Clinical trials: Frail Elderly Patients
Complication, Postoperative, Perioperative/Postoperative Complications
The Impact of Prehabilitation Bundle on Perioperative Outcome for Frail Elderly Patients Undergoing Major Abdominal Surgery
This study aims to study the efficacy of a preoperative "bundle" of interventions, which consists of preoperative physiotherapy, nutritional support and cognitive exercises on elderly frail patients undergoing major abdominal…
- Trial name
- NCT02921932
- Testing
- Ensure, Resource 2.0 and Glucerna, Cognitive Training, Memory Card Game, 'Threshold' Inspiratory Muscle Trainer, Respironics of New Jersey Inc
- Where
- Singapore
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Squamous Cell Carcinoma of the Head and Neck
FRAIL-IMMUNE (GORTEC 2018-03) - Combination of Durvalumab With Carboplatin/Paclitaxel
The primary objective of the phase II trial is to determine the efficacy and safety of a combination of Durvalumab with the Carboplatin/Paclitaxel as first line treatment in patients with recurrent/metastatic SCCHN not eligible…
- Trial name
- FRAIL-IMMUNE (NCT03723967)
- Testing
- Durvalumab with Carboplatin/Paclitaxel
- Where
- 17 sites in France
- Volunteers
- 104 people
- Sponsor
- Centre Leon Berard
Immunocompromised Patients
Immunogenicity, Efficacy and Safety of Recombinant Herpes Zoster Vaccine in Frail Patients
Herpes zoster (HZ) is a serious health problem whose incidence and severity increase with the decline of cell-mediated immunity (CMI) because of age and immunocompromised (IC) status.
- Trial name
- AID4FRAIL_RZV (NCT07321808)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Frail Elderly, Physical Activity
Effectiveness of an Intervention in Multicomponent Exercise in Patients Over 70 Years in Primary Care
Objective: To evaluate the effect of a multicomponent physical activity program, compared with the usual medical practice, to reverse prefrailty by Fried in people over 70 years, one year after the end of the intervention.
- Trial name
- MEFAP (NCT03568084)
- Testing
- MEFAP, control usual practice
- Where
- Spain
- Volunteers
- 206 people
- Sponsor
- Gerencia de Atención Primaria, Madrid
Frail Elderly, Elderly
Geriatric Education and Its Effect on Certain Aspects of Hospital Care of the Nursing Home Patients - 12 Month Retrospective Study
Nursing home patients admitted to the hospital poses significant challenge for health care providers. Geriatric teaching pays particular attention to these admissions and related problems.
- Conditions
- Frail Elderly, Elderly, Hospitalization, Geriatrics
- Trial name
- NCT01213225
- Volunteers
- 20 people
- Sponsor
- Maimonides Medical Center
NSCLC Stage IV, NSCLC, Stage III
Phase II Efficacy Study of Repotrectinib in Frail and/or Elderly Patients With ROS1-rearranged Advanced NSCLC
ROS1 rearrangements are rare, accounting for only 1-2% of NSCLC cases, but have been associated with response to ROS1 inhibitors, such as crizotinib and entrectinib.
- Trial name
- REPOROS (NCT06552234)
- Testing
- Repotrectinib
- Where
- 20 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Mantle Cell Lymphoma
Acalabrutinib and Rituximab in Previously Untreated Mantle Cell Lymphoma
This is a phase II, single-arm, open-label, multicentre study of acalabrutinib and rituximab for elderly or frail patients with previously untreated mantle cell lymphoma.
- Trial name
- CARAMEL (NCT05004064)
- Testing
- Acalabrutinib, Rituximab
- Where
- 12 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- University College, London
Medication Adherence, Medication Compliance
Supporting the Medication Adherence of Older Mexican Adults Through External Cues Provided With Ambient Displays
Background: Problems with prospective memory, which refer to the ability to remember future intentions, cause deficits in basic and instrumental activities of daily living, such as taking medications.
- Trial name
- NCT04289246
- Testing
- Medication Ambient Display (MAD)
- Where
- Mexico
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Pancreatic Cancer Non-resectable
Stereotactic Radiotherapy vs Best Supportive Care in Unfit Pancreatic Cancer Patients
SUMMARY Rationale: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, its incidence increases with age. Many patients with localized (non-metastatic) PC have significant comorbidities, advanced age or a…
- Trial name
- PANCOSAR (NCT05265663)
- Testing
- stereotactic ablative radiotherapy
- Where
- 2 sites in Netherlands
- Volunteers
- 98 people
- Sponsor
- Amsterdam UMC, location VUmc
Telemedicine, Teleradiology
Teleradiology Program for Frail Patients Living at Home or in Nursing-homes
Transporting radiology to the patient's home is challenging. Preliminary experiences conducted in Turin (Italy) and Lund (Sweden) indicate that the coupling of simple, light-weight X-ray equipments with a Computed radiography or…
- Conditions
- Telemedicine, Teleradiology, Cost-Benefit Analysis, Frail Elderly
- Trial name
- RADHOME (NCT02591602)
- Testing
- Teleradiology Service
- Volunteers
- 162 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Colorectal Neoplasms
Effect of Geriatric Intervention in Frail Elderly Patients Receiving Chemotherapy for Colorectal Cancer
GERICO is a randomized, controlled prospective trial. The aim is to investigate if frail, elderly patients with stage II-IV colorectal cancer, will profit from full comprehensive geriatric assessment and intervention before and…
- Trial name
- GERICO (NCT02748811)
- Testing
- Intervention group
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- University of Copenhagen
COVID-19, Solid Tumor
National Project on Vaccines, COVID-19 and Frail Patients
This is a multicentre observational study with the aim of evaluating the antibody and cellular response after vaccination for SARS-CoV-2 with Pfizer-BioNTech or Moderna vaccines in frail subjects with impaired immuno-competence…
- Conditions
- COVID-19, Solid Tumor, Hematologic Diseases, Neurologic Disorder
- Trial name
- VAX4FRAIL (NCT04848493)
- Testing
- COVID-19 vaccines
- Where
- 12 sites in Italy
- Volunteers
- 747 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Multiple Myeloma, Plasma Cell Leukemia
Use of Isatuximab, Dexamethasone and Lenalidomide in a Go-Slow Fashion for Ultra-Frail Patients With Multiple Myeloma
Historically, the frailest patients with multiple myeloma are under-represented in clinical trials, and have very high rates of treatment discontinuation, and early treatment mortality.
- Trial name
- UltraFrailMM (NCT06517017)
- Testing
- Isatuximab
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Utah
Geriatric Assessment, Health Services for the Aged
Geriatric-CO-mAnagement for Cardiology Patients in the Hospital
The primary objective of the evaluation study is to determine if geriatric co-management is superior to standard of care in preventing functional decline in older patients admitted for acute heart disease or Transcatheter Aortic…
- Conditions
- Geriatric Assessment, Health Services for the Aged, Cardiovascular Diseases, Activities of Daily Living
- Trial name
- G-COACH (NCT02890927)
- Testing
- Cardio-geriatric co-management
- Where
- Belgium
- Volunteers
- 454 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Elderly Inpatients, Frail
Prevalence and Influencing Factors of Frailty in Elderly Patients With Heart Failure
The goal of this observational study is to investigate the prevalence and associated factors of frailty in hospitalized elderly patients with heart failure.
- Conditions
- Elderly Inpatients, Frail, Heart Failure Hospitalization, CGA
- Trial name
- NCT07510035
- Where
- China
- Volunteers
- 298 people
- Sponsor
- Zhejiang Hospital
Diffuse Large B-cells Non-Hodgkin Lymphoma
A Phase II Study of the FIL on Elderly Frail Patients With DLBCL
A phase II study to evaluate the combination of Lenalidomide and Rituximab as front line therapy for the treatment of elderly frail patients evaluated in CGA with Diffuse Large B-cells non-Hodgkin Lymphoma.
- Trial name
- NCT02955823
- Testing
- Rituximab-Dexamethasone-Lenalidomide
- Where
- 18 sites in Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Elderly, Frail
Implementation of a Personalised Health Plan (PHP) on Patient Quality of Life Score at 2-year Follow-up
"Healthy ageing" is not limited to the absence of disease, but implies the "development and maintenance of the functional skills that enable the elderly to enjoy a state of well-being": (for example : the ability to walk, go out…
- Trial name
- FRAPA (NCT06560723)
- Testing
- Quality of life test
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Rouen
Frail Elderly Patients
A Multicenter Observational Study of an Integrated Traditional Chinese and Western Medicine Care Model in Post-Acute Treatment of Frail Elderly Patients
Exploring the Impact and Effectiveness of an Integrated Traditional Chinese and Western Medicine Treatment Model in Post-Acute Care for Frail Older Patients.
- Trial name
- NCT07136935
- Testing
- Traditional Chinese Medicine treatment
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- China Medical University Hospital
Frail Elderly Syndrome
Home-based Prehabilitation for Elderly Patients
As a consequence of the increasing life expectancy hospitals are seeing a growing number of elderly patients undergoing elective surgery.
- Trial name
- TRAilty (NCT03964363)
- Testing
- Unsupervised home-based physical prehabilitation
- Where
- 3 sites in Germany
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypertension
Relationship Between 24-hour Blood Pressure Variability and FRagility in the Elderly Patient
In the 2016's Haute Autorité de Santé (HAS) recommendations (Haute Autorité de Santé. Management of arterial hypertension in adults.
- Trial name
- VAR-24hFR (NCT05818280)
- Where
- France
- Volunteers
- 49 people
- Sponsor
- Pr. Nicolas GIRERD