Clinical trials: Fractures, Open
Orthopaedic Traumatic Open Fractures
Vacuum Assisted Closure as a Treatment for Open Fractures
This project is designed as a prospective, randomized, comparative study evaluating the use of a negative pressure vacuum device in treating traumatic wounds sustained associated with an open fracture.
- Trial name
- VAC-OF (NCT00582361)
- Testing
- Standard Wound Dressing, VAC
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Alabama at Birmingham
Mandibular Fractures
Evaluation of Customized V Plate Versus Conventional Miniplates of Mandibular Angle Fracture
The aim of the study to evaluate the effect of customized V pattern plate fixation versus a conventional superior-inferior mini plates fixation of mandibular angle fracture on mouth opening and radio graphical parameters.
- Trial name
- NCT03761524
- Testing
- Customized V plate fixation, Conventional miniplates fixation
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Calcaneus Fractures
Open Reduction Internal Fixation of Calcaneus Fractures With and Without Bone Graft
The purpose of this study is to compare patient functional outcomes for surgical fixation of calcaneus fractures with and without tricortical iliac crest bone grafting
- Trial name
- CALCANEUS (NCT00582686)
- Testing
- ORIF of Calcaneus with bone grafting, ORIF of Calcaneus without bone grafting
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Alabama at Birmingham
Mandible Fracture
Radiographic and Clinical Evaluation of Three-Dimensional Delta Plate in Internal Fixation of Mandibular Sub-condylar Fractures.
In this study, we intend to examine the efficacy of 3D delta plates through radiographic evaluation of anatomic reduction and vertical ramus height as the main outcome and clinical assessment of pain and range of mandibular…
- Trial name
- NCT07311239
- Testing
- Three Dimensional Delta Plate
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Ain Shams University
Osteoporosis in Post-menopausal Women, Osteoporosis
Intravenous Infusion of Human Mesenchymal Stem Cells (HMM910 ) in Postmenopausal Women With Osteoporosis at High Risk of Fracture
The primary objective of this study is to evaluate the safety and tolerability of human umbilical cord-derived mesenchymal stem cells for injection (HMM910 ) in postmenopausal women with osteoporosis who are at high risk of…
- Trial name
- NCT06949137
- Testing
- Human Umbilical Cord-derived Mesenchymal stem cell
- Where
- China
- Volunteers
- 9 people
- Sponsor
- HELP Therapeutics Co., Ltd.
Deep Venous Thrombosis
Low-Molecular-Weight Heparin (LMWH) for Deep Venous Thrombosis (DVT) Prophylaxis
1. The use of LMWH following open reduction and internal fixation of ankle fractures will reduce the number of thrombi formed. 2. The rates of clinically significant DVT will be equivalent between two groups.
- Trial name
- NCT01029821
- Testing
- Low-Molecular-Weight Heparin
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Non Union Fracture
A Comparative Study of 2 Doses of BM Autologous H-MSC+Biomaterial vs Iliac Crest AutoGraft for Bone Healing in Non-Union
ORTHOUNION is a multi-centre, open, comparative, randomized, clinical trial with three parallel arms that aims to compare the efficacy of three treatments to enhance bone healing in patients with long bone non-union.
- Trial name
- ORTHOUNION (NCT03325504)
- Testing
- Cultured Mesenchymal Stem Cells, Autologous iliac crest graft
- Where
- 19 sites in France, Germany and 2 more
- Volunteers
- 46 people
- Sponsor
- Universidad Autonoma de Madrid
Fracture Dislocation of Ankle Joint
A Prospective Randomized Pilot Study to Compare Open Versus Percutaneous Syndesmosis Repair of Unstable Ankle Fractures
This study evaluates fracture healing, anatomic reduction and return to functioning in patients with unstable Weber C type fractures of the ankle.
- Trial name
- ART (NCT02245893)
- Testing
- open reduction internal fixation (ORIF)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Femoral Fractures, Hemorrhage, Surgical
Effectiveness of Tranexamic Acid in Reducing Blood Loss During Femoral Nail Surgery
This clinical study aims to evaluate the safety and effectiveness of administering a single intravenous dose of tranexamic acid (TXA) before surgery to reduce blood loss in patients undergoing open intramedullary nailing for…
- Conditions
- Femoral Fractures, Hemorrhage, Surgical, Tranexamic Acid Use
- Trial name
- TXA-FemNail (NCT07261930)
- Testing
- Tranexamic Acid
- Where
- Uganda
- Volunteers
- 43 people
- Sponsor
- Masaka Regional Referral Hospital
Proximal Humeral Fracture, Fracture Dislocation
Exactech Proximal Humerus Fracture Plate System Post Market Clinical Follow-up
The objective of this study is to collect and evaluate long-term clinical outcomes data in order to better understand the safety and performance of the Equinoxe Proximal Humerus Fracture Plates over time.
- Conditions
- Proximal Humeral Fracture, Fracture Dislocation, Non-Union Fracture
- Trial name
- NCT05703958
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Exactech
Open Fractures, Degenerative Osteoarthritis and Degenerative Spinal Diseases
A Prospective Randomized Controlled Study on the Clinical Efficacy of a New Surface Modified Composite Coating Orthopedic Implant Device
This study is a prospective, randomized, controlled, double-arm, non-inferiority study that will be carried out in China. It aims to compare two implant systems (the research group uses surface-modified composite coated…
- Trial name
- NCT04481269
- Testing
- Surface-modified composite coated orthopedic implants, conventional orthopedic implants
- Volunteers
- 240 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Surgical Site Infection, Unplanned Fracture-Related Reoperation
Pre-operative Alcohol Skin Solutions in Fractured Extremities
The prevention of infection is an important goal influencing peri-operative care of extremity fracture patients. Standard practice in the operative management of extremity fractures includes sterile technique and pre-operative…
- Conditions
- Surgical Site Infection, Unplanned Fracture-Related Reoperation, Open Appendicular Fracture, Closed Lower Extremity Fracture
- Trial name
- PREPARE (NCT03523962)
- Testing
- DuraPrep, ChloraPrep
- Where
- 27 sites in United States, Canada
- Volunteers
- 8,485 people
- Sponsor
- University of Maryland, Baltimore
Lateral Malleolus Fracture, Minimally Invasive Surgical Procedure
Comparison of Patients Who Underwent Open and Minimally Invasive Fixation in Lateral Malleolar Fractures
The aim of this study was to compare the postoperative clinical, functional and radiological results of two different surgical methods, minimally invasive percutaneous plate osteosynthesis method and open reduction-internal…
- Conditions
- Lateral Malleolus Fracture, Minimally Invasive Surgical Procedure, Postoperative Pain, Patient Discharge
- Trial name
- NCT06753656
- Testing
- Open Surgery, Minimally Invasive Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Giresun University
Acetabular Fracture
Geriatric Acetabular fracTures: Open Reduction Internal Fixation Versus Replacement
Management of acetabular (hip) fractures in the geriatric population can be very challenging because of pre-existing medical comorbidities, pre-existing osteoporosis and increased risk of mortality.
- Trial name
- GATOR (NCT03713853)
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Unity Health Toronto
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Fracture, Trauma
Surgical Treatment Versus Non-surgical Treatment of Ulnar Fractures
The purpose of this study is to determine if surgery using a plate and screws to fix a forearm fracture (ulnar shaft) will improve functional outcome compared to non-operative treatment out to 1 year of follow-up.
- Conditions
- Fracture, Trauma, Ulna Fracture, Orthopedic
- Trial name
- NCT01123447
- Testing
- Open reduction and internal fixation, Closed reduction and short-arm cast
- Where
- 9 sites in Canada, United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Gustilo-Anderson Type III Open Tibia Fracture
Randomized Trial Comparing Irrisept to Saline Irrigation for Infection Prevention
Early debridement and definitive fixation, at the initial operative setting, historically led to no difference in the infection rates for Gustilo-Anderson type III open tibia fractures. However, Lenarz et al.
- Trial name
- NCT05402995
- Testing
- Irrisept (Irrigation Solution), Saline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Brett D. Crist
Intra-Articular or Extra-Articular Distal Humerus Fracture, Distal Humerus Fracture
Clinical Outcomes After Treatment of Distal Humerus Fractures With the LORRAINE 2.5/3.5 mm Distal Humerus System
Distal humerus fractures are fractures of the lower part of the upper arm bone near the elbow. These fractures often require surgery using plates and screws to stabilize the bone while it heals.
- Trial name
- NCT07774091
- Testing
- LORRAINE 2.5/3.5 mm Distal Humerus System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Bonebridge AG
Open Tibia Fracture, Open Dislocation of Ankle
Accelerated Flap Coverage in Severe Lower Extremity Trauma
The goal of this randomized controlled trial is to determine if accelerated flap coverage compared to standard flap coverage timing leads to improved infection-related complications in patients with open fractures and/or…
- Conditions
- Open Tibia Fracture, Open Dislocation of Ankle, Extremity Fracture Lower, Extremity Injuries Lower
- Trial name
- FLAP ATTACK (NCT06293469)
- Testing
- Accelerated Flap Coverage Surgery, Standard of Care Flap Timing
- Where
- 11 sites in United States, Australia and 2 more
- Volunteers
- 356 people
- Sponsor
- Johns Hopkins University
Trauma, Fractures, Open
The New Skin Stretching Device for Treatment of Limb Tension Wounds
A randomized controlled trial is performed to evaluate the effectiveness and safety of the Skin Stretching Device (SSD) on limb tension incision closure by comparing whether the differences in wounds area, wounds closure time and…
- Conditions
- Trauma, Fractures, Open, Wounds and Injuries, Skin Expander
- Trial name
- SSDRCT (NCT03141502)
- Testing
- Skin stretching device (SSD), Skin grafting
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University