Clinical trials: Frail Older Adults
Elderly People
Immune Benefits of WGP in Elderly
The aim of this research is to assess the immune enhancing property of food fibers in the elderly population.
- Trial name
- NCT02262091
- Testing
- Food fibers, Maltodextrin, Influenza vaccine (incl. criterion)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Société des Produits Nestlé (SPN)
Anesthesia, General, Aged, 70 and Over
Frail Status of Elderly Patients After Repair and Anesthesia Guided by the bispectraL Index
The first aim of this study is to compare two methods of administration of intravenous anesthetics to obtain the same level of depth (bispectral index between 40 and 60): manual or automated and to determine a mid-term (6 months)…
- Trial name
- FRAGIL (NCT02524327)
- Testing
- Toolbox: Automated group, Manual group
- Where
- 4 sites in France
- Volunteers
- 134 people
- Sponsor
- Hopital Foch
Frail Elderly Syndrome
Implementing, Evaluating, and Scaling Up of the Strengthening a Palliative Approach in Long Term Care (SPA-LTC) Program
This study will evaluate the implementation of the Strengthening a Palliative Approach in Long-Term Care (SPA-LTC) program using a cross-jurisdictional, effectiveness-implementation type II hybrid design (dual testing of clinical…
- Trial name
- NCT03935997
- Testing
- Strengthening a Palliative Approach in Long-Term Care (SPA-LTC) Program
- Where
- 4 sites in Canada
- Volunteers
- 594 people
- Sponsor
- McMaster University
Aging
Comparison of Subacute and Hospital Based Rehabilitation Care
The proposed study objective is to compare hospital-based rehabilitative care with transitional subacute rehabilitation for adults recently diagnosed with a disabling disorder.
- Trial name
- NCT00038363
- Testing
- Rehabilitation, Subacute care
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- US Department of Veterans Affairs
CLL (Chronic Lymphocytic Leukemia)
A Trial to Evaluate the Efficacy and Safety of a Fitness-adapted Thera-py Approach With Either Continuous Zanubrutinib Monotherapy or Time-limited Zanubrutinib + Sonrotoclax in Older and/or Frail Patients With Treatment-naïve CLL
The CLL-Frail2 trial will be a prospective, open-label, multicentre phase-II-trial to evaluate the efficacy and safety of a fitness-adapted therapy approach with either con-tinuous zanubrutinib (BGB-3111) monotherapy or…
- Trial name
- NCT07899398
- Testing
- Zanubrutinib, Sonrotoclax
- Volunteers
- 80 people
- Sponsor
- German CLL Study Group
Glioblastoma Multiforme
Chemoradiotherapy Versus Chemotherapy for Elderly and Frail GBM Patients
Currently, the optimal treatment regimen for elderly Glioblastoma (GBM) patients with poor performance status (PS) is unknown. Based on data for elderly GBM patients and the limited data for patients with poor PS…
- Trial name
- NCT04765514
- Testing
- Temozolomide monotherapy, Chemo-Radiotherapy with concurrent temozolomide.
- Where
- 2 sites in Canada
- Volunteers
- 107 people
- Sponsor
- AHS Cancer Control Alberta
Pre-Frailty, Aging
Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults
Frailty is associated with biological changes in the gut microbiome and immune system, along with marked declines in physical and cognitive function, leading to an overall reduction in quality of life.
- Trial name
- RtM (NCT07454616)
- Testing
- Supervised exercise program, a balanced micronutrient blend
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- National University of Singapore
Frail Elderly Syndrome
Screening of the Frailty Degree in the Emergency Department Short Stay Unit
Screen all those> 65 years of age admitted to the Short Stay Unit for frailty, and detect those who are potentially fragile.
- Trial name
- NCT04812834
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Sedentary Lifestyle, Physical Activity
Coach2Move: Sustainable in Daily Practice
Implementation of a previously shown (cost-)effective physical therapeutic treatment strategy for community-dwelling older adults.
- Conditions
- Sedentary Lifestyle, Physical Activity, Frail Elderly Syndrome
- Trial name
- NCT03212859
- Testing
- Coach2Move, Usual Care
- Where
- Netherlands
- Volunteers
- 292 people
- Sponsor
- Radboud University Medical Center
Poor Performance Status
Innovative Training Methods for Frail Elderly in the Training Gain Stage
This study aims to examine long term effects in the training gain stage of the falls management exercise programs (FaME, from Skelton and Dinan) over 10 weeks on physical functional performance after mechanical SR-WBV, dance…
- Trial name
- NCT01713790
- Testing
- Stochastic resonance whole-body vibration, Exergame, Leg press
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bern University of Applied Sciences
Osteoporosis, Postmenopausal, Osteoporosis
Preventing Osteoporosis Using Denosumab
The purpose of this research study is to find out if denosumab (Prolia®), an injection given in the arm under the skin every 6 months, works to treat bone loss and prevent it from worsening in older men and women (ages 65 and…
- Conditions
- Osteoporosis, Postmenopausal, Osteoporosis, Osteoporotic Fractures
- Trial name
- PROUD (NCT02753283)
- Testing
- denosumab, Calcium and Vitamin D
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Susan L. Greenspan
Frail Elderly Syndrome, Primary Prevention
Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams
The increase in the population over 60 years of age who could receive surgery due to changes in life expectancy and advances in surgical and anesthetic techniques.
- Conditions
- Frail Elderly Syndrome, Primary Prevention, Postoperative Delirium, Frailty
- Trial name
- NPPOD (NCT05993754)
- Testing
- Non-pharmacological intervention
- Where
- Chile
- Volunteers
- 400 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Lymphoma
Combination Chemotherapy in Treating Older Patients With Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00039351
- Testing
- cyclophosphamide, prednisone, vincristine sulfate
- Where
- 17 sites in Belgium, Egypt and 5 more
- Volunteers
- 32 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Hip Osteoarthritis, Knee Osteoarthritis
Fit-Joints: Getting Fit for Hip or Knee Replacement
Osteoarthritis leads to reduced independence and quality of life. Total hip replacement is a successful and cost-effective surgical intervention to relieve pain and improve functioning in patients with osteoarthritis.
- Trial name
- Fit-Joints (NCT02885337)
- Testing
- Multi-Modal Frailty Intervention, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- McMaster University
Frail Elderly Syndrome, Patient Admission
Geriatric Assessment and Intervention for Older Patients With Frailty in the Emergency Department
Comprehensive Geriatric Assessment (CGA) is an established approach for better detection of frailty-related problems and includes individualized treatment plan with multi-discipline supportive and treating measures for the older…
- Conditions
- Frail Elderly Syndrome, Patient Admission, Hospital Readmission, Length of Stay
- Trial name
- GAOPS (NCT03751319)
- Testing
- CGA
- Where
- Finland
- Volunteers
- 432 people
- Sponsor
- Helsinki University Central Hospital
Fractures, Hip, Femoral Neck Fractures
Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures
The goal of this clinical trial is to explore the effects of different peripheral nerve blocks in older adults with hip fractures. It will also explore the safety of preoperative administration of peripheral nerve blocks.
- Conditions
- Fractures, Hip, Femoral Neck Fractures, Intertrochanteric Fractures, Subtrochanteric Fractures
- Trial name
- NCT07130006
- Testing
- PENG and LFCN peripheral nerve blocks with spinal anesthesia, FN and LFCN peripheral nerve blocks with spinal anesthesia, FIC peripheral nerve block with spinal anesthesia
- Where
- Croatia
- Volunteers
- 256 people
- Sponsor
- University Hospital of Split
Frail
Effects of a Nutritional Supplementation on the Functional Status of Frail Elders With Low Socioeconomic Status (SES)
The purpose of this study is to determine whether protein-energy nutritional supplementation improves geriatric function in community-dwelling frail older adults of low socioeconomic status.
- Trial name
- NCT01404299
- Testing
- Nutritional Supplementation, Control
- Where
- South Korea
- Volunteers
- 87 people
- Sponsor
- Gangbuk-gu Community Health Center
Colon Cancer
PrehabPal: A Digital Tool to Help Older Adults Prepare for Cancer Surgery
This is a multi-center, randomized trial investigating the use of PrehabPal web app versus a written surgery prehabilitation instructions among individuals aged 65 years and older preparing for colon cancer surgery.
- Trial name
- NCT05520866
- Testing
- PrehabPal
- Where
- 3 sites in United States
- Volunteers
- 132 people
- Sponsor
- University of California, San Francisco
Rheumatic Arthritis
Intervention to Support Partners and Informal Caregivers of Frail RA-patients
Background Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with pain, fatigue, functional limitations, and reduced quality of life.
- Trial name
- INSPIRE (NCT07442773)
- Testing
- Caregiver support
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Pre-frail Elderly
Effects of Combined Motor and Cognitive Training in Pre-frail Elderly
The objective of this study is to investigate psychometric properties of dual-task walking assessments and compare effects of combined motor and cognitive training on physical fitness, brain fitness, and dual-task walking…
- Trial name
- NCT04605809
- Testing
- combined motor and cognitive training, motor training alone, cognitive training alone
- Where
- Taiwan
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Chang Gung University