Clinical trials: Fractures, Compression
Vertebral Body Compression
Efficacy of Kyphoplasty With a New Intervertebral Expander
Balloon kyphoplasty is a well-established treatment option to achieve pain relief and to correct kyphotic deformity caused by osteoporotic vertebral compression fracture.
- Trial name
- NCT03521661
- Testing
- Kyphoplasty
- Volunteers
- 41 people
- Sponsor
- Mohammad ARAB MOTLAGH
Osteoporotic Vertebral Compression Fractures
Continuous Mobility and Physical Activity in Vertebroplasty vs Sham for Osteoporotic Vertebral Fracture
The aim of this clinical trial is to determine if vertebroplasty is an effective treatment for acute, painful vertebral fractures due to osteoporosis.
- Trial name
- VOPE2 COMPAS (NCT06776003)
- Testing
- Vertebroplasty
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Spine Centre of Southern Denmark
Vertebral Body Compression Fractures
Evaluating Vertebroplasty and Kyphoplasty for Reducing Trauma-related Fractures
The primary objective of this study is to compare the volume of injected ciment (polymethyl methacrylate) between a group of patients treated with vertebroplasty and a group of patients treated via kyphoplasty.
- Trial name
- NCT01402167
- Testing
- Kyphoplasty, Vertebroplasty
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Vertebra Compression Fracture
Monitoring of Fluoroscopy Time on the Dose Delivered to the Patient During Vertebral Cementoplasty Procedures
The interventional radiology department of the Strasbourg University Hospital performs approximately 1,000 vertebral cementoplasties per year.
- Trial name
- CIMVER (NCT06174077)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Pain
Cannulated Bone Bolt® Screw System Versus Standard Cannulated Screw System Fixation for Pelvic Fractures
The investigators aim is to determine if the cannulated Bone Bolt® screw system will provide improved post-operative pain control as compared to standard cannulated screw system fixation for the operative treatment of LC1…
- Trial name
- NCT07209280
- Testing
- Cannulated Bone Bolt® Screw System, Standard Cannulated Screw System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Compression Fracture Spine, Osteoporosis Fracture
Postrual Reduction With Pillow in Osteoporotic Vertebral Fracture
Vertebroplasty in the symptomatic osteoporotic vertebral fracture has become increasingly popular. However, there have been some limitations in restoring the height of the collapsed vertebrae and in preventing the leaking of…
- Trial name
- NCT03451305
- Testing
- Pillow
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Compression Fracture
QOCA®-Image Medical Platform - Smart VCF Risk Management System
This project aims to develop and validate an automatic detection and classification system for vertebral compression fractures on computer tomography (CT) images using an artificial intelligence (AI) system (named Smart Bone) by…
- Trial name
- NCT04384211
- Testing
- Computer Assisted Detection Software For Vertebral Fractures
- Where
- Taiwan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Multiple Myeloma
Vertebral Augmentation With Kyphoplasty vs Nonsurgical Mgmt for Vertebral Body Compression Fractures
The purpose of this study is to find out how balloon kyphoplasty (surgical repair of the patient's fracture using balloons and bone cement) compares to non-surgical treatment in reducing vertebral compression fractures while…
- Trial name
- NCT01175278
- Testing
- Vertebral Augmentation with Balloon Kyphoplasty, Non-surgical Treatment
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Denosumab Allergy, Zoledronic Acid Allergy
Denosumab vs Zoledronate After Vertebroplasty
Osteoporotic vertebral compression fracture (OVCF) patients had a proportion of secondary fractures after percutaneous vertebroplasty (PVP).
- Trial name
- NCT05598606
- Testing
- Denosumab Injection, Zoledronate
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Shenzhen People's Hospital
Thoracolumbar Compression Fractures
Short Segment Versus Long Segment Transpedicular Screw Fixation in the Correction and Preservation of AO-Type B Thoracolumbar Fracture Alignment: A Comparative Study
To compare the radiological, clinical and functional outcomes of short-segment versus long-segment transpediclular screw fixation in patients with thoracolumbar fractures AO-type B.
- Trial name
- NCT07777653
- Testing
- Short Segment Versus Long Segment Transpedicular Screw Fixation in the Correction and Preservation of AO-Type B Thoracolumbar Fracture Alignment: A Comparative Study
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Femoral Fracture
Fracture Monitor - Femur
Thirty-seven patients diagnosed with femoral fracture to be treated with a compatible plate will be enrolled for this multicenter prospective interventional study.
- Trial name
- NCT05410587
- Testing
- Fracture Monitor (implantable device class III)
- Where
- 4 sites in Germany
- Volunteers
- 37 people
- Sponsor
- AO Innovation Translation Center
Denosumab Allergy
Denosumab vs Alendronate After Vertebroplasty
Osteoporotic vertebral compression fracture (OVCF) patients had a proportion of secondary fractures after percutaneous vertebroplasty (PVP).
- Trial name
- NCT05662358
- Testing
- Denosumab, Alendronate
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Shenzhen People's Hospital
Osteoporotic Fractures, Vertebral Fracture
Percutaneous Vertebroplasty Vs. Sham for Osteoporotic Vertebral Compression Fractures Focusing on Pain and Economy.
The purpose of this randomized double-blind clinical trial is to determine the efficacy of percutaneous vertebroplasty (PVP) in relieving severe pain in patients with MRI-verified acute or sub-acute osteoporotic vertebral…
- Trial name
- VOPE2 (NCT06141187)
- Testing
- Vertebroplasty
- Where
- Denmark
- Volunteers
- 240 people
- Sponsor
- Spine Centre of Southern Denmark
Compression Fracture of Vertebral Body, Osteoporosis
Evaluation of Outcomes for Quality of Life and Activities of Daily Living for BKP in the Treatment of VCFs
The study objective is to collect and report 12-month outcomes pertaining to activities of daily living, quality of life, and safety parameters in a Medicare population to be treated with balloon kyphoplasty in the treatment of…
- Conditions
- Compression Fracture of Vertebral Body, Osteoporosis, Cancer
- Trial name
- EVOLVE (NCT01871519)
- Testing
- Balloon kyphoplasty
- Where
- 25 sites in United States
- Volunteers
- 354 people
- Sponsor
- Medtronic Spinal and Biologics
Lumbar Post-Laminectomy Syndrome, Chronic Low Back Pain
Determining the Prognostic Value of Continuous Intrathecal Infusion
The purpose of this study will be to determine the efficacy and the prognostic value of a continuous intrathecal prognostic infusion test in an in-hospital setting for selecting patients who would have better long term outcomes…
- Conditions
- Lumbar Post-Laminectomy Syndrome, Chronic Low Back Pain, Vertebral Compression Fracture, Failed Back Surgery Syndrome
- Trial name
- NCT03523000
- Testing
- Continuous intrathecal prognostic infusion test, Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University Hospitals Cleveland Medical Center
Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring, Fragility Fracture
Early Internal Fixation Versus NonOperative Care With Early Rehabilitation for LC1 Fragility Fractures of the Pelvis
The goal of this randomized pilot study is to assess feasibility of the trial and to collect information to inform the design of a definitive trial.
- Conditions
- Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring, Fragility Fracture, Internal Fixation, Nonoperative Care
- Trial name
- PIVOT-LC1-Pi (NCT06496867)
- Testing
- Early Internal Fixation, Nonoperative Care with Early Rehabilitation
- Where
- 13 sites in United States, Spain
- Volunteers
- 48 people
- Sponsor
- University of Southern California
Cancer, Hematologic Malignancies
Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid in the treatment of bone disease from multiple myeloma.
- Conditions
- Cancer, Hematologic Malignancies, Multiple Myeloma, Oncology
- Trial name
- NCT01345019
- Testing
- Denosumab, Zoledronic acid, Denosumab (for the open-label treatment phase)
- Where
- 309 sites in United States, Australia and 27 more
- Volunteers
- 1,718 people
- Sponsor
- Amgen
Forearm Fractures
Management of Diaphyseal Forearm Fractures in Adolescents
evaluate and compare the clinical, and radiographic outcomes of 2.7 mm locking compression mini-plate osteosynthesis versus titanium elastic intramedullary nail (TEN) in the surgical management of diaphyseal fractures of both…
- Trial name
- NCT07705347
- Testing
- Open reduction and internal fixation, Closed or mini-open reduction and fixation
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
OVCF Database, Cohort Study
Osteoporotic Vertebral Compression Fracture Cohort Study
The study aims to construct an early warning model for Osteoporotic Vertebral Compression Fracture (OVCF) by integrating TCM syndrome patterns with modern risk factors.
- Trial name
- NCT07321795
- Where
- 4 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wangjing Hospital, China Academy of Chinese Medical Sciences
Osteopenia, Osteoporosis
FREE Study - Fracture Reduction Evaluation
The primary objective of this study is to compare the effectiveness of standard medical therapy alone to kyphoplasty using the KyphX system for the treatment of acute vertebral body compression fractures.
- Conditions
- Osteopenia, Osteoporosis, Multiple Myeloma, Bone Neoplasms
- Trial name
- NCT00211211
- Testing
- Balloon Kyphoplasty
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Medtronic Spine LLC