Clinical trials: Fracture Tibia
Tibia Fracture, Humerus Fracture
A Case Series: TRUMATCH Graft Cage for Segmental Long Bone Defects
This project consists of a prospective case design. Study candidates will include all patients ages 18 and over who were evaluated at UCSD and found to have a critical-sized humerus, femur, or tibia segmental defect that would be…
- Conditions
- Tibia Fracture, Humerus Fracture, Femoral Fracture, Long Bone Segmental Defect
- Trial name
- NCT05668182
- Testing
- TRUMATCH Graft Cage
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Diego
Pilon Fracture of Tibia
Does Age Matter? Outcomes of Pilon Fracture Fixation in Patients Above and Below 40 Years: A Comparative Study
Pilon fractures are severe intra-articular injuries in the distal tibial plafond that result primarily from high-energy axial compression mechanisms such as road traffic accidents or falls from height [1].
- Trial name
- NCT07315581
- Testing
- staged ORIF of pilon fracture
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Cairo University
Fracture Femur, Fracture Tibia
Oral Supplementation With a Formulation Based on Cetylated Fatty Acids for Post-fracture Long Bone Healing
This clinical study aims to evaluate the potential benefits of a formulation based on Cetylated Fatty Acids in improving fracture healing of long bones in the lower limbs.
- Trial name
- CETIULTRA-BONE (NCT07299851)
- Testing
- CFA-based food supplement
- Where
- 6 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Pharmanutra S.p.a.
Tibia Fractures, Trauma (Including Fractures)
Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool
This study aims to evaluate a preoperative fracture analysis tool that uses 3D visualization and biomechanical modeling to assist surgeons in planning screw and plate fixation for complex tibial plateau fractures.
- Conditions
- Tibia Fractures, Trauma (Including Fractures), Surgical Planning
- Trial name
- NCT07193524
- Testing
- 3D Fracture Analysis Tool
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Tibia Fracture
OIF/β-TCP in Patients With Open Tibial Fractures in Need of Bone Grafting
A prospective, randomized, evaluator-blinded, controlled study for subjects with open tibial fractures classified as Gustilo type II, IIIA or IIIB (see Appendix 1) who will receive bone graft implantation for the potential of…
- Trial name
- NCT04960722
- Testing
- OIF/β-TCP
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- BioGend Therapeutics Co.Ltd
Femur Shaft Fracture, Tibia Fractures
Assessing Bone Fracture Healing Effect of Almonds
Femur and tibia shaft fractures are common after trauma with a burden of 5% and 20% respectively. Clinicians recommend costly bone strengthening drugs/supplements while treating bone fractures.
- Conditions
- Femur Shaft Fracture, Tibia Fractures, Vitamin D, Sweet Almonds
- Trial name
- AFHEA (NCT07153302)
- Testing
- Prunus dulcis (sweet almonds)
- Where
- Pakistan
- Volunteers
- 136 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Tibial Fracture, Fracture of the Tibia Type AO/OTA 42
Fracture-Related Outcome Study for Operatively Treated Tibia Shaft Fractures
Approximately 1000 patients presenting with tibial shaft fractures (AO type 42) will be enrolled prospectively in this registry.
- Trial name
- FROST (NCT03598530)
- Testing
- Surgery
- Where
- 15 sites in United States, Belgium and 7 more
- Volunteers
- 1,000 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Femur Fracture, Tibial Fractures
Distal Targeter vs Free-hand
This study is a randomized controlled trial comparing the use of two different surgical techniques--free-hand versus distal targeting jig-based for distal interlock screw--placement and their effects on total operative time and…
- Conditions
- Femur Fracture, Tibial Fractures, Nonunion of Fracture, Nonunion of Fracture of Tibia
- Trial name
- NCT05613257
- Testing
- Distal targeting jig, Free-hand/perfect circles technique
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Cedars-Sinai Medical Center
Proximal Humeral Fracture, Proximal Tibia Fractures
PMCF Study on the Safety, Performance and Clinical Benefits Data of the Zimmer® Plates and Screws System
The study is a monocentric, retro- and prospective, non-randomized, non-controlled and consecutive series post-market study. The purpose of this study is to confirm safety, performance and clinical benefits of the Zimmer® Plates…
- Conditions
- Proximal Humeral Fracture, Proximal Tibia Fractures, Diaphyseal Fracture
- Trial name
- NCT05215613
- Where
- Italy
- Volunteers
- 57 people
- Sponsor
- Zimmer Biomet
Tibia Fracture
Limb Injuries and Post Injury Rehabilitation Trials - Tibial Shaft Fracture
Aim of our study is to compare immediate full weight-bearing and partial weight-bearing for 6 weeks after a tibial shaft fracture treated with intramedullary nailing.
- Trial name
- LIMPER-TSF (NCT05151926)
- Testing
- Full weight-bearing, Partial weight-bearing, Intramedullary nailing
- Where
- 3 sites in Finland
- Volunteers
- 240 people
- Sponsor
- Tampere University Hospital
Smoking, Tibia Fracture
Effect of Tobacco Heating System (THS) on Closed Lower Limb Fracture Healing
The goal of this clinical trial is to investigate the role of switching from cigarette smoking (CS) to tobacco heat system (THS) on the clinical outcome of closed lower limb (tibia and femur) fractures from smokers' orthopedic…
- Trial name
- NCT05859451
- Testing
- Tobacco Heating System (THS), Smoking abstinence
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Tuebingen
Fracture Non Union, Fracture Healing
Prospective Validation Study of the CD8+TEMRA Cells As a Prognostic Biomarker of Healing Outcome After Fracture
In approx. 10-15% of all fracture patients, there is a prolonged healing time or even a complete absence of fracture healing (non-union).
- Conditions
- Fracture Non Union, Fracture Healing, Long Bone Delayed-Union Fracture, Humerus Shaft Fracture
- Trial name
- BioBone (NCT06658379)
- Testing
- CD8+TEMRA
- Where
- 7 sites in Germany
- Volunteers
- 640 people
- Sponsor
- Charite University, Berlin, Germany
Fracture of Tibia Proximal Plateau
Immediate Versus Late Weight Bearing After Tibial Plateau Fractures Internal Fixation
Postoperative rehabilitation for tibial plateau fracture generally involves prolonged non-weight bearing time while other protocols use partial weight-bearing and bracing before full weight-bearing is recommended at 9 to 12 weeks…
- Trial name
- NCT05502679
- Testing
- Weight bearing as tolerated, Pragmatic Exercise protocol
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Assiut University
Tibia Fracture
Is the Expert Nail With Poller Screws Superior to the Distal Tibial Locked Plate in the Management of Short Oblique Distal Tibial Fractures?
Distal tibial fracture management is difficult because of poor blood supply resulted from subcutaneous location. Therefore, the study aims to compare expert intramedullary nail (IMN) with poller screws to the distal tibial locked…
- Trial name
- NCT06436365
- Testing
- Locking expert intramedullary nail fixation, Distal locked plate
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Kasr El Aini Hospital
Closed Transverse Fracture of Shaft of Tibia
Union Rate of Transverse Tibia Fracture
The investigators will compare the three methods of seating a tibial nail - Backslapping or Backslapping with Dynamic Locking or Internal Compression.
- Trial name
- NCT03042533
- Testing
- Conventional Compression, Standard Backslapping, Dynamic Locking with Backslapping
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Washington
Gustilo-Anderson Type III Open Tibia Fracture
Randomized Trial Comparing Irrisept to Saline Irrigation for Infection Prevention
Early debridement and definitive fixation, at the initial operative setting, historically led to no difference in the infection rates for Gustilo-Anderson type III open tibia fractures. However, Lenarz et al.
- Trial name
- NCT05402995
- Testing
- Irrisept (Irrigation Solution), Saline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Brett D. Crist
Stress Fracture Foot, Stress Fracture Ankle
Detecting and Assessing Leg and Foot Stress Fractures Using Photon Counting CT
Stress fractures (fatigue or insufficiency fracture) are caused by the mismatch between bone strength and chronic stress applied to the bone. The vast majority of these fractures occur in the lower extremity.
- Conditions
- Stress Fracture Foot, Stress Fracture Ankle, Stress Fracture of Tibia, Stress Fracture Metatarsal
- Trial name
- FootPCCT (NCT06024798)
- Testing
- Photon-Counting-Computed-Tomography
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Balgrist University Hospital
Open tíbia Fracture
Management of Open Fracture Tibia in Teenagers
The aim of this study is to study the incidence of open tibial fractures in early teenagers and evaluate the management outcomes
- Trial name
- NCT06288139
- Volunteers
- 100 people
- Sponsor
- Assiut University
Tibia Fracture
Unreamed Intramedullary Tibial Nailing in Treatment of Open IIIa Diaphyseal Tibial Fractures in Adults
To study the incidence of non union of Unreamed intramedullary nailing in type IIIa Open diaphyseal fractures of the tibia as a primary outcome and the incidence of complications and clinical and functional outcome as a secondary…
- Trial name
- NCT06280417
- Testing
- Unreamed intramedullary tibial nail
- Volunteers
- 25 people
- Sponsor
- Assiut University
Open Tibia Fracture
Pilot RCT Local Gentamicin for Open Tibial Fractures in Tanzania
Local application of antibiotics directly to the traumatic wound is a promising strategy for the prevention of infection after open tibia fractures, which are a significant source of disease burden globally, particularly in…
- Trial name
- pGO-Tibia (NCT03559400)
- Testing
- local gentamicin injection
- Where
- Tanzania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco