Clinical trials: Frail Older Adults
NSCLC, Stage III
Thoracic Radiotherapy Plus Durvalumab in Elderly and/or Frail NSCLC Stage III Patients Unfit for Chemotherapy
This is a randomized, open-label, multicenter, phase II trial investigating the combination of thoracic radiotherapy plus Durvalumab in patients with locally advanced, unresectable NSCLC (stage III) that are unfit for…
- Trial name
- TRADE-hypo (NCT04351256)
- Testing
- Durvalumab Injection [Imfinzi], Thoracic Radiotherapy (TRT) conventionally, Thoracic Radiotherapy (TRT) hypofractionated
- Where
- 14 sites in Germany
- Volunteers
- 51 people
- Sponsor
- Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Frailty
Home-based Empowerment Through Physical Exercise Assisted by Technology for Frail Patients
This project, that lays in Health Ageing mission promoted by European Commission, aims to address the issue of frailty, a condition that poses the elderlies to increased vulnerability, deconditioning, and, ultimately, loss of…
- Trial name
- ARTIDE (NCT07118761)
- Testing
- Home-based walking training
- Where
- 2 sites in Italy, Spain
- Volunteers
- 120 people
- Sponsor
- University Hospital of Ferrara
Geriatrics
Comparative Effects of Modified Otago and Frenkel's Exercises in Geriatric Population
The goal of this randomized clinical trial is to compare the effects of modified Otago and Frenkel's exercises on balance, motor function, fear of fall and quality of life in the geriatric population.
- Trial name
- NCT06460337
- Testing
- Modified Otago exercises, Frenkel's exercises
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Muscle Weakness
CAPABLE for Frail Dually Eligible Older Adults
The Johns Hopkins School of Nursing offers this research study which aims to learn more about whether services that help with medications, muscle strengthening, pain management and changes to houses can help improve older adults'…
- Trial name
- CAPABLE500 (NCT01743495)
- Testing
- 10 home-based functional services sessions over 4 months.
- Where
- United States
- Volunteers
- 281 people
- Sponsor
- Johns Hopkins University
Frailty, Older Adults
+AGIL Barcelona: Integrated Care for Community-Dwelling Frail Older Adults
The goal of this clinical trial is to evaluate the effectiveness of the +AGIL Barcelona program in helping older adults improve their physical abilities and delay disability.
- Conditions
- Frailty, Older Adults, Healthy Aging
- Trial name
- +AGIL (NCT06836167)
- Testing
- exercise promotion, review medication, promoting healthy aging
- Where
- 3 sites in Spain
- Volunteers
- 396 people
- Sponsor
- Parc Sanitari Pere Virgili
Colorectal Cancer
Aflibercept and 5-FU vs. FOLFOX as 1st Line Treatment for Elderly or Frail Elderly Patients With Met. Colorectal Cancer
This is a controlled, open-label, randomized phase- II trial (1:1 randomization) investigating 5-FU + aflibercept and 5-FU + oxaliplatin in elderly and frail elderly patients with mCRC scheduled to receive first line treatment.
- Trial name
- ELDERLY (NCT03530267)
- Testing
- Aflibercept + mLV5FU2, mFOLFOX7
- Where
- 25 sites in Germany
- Volunteers
- 124 people
- Sponsor
- Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Frail Elderly
PReGe in Outdoor Fitness Parks
Older people have been one of the most affected by the Covid-19 pandemic. Restrictive measures to prevent the spread of the virus have affected the lifestyle of older people, which have reduced their level of physical activity.
- Trial name
- PReGe-BIO (NCT04885608)
- Testing
- PReGe
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Lymphoma
Combination Chemotherapy in Treating Older Patients With Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00039351
- Testing
- cyclophosphamide, prednisone, vincristine sulfate
- Where
- 17 sites in Belgium, Egypt and 5 more
- Volunteers
- 32 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Cardiovascular Disease
The Effects of Tai Chi in Older Patients With Cardiovascular Disease
Cardiac exercise rehabilitation consists of walking and bicycling activities. As the population requiring rehabilitation is aging, other forms of exercise may be useful and better tolerated.
- Trial name
- NCT01592357
- Testing
- Tai Chi exercise
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- McMaster University
Older Adults
Exercise Intervention for Pre-frail Elderly
The aim of this study is to evaluate the effectiveness of multicomponet exercise for reversing pre-frailty among Chinese community-dwelling pre-frail older adults.Meanwhile,to explore the effects of multicomponent exercise on…
- Trial name
- NCT06519695
- Testing
- Multicomponent exercises
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Hangzhou Normal University
Complication, Postoperative, Perioperative/Postoperative Complications
The Impact of Prehabilitation Bundle on Perioperative Outcome for Frail Elderly Patients Undergoing Major Abdominal Surgery
This study aims to study the efficacy of a preoperative "bundle" of interventions, which consists of preoperative physiotherapy, nutritional support and cognitive exercises on elderly frail patients undergoing major abdominal…
- Trial name
- NCT02921932
- Testing
- Ensure, Resource 2.0 and Glucerna, Cognitive Training, Memory Card Game, 'Threshold' Inspiratory Muscle Trainer, Respironics of New Jersey Inc
- Where
- Singapore
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Headache, Migraine
Treatment Response to GON Pulsed Radiofrequency in Elderly Patients With Chronic Migraine
Headache disorders are highly prevalent in older adults, yet their management remains challenging due to comorbidities, polypharmacy, and the paucity of evidence derived from geriatric populations.
- Trial name
- FRAIL-GON (NCT07363083)
- Volunteers
- 100 people
- Sponsor
- Ankara City Hospital Bilkent
Healthy Volunteers, Frail Volunteers
Sampling of Human Microbiota in Order to Test, on a Mouse Model, Individualized Intervention Strategies During Aging
Human microbial flora transfer studies in rodent models have clearly identified that age-associated microbiota dysbiosis can play a decisive role with respect to pathologies or complications linked to aging: increased intestinal…
- Trial name
- FRAGIBIOTE (NCT04753580)
- Testing
- Stool collection
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Anticoagulants Causing Adverse Effects in Therapeutic Use, Atrial Fibrillation
Atrial Fibrillation: Risk and Benefits of Anti-coagulation in the Elderly
This study was designed to assess the effectiveness of oral anticoagulants in elderly patients (>=75 years) with atrial fibrillation.
- Conditions
- Anticoagulants Causing Adverse Effects in Therapeutic Use, Atrial Fibrillation, Frail Elderly Syndrome
- Trial name
- Carebbean-e (NCT03828162)
- Testing
- Anticoagulants
- Volunteers
- 2,943 people
- Sponsor
- Karolinska Institutet
Muscle Strengh, Frailty
Effectiveness of Intervention in Prevention of Sarcopenia, Frailty and Functional Decline in Pre-frail Community Elderly
Frailty is a geriatric syndrome characterized by a decrease in the function of various organs and systems that leads to a greater risk of suffering from diseases or disabilities.
- Conditions
- Muscle Strengh, Frailty, Sarcopenia
- Trial name
- ESPAI-F (NCT06280586)
- Testing
- Multidisciplinary intervention
- Where
- 2 sites in Spain
- Volunteers
- 232 people
- Sponsor
- Consorci Sanitari del Maresme
Frail Elderly Syndrome, Coronary Heart Disease
Frailty Syndrome in Daily Practice of Interventional Cardiology Ward
The impact of frailty on immediate and long term outcomes of invasive treatment of coronary artery disease is not fully characterized.
- Conditions
- Frail Elderly Syndrome, Coronary Heart Disease, Acute Coronary Syndrome, Coronary Artery Bypass Grafting
- Trial name
- FRAPICA (NCT03209414)
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Silesia
Frail Elderly Syndrome
Transforming Primary Care for Older Canadians Living With Frailty
It is well known that older Canadians are high users of health care services. What is less well known is that the health care system is not well-designed to meet the needs of those who use it most.
- Trial name
- NCT03442426
- Testing
- Integrated model of primary care
- Where
- 3 sites in Canada
- Volunteers
- 695 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Frail Elderly Syndrome
Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults
This is a pilot study to test the efficacy of the anti-inflammatory drug (Fisetin) in reducing inflammatory factors in blood in elderly adults and to test the efficacy of the drug (Fisetin) in reducing frailty and markers of…
- Trial name
- AFFIRM-LITE (NCT03675724)
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Obesity
MOWI Qualitative Assessment
This qualitative study seeks to assess whether mobile health technologies are helpful for older adults. It is the first in a series of four studies whose overarching goal is to conduct a program of pilot research aimed at…
- Trial name
- NCT03041831
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Frail Elderly, Frailty
Frailty Training for Emergency Nurses: A Cluster RCT in Morocco
This study tests whether a training program helps nurses better recognize and care for older adults with frailty in hospital emergency departments.
- Trial name
- NCT07892612
- Testing
- Structured Educational Program on Geriatric Frailty
- Where
- Morocco
- Volunteers
- 144 people
- Sponsor
- Cadi Ayyad University