Clinical trials: Fracture Non Union
Nonunion of Fracture
NGS for Non-unions
The purpose of this study is to investigate the role of genetic testing to look for possible infection as a cause for failure of non-healing fractures.
- Trial name
- NCT03937310
- Testing
- Next-generation sequencing of swabs collected during surgery
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rothman Institute Orthopaedics
Non Union Diaphyseal Fractures
A Randomized Controlled Cost Study of Infuse BMP 2 vs Iliac Crest Autograft for Non Union of Long Bone Fractures
We are inviting individuals such as yourself, who have diaphyseal fracture (broken bone) with a non union to participate in this research study.
- Trial name
- Infuse (NCT00856479)
- Testing
- Infuse Bone Morphogenic Protein (BMP) 2, iliac crest autograft
- Where
- Canada
- Sponsor
- Ross Leighton
Fractures, Bone
855303-RNA Biomarker Validation
The purpose of this study is to test the accuracy of using RNA in blood as a way to forecast new fracture healing outcome.
- Trial name
- 855303-RNAVal (NCT06872775)
- Testing
- Blood draws to assess RNA expression levels
- Where
- 7 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Pennsylvania
Nonunion of Fracture of Tibia (Diagnosis)
Risk Factors for Post-Operative Nonunion of Tibial Shaft Fractures Based on a Path Analysis Model
Tibial shaft fractures is common long tubular fracture that account for about 13.7% of all fractures. And the incidence of nonunion of tibial shaft fracture varied from 1% to 80%.
- Trial name
- NCT03928912
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Non-union of Fractures
Risk Factors for Development of Non-union of Displaced Midshaft Clavicle Fractures
Clavicle fractures are common and usually heal well without surgery. Most patients recover full shoulder function within a few weeks with conservative treatment, which is the standard in Denmark.
- Trial name
- RisC (NCT06652659)
- Testing
- Non-union
- Where
- 2 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Bispebjerg Hospital
Rheumatoid Arthritis, Osteoarthritis
G7 BiSpherical Acetabular Shell PMCF Study
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for the commercially available G7 BiSpherical Acetabular Shell.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Noninflammatory Degenerative Joint Disease, Avascular Necrosis
- Trial name
- NCT03266874
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 160 people
- Sponsor
- Zimmer Biomet
Distal Femur Fracture
Carbo-fix Lateral Plate Devices and Standard Plate-Nail Constructs in Distal Femur Fractures
The purpose of this randomized clinical trial is to decrease non-union rates in distal femur fracture fixation. Carbo-fix lateral femur plate and standard intramedullary nail-plate constructs have been shown to have lower…
- Trial name
- NCT07280169
- Testing
- Carbo-fix Lateral Plate Device, Standard Plate-Nail Construct
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Missouri-Columbia
Healing of Fracture
Mesenchymal Stem Cells; Donor and Role in Management and Reconstruction of Nonunion Fracture
The investigators hypothesized that mesenchymal stem cells can be isolated from fracture site, iliac crest, and tibial crest, and can be expanded to be used in the management of nonunion fracture.
- Trial name
- NCT01626625
- Testing
- stem cells + hydroxy apatite, autograft taken from iliac crest
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Universitas Indonesia
Fractures, Bone, Fractures, Closed
Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System
This is an open-label, prospective, observational, post-market, uncontrolled, multi-center study intended to evaluate the safety and clinical performance of the FITBONE Transport and Lengthening Nail when used according to the…
- Conditions
- Fractures, Bone, Fractures, Closed, Fractures, Open, Fracture of Femur
- Trial name
- NCT06400732
- Testing
- Fitbone Transport and Lengthening System
- Where
- 9 sites in United States
- Volunteers
- 1 people
- Sponsor
- Orthofix Inc.
Non Union/Delayed Fractures
Mononucleotide Autologous Stem Cells and Demineralized Bone Matrix in the Treatment of Non Union/Delayed Fractures
The study is a prospective, trial to test the safety and feasibility of injecting autologous, isolated, sterile centrifuged NBMC, and Ignite® DBM in the treatment of high risk non union/delayed fractures.
- Trial name
- NCT01435434
- Testing
- the Sepax is a tool to standardize adult stem cell. Ignite ®ICS injectable scaffold manufactured by Wright Medical Technology.
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Long Bone Non-union
Effect of rhBMP-2 or rhBMP-7 on Long Bone Fractures and Non-unions.
Delayed fracture healing continues to cause significant patient morbidity and economic burden to society. Biological stimulation of acute fractures and non-unions includes application of rhBMP-2 and rhBMP-7.
- Trial name
- NCT05065684
- Volunteers
- 150 people
- Sponsor
- University Hospital Muenster
Scaphoid Fracture Non Union
Arthroscopic Scaphoid Grafting Versus Open Grafting in Scaphoid Non Union
the investigators compare the arthroscopic grafting technique with the traditional open technique in th treatment of scaphoid non union as regards the union rate, time to union and functional outcomes to provide the best…
- Trial name
- NCT07320404
- Testing
- Arthroscopic grafting and k wires fixation, open scaphoid grafting with K wires fixation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Scaphoid Fracture, Scaphoid Nonunion
Arthroscopic vs. Open Bone Grafting for Scaphoid Delayed/Nonunion
Single site, prospective, observer-blinded randomized controlled trial. Eighty-eight patients aged 18-68 years with scaphoid delayed/non-union, will be randomized, 1:1, to either open iliac crest cancellous graft reconstruction…
- Trial name
- NCT05574582
- Testing
- Graft reconstruction and internal fixation with compression screw
- Where
- Denmark
- Volunteers
- 88 people
- Sponsor
- Herlev and Gentofte Hospital
Rib Fracture, Flail Chest
Clinical Study of the U-Plate Fracture Repair System to Treat Rib Fractures
The purpose of this study is to gather information about a device used to help fix broken ribs. Hypothesis: Rib fracture repair with the U-plate system is clinically durable and safe for the indications of flail chest repair…
- Trial name
- NCT00556543
- Testing
- U-plate fracture repair system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Long Bone Delayed-Union Fracture
Phase 1/2a Study on Allogeneic Osteoblastic Cells Implantation in Delayed-Union Fractures
Fracture healing is a complex physiological process caused by interaction of cellular elements, cytokines and signaling proteins, which results in the formation of new bone.
- Trial name
- NCT02020590
- Testing
- ALLOB® implantation
- Volunteers
- 25 people
- Sponsor
- Bone Therapeutics S.A
Nonunion of Fracture of Scaphoid Bone, Fractures, Ununited
Scaphoid Non-union and Low-intensity Pulsed Ultrasound Trial
This is a prospective, double-blind, multicentered, randomized controlled trial to determine the effectiveness of low-intensity pulsed ultrasound in decreasing the time to union of scaphoid non-unions after operative fixation as…
- Trial name
- SNAPU (NCT02383160)
- Testing
- Bioventus Exogen 4000: Low-intensity pulsed ultrasound
- Where
- 6 sites in Canada
- Volunteers
- 154 people
- Sponsor
- University of Calgary
Non-union of Fractures
Autologous Stem Cell Therapy for Fracture Non-union Healing
Do mesenchymal stem cells accelerate new bone formation in persistent non-unions.
- Trial name
- NCT02177565
- Testing
- carrier plus in vitro expanded autologous BMSCs
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Lateral Malleolus Fractures
Double Compression Screw Fixation for Symptomatic Non-union of Lateral Malleolar Ankle Fractures
The aim of this prospective clinical trial study is to evaluate the clinical and radiological outcomes of treating non-union of the lateral malleolar ankle fractures by double compression screw fixation technique.
- Trial name
- NCT07539922
- Testing
- Double Compression Screw Fixation for Symptomatic Non-union of Lateral Malleolar Ankle Fractures
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Sohag University
Scaphoid Non-union Advanced Collapse (SNAC Wrist)
The Use of Adaptive Proximal Scaphoid Implant (APSI): Long Term Follow-up
Scaphoid proximal pole fracture with avascular necrosis is a complex surgical problem. In some cases, it's possible to perform a scaphoid hemiarthroplasty with an adaptative proximal scaphoid implant (APSI), made of pyrocarbon…
- Trial name
- NCT06808594
- Testing
- APSI prosthesis implant
- Volunteers
- 36 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Union, Scaphoid
Union Rate of Scaphoid Non-Union Fracture in Adults by Herbert Screw Versus Volar Buttress Plate
This study aimed to evaluate the short-term results of treating non-united scaphoid waist fractures with a humpback deformity by graft and internal fixation using a volar buttress plate versus the use of a Herbert screw.
- Conditions
- Union, Scaphoid, Non-Union Fracture, Herbert Screw
- Trial name
- NCT07039695
- Testing
- Volar buttress plate, Herbert screw
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Helwan University