Clinical trials: Fractures in the Elderly
Femoral Neck Fractures
Recovery of Physical Functioning After Hip Fracture
The survivors after hip fracture often report severe pain and loss of physical functioning. The poor outcomes cause negative impact on the person's physical functioning and quality of life and put a financial burden on society.
- Trial name
- HIPFRAC (NCT02780076)
- Testing
- Functional training program
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- Vestre Viken Hospital Trust
Osteoporosis
General Practitioner's Place in the Treatment of Fracture Osteoporosis in the Elderly
Osteoporosis is a major public health problem. Its screening and its treatment remain largely insufficient while therapies have demonstrated their effectiveness.
- Trial name
- GEOFRAGE (NCT03402958)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Rennes University Hospital
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Stomach Neoplasms, Colonic Neoplasms
Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients
Postoperative delirium（POD）is a common complication that can directly affect important clinical outcomes, and exert an enormous burden on patients, their families, hospitals, and public resources.
- Conditions
- Stomach Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Sigmoid Neoplasms
- Trial name
- NCT05068180
- Testing
- low-dose neuroleptanalgesia
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Delirium in Old Age, Frailty
Association of Frailty and Delirium in Elderly Hip Fracture Patients
Several studies have shown that frailty can be used as a marker for risk of adverse outcomes in elderly patients such as falls, disability, hospitalization, mortality, and can be used to predict patient clinical outcomes.
- Trial name
- NCT05246254
- Testing
- Frailty index scale
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Healthy, Osteopenia
Clinical Study to Predict the Risk of Bone Fractures With the POROUS Ultrasound Device
Osteoporosis is a widespread medical condition among older people. It causes the bones to weaken and become more likely to break.
- Conditions
- Healthy, Osteopenia, Osteoporosis
- Trial name
- POROUS-preFX (NCT06567054)
- Testing
- Measurements with the POROUS R3C ultrasound device at the midshaft tibia, DXA measurement of the hip and lumbar spine, DXA-based Vertebral Fracture Assessment (VFA)
- Where
- 6 sites in Austria, Germany and 1 more
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- POROUS GmbH
Humeral Fracture
Proximal Humeral Comminuted Fractures in the Elderly - PERCELE Trial
Fractures of the proximal humerus are common in elderly patients. The optimal treatment of comminuted, displaced fractures is subject to controversy, and the results of operative treatment have not been shown to be superior to…
- Trial name
- NCT00999193
- Testing
- locking plate, ORIF, Hemiarthroplasty, Conservative treatment
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- University of Helsinki
Delirium - Postoperative
The Effect of Aromatherapy on Delirium in Critically Elderly Patients Undergoing Fracture Surgery
The aim of this quasi-experimental study was to examine the effect of lavender aromatherapy on delirium in patients who underwent fracture surgery, were in intensive care, and were over 60 years old.
- Trial name
- NCT06772129
- Testing
- Aromatherapy
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Senay Gokdemir
Pain Relief in Proximal Femoral Fracture
PENG-block Versus FIB-block in Emergency Room
The trial aims to verify a possible greater analgesic efficacy of PENG (Pericapsular Nerve Group) block compared to iliac fascia block (FIB block) in elderly patients (age > 65 years) suffering from traumatic fracture of proximal…
- Trial name
- NCT04278807
- Testing
- Regional Anesthesia - Nerve Blocks
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Santo Spirito Hospital, Italy
Elderly (People Aged 65 or More), Hip Fracture
The Role of Precision Anesthesia Strategy on Perioperative Organ Protection in Hip Surgery [PASPOP]
The goal of this clinical trial is to investigate the effect of three anesthetic strategies on organ protection in elderly patients undergoing hip fracture surgery.
- Conditions
- Elderly (People Aged 65 or More), Hip Fracture, Delirium - Postoperative, Organ Protection
- Trial name
- PASPOP (NCT06696404)
- Testing
- Combined Lumbar Plexus and Sacral Plexus Block, iliac fascial block, spinal anesthesia
- Where
- 2 sites in China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Hip Fracture, Proximal Femoral Fracture
Cemented vs Non-cemented Semiendoprosthesis in the Treatment of Proximal Femoral Fractures
The hip semiendoprosthesis is an acceptable method to treat the proximal femoral fractures. Traditionally, the cemented version of the semiendoprosthesis has been used for this indication.
- Trial name
- NCT00859378
- Testing
- Cemented semiendoprosthesis, non-cemented
- Where
- 2 sites in Finland
- Volunteers
- 400 people
- Sponsor
- Kuopio University Hospital
Delirium - Postoperative
Effects of PNB Timing on Postoperative Delirium for Hip Fracture
Hip fracture is a common cause of hospitalization in older adults and is associated with substantial pain and a high risk of delirium.
- Trial name
- NCT07856108
- Testing
- Peripheral Nerve Block for Hip Fracture
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hip Fractures
The Safety of Anesthesia Management for Traumatic Hip Surgery in Elderly
Trauma for hip joint is common in old people. Anesthesia in these types of old patients carries more risk than the adult population.
- Trial name
- NCT02692989
- Testing
- Hip fracture surgery and anesthesia
- Where
- Jordan
- Volunteers
- 1,270 people
- Sponsor
- University of Jordan
Lower Limb Fracture
Prognostic Value of Preoperative Frailty Assessment in Geriatric Lower Limb Orthopedic Surgery
This retrospective study evaluates the effectiveness of frailty assessment tools-specifically the Risk Analysis Index (RAI) and the 5-Item Modified Frailty Index (5-mFI)-in predicting postoperative outcomes for elderly patients…
- Trial name
- NCT07422025
- Testing
- Preoperative Frailty Scoring
- Where
- Egypt
- Volunteers
- 149 people
- Sponsor
- Benha University
Pelvic Ring Fractures
The Use of Intranasal Calcitonin to Improve Pain and Activity in Elderly Pelvic Ring Injuries
Pelvic ring fractures in the geriatric population are a rising problem for surgeons in industrialized countries. Many of these low-energy fractures are treated nonoperatively; however, pain is a significant factor in recovery of…
- Trial name
- NCT03812991
- Testing
- Miacalcin Calcitonin Salmon Nasal Spray
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Missouri-Columbia
Delirium
The Clinical Changes Before and After Sugammadex in the Patients Undergoing Hip Surgery on the Aspect of Delirium
This study evaluated the effect of sugammadex on postoperative delirium in elderly patients undergoing hip fracture surgery. Medical records from 235 consecutive patients undergoing hip fracture surgery were retrospectively…
- Trial name
- NCT02305589
- Testing
- Sugammadex
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Konkuk University Medical Center
Hip Fractures
Stroke Volume Optimisation in Patients With Hip Fracture
The aim of this study is to assess whether intra-operative fluid supplementation (to improve tissue perfusion) can reduce the incidence of postoperative complications in elderly patients with hip fracture.
- Trial name
- FRACTALE (NCT00444262)
- Testing
- hemodynamic optimisation guided using esophageal Doppler, VOLUVEN and others solute
- Where
- 19 sites in France
- Volunteers
- 215 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Elderly, Acetabular Fractures
Acetabular Cerclage and Total Hip Arthroplasty in the Treatment of Acetabular Fractures in Elderly Patients.
We want to present the outcome of complex multifragmented acetabular fractures in the elderly treated with acetabular cerclage and total hip arthroplasty.
- Conditions
- Elderly, Acetabular Fractures, Cerclage Acetabular Fractures, Total Hip Arthroplasty
- Trial name
- jantjeVL (NCT03581669)
- Testing
- Cerclage and total hip arthroplasty
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hip Fractures
Evaluation of TXA Prior to Surgery in the Geriatric Hip Fracture Population
The overall design of the study is a prospective, double-blinded, randomized study in the geriatric hip fracture population comparing those who receive intravenous tranexamic acid prior to incision to those who receive a placebo.
- Trial name
- TAHFT (NCT03923959)
- Testing
- Tranexamic Acid Injectable Solution
- Where
- United States
- Volunteers
- 283 people
- Sponsor
- Lancaster General Hospital
Postoperative Cognitive Dysfunction
The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery
The purpose of this study is to determine whether epidural levobupivacaine applied for the purpose of post-operative analgesia compared to systemic analgesia with morphine leads to better pain control, stronger suppression of the…
- Trial name
- NCT02848599
- Testing
- morphine, levobupivacaine
- Where
- Croatia
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Osijek University Hospital