Clinical trials: Fracture Lower Leg
Chronic Postsurgical Pain
CSF Single-cell Sequencing and Proteomics of Chronic Postsurgical Pain in Patients With Lower Limb Fractures
The purpose of this study is to assess the proteomics and transcriptomic differences between pain-free control subjects and patients with chronic postoperative pain through single-cell sequencing technology.
- Trial name
- NCT06126289
- Volunteers
- 20 people
- Sponsor
- Xuzhou Central Hospital
Pelvic Fracture
Fragility Fractures of the Pelvis (FFP)
Prospective data will be collected in approximately 420 patients, above the age of 65, suffering from an FFP type fracture equal to or higher than type II, according to Rommens and Hofmann.
- Trial name
- NCT04182776
- Where
- 10 sites in United States, Canada and 5 more
- Volunteers
- 420 people
- Sponsor
- AO Innovation Translation Center
Femoral Neck Fractures
Dual Mobility Cups in Hip Fracture Patients
Our aim is to develop a strategy that reduces the risk of dislocations after total hip arthroplasty surgery performed due to femoral neck fracture.
- Trial name
- DUALITY (NCT03909815)
- Testing
- Dual mobility cup, Standard cup
- Where
- 2 sites in Sweden, United Kingdom
- Volunteers
- 1,600 people
- Sponsor
- Uppsala University
Tibial Plateau Fracture
Personalized Weight-Bearing With Smart Crutch Tips After Surgery for Tibial Plateau Fractures
This study will compare two approaches to rehabilitation after surgery for a fracture of the upper part of the shinbone that involves the knee joint (tibial plateau fracture).
- Trial name
- NCT07897149
- Testing
- Crutch Tip Biofeedback System, Individualized FEA-Guided Postoperative Weight-Bearing, Usual-Care Postoperative Weight-Bearing
- Volunteers
- 86 people
- Sponsor
- Comeback Mobility Inc
Tibial Fractures
Trial to Evaluate UltraSound in the Treatment of Tibial Fractures
The purpose of this study is to determine the effect of low-intensity, pulsed ultrasound on tibial fractures treated with intramedullary nailing.
- Trial name
- TRUST (NCT00667849)
- Testing
- Exogen 4000+
- Where
- 16 sites in United States, Canada
- Volunteers
- 501 people
- Sponsor
- Bioventus LLC
Hip Fractures (ICD-10 72.01-72.2)
Risk Early Warning Management for Postoperative Hip Fracture Rehabilitation and Delirium Prevention in Elderly Patients
This clinical study aims to evaluate the effectiveness of a perioperative risk early warning management strategy in patients undergoing surgical treatment for hip fractures.
- Trial name
- NCT06966947
- Testing
- Risk Early Warning Management, Standard Perioperative Care
- Where
- China
- Volunteers
- 284 people
- Sponsor
- People's Hospital Affiliated to Hubei University of Medicine
Intertrochanteric Fractures, Intertrochanteric Fractures of the Hip
Robot-Assisted Closed Reduction and Internal Fixation for Intertrochanteric Femoral Fractures
The goal of this clinical trial is to compare the clinical effectiveness and safety of robot-assisted autonomous closed reduction versus traditional manual closed reduction in adult patients aged 18 to 80 years with acute, closed…
- Conditions
- Intertrochanteric Fractures, Intertrochanteric Fractures of the Hip, Intertrochanteric Fractures of the Femur
- Trial name
- NCT07738458
- Testing
- Robot-assisted closed reduction and internal fixation, Conventional manual closed reduction and internal fixation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Jishuitan Hospital
Elderly, Wrist Fracture
Evaluation of Health and Social Interventions Aimed to Old People Discharged From Hospital After a Hip or Wrist Fracture Due to a Fall
Objectives: To describe social and health care provided to our older patients who have been admitted in the emergency department (ED) after suffering from a hip or wrist fracture due to a fall.
- Conditions
- Elderly, Wrist Fracture, Hip Fracture
- Trial name
- NCT02802358
- Testing
- Surgery or non-invasive procedure (reduction of the fracture, immobilization, stabilization)
- Volunteers
- 1,824 people
- Sponsor
- Hospital Galdakao-Usansolo
Distal Femur Fractures
Radiostereometric Analysis of Fracture Healing in Distal Femur Fractures
The investigators are doing this research study to look at how distal femoral fractures (knee bone break) heal. In this study, the investigators will use Radiostereometric Analysis (RSA) to look at how the pieces of femur bone…
- Trial name
- RSA (NCT01593176)
- Testing
- Placement of RSA beads
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Tibial Fractures
Posterior Plating Versus Anterior to Posterior Screws in Fixation of Posterior Column in Pilon Fractures
Management of comminuted distal tibia fracture (pilon fracture) is still a challenging field. It is recently done guided by the new four column theory of distal tibia.
- Trial name
- NCT05303389
- Testing
- Fixation of 2,3 or 4 column pilon fracture of the tibia
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Neck of Femur Fracture
Comparative Effects of Closed Kinetic Chain Exercises and Mobilization Exercises in Elderly Females With NFF
This study investigates the additional benefits of Mobilization Exercises and Closed Kinetic Chain Exercises (CKCE) in elderly individuals with post-operative neck of femur fracture.
- Trial name
- NCT06901843
- Testing
- Mobilizations Exercises, Closed Kinetic Chain Exercises
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Superior University
Orthopedic Surgery
Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients
Postoperative delirium (POD) is one of the most frequent complications after surgery in elderly patients, affecting between 20 and 40% of patients older than 60 after major surgery.
- Trial name
- DELIRLESS (NCT04335968)
- Testing
- Melatonin 4 mg
- Where
- France
- Volunteers
- 357 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fractures
Evaluation of the Change in Length of the Leg in Children After Treatment of Femur Fractures.
Femur fractures are a common injury in the Pediatric population. Despite their high incidence little do we know about the long term implications on the bones' length.
- Trial name
- NCT00355420
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Fracture of Tibia
Conservative Versus Intramedullary Nailing for Pediatric Tibial Shaft Fractures
Tibial shaft fracture is a common fracture in the pediatric and adolescent population. The outcomes of both conservative and operative treatment are not clear and to date there is no randomized prospective trial comparing…
- Trial name
- CINPED (NCT05501496)
- Testing
- intramedullary nailing, casting
- Where
- 2 sites in Finland
- Volunteers
- 66 people
- Sponsor
- Turku University Hospital
Blood Transfusion, Hip Fracture Surgeries
Hip Fracture Surgery Timing and Blood Transfusion Risk in Patients on DOACs
This study looks at patients with hip fractures who are taking direct oral anticoagulants (DOACs), a type of blood thinner. In many hospitals, surgery for these patients is delayed because of concerns about bleeding, but waiting…
- Conditions
- Blood Transfusion, Hip Fracture Surgeries, Geriatric, Bleeding Complications
- Trial name
- OPTIMIZEDOAC (NCT07309848)
- Where
- 7 sites in Netherlands
- Volunteers
- 374 people
- Sponsor
- St. Antonius Hospital
Ankle Fractures
Treatment Strategy of Ankle Fracture Combined With Deltoid Ligament Rupture
Ankle fracture is very common which is often combined with deltoid ligament injury. Although the incidence of deltoid ligament injury is high, but there is no unified and effective diagnosis method.
- Trial name
- NCT02977910
- Testing
- repair of deltoid ligament
- Volunteers
- 200 people
- Sponsor
- Liming Cheng
Hip Fracture
Strength Training After Hip Fracture Surgery
The purpose of this study is to examine the effect of progressive strength training of the fractured limb in patients with hip fracture, during admittance in an acute orthopedic ward.
- Trial name
- NCT00848913
- Testing
- Rehabilitation with strength training, Rehabilitation without strength training
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Hvidovre University Hospital
Hip Fractures
PENG Block vs Fascia Iliaca Block for Emergency Department Analgesia in Hip Fractures
Pain management is a crucial aspect of the care of hip fracture patients. Patients with poorly controlled pain have an increased risk of delirium, long-term functional impairment, and remain hospitalized longer.
- Trial name
- NCT05370586
- Testing
- Pericapsular nerve Group Block, Infrainguinal Fascia Iliaca Block
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Distal Femur Fracture
Locking Plates for Distal Femur Fractures - a Multicenter Case Review
In order to assess the rate and mode of failure cases observed in patients with distal femur fractures treated with a distal femur plates, anonymized radiographs from those patients will be collected retrospectively.
- Trial name
- VA_LCP (NCT04008940)
- Testing
- Distal femur plates
- Where
- 5 sites in United States, Switzerland
- Volunteers
- 100 people
- Sponsor
- AO Innovation Translation Center
Tibial Fractures, Nonunion of Fracture
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia.
- Conditions
- Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
- Trial name
- NCT03891888
- Testing
- Intramedullary Bone Graft
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville