Clinical trials: Frail Elderly Patients
Osteoporosis, Postmenopausal, Osteoporosis
Preventing Osteoporosis Using Denosumab
The purpose of this research study is to find out if denosumab (Prolia®), an injection given in the arm under the skin every 6 months, works to treat bone loss and prevent it from worsening in older men and women (ages 65 and…
- Conditions
- Osteoporosis, Postmenopausal, Osteoporosis, Osteoporotic Fractures
- Trial name
- PROUD (NCT02753283)
- Testing
- denosumab, Calcium and Vitamin D
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Susan L. Greenspan
Frailty, Frail Elderly Syndrome
Education for Prevention and Treatment of Frailty
Frailty is a condition with a high prevalence in older adults, leading to higher vulnerability and increasing the risk of adverse health outcomes and disabilities.
- Trial name
- FRAGSALUD (NCT05610605)
- Testing
- Health intervention programme: FRAGSALUD
- Where
- Spain
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
Colon Cancer, Fragility
Prehabilitation of Frail Surgical Cancer Patients Using Remote Ischemic Preconditioning
This project will examine the efficacy of a simple, cost-effective, non-invasive intervention, called remote ischemic preconditioning (RIPC), to reduce frailty in pre-surgical, frail, elderly patients with colon cancer.
- Conditions
- Colon Cancer, Fragility, Prehabilitation, Surgery
- Trial name
- Prehab (NCT03853473)
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Medical College of Wisconsin
Cognitive Impairment, Frail Elderly Syndrome
Preoperative Cognitive Screening in Older Spinal Surgical Patients
The objectives of this study are to determine whether identifying patients with baseline cognitive deficits or frailty predict postoperative delirium.
- Trial name
- NCT02922634
- Testing
- Mini Cog
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Weight Loss, Thinness
Low Indexes of Metabolism - Information to Teams (LIMIT)
The purpose of this study is to determine whether alerting primary care providers by email about low values of BMI, HbA1c% or cholesterol will affect treatment and improve overall survival and other health indexes of people older…
- Conditions
- Weight Loss, Thinness, Malnutrition
- Trial name
- LIMIT (NCT02476578)
- Testing
- Volunteers
- 8,584 people
- Sponsor
- Clalit Health Services
Colorectal Cancer
Bevacizumab Plus Capecitabine (Xeloda) in Patients With Untreated Metastatic Colorectal Cancer
The purpose of this study is to evaluate the safety and effectiveness of the bevacizumab and capecitabine combination in frail patients with untreated metastatic colorectal cancer.
- Trial name
- NCT00203411
- Testing
- Capecitabine (Xeloda), Bevacizumab
- Where
- 12 sites in United States
- Volunteers
- 45 people
- Sponsor
- Translational Oncology Research International
Diffuse Large B-cell Lymphoma
A Study of Loncastuximab Tesirine and Rituximab (Lonca-R) in Previously Untreated Unfit/Frail Participants With Diffuse Large B-cell Lymphoma (DLBCL)
The main objective of the trial is to assess the efficacy and tolerability of Lonca-R in unfit and frail participants with previously untreated DLBCL.
- Trial name
- LOTIS-9 (NCT05144009)
- Testing
- Loncastuximab Tesirine, Rituximab
- Where
- 41 sites in United States, Italy and 2 more
- Volunteers
- 41 people
- Sponsor
- ADC Therapeutics S.A.
Hip Fracture, Vitamin D Deficiency
Vitamin D Levels in Frail Elderly Patients With a Hip Fracture
The purpose of this study is to assess whether all frail elderly admitted with hip fracture has a vitamin D deficiency, and if s-25(OH)D deficiency increases the risk of hip fracture in frail elderly.
- Trial name
- NCT01816711
- Where
- Denmark
- Volunteers
- 447 people
- Sponsor
- University of Aarhus
Osteoporosis, Bone Loss
Zoledronic Acid for Osteoporosis in the Elderly
This trial will examine the safety, efficacy and feasibility of a single dose of intravenous zoledronic acid in the maintenance of skeletal integrity for frail, institutionalized women, who are most at risk for the deleterious…
- Conditions
- Osteoporosis, Bone Loss, Fragility Fractures
- Trial name
- ZEST (NCT00558012)
- Testing
- Intravenous zoledronic acid, Vitamin D 800 IU/daily, Calcium 1200 mg/daily
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- University of Pittsburgh
Kidney Failure, Chronic
Advance Care Planning With Older Patients Who Have End-stage Kidney Disease
This study will test the feasibility of carrying out a randomised controlled trial, incorporating a mixed methods process evaluation, to evaluate advance care planning with older patients who have end-stage kidney disease.
- Trial name
- ACREDiT (NCT02631200)
- Testing
- Advance care plan
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Queen's University, Belfast
Fecal Incontinence
Educational-Medical-Behavioral Treatment of Fecal Incontinence
In previous studies at a university referral center the investigators demonstrated that a multicomponent conservative treatment for fecal incontinence was effective.
- Trial name
- FIX (NCT01717456)
- Testing
- Education, Fiber supplements, Laxatives or anti-diarrheals
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of North Carolina, Chapel Hill
Geriatric Assessment, Frail Elderly
Drug Reduction in Older Patients: The DROP Trial
Project Objectives: The proposed randomized, controlled trial will evaluate the effects of procedures to reduce medications among hospitalized older Veterans discharged to nursing homes using an hybrid study design to inform…
- Conditions
- Geriatric Assessment, Frail Elderly, Skilled Nursing Facilities, Patient-centered Care
- Trial name
- DROP (NCT03722017)
- Testing
- Deprescribing intervention
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- VA Office of Research and Development
Chronic Kidney Disease
Chronic Kidney Disease Among Frail Elderly
Chronic kidney disease is a common diagnosis in the elderly population and it is associated with significant morbidity and health care costs. The prevalence rates increase with age to about 40% for adults aged > 65 years.
- Trial name
- FRED-CKD (NCT02351349)
- Testing
- multidisciplinary intervention
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Sameena Iqbal
Osteoporotic Fractures, Osteoporosis, Postmenopausal
Zoledronic Acid for Osteoporotic Fracture Prevention (ZEST II)
The goal of this study is to perform the first fracture reduction clinical trial with a potent antiresorptive agent (intravenous zoledronic acid) in the most vulnerable long-term care population.
- Trial name
- ZEST II (NCT02589600)
- Testing
- Zoledronic acid, vitamin D, calcium
- Where
- United States
- Volunteers
- 310 people
- Sponsor
- Susan L. Greenspan
Frailty, Frail Elderly
Synergizing Home Health Rehabilitation Therapy
The objective of this project is to pilot test an ADL (activities of daily living)-enhanced program as an adjuvant therapy to usual home health rehabilitation to improve patient outcomes.
- Conditions
- Frailty, Frail Elderly, Occupational Therapy, Activities of Daily Living
- Trial name
- NCT05411393
- Testing
- ADL-enhanced program, Usual home health rehabilitation therapy
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Florida