Clinical trials: Fragility Fractures
Fragility Fractures of the Pelvis (FFP), Osteoporotic Fractures
Functional Outcomes in Older Adults With Fragility Fractures of the Pelvis: The FFP-France Study
Fragility fractures of the pelvis (FFP) are an increasingly common complication of osteoporosis in older adults and are associated with substantial morbidity, loss of independence, and mortality.
- Trial name
- NCT07871084
- Testing
- Observational Assessment of Fragility Fractures of the Pelvis
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Femoral Fracture, Fragility Fracture
Essential Amino Acid Supplementation for Femoral Fragility Fractures
This trial will evaluate the impact of 4 weeks of postoperative essential amino acid (EAA)-based supplementation on muscle morphology after femoral fragility fracture.
- Conditions
- Femoral Fracture, Fragility Fracture, Muscle Atrophy
- Trial name
- NCT06050668
- Testing
- Essential Amino Acid Supplementation
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Michael C Willey
Living Kidney Donor, Living Kidney Donation
Fracture Risk in Living Kidney Donors
This study will be a population-based, matched retrospective cohort study using linked administrative healthcare databases from Ontario, Alberta, and British Columbia to evaluate the long-term risk of fractures among living…
- Conditions
- Living Kidney Donor, Living Kidney Donation, Fractures, Nephrectomy,Kidney Donation
- Trial name
- NCT07401953
- Testing
- Nephrectomy
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring, Fragility Fracture
Early Internal Fixation Versus NonOperative Care With Early Rehabilitation for LC1 Fragility Fractures of the Pelvis
The goal of this randomized pilot study is to assess feasibility of the trial and to collect information to inform the design of a definitive trial.
- Conditions
- Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring, Fragility Fracture, Internal Fixation, Nonoperative Care
- Trial name
- PIVOT-LC1-Pi (NCT06496867)
- Testing
- Early Internal Fixation, Nonoperative Care with Early Rehabilitation
- Where
- 13 sites in United States, Spain
- Volunteers
- 48 people
- Sponsor
- University of Southern California
Fracture; Pelvic, Insufficiency Fractures
Real World Evidence of SI-BONE's iFuse TORQ TNT Advancing Treatment of Pelvic Ring Fractures
The purpose of this study is to evaluate outcomes in patients treated with iFuse TORQ TNT for pelvic fragility fractures.
- Conditions
- Fracture; Pelvic, Insufficiency Fractures, Fragility Fracture, Sacroiliac; Fusion
- Trial name
- REBAR (NCT07530497)
- Testing
- iFuse TORQ TNT Implant System
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- SI-BONE, Inc.
Postmenopausal Osteoporosis, Accidental Falls, Aged, Exercise Movement Techniques
Progressive Strength and Balance Exercise for Fall Prevention in Postmenopausal Women With Osteoporosis
Postmenopausal osteoporosis increases the risk of fragility fractures, and falls are a major modifiable pathway leading to fracture.
- Conditions
- Postmenopausal Osteoporosis, Accidental Falls, Aged, Exercise Movement Techniques, Fragility Fractures
- Trial name
- NCT07685392
- Testing
- Supervised Progressive Strength and Balance Exercise Program, Home-Based Conventional Exercise Program
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Osteoporosis, Postmenopausal Osteoporosis
Can Serum Lumican Level Identify a Hidden Fragility Phenotype Beyond Bone Mineral Density in Postmenopausal Women?
Osteoporosis is a major cause of morbidity and fragility fractures in postmenopausal women. Bone mineral density (BMD) alone may not fully reflect fracture risk and skeletal fragility.
- Conditions
- Osteoporosis, Postmenopausal Osteoporosis, Frailty, Fragility Fractures
- Trial name
- LUMINOS (NCT07677072)
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Fragility Fracture
Longitudinal Evaluation of Preoperative eHealth Literacy and Nutritional Index on Early Functional Recovery After Fragility Fractures
The integration of digital technologies into chronic disease rehabilitation has transformed people care, yet the specific impact of electronic health literacy on early functional outcomes in fragility fracture people remains…
- Trial name
- NCT07646756
- Where
- China
- Volunteers
- 353 people
- Sponsor
- Shandong University
Fragility Fractures of the Pelvis (FFP), Osteoporosis
Robot Assisted Minimally Invasive Treatment Versus Conventional Surgery for FFP3-4 Fragility Fractures of the Pelvis in Elderly Patients
This prospective randomized controlled trial aims to compare the efficacy and safety of robot assisted minimally invasive treatment versus conventional surgery in elderly patients with FFP3-4 fragility fractures of the pelvis.
- Trial name
- NCT07639619
- Testing
- Robot Assisted Minimally Invasive Fixation, Conventional Open Fixation
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Junbo Liang
Fragility Fractures of the Pelvis (FFP)
Robot Assisted Minimally Invasive Treatment Versus Conservative Treatment for Fragility Fractures of the Pelvis Type 1-2 in Elderly Patients
This prospective randomized controlled trial aims to compare the efficacy and safety of robot assisted minimally invasive treatment versus conservative treatment in elderly patients with FFP1-2 fragility fractures of the pelvis.
- Trial name
- FFP (NCT07636616)
- Testing
- Robot Assisted Minimally Invasive Fixation
- Volunteers
- 152 people
- Sponsor
- Junbo Liang
Pelvic Fractures, Fragility Fractures of the Pelvis (FFP)
Assessment of Treatment Variability for Pelvic Ring Fragility Fractures
Fragility fractures of the pelvic ring are a common injury associated with poor patient outcomes and high healthcare costs. Management of these injuries is evolving with increasing frequency of operative stabilization of the…
- Trial name
- Pelvis ATV (NCT07351123)
- Testing
- Surgical stabilization of pelvic fracture, Closed treatment of pelvic fracture
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Maryland, Baltimore
Chronic Obstructive Pulmonary Disease (COPD), Acute Coronary Syndrome
Feasibility Study of a Digital Interactive Life-style Platform for Individuals After Rehabilitation
The goal of this clinical trial is to evaluate the feasibility and usability of a digital lifestyle platform designed to support patients after discharge from inpatient rehabilitation.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Coronary Syndrome, Fragility Fracture, Minor Stroke
- Trial name
- Feas Platf (NCT07597031)
- Testing
- Digital Lifestyle Platform, Usual Care (Standard Post-Rehabilitation Care)
- Where
- 2 sites in Switzerland
- Volunteers
- 240 people
- Sponsor
- Matthias Wilhelm, MD
Fragility Fracture, Hip Fractures
RESTORE - Study of AGN1 LOEP to Prevent Secondary Hip Fractures
A randomized controlled trial to evaluate AGN1 to prevent secondary hip fractures in osteoporotic women undergoing treatment of index hip fractures.
- Conditions
- Fragility Fracture, Hip Fractures, Osteoporosis
- Trial name
- NCT04796350
- Testing
- AGN1 LOEP treatment
- Where
- 66 sites in Austria, Belgium and 9 more
- Volunteers
- 2,400 people
- Sponsor
- AgNovos Healthcare, LLC
Osteoporosis, Osteoporotic Fractures
RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE
RESTORE tests whether Augmented-FLS, where patients are contacted by a patient navigator (serving as the liaison) and referred to a bone health provider, is better than Enhanced Usual Care, which includes patient and PCP…
- Conditions
- Osteoporosis, Osteoporotic Fractures, Fragility Fracture
- Trial name
- RESTORE (NCT06455085)
- Testing
- Augmented-Fracture Liaison Service Arm, Enhanced Usual Care Arm
- Where
- 23 sites in United States
- Volunteers
- 2,634 people
- Sponsor
- University of Alabama at Birmingham
Depression in Old Age, Fragility Fracture
Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures
The goal of this pilot study is to learn about the feasibility about prescribing anti-depressants at discharge in patients aged 50 years and older with a lower extremity fragility fracture.
- Trial name
- SNRI (NCT05851898)
- Testing
- Duloxetine 30 mg
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Severe Fragility Fracture
Outcomes of Severe Osteoporotic Fractures Hospitalized in France: the CROSS Cohort
The purpose of this study is to determine the outcomes of severe osteoporotic fractures hospitalized in France, the risk of incident severe fracture at 2 years and 5 years and the risk of mortality over 2 and 5 years.
- Trial name
- CROSS (NCT02606162)
- Where
- France
- Volunteers
- 912 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoporosis, Fragility Fracture
Image-guided Computational and Experimental Analyses of Fractured Patient's Bone (GAP)
Due to the increase in the average age of the population, the projections on the number of age-dependent bone fractures appear to be constantly increasing. They are mainly due to bone pathologies, including osteoporosis.
- Trial name
- GAP (NCT04787679)
- Testing
- Hip replacement surgery
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Laura Maria Vergani
Fragility Fracture
MyNOURISH: Hydrolysed Collagen Supplementation in Older Adults With Fragility Fractures
The goal of this clinical trial is to learn whether hydrolysed collagen supplementation (PROTÉGEN Plus) within multidisciplinary care can improve nutrition and recovery in older adults with fragility fractures.
- Trial name
- MyNOURISH (NCT07347236)
- Testing
- Hydrolysed Collagen (PROTÉGEN Plus), Standard Multidisciplinary Care
- Where
- Malaysia
- Volunteers
- 76 people
- Sponsor
- Hospital Pengajar Universiti Putra Malaysia
Osteoporosis With Current Fragility Fracture
Evaluation of an Osteoporosis Prevention Strategy in Women With Osteoporotic Fracture of the Upper Limb
Osteoporosis is a disease characterized by reduced bone mass and increased skeletal fragility, predisposing to an increased fracture risk.
- Trial name
- PREVOST (NCT01780012)
- Testing
- Osteoporosis prevention program
- Where
- France
- Volunteers
- 436 people
- Sponsor
- Hospices Civils de Lyon
Osteoporosis, Arthroplasty Complications
Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
The goal of this clinical trial is to observe the impact of a surgeon-driven bone health referral pathway following lower extremity arthroplasty.
- Conditions
- Osteoporosis, Arthroplasty Complications, Fragility Fracture
- Trial name
- NCT05845021
- Testing
- Surgeon-Initiated Bone Health Referral Pathway
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University