Clinical trials: Fractures in the Elderly
Distal Radius Fracture
Four or Six Weeks of Immobilization in the Conservative Treatment of Distal Radius Fractures in Elderly Population?
The purpose of this study is to compare if there are differences in wrist function and pain after a distal radius fracture treated conservatively with immobilization for 4 or 6 weeks in elderly patients after six months of…
- Trial name
- NCT05370365
- Testing
- Below elbow cast
- Where
- Spain
- Volunteers
- 135 people
- Sponsor
- Parc de Salut Mar
Hip Fractures, Femoral Neck Fractures
Functional Outcome After ORIF or Arthroplasty for Femoral Neck Fracture
Aim To investigate the effect of internal fixation versus hip arthroplasty on physical function and pain in elderly patients. Methods This is a substudy of an on-going nationwide multicenter registry-based RCT named HipSTHeR…
- Conditions
- Hip Fractures, Femoral Neck Fractures, Undisplaced Fracture, Treatment Complication
- Trial name
- HipFunct (NCT06152198)
- Testing
- Treatment
- Where
- Sweden
- Volunteers
- 340 people
- Sponsor
- Uppsala University
Osteoporosis With Current Fragility Fracture
Partnership for Applied Research in Fracture Prevention Programs for the Elderly
During their lifetime, approximately 50% of Canadian women and 30% of Canadian men will experience at least one fracture due to bone fragility (FF).
- Trial name
- OPTI-FRAC (NCT01745068)
- Testing
- Integrated program
- Where
- 10 sites in Canada
- Volunteers
- 631 people
- Sponsor
- Université de Sherbrooke
Pain, Postoperative
Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia
The purpose of this study is to determine whether, for surgery of the tibia, one dose of methadone provides better control of pain afterward as compared to morphine, which is the usual drug given to control pain after surgery.
- Trial name
- NCT01430182
- Testing
- Methadone, Morphine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Postoperative Delirium
The Effect of Bupivacaine Liposome Preemptive Analgesia on Postoperative Pain and Delirium in Elderly Patients Undergoing Hip Fracture Surgery
To explore the effects of bupivacaine liposomes in preemptive analgesia for iliofascial block on postoperative pain and postoperative delirium in elderly patients with hip fractures, to optimize perioperative analgesia…
- Trial name
- NCT07066111
- Testing
- Tramadol, bupivacaine liposome (ultrasound-guided high iliofascial space block)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Hip Fracture
Comparison of the Ultrasound Supra-inguinal Fascia Iliaca Block vs Femoral Nerve Block
Patients were randomly assigned to tow groups: infrainguinal ultrasound guided iliaca fascia block (FIBSI) and femoral nerve block (FNB) for FIBSI, the probe is placed transversely between anterior superior iliac spine (ASIS) and…
- Trial name
- NCT04692428
- Testing
- Locoregional analgesia
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- University Tunis El Manar
Osteoporosis, Bone Loss
Zoledronic Acid for Osteoporosis in the Elderly
This trial will examine the safety, efficacy and feasibility of a single dose of intravenous zoledronic acid in the maintenance of skeletal integrity for frail, institutionalized women, who are most at risk for the deleterious…
- Conditions
- Osteoporosis, Bone Loss, Fragility Fractures
- Trial name
- ZEST (NCT00558012)
- Testing
- Intravenous zoledronic acid, Vitamin D 800 IU/daily, Calcium 1200 mg/daily
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- University of Pittsburgh
Hip Fractures, Pain, Acute
The Impact of Integrated Preoperative Fascia Iliaca Compartment Block in Elderly Hip Fracture
This prospective randomized controlled study is aimed to determine the advantages of post-admission fascia iliaca compartment block (FICB) in geriatric hip fracture surgery combination with multimodal analgesia compared with no…
- Conditions
- Hip Fractures, Pain, Acute, Hip Fracture Surgery, Delirium in Old Age
- Trial name
- NCT05857462
- Testing
- Post-admission FICB
- Where
- Thailand
- Volunteers
- 420 people
- Sponsor
- Mahidol University
Fracture
Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department
The goal of this clinical trial is to learn if buprenorphine can treat pain in older adults who have broken bones. The main questions it aims to answer are: Is buprenorphine as effective as opioids to treat pain? Are there less…
- Trial name
- NCT07430345
- Testing
- Buprenorphine 0.15 MG, Hydromorphone 0.25 mg IV
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- The Cooper Health System
Postoperative Delirium, Hip Fractures
Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery
Postoperative delirium (POD) is a common and serious complication in elderly patients undergoing surgical repair for hip fractures, often triggered by acute pain, surgical stress, neuroinflammation, and opioid consumption.
- Trial name
- NCT07810556
- Testing
- Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline
- Volunteers
- 130 people
- Sponsor
- Assiut University
Intertrochanteric Fractures
Efficacy and Safety of Cemented and Cementless Prostheses for Unstable Intertrochanteric Fractures in the Elderly
This trial explores the application of different hip replacement materials in elderly patients with unstable intertrochanteric fracture, and aims to provide the experience and basis for hip arthroplasty in elderly osteoporosis…
- Trial name
- NCT03193697
- Testing
- cemented SPII prosthesis, cementless Wagner prosthesis
- Volunteers
- 86 people
- Sponsor
- Harrison International Peace Hospital
Ankle Fractures, Pilon Fracture
FRAME Study (Frailty-Related Ankle Fracture Management and Evaluation)
This will be a multi-centre randomized controlled trial, with London Health Sciences Centre (LHSC) as the lead site. Elderly patients with complex ankle fractures who meet the inclusion criteria and provide consent will be…
- Trial name
- FRAME (NCT05131321)
- Testing
- Primary ankle arthrodesis (fusion), ORIF (open reduction and internal fixation), Intramedullary Fibular Nailing (IMFN)
- Where
- Canada
- Volunteers
- 172 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Femoral Neck Fractures
Hemiarthroplasty Compared to Total Hip Arthroplasty for Displaced Femoral Neck Fractures in the Elderly-elderly
Total Hip Arthroplasty is equal to or better than Hemiarthroplasty in the treatment of displaced femoral neck fractures in the elderly-elderly
- Trial name
- HOPE (NCT02246335)
- Testing
- Cemented total hip arthroplasty, Cemented hemiarthroplasty
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Danderyd Hospital
Sensory Disorder, Sensory Processing Disorder
Investigation of Sensory Processing Patterns of Elderly Individuals Who Have Had Hip Fracture Surgery
This study aims to evaluate the sensory processing processes of elderly adults who have undergone fall-related hip fracture surgery in the last 6 months, according to different patterns, and to examine the relationship between…
- Conditions
- Sensory Disorder, Sensory Processing Disorder, Hip Fractures, Fall Injury
- Trial name
- NCT05811559
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Atlas University
Humerus Fractures, Closed Fracture of the Proximal Humerus
PHILOS Augmented - a Multicenter Randomized Controlled Trial
The primary objective is to compare the mechanical failure risks in the first year after treatment.
- Trial name
- NCT01847508
- Testing
- PHILOS+, PHILOS
- Where
- 9 sites in Austria, Belgium and 2 more
- Volunteers
- 69 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Olecranon Fracture
Treatment of Olecranon Fractures in the Elderly
Operative treatment, with tension band wiring or plate fixation, will be compared with non-operative treatment of displaced olecranon fractures (Mayo classification 2A and 2B) in patients 75 years or older.
- Trial name
- CROFT2 (NCT04670900)
- Testing
- Tension band wiring or plate fixation, Active non-operative treatment with optional plaster cast
- Where
- 12 sites in Norway, Sweden
- Volunteers
- 76 people
- Sponsor
- Oslo University Hospital
Fracture of Femur
Tranexamic Acid in Chinese Elderly Patients With Intertrochanteric Fracture RCT
Hip fracture posed a major challenge to the health care system, with the one-year mortality of hip fracture reported as being approximately 20%.
- Trial name
- NCT04290884
- Testing
- Tranexamic Acid
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- The University of Hong Kong
Hypoalbuminemia, Acute Kidney Failure
The Relationship Between Hypoalbuminemia and Development of Acute Kidney Failure (AKI) According to KDIGO Criteria
This study was designed to determine the association between preoperative and postoperative hypoalbuminemia and AKI in older age hip fracture surgeons, to determine which period of hypoalbuminemia contributes more to AKI…
- Trial name
- NCT03675906
- Testing
- hypoalbuminemia
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Erzincan University
Hip Fracture, Anemia
The Effects of Intravenous Iron on Mobility in Elderly Patients Following Hip Fracture Surgery
The primary aim of this clinical trial is to investigate the effects of intravenous iron on recovery in mobility compared to the pre-fracture level in patients with a hip fracture The main questions it aims to answer are: It is…
- Trial name
- IronHip (NCT06898814)
- Testing
- Ferric Derisomaltose
- Where
- 3 sites in Denmark
- Volunteers
- 210 people
- Sponsor
- Soren Overgaard
GERIATRIC SYNDROMES, Hip Fractures
Incidence of Geriatric Syndromes Overlap
The overlap of depression and delirium as geriatric syndromes present in elderly patients with hospital admission due to hip fracture has been previously studied.
- Conditions
- GERIATRIC SYNDROMES, Hip Fractures, GERIATRIC ASSESSMENT, Delirium
- Trial name
- NCT03647436
- Testing
- Comprehensive Geriatric Assessment. Both groups.
- Where
- Spain
- Volunteers
- 506 people
- Sponsor
- Hospital de la Ribera