Clinical trials: Fracture of Lower Limb
Femoral Fracture
Analysis of the Relationship Between Early Postoperative Anemia and the Evolution of Autonomy at 6 Months in Patients 75 Years of Age and Older Operated on Following a Fracture of the Upper End of the Femur
Fracture of the upper extremity of the femur is a condition whose frequency increases with age. It is a serious disease, with multiple consequences such as a decrease in life expectancy, quality of life and patient autonomy.
- Trial name
- PAAF (NCT03810092)
- Where
- 5 sites in France
- Volunteers
- 255 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Femur Fracture
Intramedullary Nailing of the Femur:Trochanteric vs Piriformis Starting Portals
This project is designed to determine whether or not the trochanteric insertion portal will show any difference when compared with the piriformis fossa portal in terms of pain and strength of the hip abductor muscles, while…
- Trial name
- TROCHNAIL (NCT00593333)
- Testing
- Antegrade Intramedullary Nail, Trigen Trochanteric Femoral Nail
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Alabama at Birmingham
Hip Fractures
Evaluation of TXA Prior to Surgery in the Geriatric Hip Fracture Population
The overall design of the study is a prospective, double-blinded, randomized study in the geriatric hip fracture population comparing those who receive intravenous tranexamic acid prior to incision to those who receive a placebo.
- Trial name
- TAHFT (NCT03923959)
- Testing
- Tranexamic Acid Injectable Solution
- Where
- United States
- Volunteers
- 283 people
- Sponsor
- Lancaster General Hospital
Fracture of Ankle
Analgesic Benefits of Perineural Versus Intravenous Dexamethasone in Patients Receiving Sciatic Nerve Block
Patients scheduled to have foot and ankle surgery will typically receive a single shot sciatic nerve block to serve as the primary anesthetic and as part of a multi-modal post-operative analgesic plan.
- Trial name
- NCT01616173
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Intracapsular Fracture of Femur, Femoral Neck Fractures
Hip Fracture Exparel Administration Trial Capsule During Hemiarthroplasty
This study will examine the efficacy of Liposomal Bupivacaine (Exparel) in hip fracture patients undergoing hip hemiarthroplasty for femoral neck fractures through a posterior approach.
- Conditions
- Intracapsular Fracture of Femur, Femoral Neck Fractures, Hip Hemiarthroplasty
- Trial name
- HEAT (NCT03502018)
- Testing
- Bupivacaine liposome, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Maimonides Medical Center
Non-inflammatory Degenerative Joint Disease, Osteoarthritis
Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Unicondylar Knee Arthroplasty (UKA) Procedures
This is a prospective study to demonstrate the safety and effectiveness of CORI and to register CORI in China mainland.
- Conditions
- Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Requires Correction of Functional Deformity
- Trial name
- CORI RCT UKA (NCT04797897)
- Testing
- CORI, Conventional
- Where
- 3 sites in Australia, Hong Kong and 1 more
- Volunteers
- 4 people
- Sponsor
- Smith & Nephew, Inc.
Hip Fracture, Pressure Ulcer
Polyurethane Foam on the Sacrum for Prevention
The aim of the present study is to assess whether the application of a new hydrocellular polyurethane foam multilayer dressing shaped for the sacral area (MSP) in addition to standard care reduces the rate of pressure sores (PU)…
- Trial name
- NCT02692482
- Testing
- hydrocellular polyurethane foam multilayer dressing, standard care
- Where
- Italy
- Volunteers
- 359 people
- Sponsor
- Istituto Ortopedico Rizzoli
Femur Neck Fracture
Second Study of the Effect of Teriparatide on Hip Fracture Healing
The purpose of this study is to see whether teriparatide, given for 6 months versus placebo, will improve the healing of hip (femoral neck) fractures that are repaired during surgery using certain types of orthopedic screws.
- Trial name
- NCT01473602
- Testing
- Teriparatide, Calcium supplementation, Vitamin D supplementation
- Where
- 75 sites in United States, Belgium and 12 more
- Volunteers
- 39 people
- Sponsor
- Eli Lilly and Company
Femur Fracture, Tibial Fractures
Distal Targeter vs Free-hand
This study is a randomized controlled trial comparing the use of two different surgical techniques--free-hand versus distal targeting jig-based for distal interlock screw--placement and their effects on total operative time and…
- Conditions
- Femur Fracture, Tibial Fractures, Nonunion of Fracture, Nonunion of Fracture of Tibia
- Trial name
- NCT05613257
- Testing
- Distal targeting jig, Free-hand/perfect circles technique
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Cedars-Sinai Medical Center
Knee Injuries
Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee
This study will investigate whether the treatment of damaged cartilage in the knee with BST-CarGel will increase the amount and quality of cartilage repair tissue when compared with microfracture alone.
- Trial name
- NCT00314236
- Testing
- BST-CarGel with Microfracture, Microfracture without BST-CarGel
- Where
- 18 sites in Canada, South Korea and 1 more
- Volunteers
- 80 people
- Sponsor
- Piramal Healthcare Canada Ltd
Hip Fractures
Randomized Controlled Trial for Exparel Hip Fracture
This is a prospective, randomized study looking at the effect that a long-acting local anesthetic has on pain control in patients having surgery for hip fractures.
- Trial name
- NCT03289858
- Testing
- Exparel, Sodium Chloride
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Massachusetts, Worcester
Tibial Fractures
Use of a Reinforced Injectable Calcium Phosphate Bone Cement in the Treatment of Tibial Plateau Fractures
Case series of tibial plateau fractures using Norian Drillable.
- Trial name
- NCT01132508
- Testing
- Norian Drillable Bone Void Filler
- Where
- 6 sites in Australia, China and 2 more
- Volunteers
- 33 people
- Sponsor
- Synthes GmbH
Inguinal Hernia, Pelvic Fracture
Corona Mortis in Patients Undergoing TEP for Inguinal Hernia
This study aim to describe the presence, type and size of Corona mortis (CMOR) in patients undergoing total extraperitoneal (TEP) inguinal hernia repair procedures.
- Conditions
- Inguinal Hernia, Pelvic Fracture, Acetabular Fracture, Bleeding
- Trial name
- NCT04303442
- Testing
- TEP
- Where
- Bulgaria
- Volunteers
- 300 people
- Sponsor
- Sofia Med Hospital
Femoral Neck Fractures
Safety Study of Femoral Neck Fracture System
The purpose of this study is to assess the reoperation rate of fractures that have occurred at the neck of the femur that are treated with the CONQUEST FN Femoral Neck Fracture System.
- Trial name
- CONQUEST FN (NCT03721835)
- Testing
- CONQUEST FN Femoral Neck Fracture System
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Smith & Nephew, Inc.
Fracture of Calcaneus, Pilon or Tibial Plateau
Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries
This project is designed as a prospective, randomized, comparative study evaluating the use of a negative pressure vacuum device in treating soft tissue injuries and the surgical incision following open reduction and internal…
- Trial name
- VAC-ST (NCT00582998)
- Testing
- Standard Wound Dressing, Vacuum Assisted Closure Device
- Where
- United States
- Volunteers
- 249 people
- Sponsor
- University of Alabama at Birmingham
Metatarsal Stress Fracture, Stress Fracture of Tibia
Photobiomodulation Therapy for the Treatment of Lower Extremity Stress Fractures in a Military Training Setting
The goal of this clinical trial is to compare photobiomodulation therapy (PBMT) in addition to standard of care in the treatment of tibial and metatarsal bone stress injuries in a military training setting.
- Trial name
- PM12 (NCT05843864)
- Testing
- Photobiomodulation Therapy with Standard Physical Therapy
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Brooke Army Medical Center
Pelvic Fracture
Use of Teriparatide to Accelerate Fracture Healing
The purpose of this study is to compare the effect of the drug teriparatide to the effect of placebo on pelvic fracture healing.
- Trial name
- NCT00594906
- Testing
- Teriparatide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Hallux Valgus and Bunion (Disorder), Morton Neuroma
Feasibility of Specific Anesthesia of the Forefoot Preserving the Sensitivity of the Heel for Foot Surgery
Foot surgery is a painful surgery that is usually scheduled in outpatients. A good management of analgesia is the crucial point.
- Conditions
- Hallux Valgus and Bunion (Disorder), Morton Neuroma, Metatarsal Fracture, Ingrown Nail
- Trial name
- DISTIB (NCT03504462)
- Testing
- Specific block of medial and lateral plantar nerves
- Where
- France
- Volunteers
- 27 people
- Sponsor
- CMC Ambroise Paré
Hip Fractures
Surgical Treatment of Hip Fractures Under Peripheral Regional Anesthesia
The study investigates whether treatment of proximal femoral fractures is possible using a peripheral regional anesthesia technique.
- Trial name
- NCT04005404
- Testing
- Ropivacaine (sciatic nerve block), Ropivacaine (lumbar plexus block L2-L4), Ropivacaine (lumbar plexus block Th12-L1)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Helios Research Center
Ankle Fracture
Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)
This study is a randomized controlled trial assessing pain control in ankle fractures repaired with open reduction and internal fixation.
- Trial name
- NCT02480621
- Testing
- Liposomal Bupivacaine with Bupivacaine
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Jamaica Hospital Medical Center