Clinical trials: Frail Elderly Syndrome
Aging, Sarcopenia
Effects of Resistance Training With High vs. Light-moderate Loads on Muscle-tendon Function in the Elderly
There are no unbiased studies that have analyzed the effects of resistance training with traditional, heavy versus light-moderate loads on muscle, tendon and bone in elderly people.
- Conditions
- Aging, Sarcopenia, Frail Elderly Syndrome
- Trial name
- NCT03724461
- Testing
- High Intensity resistance training (12 weeks), Light-moderate intensity resistance training (12 weeks), Control (12 weeks)
- Where
- Spain
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Aortic Valve Stenosis, Clinical Trial
Effect of TF-TAVR on Emotional Status, Quality of Life, Frailty and Inflammation
Aortic valve stenosis (AS) shows high and increasing prevalence in Western civilizations and leads to high morbidity and mortality.
- Conditions
- Aortic Valve Stenosis, Clinical Trial, Depression, Frail Elderly Syndrome
- Trial name
- NCT03308435
- Testing
- Geriatric assessment, Psychiatric assessment, Inflammatory assessment
- Where
- Austria
- Volunteers
- 18 people
- Sponsor
- Medical University of Graz
Sedentary Lifestyle, Physical Activity
Coach2Move: Sustainable in Daily Practice
Implementation of a previously shown (cost-)effective physical therapeutic treatment strategy for community-dwelling older adults.
- Conditions
- Sedentary Lifestyle, Physical Activity, Frail Elderly Syndrome
- Trial name
- NCT03212859
- Testing
- Coach2Move, Usual Care
- Where
- Netherlands
- Volunteers
- 292 people
- Sponsor
- Radboud University Medical Center
Frail Elderly Syndrome, Postoperative Delirium
Different Frailty Scores to Incidence of Post-operative Delirium and Cognitive Dysfunction
Patients who are frail will have higher rate for post-operative morbidities, mortality, prolonged hospital stays, loss of independence, increase in institutionalization, post-operative cognitive dysfunction (POCD) and delirium…
- Conditions
- Frail Elderly Syndrome, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Trial name
- NCT04056871
- Testing
- Frailty Screening Tools
- Where
- Malaysia
- Volunteers
- 400 people
- Sponsor
- University of Malaya
Cognitive Deterioration
Safe & Easy Environment at Home for Patients Presenting a Frail Syndrome
All over the world the increasing prevalence of chronic disorders and its impact on functional decline is challenging the sustainability of health care systems.
- Trial name
- SafEE (NCT02288221)
- Testing
- Patient's answer with non pharmacological therapeutic, Patient's answer without non pharmacological therapeutic
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Ageing, Sleep Apnea
Sleep Apnea in Frail Elderly
Sleep apnea syndrome is common and increases with age. In the elderly, symptoms might be different than in the youngest people, and its consequences might be severe and atypical (falls, functional and cognitive decline).
- Trial name
- SAFE (NCT01294137)
- Testing
- ventilatory polygraphy
- Where
- France
- Volunteers
- 80 people
- Sponsor
- AGIR à Dom
Frailty Syndrome, Older Adults
Feasibility and Effects of Inspiratory Muscle Training Combined With Blood Flow Restriction for Frail Older Adults
This randomized controlled trial study aims to evaluate the feasibility and preliminary efficacy of a combined inspiratory muscle training (IMT) and blood flow restriction (BFR) intervention in frail older adults.
- Conditions
- Frailty Syndrome, Older Adults, Blood Flow Restriction (BFR) Training Effects, Inspiratory Muscle Training
- Trial name
- NCT07573995
- Testing
- Exercise
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University
Frailty, Frailty Syndrome
Characterising Frailty Using Magnetic Resonance Imaging
Ageing is associated with the development of various negative conditions, such as frailty. Defined as a decreased ability to combat negative stressors (e.g.
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome
- Trial name
- PHENOFRIM (NCT04612686)
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Frail Elderly Syndrome
Integrated Care for Frail Older People
This is a qualitative interview study investigating patients', carers' and providers' perspectives on integrated care and integrated care pathways for frail older people in Lambeth and Southwark, south London.
- Trial name
- NCT03260933
- Testing
- No intervention given. This is a qualitative interview study
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- King's College London
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI)
CPAP Randomized Controlled Trial
The overall goal of this randomized controlled trial is to test the hypothesis that in older adults with mild cognitive impairment (MCI) and previously untreated obstructive sleep apnea (OSA), 4 months of web-based sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
- Trial name
- NCT06773416
- Testing
- CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
- Where
- Canada
- Volunteers
- 206 people
- Sponsor
- Sunnybrook Health Sciences Centre
ACS, Frail Elderly Syndrome
The Effect of Frailty and Other Geriatric Syndromes on the Prognosis of Elderly Patients With Acute Coronary Syndrome
This is a prospective observational clinical trail which will recruit 1000-1500 participants over 65 years with frailty and acute coronary syndrome (ACS) in Beijing Friendship hospital.
- Conditions
- ACS, Frail Elderly Syndrome, Elderly Patient
- Trial name
- NCT04580706
- Testing
- this is an observational study with none intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Friendship Hospital
Frail Elderly Syndrome
Development of Clinical Indicators From the Swiss RAI-HC
The project aims at deriving frailty (FI) and complexity (CI) indices from data collected with the Resident Instrument Assessment - Home Care adapted for Switzerland (RAI-HC).
- Trial name
- IndiRAI (NCT03139162)
- Testing
- Swiss RAI-HC assessment
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Frail Elderly Syndrome, Balance; Distorted
Validity Reliability of FrailBESTest in Older Adults
Fraility; It is an age-related biological syndrome. It is characterized by decreased resistance to stressors due to changes in functional reserves and physiological systems.
- Conditions
- Frail Elderly Syndrome, Balance; Distorted, Assessment, Self
- Trial name
- NCT04615533
- Testing
- Frail older adults, assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Kırıkkale University
Frail Elderly Syndrome
Enhanced Primary Care for Elderly
The present health care situation for the elderly in many countries is insufficient and not designed according to the health care needs of the aged population.
- Trial name
- NCT03180606
- Testing
- Multi-disciplinary and personalized primary care
- Where
- 2 sites in Sweden
- Volunteers
- 1,304 people
- Sponsor
- Region Östergötland
Aging, Frail Elderly
EFFECT OF ANIMATION-BASED DIGITAL EDUCATION ON RISK KNOWLEDGE AND FRAILTY IN OLDER ADULTS
With the global aging trend, the management of geriatric risks faced by older adults and the effectiveness of health education for this population are gaining increasing importance.
- Conditions
- Aging, Frail Elderly, Geriatric Syndromes
- Trial name
- NCT07547358
- Testing
- Branching Scenario Animation Education
- Volunteers
- 66 people
- Sponsor
- Saglik Bilimleri Universitesi
Chronic Myeloproliferative Disorders, Leukemia
Donor Stem Cell Transplant in Treating Older or Frail Patients With Hematologic Cancer
RATIONALE: Giving low doses of chemotherapy, such as fludarabine and busulfan, before a donor bone marrow or peripheral blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00296023
- Testing
- anti-thymocyte globulin, filgrastim, therapeutic allogeneic lymphocytes
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Francisco
Polypharmacy, Frail Elderly Syndrome
Discontinuation of Long-term Medications in Older People Entering Nursing Home Care
Older people often have several chronic diseases requiring several medications all at once. Taking several medications all at once is called polypharmacy. Polypharmacy is common in nursing home residents.
- Conditions
- Polypharmacy, Frail Elderly Syndrome, Inappropriate Prescribing, Drug-Related Side Effects and Adverse Reactions
- Trial name
- STOPPFrail (NCT03501108)
- Testing
- STOPPFrail deprescribing criteria
- Where
- Ireland
- Volunteers
- 160 people
- Sponsor
- University College Cork
Frail Elderly Syndrome, Congestive Heart Failure
SMARTCARE Project: Deploying Integrated Health & Social Services for Independent Living by Older People
Against the background of the European Innovation Partnership on Active \& Healthy Ageing, SmartCare aims to define a common set of standard functional specifications for an open ICT platform enabling the delivery of integrated…
- Conditions
- Frail Elderly Syndrome, Congestive Heart Failure, Falls Prevention
- Trial name
- SmartCare (NCT03112109)
- Testing
- 'New care'
- Volunteers
- 2,111 people
- Sponsor
- Him SA
Frailty, Fall
Nicotinamide Supplementation Improves Physical Performance in Older Adults at Risk of Falls
Falls are unplanned events resulting in contact with a lower surface. They are common in older adults, affecting one in three individuals over 65 years old.
- Conditions
- Frailty, Fall, Frailty Syndrome, Falls
- Trial name
- NICE-FIT (NCT06465602)
- Testing
- Nicotinamide
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- University of Chile
Frailty, Surgery--Complications
Protocol for Patients Above 75 Years Undergoing Emergency Laparotomy
In the ProPEL study the effect of a protocol designed for elderly patients about to undergo emergency abdominal surgery will be investigated. The protocol addresses issues of both frailty and ceiling-of -care decisions.
- Conditions
- Frailty, Surgery--Complications, Outcome, Fatal, Frail Elderly Syndrome
- Trial name
- (ProPEL) (NCT04293653)
- Testing
- Protocol for patients above 75 undergoing emergency laparotomy or laparoscopy
- Where
- Norway
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital