Where
- 128 sites in Argentina, Australia and 21 more
- Volunteers
- 1,199 people
- Sponsor
- Novartis Pharmaceuticals
Tibial Fractures
Trial to Evaluate UltraSound in the Treatment of Tibial Fractures
The purpose of this study is to determine the effect of low-intensity, pulsed ultrasound on tibial fractures treated with intramedullary nailing.
- Trial name
- TRUST (NCT00667849)
- Testing
- Exogen 4000+
- Where
- 16 sites in United States, Canada
- Volunteers
- 501 people
- Sponsor
- Bioventus LLC
Pediatric Extremity Fracture, Pediatric Extremity Soft Tissue Injury
Peripheral Nerve Blocks in Pediatric Orthopedic Patients
Context: Single shot peripheral nerve blocks have limited duration of action depending on the local anesthetic agent used in the block. But it rarely lasts longer than 12 hrs.
- Trial name
- NCT02236130
- Testing
- Regional block, General Anesthesia, Local Anesthetic Ropivacaine
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Syndesmotic Injuries, Ligament Rupture
Internal Brace Augmented Anterior Inferior Tibiofibular Ligament Repair: Post-operative Syndesmotic Volumes.
Over the course of a year from the start of the research study, twenty subjects will be randomized evenly into one of two groups after an informed consent is obtained: a traditional tight rope fixation group or a tight rope…
- Conditions
- Syndesmotic Injuries, Ligament Rupture, Bimalleolar Fractures, Trimalleolar Fractures
- Trial name
- NCT05062265
- Testing
- Tight rope fixation, Tight rope fixation with an anterior inferior tibiofibular ligament (AITFL) repair augmentation with an internal brace
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Vann Virginia Center for Orthopaedics dba Atlantic Orthopaedic Specialists
Fractures, Closed
Incisional Vacuum Assisted Closure (IVAC) Device and Its Effect on Implanted Bone Morphogenic Protein (BMP-2)
People who have been scheduled for surgery using Bone Morphogenic Protein (called BMP-2) and an incisional vacuum assisted closure device (called IVAC) will be asked to join this study.
- Trial name
- NCT00829621
- Testing
- 75 mmHg suction, 125 mmHg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Missouri-Columbia
Spinal Fractures, Osteoporosis
Vertebroplasty for the Treatment of Fractures Due to Osteoporosis
Vertebroplasty is a procedure used to stabilize broken vertebrae, the bones that form the spine. This study will evaluate the effectiveness of vertebroplasty for the treatment of fractures due to osteoporosis.
- Trial name
- NCT00068822
- Testing
- Percutaneous vertebroplasty
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Mayo Clinic
Neck Injuries
A Pragmatic Evaluation of the Canadian C-Spine Rule by Paramedics
Each year, half a million patients with a potential neck (c-spine) injury are transported to Ontario emergency departments (ED). Less than 1% of all these patients actually have a neck bone fracture.
- Trial name
- NCT02786966
- Testing
- Canadian C-Spine Rule
- Where
- Canada
- Volunteers
- 3,646 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoporosis, Fractures, Bone
A Comparison of Serum and Urine N-telopeptide Marker
This is a prospective specimen collection cohort study to evaluate the correlation between serum and urine values of the bone marker of interest, and their association with baseline DEXA scan measures and fracture risk within 6…
- Trial name
- NCT05326815
- Testing
- N-Telopeptide, Bone Marker
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- The Cleveland Clinic
Closed Transverse Fracture of Shaft of Tibia
Union Rate of Transverse Tibia Fracture
The investigators will compare the three methods of seating a tibial nail - Backslapping or Backslapping with Dynamic Locking or Internal Compression.
- Trial name
- NCT03042533
- Testing
- Conventional Compression, Standard Backslapping, Dynamic Locking with Backslapping
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Washington
Arthroplasty, Hemiarthroplasty
A Post-Market Clinical Evaluation of the ReUnion Reversible Fracture (RFX) System
This investigation is a prospective, multi-center clinical investigation. It is anticipated that a total of one hundred (100) subjects will be enrolled at approximately 5-10 sites.
- Conditions
- Arthroplasty, Hemiarthroplasty, Shoulder Pain
- Trial name
- NCT04089371
- Testing
- ReUnion Total Shoulder Arthroplasty (TSA), ReUnion Reverse Shoulder Arthroplasty (RSA)
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Stryker Trauma and Extremities
Hemorrhage, Pelvic Fracture
Pre-hospital Advanced Therapies for Control of Hemorrhage - Pelvis
The purpose of this study is to determine whether the use of pelvic binders in the ambulance setting improves outcomes including mortality in patients with pelvic fractures.
- Trial name
- PATCH (NCT02855060)
- Testing
- Pelvic Binder
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Wake Forest University Health Sciences
Maxillofacial Injuries, Maxillofacial Prosthesis Implantation
A Clinical Trial of Locally Made Titanium Miniplate and Screw in Maxillofacial Fractures Management
The study is a blind randomized clinical study on patients with midface maxillofacial fractures coming to Cipto Mangunkusumo Hospital.
- Conditions
- Maxillofacial Injuries, Maxillofacial Prosthesis Implantation, Fracture Fixation, Internal
- Trial name
- NCT04279925
- Testing
- ORIF (Open reduction internal fixation): locally-made miniplate and screw, ORIF: Imported miniplate and screw
- Where
- Indonesia
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Metastatic Cancers, Multiple Myeloma
Vertebral Augmentation and Radiotherapy of Collapse Spinal Metastatic Cancer
Vertebral augmentation with radiotherapy to increase the functional status and quality of life for patients with vertebral body metastatic cancers.
- Conditions
- Metastatic Cancers, Multiple Myeloma, Vertebral Fracture
- Trial name
- NCT02376933
- Testing
- Vertebroplasty, Radiotherapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Arizona
Fracture
Wrist Fracture Evaluation With a Desktop Orthopedic Tomosynthesis System
Trauma to the extremities such wrist, ankle, limb is very common and affects all population groups. It constitutes a significant public health issue. Standard radiography remains the basic imaging tool.
- Trial name
- NCT03993691
- Testing
- Tomo-E scan, Radiograph
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoporosis
A Study to Evaluate Denosumab in the Treatment of Postmenopausal Osteoporosis
This study will evaluate the effectiveness and safety of denosumab in treating women with Postmenopausal Osteoporosis.
- Trial name
- NCT00089791
- Testing
- Denosumab
- Volunteers
- 7,808 people
- Sponsor
- Amgen
Hip Fractures, Delirium
Post-Operative Delirium in Elderly Surgical Patients
This research is being done to see what effects sedative drugs during surgery have on peoples' thinking processes after they wake up.
- Trial name
- STRIDE (NCT00590707)
- Testing
- Deeper sedation, Moderate sedation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins University
Femoral Neck Fractures
Safety Study of Femoral Neck Fracture System
The purpose of this study is to assess the reoperation rate of fractures that have occurred at the neck of the femur that are treated with the CONQUEST FN Femoral Neck Fracture System.
- Trial name
- CONQUEST FN (NCT03721835)
- Testing
- CONQUEST FN Femoral Neck Fracture System
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Rheumatoid Arthritis
A Clinical Investigation of the Discovery™ Elbow System
The purpose of this study is to perform a five-year, multi-center prospective evaluation of the Discovery™ Elbow System for outcome and durability.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Avascular Necrosis, Humeral Fractures
- Trial name
- NCT00698867
- Where
- 4 sites in United States
- Volunteers
- 118 people
- Sponsor
- Biomet Orthopedics, LLC
Vitamin D Receptor Defect
Association Between Vitamin D Receptor Polymorphism and Serum Vitamin D Levels in Children With Low-Energy Fractures
This study was designed to determine the impact of vitamin D serum levels and vitamin D receptor (VDR) polymorphisms on the occurrence of low energy fractures in children.
- Trial name
- NCT02805647
- Where
- Poland
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Juvenile Osteoporosis, Low Bone Density
Alendronate in Juvenile Osteoporosis
The investigators earlier have shown that treatment of patients with juvenile osteoporosis with alendronate (Fosamax) for 12 months increased the bone density without side effects.
- Conditions
- Juvenile Osteoporosis, Low Bone Density, Fractures
- Trial name
- NCT00920075
- Testing
- Alendronate (Fosamax)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina