Clinical trials: Fracture of Lower Limb
Ankle Fracture
The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture
The use of prophylactic treatment with vitamin c may prevent complex regional pain syndrome (CRPS)
- Trial name
- CRPS (NCT01338129)
- Testing
- vitamin c
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Lower Extremity Fracture
Atropine Versus Glycopyrrolate in Preventing Spinal Anesthesia Induced Hypotension in Lower Limb Surgeries
A study to compare between intravenous atropine and glycopyrrolate in preventing spinal anesthesia induced hypotension in patients undergoing major lower limb orthopedic surgeries.
- Trial name
- NCT03580889
- Testing
- Atropine, Glycopyrrolate, Normal Saline Flush, 0.9% Injectable Solution
- Where
- Nepal
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Hip Injuries, Hip Fractures
Is the Rate of Early Mobilisation in Hip Fracture Patients Using Alfentanil Better Than Standard Opioid Analgesia?
Hip fracture injuries are linked with increased morbidity, frailty, and mortality risk. Studies have shown that in hip fracture surgery, early mobilisation confers better pain control, 30-day complication and mortality rates and…
- Conditions
- Hip Injuries, Hip Fractures, Pain, Post Operative Pain
- Trial name
- REHAB (NCT06212622)
- Testing
- Alfentanil, Oxycodone
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Unstable Trochanteric Fractures
Proximal Femoral Nail Antirotation™ (PFNA) Versus Gamma Nail 3™ (Gamma3) for Intramedullary Nailing of Unstable Trochanteric Fractures
The purpose of this study is to compare rates of any fracture fixation complication and revision rates after intramedullary fixation of unstable trochanteric fractures between the Proximal Femoral Nail Antirotation™…
- Trial name
- PROGAINT-ES (NCT00736684)
- Testing
- Proximal Femoral Nail AntirotationTM (PFNA), Gamma Nail 3TM (Gamma3)
- Where
- 6 sites in Spain
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Hip Fractures
Treatment of Sub-capital Fractures of Hip Joint by Using TriboFit™ Acetabular Buffer
The purpose of this study is to determine the performance and efficacy during 6 and 12 month post operation. 1. determine changes in patient pain level 2. determine changes in patient functionality 3.
- Trial name
- NCT00663468
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Phoenix Kinetics
Degenerative Joint Disease, Femoral Fracture
Prospective Post-market Study Examining the Effectiveness of the EcoFit®
The purpose of this study is to evaluate the safety and effectiveness of the EcoFit Hip with implacross E polyethylene for total hip replacement surgery.
- Conditions
- Degenerative Joint Disease, Femoral Fracture, Osteoarthritis, Hip, Traumatic Arthritis
- Trial name
- NCT04918680
- Testing
- EcoFit® Total Hip System with implacross® E Polyethylene
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Implantcast North America, LLC
Arthralgia, Trouble Balancing
Even-Up to Minimize Secondary Site Pain For Ankle Fracture
Evaluating impact of use of Even-Up shoe wear device for patients treated in CAM boot walker for an ankle fracture. Randomized controlled trial, randomizing patients into control group with boot treatment only versus boot…
- Trial name
- NCT04164563
- Testing
- Even-Up
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hip Fractures, Anesthesia Local
Shamrock Versus Lumbar Ultrasound Trident - Ultrasound Guided Block of the Lumbar Plexus
The main objective of the trial is to complete a double-blinded randomized controlled trial of a lumbar plexus block with the Shamrock technique versus the Lumbar Ultrasound Trident technique by estimating the time of performance…
- Conditions
- Hip Fractures, Anesthesia Local, Pain, Postoperative
- Trial name
- NCT02255591
- Testing
- Lidocaine-adrenaline added gadolinium.
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Learning Curves and Outcomes of Simulation-based Training
Is Two-on-one Instruction in Virtual Reality Simulation-based Training of Operating Fractures of the Hip for Medical Students as Effective as One-on-one Instruction
The training of orthopedic surgeons has historically relied heavily on an apprenticeship model as the primary way of teaching the various procedures an aspiring surgeon needs to master.
- Trial name
- NCT06612619
- Testing
- Dyad instruction
- Where
- Denmark
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Myocardial Injury
Sufentanil in Patients With Lower Extremity Fracture Surgery Myocardial Damage Function Study
1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3.
- Trial name
- Sipwlefsmdfs (NCT06808841)
- Testing
- Sufentanil injection
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Patella, Joint Instability
Development of a Test Battery for Measurement of Knee Function in Patients With Patellar Instability
About six months after patella stabilizing surgery postoperative restrictions are commonly lifted and patients may consider whether a return to activity/sports is feasible.
- Conditions
- Patella, Joint Instability, Patellofemoral Joint Dislocation
- Trial name
- NCT05119088
- Testing
- Return to Sport testbattery
- Where
- Norway
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Haraldsplass Deaconess Hospital
Educational Problems, Simulation of Physical Illness
Learning Management of Open Fractures on Virtual Patient
A novel virtual world programme with over 240 multiple choice questions was developed to assess the competencies in managing an open fracture of the lower limb according to the British Orthopaedic Association Standards for Trauma…
- Conditions
- Educational Problems, Simulation of Physical Illness, Fractures, Bone, Emergencies
- Trial name
- NCT04605380
- Testing
- Virtual reality online world
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Prevention of Postspinal Shivering
the Use of Magnesium Sulfate for Prevention of Postspinal Shivering
Shivering is an unpleasant experience after spinal anesthesia. Shivering is defined as an involuntary, repetitive activity of skeletal muscles.
- Trial name
- NCT04249804
- Testing
- Magnesium Sulfate 1000 MG
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Distal Radius Fracture, Osteoporosis
Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk
The objective of this study is to determine whether a new minimally invasive method for in vivo measurement of cortical bone tissue properties can identify those who are at risk for fragility fractures of the hip and radius.
- Conditions
- Distal Radius Fracture, Osteoporosis, Hip Fractures
- Trial name
- NCT03076034
- Testing
- Reference Point Indentation
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Femoral Neck Fractures
the Effects of Perioperative Goal Directed and Conventional Fluid Management on the IVC Collapsibility Index
The investigators aimed to compare the effects of targeted fluid management and traditional fluid management on the inferior vena cava collapsibility index in participants who will undergo proximal femoral surgery.
- Trial name
- NCT05154435
- Testing
- mostcare hemodynamic monitor
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Tibial Fractures, Lower Extremity Fracture
Blood Flow Restriction Training in Patients With Lower Extremity Fractures
This study will look at the effect of using a blood flow restriction device during low load strengthening exercises on patients with tibial shaft fractures, compared to patients performing exercise without the device.
- Trial name
- NCT06496035
- Testing
- Blood Flow Restriction with low load exercise, Therapeutic Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Fracture, Lengthening; Leg
Pediatric Orthopaedic Implant Safety & Efficacy
Implant devices are important tools - their use is essential across a number of orthopaedic indications, including hip conditions, trauma and limb deformity.
- Conditions
- Fracture, Lengthening; Leg, Orthopedic Disorder, Deformity of Limb
- Trial name
- Global POISE (NCT05361980)
- Testing
- Pediatric orthopaedic implant
- Where
- Canada
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia